125041

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/ParE-Phd
Location 931959..932537 Replicon chromosome
Accession NZ_CP040173
Organism Vibrio cholerae strain VC1374

Toxin (Protein)


Gene name parE Uniprot ID O68848
Locus tag FDZ90_RS18955 Protein ID WP_001180243.1
Coordinates 931959..932276 (-) Length 106 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID Q7DCR7
Locus tag FDZ90_RS18960 Protein ID WP_000557292.1
Coordinates 932295..932537 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FDZ90_RS18910 927189..927545 + 357 WP_001094969.1 hypothetical protein -
FDZ90_RS18915 927848..928029 + 182 Protein_836 DUF645 family protein -
FDZ90_RS18920 928206..928601 + 396 WP_000046953.1 hypothetical protein -
FDZ90_RS18925 928745..929281 + 537 WP_000644491.1 nucleotidyltransferase family protein -
FDZ90_RS18930 929578..929757 + 180 WP_001883039.1 DUF645 family protein -
FDZ90_RS18935 929953..930378 + 426 WP_000403014.1 GNAT family N-acetyltransferase -
FDZ90_RS18940 930527..930874 + 348 WP_000933409.1 hypothetical protein -
FDZ90_RS18945 931021..931314 + 294 WP_125460920.1 hypothetical protein -
FDZ90_RS18950 931670..931765 + 96 WP_001907607.1 DUF645 family protein -
FDZ90_RS18955 931959..932276 - 318 WP_001180243.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
FDZ90_RS18960 932295..932537 - 243 WP_000557292.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
FDZ90_RS18965 932779..933288 + 510 WP_000405987.1 GNAT family N-acetyltransferase -
FDZ90_RS18970 933345..933998 + 654 WP_000226874.1 hypothetical protein -
FDZ90_RS18975 934308..934526 + 219 WP_001917086.1 DUF3709 domain-containing protein -
FDZ90_RS18980 934929..935162 + 234 WP_032482776.1 DUF3709 domain-containing protein -
FDZ90_RS18985 935587..935767 + 181 Protein_850 DUF645 family protein -
FDZ90_RS18990 936034..936321 + 288 WP_001162670.1 type II toxin-antitoxin system RelE/ParE family toxin -
FDZ90_RS18995 936332..936649 + 318 WP_001232701.1 HigA family addiction module antidote protein -
FDZ90_RS19000 936646..936756 + 111 WP_134814058.1 DUF3265 domain-containing protein -
FDZ90_RS19005 936933..937058 + 126 WP_001944767.1 DUF645 family protein -
FDZ90_RS19010 937074..937112 + 39 WP_106019119.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island catB9 - 882589..977840 95251
inside Integron catB9 - 887669..977464 89795


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-93)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-71)


Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 12158.97 Da        Isoelectric Point: 9.7495

>T125041 WP_001180243.1 NZ_CP040173:c932276-931959 [Vibrio cholerae]
MQNKQYKLSQLAQEHLLKIKHYTIENFAEAQWQKYKSTLLSGFQTLADNPGLGKSCEDIYQNGFYFPVGKHMAYYTKEAN
FILIVAVLGQSQLPQKHLKQSRFVS

Download         Length: 318 bp

>T125041 NZ_CP040173:c932276-931959 [Vibrio cholerae]
ATGCAAAATAAACAATATAAGCTCAGCCAATTAGCCCAAGAGCACTTACTCAAGATTAAACACTACACCATTGAAAATTT
CGCTGAAGCGCAGTGGCAAAAATATAAGTCGACCTTGCTTTCAGGTTTCCAAACTCTTGCGGATAACCCAGGACTAGGAA
AAAGCTGTGAAGATATTTACCAAAATGGTTTTTACTTTCCAGTGGGGAAACACATGGCTTATTACACCAAAGAAGCAAAC
TTCATTCTCATTGTTGCGGTATTAGGGCAATCACAACTGCCCCAAAAGCATCTCAAACAGTCACGCTTTGTTTCTTAG

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8961.25 Da        Isoelectric Point: 5.6630

>AT125041 WP_000557292.1 NZ_CP040173:c932537-932295 [Vibrio cholerae]
MHTLTANDAKRNFGELLLSAQREPVIISKNSKNTVVVMSIKDFEELEAMKLDYLKHCFESAQKDLDSGKTVDGATFLNTL

Download         Length: 243 bp

>AT125041 NZ_CP040173:c932537-932295 [Vibrio cholerae]
ATGCACACACTAACAGCAAATGATGCTAAACGAAATTTTGGTGAACTTCTTCTAAGCGCACAACGCGAACCTGTCATCAT
CAGCAAAAACAGTAAGAATACTGTCGTTGTCATGTCCATTAAGGACTTTGAAGAACTTGAAGCAATGAAACTCGATTATC
TCAAACACTGCTTTGAGTCTGCTCAGAAAGACTTAGATAGTGGCAAAACCGTTGATGGTGCCACTTTTCTAAACACCCTT
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0K9UJR8

Antitoxin

Source ID Structure
AlphaFold DB Q7DCR7

References