Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /GNAT-DUF1778
Location 297326..298092 Replicon chromosome
Accession NZ_AP024554
Organism Vibrio cholerae strain IDH-03329

Toxin (Protein)


Gene name - Uniprot ID Q9K2P7
Locus tag K6J80_RS15535 Protein ID WP_000982260.1
Coordinates 297595..298092 (+) Length 166 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID Q9K2J6
Locus tag K6J80_RS15530 Protein ID WP_000246253.1
Coordinates 297326..297598 (+) Length 91 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K6J80_RS15475 292823..293065 - 243 WP_000107461.1 hypothetical protein -
K6J80_RS19085 293157..293306 - 150 WP_071908333.1 DUF3265 domain-containing protein -
K6J80_RS15480 293279..293530 - 252 WP_001890111.1 TIGR03643 family protein -
K6J80_RS15485 293725..294111 - 387 WP_000703163.1 VOC family protein -
K6J80_RS15490 294101..294202 - 102 WP_001921603.1 hypothetical protein -
K6J80_RS19090 294402..294500 - 99 WP_223225486.1 DUF3709 domain-containing protein -
K6J80_RS15500 294860..295138 - 279 WP_001921601.1 DUF3709 domain-containing protein -
K6J80_RS19095 295256..295373 - 118 Protein_348 DUF3265 domain-containing protein -
K6J80_RS15505 295424..295702 + 279 WP_001258569.1 type II toxin-antitoxin system RelB/DinJ family antitoxin -
K6J80_RS15510 295695..295964 + 270 WP_000277238.1 type II toxin-antitoxin system YafQ family toxin -
K6J80_RS15515 296112..296558 - 447 WP_000006157.1 hypothetical protein -
K6J80_RS15525 296808..296933 - 126 WP_001900195.1 DUF645 family protein -
K6J80_RS15530 297326..297598 + 273 WP_000246253.1 DUF1778 domain-containing protein Antitoxin
K6J80_RS15535 297595..298092 + 498 WP_000982260.1 GNAT family N-acetyltransferase Toxin
K6J80_RS19100 298109..298177 - 69 Protein_355 acetyltransferase -
K6J80_RS15540 298242..298703 - 462 WP_001903091.1 lipocalin family protein -
K6J80_RS15545 298894..299430 - 537 WP_000469482.1 GNAT family protein -
K6J80_RS15550 299688..299909 - 222 WP_032467793.1 DUF1289 domain-containing protein -
K6J80_RS15555 299918..300031 - 114 WP_001900214.1 hypothetical protein -
K6J80_RS15560 300088..300474 - 387 WP_001015867.1 NUDIX hydrolase -
K6J80_RS15565 300718..300960 + 243 WP_000557292.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
K6J80_RS15570 300979..301296 + 318 WP_001180243.1 type II toxin-antitoxin system RelE/ParE family toxin -
K6J80_RS15575 301450..301788 - 339 WP_000713853.1 hypothetical protein -
K6J80_RS15580 301946..302650 - 705 WP_000087610.1 HNH endonuclease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island catB9 - 213119..319686 106567
inside Integron - - 213119..312856 99737


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(86-152)

Antitoxin

Vibrio phage ICP1, Orf50

(7-86)


Sequences

Toxin        


Download         Length: 166 a.a.        Molecular weight: 18527.18 Da        Isoelectric Point: 8.7753

>T38683 WP_000982260.1 NZ_AP024554:297595-298092 [Vibrio cholerae]
MMNTVLLDKDKHDRNRFNCGTEALNNYLKVMASQQAKKDNTRTFVLEDDNNSAYIIGFYTLTMTPIDLKALPDKLQKKHQ
SSTSGGLIARLAVDDRYKGKGFGEWLLIDALRKLLAASDSVAFPVVIVDAKDGAKHFYERYGFQAFQDAENKLFITIADI
RASLG

Download         Length: 498 bp

>T38683 NZ_AP024554:297595-298092 [Vibrio cholerae]
ATGATGAATACGGTACTTCTCGATAAAGATAAGCACGATAGGAACCGTTTCAATTGTGGCACTGAAGCACTCAACAATTA
CTTAAAAGTAATGGCGAGTCAGCAAGCCAAAAAAGACAACACCAGAACCTTCGTTTTGGAAGATGACAATAACAGTGCTT
ATATCATCGGCTTTTACACTCTGACTATGACGCCCATTGATTTGAAAGCCTTGCCCGACAAGTTACAAAAGAAGCACCAA
TCCTCAACCTCTGGAGGGCTCATTGCTCGTTTAGCTGTCGACGATAGATACAAAGGAAAAGGTTTTGGTGAGTGGCTACT
CATTGACGCTCTCAGAAAGCTACTCGCAGCCAGTGACAGTGTAGCGTTCCCTGTTGTCATTGTTGATGCCAAAGATGGTG
CAAAACATTTCTATGAGCGCTATGGGTTTCAAGCGTTTCAAGATGCCGAAAACAAACTCTTCATCACCATTGCTGATATC
AGAGCAAGCTTAGGCTAG

Antitoxin


Download         Length: 91 a.a.        Molecular weight: 9683.22 Da        Isoelectric Point: 6.2988

>AT38683 WP_000246253.1 NZ_AP024554:297326-297598 [Vibrio cholerae]
MATTLPRITARVDVDTQDLLAKAAALAGMSSINSFVLNAAIEKAKQVIEREQALKLSQADAVLLMEALDNPAVVNAKLKL
ASERYESKTQ

Download         Length: 273 bp

>AT38683 NZ_AP024554:297326-297598 [Vibrio cholerae]
ATGGCAACGACTTTGCCTCGCATCACCGCTAGAGTTGATGTCGATACTCAAGATTTACTCGCTAAGGCTGCTGCTCTTGC
TGGTATGTCTAGTATTAACTCATTTGTTTTGAATGCAGCAATCGAAAAAGCAAAACAAGTCATTGAACGTGAGCAAGCTC
TAAAGCTTAGCCAAGCTGATGCCGTATTGCTGATGGAAGCTCTTGATAATCCAGCTGTAGTAAATGCAAAGCTCAAATTG
GCATCCGAACGTTATGAGAGCAAAACTCAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0Q0KGB1

Antitoxin

Source ID Structure
PDB 1Y9B
AlphaFold DB A0A0F2IC79

References