Detailed information of TA system TA038619

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): /BrnT(toxin)
• Location: 36118..36616
• Replicon: chromosome
• Accession: NZ_AP024548
• Organism: Vibrio cholerae strain BCH-01536

Toxin (Protein)

• Gene name: -
• Uniprot ID: Q9KMK7
• Locus tag: K6J77_RS14125
• Protein ID: WP_000589156.1
• Coordinates: 36118..36384 (+)
• Length: 89 a.a.

Antitoxin (Protein)

• Gene name: -
• Uniprot ID: Q9KMK6
• Locus tag: K6J77_RS14130
• Protein ID: WP_000643598.1
• Coordinates: 36371..36616 (+)
• Length: 82 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
K6J77_RS18950	31646..31744	+	99	WP_223225486.1	DUF3709 domain-containing protein	-
K6J77_RS14080	31944..32045	+	102	WP_001921603.1	hypothetical protein	-
K6J77_RS14085	32035..32421	+	387	WP_000703163.1	VOC family protein	-
K6J77_RS14090	32616..32867	+	252	WP_001890111.1	TIGR03643 family protein	-
K6J77_RS18955	32840..32989	+	150	WP_071908333.1	DUF3265 domain-containing protein	-
K6J77_RS14095	33081..33323	+	243	WP_000107461.1	hypothetical protein	-
K6J77_RS14100	33575..33853	+	279	WP_000280324.1	DUF3709 domain-containing protein	-
K6J77_RS18960	34285..34328	+	44	Protein_57	hypothetical protein	-
K6J77_RS18965	34310..34403	+	94	Protein_58	ggdef family protein	-
K6J77_RS18970	34372..34503	+	132	WP_001883067.1	hypothetical protein	-
K6J77_RS14115	34675..35142	+	468	WP_001289288.1	OsmC family protein	-
K6J77_RS14120	35270..35933	+	664	Protein_61	hypothetical protein	-
K6J77_RS18975	35923..36051	+	129	WP_088124358.1	DUF3265 domain-containing protein	-
K6J77_RS14125	36118..36384	+	267	WP_000589156.1	BrnT family toxin	Toxin
K6J77_RS14130	36371..36616	+	246	WP_000643598.1	hypothetical protein	Antitoxin
K6J77_RS14135	36712..37506	+	795	WP_001911581.1	hypothetical protein	-
K6J77_RS18980	37503..37619	+	117	WP_086010881.1	DUF3265 domain-containing protein	-
K6J77_RS14140	37609..37737	+	129	WP_071908338.1	general secretion pathway protein GspI	-
K6J77_RS14145	37798..37980	+	183	WP_000923182.1	DUF645 family protein	-
K6J77_RS14150	38196..39200	+	1005	WP_000964920.1	LD-carboxypeptidase	-
K6J77_RS14155	39353..39712	+	360	WP_001071541.1	VOC family protein	-
K6J77_RS18985	39779..39964	+	186	WP_001999468.1	hypothetical protein	-
K6J77_RS18990	40096..40218	+	123	WP_001937972.1	DUF3709 domain-containing protein	-
K6J77_RS14165	40486..40992	+	507	WP_000393074.1	hypothetical protein	-
K6J77_RS14170	41149..41535	+	387	WP_000703163.1	VOC family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	Similar MGE(s) Similar MGE(s) is defined as other TA-related MGE(s) with Mash distance < 0.01 to this MGE. Detail Genome accession Organism MGE type Related TA Coordinates Mash distance View NC_002506 Vibrio cholerae O1 biovar El Tor str. N16961 Integron TA000164, TA000169, TA000166, TA000167, TA000179, TA000170, TA000171, TA000172, TA000173, TA000174, TA000175, TA000176, TA000177, TA000178, TA000168, TA000165, TA010030, TA010035 309750..435387 0.004	inside	Integron	-	-	11978..113648	101670

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Ribonuclease toxin, BrnT, of type II toxin-antitoxin system (6-81)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 89 a.a.
• Molecular weight: 10092.34 Da
• Isoelectric Point: 7.3171

>T38619 WP_000589156.1 NZ_AP024548:36118-36384 [Vibrio cholerae]
MIKFEFDENKSRSNLEKHGIDFHTAQGLWNDSDLIEIPANTSDEPRYLVVGLLNGKHWSGVITYRGTNIRIISVRRSRKA
EVSLYESA

Nucleotide

• Length: 267 bp

>T38619 NZ_AP024548:36118-36384 [Vibrio cholerae]
ATGATTAAATTTGAATTTGATGAAAACAAAAGCAGAAGTAATCTCGAAAAGCACGGTATTGATTTTCATACAGCTCAAGG
ATTGTGGAATGATTCAGATCTTATCGAGATCCCTGCTAACACGAGTGATGAGCCCAGATATTTGGTTGTCGGCTTACTAA
ACGGTAAGCATTGGTCAGGAGTAATTACCTACCGAGGTACGAATATCAGGATCATCTCAGTTCGGCGTTCACGGAAAGCG
GAGGTAAGCCTTTATGAAAGCGCATGA

Antitoxin

Protein

• Length: 82 a.a.
• Molecular weight: 9478.77 Da
• Isoelectric Point: 6.4832

>AT38619 WP_000643598.1 NZ_AP024548:36371-36616 [Vibrio cholerae]
MKAHEFDAKFESDDDDIVMDLDLSQAKRPMHKQKRVNVDFPAWMLESLDREASRIGVTRQSIIKIWLAERLESVSHHSSV
R

Nucleotide

• Length: 246 bp

>AT38619 NZ_AP024548:36371-36616 [Vibrio cholerae]
ATGAAAGCGCATGAATTTGATGCCAAGTTTGAAAGTGACGACGATGATATCGTAATGGACTTGGATCTATCGCAAGCTAA
AAGACCGATGCATAAGCAAAAACGAGTCAATGTAGATTTTCCAGCCTGGATGCTTGAGTCCTTGGACAGAGAAGCGAGTC
GTATTGGTGTAACACGTCAATCAATCATTAAAATTTGGCTGGCAGAAAGGTTAGAGAGCGTGTCTCATCATTCAAGTGTG
AGATAA

Structures

Toxin

• AlphaFold DB: A0A271VMP7

Antitoxin

• AlphaFold DB: A0A271VME2