26149

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/ParE-Phd
Location 365169..365747 Replicon chromosome II
Accession NC_016945
Organism Vibrio cholerae IEC224

Toxin (Protein)


Gene name parE Uniprot ID O68848
Locus tag O3Y_RS15760 Protein ID WP_001180243.1
Coordinates 365169..365486 (-) Length 106 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID Q7DCR7
Locus tag O3Y_RS15765 Protein ID WP_000557292.1
Coordinates 365505..365747 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
O3Y_RS15725 360360..360755 + 396 WP_000046949.1 hypothetical protein -
O3Y_RS19715 361058..361239 + 182 Protein_348 DUF645 family protein -
O3Y_RS15730 361416..361811 + 396 WP_000046953.1 hypothetical protein -
O3Y_RS15735 361955..362491 + 537 WP_000644491.1 nucleotidyltransferase family protein -
O3Y_RS15745 362788..362967 + 180 WP_001883039.1 DUF645 family protein -
O3Y_RS15750 363163..363588 + 426 WP_000403014.1 GNAT family N-acetyltransferase -
O3Y_RS15755 363737..364084 + 348 WP_000933409.1 hypothetical protein -
O3Y_RS20225 364231..364524 + 294 WP_125460920.1 hypothetical protein -
O3Y_RS20595 364880..364975 + 96 WP_001907607.1 DUF645 family protein -
O3Y_RS15760 365169..365486 - 318 WP_001180243.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
O3Y_RS15765 365505..365747 - 243 WP_000557292.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
O3Y_RS15770 365989..366498 + 510 WP_000405987.1 GNAT family N-acetyltransferase -
O3Y_RS15775 366555..367208 + 654 WP_000226875.1 hypothetical protein -
O3Y_RS15780 367518..367736 + 219 WP_001917086.1 DUF3709 domain-containing protein -
O3Y_RS19730 368139..368372 + 234 WP_032482776.1 DUF3709 domain-containing protein -
O3Y_RS15785 368797..368977 + 181 Protein_362 DUF645 family protein -
O3Y_RS15790 369244..369531 + 288 WP_001162670.1 type II toxin-antitoxin system RelE/ParE family toxin -
O3Y_RS15795 369542..369859 + 318 WP_001232701.1 HigA family addiction module antidote protein -
O3Y_RS20600 369856..369966 + 111 WP_134814058.1 DUF3265 domain-containing protein -
O3Y_RS20605 370143..370268 + 126 WP_001944767.1 DUF645 family protein -
O3Y_RS20610 370284..370322 + 39 WP_106019119.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island catB9 - 304637..435582 130945
inside Integron - - 309717..435206 125489


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-93)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-71)


Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 12158.97 Da        Isoelectric Point: 9.7495

>T26149 WP_001180243.1 NC_016945:c365486-365169 [Vibrio cholerae IEC224]
MQNKQYKLSQLAQEHLLKIKHYTIENFAEAQWQKYKSTLLSGFQTLADNPGLGKSCEDIYQNGFYFPVGKHMAYYTKEAN
FILIVAVLGQSQLPQKHLKQSRFVS

Download         Length: 318 bp

>T26149 NC_016945:c365486-365169 [Vibrio cholerae IEC224]
ATGCAAAATAAACAATATAAGCTCAGCCAATTAGCCCAAGAGCACTTACTCAAGATTAAACACTACACCATTGAAAATTT
CGCTGAAGCGCAGTGGCAAAAATATAAGTCGACCTTGCTTTCAGGTTTCCAAACTCTTGCGGATAACCCAGGACTAGGAA
AAAGCTGTGAAGATATTTACCAAAATGGTTTTTACTTTCCAGTGGGGAAACACATGGCTTATTACACCAAAGAAGCAAAC
TTCATTCTCATTGTTGCGGTATTAGGGCAATCACAACTGCCCCAAAAGCATCTCAAACAGTCACGCTTTGTTTCTTAG

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8961.25 Da        Isoelectric Point: 5.6630

>AT26149 WP_000557292.1 NC_016945:c365747-365505 [Vibrio cholerae IEC224]
MHTLTANDAKRNFGELLLSAQREPVIISKNSKNTVVVMSIKDFEELEAMKLDYLKHCFESAQKDLDSGKTVDGATFLNTL

Download         Length: 243 bp

>AT26149 NC_016945:c365747-365505 [Vibrio cholerae IEC224]
ATGCACACACTAACAGCAAATGATGCTAAACGAAATTTTGGTGAACTTCTTCTAAGCGCACAACGCGAACCTGTCATCAT
CAGCAAAAACAGTAAGAATACTGTCGTTGTCATGTCCATTAAGGACTTTGAAGAACTTGAAGCAATGAAACTCGATTATC
TCAAACACTGCTTTGAGTCTGCTCAGAAAGACTTAGATAGTGGCAAAACCGTTGATGGTGCCACTTTTCTAAACACCCTT
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0K9UJR8

Antitoxin

Source ID Structure
AlphaFold DB Q7DCR7

References