Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/ParE-Phd
Location 323554..324132 Replicon chromosome
Accession NZ_CP028895
Organism Vibrio cholerae strain A1552

Toxin (Protein)


Gene name parE Uniprot ID O68848
Locus tag A1552VC_RS15720 Protein ID WP_001180243.1
Coordinates 323554..323871 (-) Length 106 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID Q7DCR7
Locus tag A1552VC_RS15725 Protein ID WP_000557292.1
Coordinates 323890..324132 (-) Length 81 a.a.

Genomic Context

A1552VC_RS15680A1552VC_RS15685A1552VC_RS15695A1552VC_RS15700A1552VC_RS15705A1552VC_RS15710A1552VC_RS15730A1552VC_RS15735A1552VC_RS15740A1552VC_RS15755A1552VC_RS15760A1552VC_RS15775A1552VC_RS15780A1552VC_RS15790A1552VC_RS15720A1552VC_RS15725A1552VC_RS15765A1552VC_RS15770
Location: 319078..319260 (183 bp)
Type: Others
Protein ID: WP_000923340.1
Location: 319614..319796 (183 bp)
Type: Others
Protein ID: WP_000923153.1
Location: 319991..320668 (678 bp)
Type: Others
Protein ID: WP_000254617.1
Location: 320830..322038 (1209 bp)
Type: Others
Protein ID: WP_000272282.1
Location: 322200..322904 (705 bp)
Type: Others
Protein ID: WP_000087610.1
Location: 323062..323400 (339 bp)
Type: Others
Protein ID: WP_000713853.1
Location: 324376..324762 (387 bp)
Type: Others
Protein ID: WP_001015867.1
Location: 324819..324932 (114 bp)
Type: Others
Protein ID: WP_001900214.1
Location: 324881..325162 (282 bp)
Type: Others
Protein ID: WP_001894429.1
Location: 325420..325956 (537 bp)
Type: Others
Protein ID: WP_000469482.1
Location: 326093..326608 (516 bp)
Type: Others
Protein ID: WP_001201509.1
Location: 327917..328042 (126 bp)
Type: Others
Protein ID: WP_001900195.1
Location: 328058..328096 (39 bp)
Type: Others
Protein ID: WP_106019118.1
Location: 328292..328738 (447 bp)
Type: Others
Protein ID: WP_000006157.1
Location: 323554..323871 (318 bp)
Type: Toxin
Protein ID: WP_001180243.1
Location: 323890..324132 (243 bp)
Type: Antitoxin
Protein ID: WP_000557292.1
Location: 326758..327255 (498 bp)
Type: Others
Protein ID: WP_000982260.1
Location: 327252..327524 (273 bp)
Type: Others
Protein ID: WP_000246253.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
A1552VC_RS15680319078..319260+183WP_000923340.1DUF645 family protein-
A1552VC_RS15685319614..319796+183WP_000923153.1DUF645 family protein-
A1552VC_RS15695319991..320668+678WP_000254617.1HNH endonuclease-
A1552VC_RS15700320830..322038+1209WP_000272282.1deoxyguanosinetriphosphate triphosphohydrolase family protein-
A1552VC_RS15705322200..322904+705WP_000087610.1HNH endonuclease-
A1552VC_RS15710323062..323400+339WP_000713853.1hypothetical protein-
A1552VC_RS15720323554..323871-318WP_001180243.1type II toxin-antitoxin system RelE/ParE family toxinToxin
A1552VC_RS15725323890..324132-243WP_000557292.1type II toxin-antitoxin system Phd/YefM family antitoxinAntitoxin
A1552VC_RS15730324376..324762+387WP_001015867.1NUDIX hydrolase-
A1552VC_RS15735324819..324932+114WP_001900214.1hypothetical protein-
A1552VC_RS15740324881..325162+282WP_001894429.1DUF1289 domain-containing protein-
A1552VC_RS15755325420..325956+537WP_000469482.1GNAT family N-acetyltransferase-
A1552VC_RS15760326093..326608+516WP_001201509.1lipocalin family protein-
A1552VC_RS15765326758..327255-498WP_000982260.1GNAT family N-acetyltransferase-
A1552VC_RS15770327252..327524-273WP_000246253.1DUF1778 domain-containing protein-
A1552VC_RS15775327917..328042+126WP_001900195.1DUF645 family protein-
A1552VC_RS15780328058..328096+39WP_106019118.1hypothetical protein-
A1552VC_RS15790328292..328738+447WP_000006157.1hypothetical protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideGenomic islandcatB9-306914..436175129261
insideIntegron--311994..435799123805


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-93)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-71)


Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 12158.97 Da        Isoelectric Point: 9.7495

>T104335 WP_001180243.1 NZ_CP028895:c323871-323554 [Vibrio cholerae]
MQNKQYKLSQLAQEHLLKIKHYTIENFAEAQWQKYKSTLLSGFQTLADNPGLGKSCEDIYQNGFYFPVGKHMAYYTKEAN
FILIVAVLGQSQLPQKHLKQSRFVS

Download         Length: 318 bp

>T104335 NZ_CP028895:c323871-323554 [Vibrio cholerae]
ATGCAAAATAAACAATATAAGCTCAGCCAATTAGCCCAAGAGCACTTACTCAAGATTAAACACTACACCATTGAAAATTT
CGCTGAAGCGCAGTGGCAAAAATATAAGTCGACCTTGCTTTCAGGTTTCCAAACTCTTGCGGATAACCCAGGACTAGGAA
AAAGCTGTGAAGATATTTACCAAAATGGTTTTTACTTTCCAGTGGGGAAACACATGGCTTATTACACCAAAGAAGCAAAC
TTCATTCTCATTGTTGCGGTATTAGGGCAATCACAACTGCCCCAAAAGCATCTCAAACAGTCACGCTTTGTTTCTTAG

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8961.25 Da        Isoelectric Point: 5.6630

>AT104335 WP_000557292.1 NZ_CP028895:c324132-323890 [Vibrio cholerae]
MHTLTANDAKRNFGELLLSAQREPVIISKNSKNTVVVMSIKDFEELEAMKLDYLKHCFESAQKDLDSGKTVDGATFLNTL

Download         Length: 243 bp

>AT104335 NZ_CP028895:c324132-323890 [Vibrio cholerae]
ATGCACACACTAACAGCAAATGATGCTAAACGAAATTTTGGTGAACTTCTTCTAAGCGCACAACGCGAACCTGTCATCAT
CAGCAAAAACAGTAAGAATACTGTCGTTGTCATGTCCATTAAGGACTTTGAAGAACTTGAAGCAATGAAACTCGATTATC
TCAAACACTGCTTTGAGTCTGCTCAGAAAGACTTAGATAGTGGCAAAACCGTTGATGGTGCCACTTTTCTAAACACCCTT
TGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A0K9UJR8

Antitoxin

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Source
ID
Structure
AlphaFold DBQ7DCR7

References