Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-Phd
Location 282896..283443 Replicon chromosome
Accession NZ_LT992493
Organism Vibrio cholerae strain 4295STDY6534248

Toxin (Protein)


Gene name relE Uniprot ID Q9KM92
Locus tag DG169_RS16160 Protein ID WP_000229317.1
Coordinates 283141..283443 (+) Length 101 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID Q9KM93
Locus tag DG169_RS16155 Protein ID WP_000861987.1
Coordinates 282896..283153 (+) Length 86 a.a.

Genomic Context

DG169_RS16100DG169_RS16105DG169_RS16125DG169_RS16130DG169_RS16135DG169_RS16140DG169_RS16145DG169_RS16155DG169_RS16160DG169_RS16170DG169_RS16175DG169_RS16180DG169_RS16185DG169_RS16190DG169_RS16195DG169_RS16200DG169_RS16205DG169_RS16115DG169_RS16120
Location: 277925..278380 (456 bp)
Type: Others
Protein ID: WP_001245327.1
Location: 278702..278854 (153 bp)
Type: Others
Protein ID: WP_001884520.1
Location: 280053..280721 (669 bp)
Type: Others
Protein ID: WP_000043871.1
Location: 280873..281160 (288 bp)
Type: Others
Protein ID: WP_000426470.1
Location: 281301..281672 (372 bp)
Type: Others
Protein ID: WP_001164080.1
Location: 281739..282164 (426 bp)
Type: Others
Protein ID: WP_001882332.1
Location: 282161..282694 (534 bp)
Type: Others
Protein ID: WP_000118351.1
Location: 282896..283153 (258 bp)
Type: Antitoxin
Protein ID: WP_000861987.1
Location: 283141..283443 (303 bp)
Type: Toxin
Protein ID: WP_000229317.1
Location: 283677..284594 (918 bp)
Type: Others
Protein ID: WP_000186333.1
Location: 284751..285140 (390 bp)
Type: Others
Protein ID: WP_001081302.1
Location: 285276..285485 (210 bp)
Type: Others
Protein ID: Protein_325
Location: 285604..286041 (438 bp)
Type: Others
Protein ID: WP_000503169.1
Location: 286105..286323 (219 bp)
Type: Others
Protein ID: WP_071908318.1
Location: 286498..287370 (873 bp)
Type: Others
Protein ID: WP_000254716.1
Location: 287520..288119 (600 bp)
Type: Others
Protein ID: WP_001891245.1
Location: 288176..288280 (105 bp)
Type: Others
Protein ID: WP_099607150.1
Location: 279056..279553 (498 bp)
Type: Others
Protein ID: WP_000982260.1
Location: 279550..279822 (273 bp)
Type: Others
Protein ID: WP_000246253.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
DG169_RS16100277925..278380+456WP_001245327.1GNAT family N-acetyltransferase-
DG169_RS16105278702..278854+153WP_001884520.1DUF645 family protein-
DG169_RS16115279056..279553-498WP_000982260.1GNAT family N-acetyltransferase-
DG169_RS16120279550..279822-273WP_000246253.1DUF1778 domain-containing protein-
DG169_RS16125280053..280721+669WP_000043871.1hypothetical protein-
DG169_RS16130280873..281160+288WP_000426470.1hypothetical protein-
DG169_RS16135281301..281672+372WP_001164080.1nucleotide pyrophosphohydrolase-
DG169_RS16140281739..282164+426WP_001882332.1DUF1778 domain-containing protein-
DG169_RS16145282161..282694+534WP_000118351.1GNAT family N-acetyltransferase-
DG169_RS16155282896..283153+258WP_000861987.1type II toxin-antitoxin system Phd/YefM family antitoxinAntitoxin
DG169_RS16160283141..283443+303WP_000229317.1type II toxin-antitoxin system RelE/ParE family toxinToxin
DG169_RS16170283677..284594+918WP_000186333.1alpha/beta hydrolase-
DG169_RS16175284751..285140+390WP_001081302.1hypothetical protein-
DG169_RS16180285276..285485+210Protein_325GNAT family N-acetyltransferase-
DG169_RS16185285604..286041+438WP_000503169.1IS200/IS605-like element IS1004 family transposase-
DG169_RS16190286105..286323+219WP_071908318.1GNAT family N-acetyltransferase-
DG169_RS16195286498..287370+873WP_000254716.1DUF3800 domain-containing protein-
DG169_RS16200287520..288119+600WP_001891245.1glutathione S-transferase N-terminal domain-containing protein-
DG169_RS16205288176..288280+105WP_099607150.1acetyltransferase-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideGenomic islandcatB9-197768..29303295264
insideIntegroncatB9-202848..29265689808
flankIS/Tn--285604..286041437


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-87)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-69)


Sequences

Toxin        


Download         Length: 101 a.a.        Molecular weight: 11726.68 Da        Isoelectric Point: 5.1972

>T294419 WP_000229317.1 NZ_LT992493:283141-283443 [Vibrio cholerae]
MVEIIWTELALSDLNDIAEYIALENVVAAKQLVQTVFTKVERLADFPESGRVPPELEHLNYREVVVSPCRVFYKYDDAKV
RILFVMRAERDLRRLMLTKQ

Download         Length: 303 bp

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9647.15 Da        Isoelectric Point: 7.3178

>AT294419 WP_000861987.1 NZ_LT992493:282896-283153 [Vibrio cholerae]
MKVELVTSLKRQATKILADLHDTKEPVLITEHGKPSAYLIDVDDYEFMQNRLAILEGIARGERALADGKVVSHQDAKDRM
SKWLK

Download         Length: 258 bp


Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBQ9KM92

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A1T4SLM9

References