Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /BrnT(toxin)
Location 36118..36616 Replicon chromosome
Accession NZ_AP024548
Organism Vibrio cholerae strain BCH-01536

Toxin (Protein)


Gene name - Uniprot ID Q9KMK7
Locus tag K6J77_RS14125 Protein ID WP_000589156.1
Coordinates 36118..36384 (+) Length 89 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID Q9KMK6
Locus tag K6J77_RS14130 Protein ID WP_000643598.1
Coordinates 36371..36616 (+) Length 82 a.a.

Genomic Context

K6J77_RS18950K6J77_RS14080K6J77_RS14085K6J77_RS14090K6J77_RS18955K6J77_RS14095K6J77_RS14100K6J77_RS18960K6J77_RS18965K6J77_RS18970K6J77_RS14115K6J77_RS14120K6J77_RS18975K6J77_RS14125K6J77_RS14130K6J77_RS14135K6J77_RS18980K6J77_RS14140K6J77_RS14145K6J77_RS14150K6J77_RS14155K6J77_RS18985K6J77_RS18990K6J77_RS14165K6J77_RS14170
Location: 31646..31744 (99 bp)
Type: Others
Protein ID: WP_223225486.1
Location: 31944..32045 (102 bp)
Type: Others
Protein ID: WP_001921603.1
Location: 32035..32421 (387 bp)
Type: Others
Protein ID: WP_000703163.1
Location: 32616..32867 (252 bp)
Type: Others
Protein ID: WP_001890111.1
Location: 32840..32989 (150 bp)
Type: Others
Protein ID: WP_071908333.1
Location: 33081..33323 (243 bp)
Type: Others
Protein ID: WP_000107461.1
Location: 33575..33853 (279 bp)
Type: Others
Protein ID: WP_000280324.1
Location: 34285..34328 (44 bp)
Type: Others
Protein ID: Protein_57
Location: 34310..34403 (94 bp)
Type: Others
Protein ID: Protein_58
Location: 34372..34503 (132 bp)
Type: Others
Protein ID: WP_001883067.1
Location: 34675..35142 (468 bp)
Type: Others
Protein ID: WP_001289288.1
Location: 35270..35933 (664 bp)
Type: Others
Protein ID: Protein_61
Location: 35923..36051 (129 bp)
Type: Others
Protein ID: WP_088124358.1
Location: 36118..36384 (267 bp)
Type: Toxin
Protein ID: WP_000589156.1
Location: 36371..36616 (246 bp)
Type: Antitoxin
Protein ID: WP_000643598.1
Location: 36712..37506 (795 bp)
Type: Others
Protein ID: WP_001911581.1
Location: 37503..37619 (117 bp)
Type: Others
Protein ID: WP_086010881.1
Location: 37609..37737 (129 bp)
Type: Others
Protein ID: WP_071908338.1
Location: 37798..37980 (183 bp)
Type: Others
Protein ID: WP_000923182.1
Location: 38196..39200 (1005 bp)
Type: Others
Protein ID: WP_000964920.1
Location: 39353..39712 (360 bp)
Type: Others
Protein ID: WP_001071541.1
Location: 39779..39964 (186 bp)
Type: Others
Protein ID: WP_001999468.1
Location: 40096..40218 (123 bp)
Type: Others
Protein ID: WP_001937972.1
Location: 40486..40992 (507 bp)
Type: Others
Protein ID: WP_000393074.1
Location: 41149..41535 (387 bp)
Type: Others
Protein ID: WP_000703163.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
K6J77_RS1895031646..31744+99WP_223225486.1DUF3709 domain-containing protein-
K6J77_RS1408031944..32045+102WP_001921603.1hypothetical protein-
K6J77_RS1408532035..32421+387WP_000703163.1VOC family protein-
K6J77_RS1409032616..32867+252WP_001890111.1TIGR03643 family protein-
K6J77_RS1895532840..32989+150WP_071908333.1DUF3265 domain-containing protein-
K6J77_RS1409533081..33323+243WP_000107461.1hypothetical protein-
K6J77_RS1410033575..33853+279WP_000280324.1DUF3709 domain-containing protein-
K6J77_RS1896034285..34328+44Protein_57hypothetical protein-
K6J77_RS1896534310..34403+94Protein_58ggdef family protein-
K6J77_RS1897034372..34503+132WP_001883067.1hypothetical protein-
K6J77_RS1411534675..35142+468WP_001289288.1OsmC family protein-
K6J77_RS1412035270..35933+664Protein_61hypothetical protein-
K6J77_RS1897535923..36051+129WP_088124358.1DUF3265 domain-containing protein-
K6J77_RS1412536118..36384+267WP_000589156.1BrnT family toxinToxin
K6J77_RS1413036371..36616+246WP_000643598.1hypothetical proteinAntitoxin
K6J77_RS1413536712..37506+795WP_001911581.1hypothetical protein-
K6J77_RS1898037503..37619+117WP_086010881.1DUF3265 domain-containing protein-
K6J77_RS1414037609..37737+129WP_071908338.1general secretion pathway protein GspI-
K6J77_RS1414537798..37980+183WP_000923182.1DUF645 family protein-
K6J77_RS1415038196..39200+1005WP_000964920.1LD-carboxypeptidase-
K6J77_RS1415539353..39712+360WP_001071541.1VOC family protein-
K6J77_RS1898539779..39964+186WP_001999468.1hypothetical protein-
K6J77_RS1899040096..40218+123WP_001937972.1DUF3709 domain-containing protein-
K6J77_RS1416540486..40992+507WP_000393074.1hypothetical protein-
K6J77_RS1417041149..41535+387WP_000703163.1VOC family protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
insideIntegron--11978..113648101670


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Ribonuclease toxin, BrnT, of type II toxin-antitoxin system

(6-81)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10092.34 Da        Isoelectric Point: 7.3171

>T38619 WP_000589156.1 NZ_AP024548:36118-36384 [Vibrio cholerae]
MIKFEFDENKSRSNLEKHGIDFHTAQGLWNDSDLIEIPANTSDEPRYLVVGLLNGKHWSGVITYRGTNIRIISVRRSRKA
EVSLYESA

Download         Length: 267 bp

>T38619 NZ_AP024548:36118-36384 [Vibrio cholerae]
ATGATTAAATTTGAATTTGATGAAAACAAAAGCAGAAGTAATCTCGAAAAGCACGGTATTGATTTTCATACAGCTCAAGG
ATTGTGGAATGATTCAGATCTTATCGAGATCCCTGCTAACACGAGTGATGAGCCCAGATATTTGGTTGTCGGCTTACTAA
ACGGTAAGCATTGGTCAGGAGTAATTACCTACCGAGGTACGAATATCAGGATCATCTCAGTTCGGCGTTCACGGAAAGCG
GAGGTAAGCCTTTATGAAAGCGCATGA

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 9478.77 Da        Isoelectric Point: 6.4832

>AT38619 WP_000643598.1 NZ_AP024548:36371-36616 [Vibrio cholerae]
MKAHEFDAKFESDDDDIVMDLDLSQAKRPMHKQKRVNVDFPAWMLESLDREASRIGVTRQSIIKIWLAERLESVSHHSSV
R

Download         Length: 246 bp

>AT38619 NZ_AP024548:36371-36616 [Vibrio cholerae]
ATGAAAGCGCATGAATTTGATGCCAAGTTTGAAAGTGACGACGATGATATCGTAATGGACTTGGATCTATCGCAAGCTAA
AAGACCGATGCATAAGCAAAAACGAGTCAATGTAGATTTTCCAGCCTGGATGCTTGAGTCCTTGGACAGAGAAGCGAGTC
GTATTGGTGTAACACGTCAATCAATCATTAAAATTTGGCTGGCAGAAAGGTTAGAGAGCGTGTCTCATCATTCAAGTGTG
AGATAA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A271VMP7

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A271VME2

References