Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/RelE-MqsA
Location 399506..400139 Replicon chromosome
Accession NZ_LT992489
Organism Vibrio cholerae strain 4295STDY6534232

Toxin (Protein)


Gene name higB Uniprot ID Q9KMA6
Locus tag DG176_RS16225 Protein ID WP_000843587.1
Coordinates 399807..400139 (-) Length 111 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag DG176_RS16220 Protein ID WP_000071008.1
Coordinates 399506..399820 (-) Length 105 a.a.

Genomic Context

DG176_RS16210DG176_RS16175DG176_RS16180DG176_RS16185DG176_RS16190DG176_RS16195DG176_RS16200DG176_RS16205DG176_RS19665DG176_RS16215DG176_RS16220DG176_RS16225DG176_RS16235DG176_RS19790DG176_RS16255DG176_RS19795DG176_RS16260DG176_RS16265DG176_RS16270DG176_RS19865DG176_RS16280DG176_RS16285DG176_RS19715
Location: 397507..398487 (981 bp)
Type: Others
Protein ID: WP_000019370.1
Location: 394560..394847 (288 bp)
Type: Others
Protein ID: WP_000221354.1
Location: 394837..395088 (252 bp)
Type: Others
Protein ID: WP_001250179.1
Location: 395302..395715 (414 bp)
Type: Others
Protein ID: WP_000049417.1
Location: 395790..395933 (144 bp)
Type: Others
Protein ID: WP_071908341.1
Location: 395903..396304 (402 bp)
Type: Others
Protein ID: WP_000351248.1
Location: 396304..396996 (693 bp)
Type: Others
Protein ID: WP_001047169.1
Location: 397133..397439 (307 bp)
Type: Others
Protein ID: Protein_349
Location: 398612..398767 (156 bp)
Type: Others
Protein ID: WP_000751734.1
Location: 398935..399369 (435 bp)
Type: Others
Protein ID: WP_000256036.1
Location: 399506..399820 (315 bp)
Type: Antitoxin
Protein ID: WP_000071008.1
Location: 399807..400139 (333 bp)
Type: Toxin
Protein ID: WP_000843587.1
Location: 400480..400707 (228 bp)
Type: Others
Protein ID: WP_001894457.1
Location: 400656..400769 (114 bp)
Type: Others
Protein ID: WP_001889158.1
Location: 400935..401216 (282 bp)
Type: Others
Protein ID: WP_001894453.1
Location: 401165..401279 (115 bp)
Type: Others
Protein ID: Protein_358
Location: 401336..401713 (378 bp)
Type: Others
Protein ID: WP_000411109.1
Location: 401884..402126 (243 bp)
Type: Others
Protein ID: WP_000107461.1
Location: 402328..402714 (387 bp)
Type: Others
Protein ID: WP_000703163.1
Location: 402923..403094 (172 bp)
Type: Others
Protein ID: Protein_362
Location: 403412..403681 (270 bp)
Type: Others
Protein ID: WP_001198131.1
Location: 404041..404214 (174 bp)
Type: Others
Protein ID: WP_001882305.1
Location: 404495..404698 (204 bp)
Type: Others
Protein ID: WP_001911745.1
ToxinAntitoxinOther genes
Loading, please wait
Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
DG176_RS16175394560..394847-288WP_000221354.1type II toxin-antitoxin system RelE/ParE family toxin-
DG176_RS16180394837..395088-252WP_001250179.1type II toxin-antitoxin system Phd/YefM family antitoxin-
DG176_RS16185395302..395715-414WP_000049417.1VOC family protein-
DG176_RS16190395790..395933-144WP_071908341.1DUF3265 domain-containing protein-
DG176_RS16195395903..396304-402WP_000351248.1type II toxin-antitoxin system death-on-curing family toxin-
DG176_RS16200396304..396996-693WP_001047169.1GNAT family N-acetyltransferase-
DG176_RS16205397133..397439-307Protein_349CatB-related O-acetyltransferase-
DG176_RS16210397507..398487+981WP_000019370.1IS5-like element ISVch5 family transposase-
DG176_RS19665398612..398767-156WP_000751734.1hypothetical protein-
DG176_RS16215398935..399369-435WP_000256036.1GNAT family N-acetyltransferase-
DG176_RS16220399506..399820-315WP_000071008.1DNA-binding transcriptional regulatorAntitoxin
DG176_RS16225399807..400139-333WP_000843587.1type II toxin-antitoxin system RelE/ParE family toxinToxin
DG176_RS16235400480..400707-228WP_001894457.1DUF1289 domain-containing protein-
DG176_RS19790400656..400769-114WP_001889158.1hypothetical protein-
DG176_RS16255400935..401216-282WP_001894453.1DUF1289 domain-containing protein-
DG176_RS19795401165..401279-115Protein_358acetyltransferase-
DG176_RS16260401336..401713-378WP_000411109.1hypothetical protein-
DG176_RS16265401884..402126-243WP_000107461.1hypothetical protein-
DG176_RS16270402328..402714-387WP_000703163.1VOC family protein-
DG176_RS19865402923..403094-172Protein_362DUF645 family protein-
DG176_RS16280403412..403681-270WP_001198131.1hypothetical protein-
DG176_RS16285404041..404214-174WP_001882305.1DUF3709 domain-containing protein-
DG176_RS19715404495..404698-204WP_001911745.1hypothetical protein-

Associated MGEs

Loading, please wait
MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideGenomic islandcatB9-379325..47629796972
flankIS/Tn--397507..398487980
insideIntegroncatB9-379701..46950989808


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-2

(4-100)

Antitoxin

Cro/C1-type helix-turn-helix domain

(43-92)


Sequences

Toxin        


Download         Length: 111 a.a.        Molecular weight: 13005.95 Da        Isoelectric Point: 9.9244

>T294376 WP_000843587.1 NZ_LT992489:c400139-399807 [Vibrio cholerae]
MKSVFVESTIFEKYRDEYLSDEEYRLFQAELMLNPKLGDVIQGTGGLRKIRVASKGKGKRGGSRIIYYFLDEKRRFYLLT
IYGKNEMSDLNANQRKQLMAFMEAWRNEQS

Download         Length: 333 bp

Antitoxin


Download         Length: 105 a.a.        Molecular weight: 11696.20 Da        Isoelectric Point: 6.7600

>AT294376 WP_000071008.1 NZ_LT992489:c399820-399506 [Vibrio cholerae]
MSNRDLFAELSSALVEAKQHSEGKLTLKTHHVNDVGELNISPDEIVSIREQFNMSRGVFARLLHTSSRTLENWEQGRSVP
NGQAVTLLKLVQRHPETLSHIAEL

Download         Length: 315 bp


Similar Proteins

Only experimentally validated proteins are listed.

Loading, please wait
Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
Loading, please wait
Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

Loading, please wait
Source
ID
Structure
PDB5JA9
PDB8A0X
PDB5MJE
PDB5JA8
PDB5JAA

Antitoxin

Loading, please wait
Source
ID
Structure
No matching records found

References