Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /GNAT-DUF1778
Location 297326..298092 Replicon chromosome
Accession NZ_AP024554
Organism Vibrio cholerae strain IDH-03329

Toxin (Protein)


Gene name - Uniprot ID Q9K2P7
Locus tag K6J80_RS15535 Protein ID WP_000982260.1
Coordinates 297595..298092 (+) Length 166 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID Q9K2J6
Locus tag K6J80_RS15530 Protein ID WP_000246253.1
Coordinates 297326..297598 (+) Length 91 a.a.

Genomic Context

K6J80_RS15505K6J80_RS15510K6J80_RS15530K6J80_RS15535K6J80_RS15565K6J80_RS15570K6J80_RS15475K6J80_RS19085K6J80_RS15480K6J80_RS15485K6J80_RS15490K6J80_RS19090K6J80_RS15500K6J80_RS19095K6J80_RS15515K6J80_RS15525K6J80_RS19100K6J80_RS15540K6J80_RS15545K6J80_RS15550K6J80_RS15555K6J80_RS15560K6J80_RS15575K6J80_RS15580
Location: 295424..295702 (279 bp)
Type: Others
Protein ID: WP_001258569.1
Location: 295695..295964 (270 bp)
Type: Others
Protein ID: WP_000277238.1
Location: 297326..297598 (273 bp)
Type: Antitoxin
Protein ID: WP_000246253.1
Location: 297595..298092 (498 bp)
Type: Toxin
Protein ID: WP_000982260.1
Location: 300718..300960 (243 bp)
Type: Others
Protein ID: WP_000557292.1
Location: 300979..301296 (318 bp)
Type: Others
Protein ID: WP_001180243.1
Location: 292823..293065 (243 bp)
Type: Others
Protein ID: WP_000107461.1
Location: 293157..293306 (150 bp)
Type: Others
Protein ID: WP_071908333.1
Location: 293279..293530 (252 bp)
Type: Others
Protein ID: WP_001890111.1
Location: 293725..294111 (387 bp)
Type: Others
Protein ID: WP_000703163.1
Location: 294101..294202 (102 bp)
Type: Others
Protein ID: WP_001921603.1
Location: 294402..294500 (99 bp)
Type: Others
Protein ID: WP_223225486.1
Location: 294860..295138 (279 bp)
Type: Others
Protein ID: WP_001921601.1
Location: 295256..295373 (118 bp)
Type: Others
Protein ID: Protein_348
Location: 296112..296558 (447 bp)
Type: Others
Protein ID: WP_000006157.1
Location: 296808..296933 (126 bp)
Type: Others
Protein ID: WP_001900195.1
Location: 298109..298177 (69 bp)
Type: Others
Protein ID: Protein_355
Location: 298242..298703 (462 bp)
Type: Others
Protein ID: WP_001903091.1
Location: 298894..299430 (537 bp)
Type: Others
Protein ID: WP_000469482.1
Location: 299688..299909 (222 bp)
Type: Others
Protein ID: WP_032467793.1
Location: 299918..300031 (114 bp)
Type: Others
Protein ID: WP_001900214.1
Location: 300088..300474 (387 bp)
Type: Others
Protein ID: WP_001015867.1
Location: 301450..301788 (339 bp)
Type: Others
Protein ID: WP_000713853.1
Location: 301946..302650 (705 bp)
Type: Others
Protein ID: WP_000087610.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
K6J80_RS15475292823..293065-243WP_000107461.1hypothetical protein-
K6J80_RS19085293157..293306-150WP_071908333.1DUF3265 domain-containing protein-
K6J80_RS15480293279..293530-252WP_001890111.1TIGR03643 family protein-
K6J80_RS15485293725..294111-387WP_000703163.1VOC family protein-
K6J80_RS15490294101..294202-102WP_001921603.1hypothetical protein-
K6J80_RS19090294402..294500-99WP_223225486.1DUF3709 domain-containing protein-
K6J80_RS15500294860..295138-279WP_001921601.1DUF3709 domain-containing protein-
K6J80_RS19095295256..295373-118Protein_348DUF3265 domain-containing protein-
K6J80_RS15505295424..295702+279WP_001258569.1type II toxin-antitoxin system RelB/DinJ family antitoxin-
K6J80_RS15510295695..295964+270WP_000277238.1type II toxin-antitoxin system YafQ family toxin-
K6J80_RS15515296112..296558-447WP_000006157.1hypothetical protein-
K6J80_RS15525296808..296933-126WP_001900195.1DUF645 family protein-
K6J80_RS15530297326..297598+273WP_000246253.1DUF1778 domain-containing proteinAntitoxin
K6J80_RS15535297595..298092+498WP_000982260.1GNAT family N-acetyltransferaseToxin
K6J80_RS19100298109..298177-69Protein_355acetyltransferase-
K6J80_RS15540298242..298703-462WP_001903091.1lipocalin family protein-
K6J80_RS15545298894..299430-537WP_000469482.1GNAT family protein-
K6J80_RS15550299688..299909-222WP_032467793.1DUF1289 domain-containing protein-
K6J80_RS15555299918..300031-114WP_001900214.1hypothetical protein-
K6J80_RS15560300088..300474-387WP_001015867.1NUDIX hydrolase-
K6J80_RS15565300718..300960+243WP_000557292.1type II toxin-antitoxin system Phd/YefM family antitoxin-
K6J80_RS15570300979..301296+318WP_001180243.1type II toxin-antitoxin system RelE/ParE family toxin-
K6J80_RS15575301450..301788-339WP_000713853.1hypothetical protein-
K6J80_RS15580301946..302650-705WP_000087610.1HNH endonuclease-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideGenomic islandcatB9-213119..319686106567
insideIntegron--213119..31285699737


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(86-152)

Antitoxin

Vibrio phage ICP1, Orf50

(7-86)


Sequences

Toxin        


Download         Length: 166 a.a.        Molecular weight: 18527.18 Da        Isoelectric Point: 8.7753

>T38683 WP_000982260.1 NZ_AP024554:297595-298092 [Vibrio cholerae]
MMNTVLLDKDKHDRNRFNCGTEALNNYLKVMASQQAKKDNTRTFVLEDDNNSAYIIGFYTLTMTPIDLKALPDKLQKKHQ
SSTSGGLIARLAVDDRYKGKGFGEWLLIDALRKLLAASDSVAFPVVIVDAKDGAKHFYERYGFQAFQDAENKLFITIADI
RASLG

Download         Length: 498 bp

>T38683 NZ_AP024554:297595-298092 [Vibrio cholerae]
ATGATGAATACGGTACTTCTCGATAAAGATAAGCACGATAGGAACCGTTTCAATTGTGGCACTGAAGCACTCAACAATTA
CTTAAAAGTAATGGCGAGTCAGCAAGCCAAAAAAGACAACACCAGAACCTTCGTTTTGGAAGATGACAATAACAGTGCTT
ATATCATCGGCTTTTACACTCTGACTATGACGCCCATTGATTTGAAAGCCTTGCCCGACAAGTTACAAAAGAAGCACCAA
TCCTCAACCTCTGGAGGGCTCATTGCTCGTTTAGCTGTCGACGATAGATACAAAGGAAAAGGTTTTGGTGAGTGGCTACT
CATTGACGCTCTCAGAAAGCTACTCGCAGCCAGTGACAGTGTAGCGTTCCCTGTTGTCATTGTTGATGCCAAAGATGGTG
CAAAACATTTCTATGAGCGCTATGGGTTTCAAGCGTTTCAAGATGCCGAAAACAAACTCTTCATCACCATTGCTGATATC
AGAGCAAGCTTAGGCTAG

Antitoxin


Download         Length: 91 a.a.        Molecular weight: 9683.22 Da        Isoelectric Point: 6.2988

>AT38683 WP_000246253.1 NZ_AP024554:297326-297598 [Vibrio cholerae]
MATTLPRITARVDVDTQDLLAKAAALAGMSSINSFVLNAAIEKAKQVIEREQALKLSQADAVLLMEALDNPAVVNAKLKL
ASERYESKTQ

Download         Length: 273 bp

>AT38683 NZ_AP024554:297326-297598 [Vibrio cholerae]
ATGGCAACGACTTTGCCTCGCATCACCGCTAGAGTTGATGTCGATACTCAAGATTTACTCGCTAAGGCTGCTGCTCTTGC
TGGTATGTCTAGTATTAACTCATTTGTTTTGAATGCAGCAATCGAAAAAGCAAAACAAGTCATTGAACGTGAGCAAGCTC
TAAAGCTTAGCCAAGCTGATGCCGTATTGCTGATGGAAGCTCTTGATAATCCAGCTGTAGTAAATGCAAAGCTCAAATTG
GCATCCGAACGTTATGAGAGCAAAACTCAATGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A0Q0KGB1

Antitoxin

Loading, please wait
Source
ID
Structure
PDB1Y9B
AlphaFold DBA0A0F2IC79

References