294376

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/RelE-MqsA
Location 399506..400139 Replicon chromosome
Accession NZ_LT992489
Organism Vibrio cholerae strain 4295STDY6534232

Toxin (Protein)


Gene name higB Uniprot ID Q9KMA6
Locus tag DG176_RS16225 Protein ID WP_000843587.1
Coordinates 399807..400139 (-) Length 111 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag DG176_RS16220 Protein ID WP_000071008.1
Coordinates 399506..399820 (-) Length 105 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DG176_RS16175 394560..394847 - 288 WP_000221354.1 type II toxin-antitoxin system RelE/ParE family toxin -
DG176_RS16180 394837..395088 - 252 WP_001250179.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
DG176_RS16185 395302..395715 - 414 WP_000049417.1 VOC family protein -
DG176_RS16190 395790..395933 - 144 WP_071908341.1 DUF3265 domain-containing protein -
DG176_RS16195 395903..396304 - 402 WP_000351248.1 type II toxin-antitoxin system death-on-curing family toxin -
DG176_RS16200 396304..396996 - 693 WP_001047169.1 GNAT family N-acetyltransferase -
DG176_RS16205 397133..397439 - 307 Protein_349 CatB-related O-acetyltransferase -
DG176_RS16210 397507..398487 + 981 WP_000019370.1 IS5-like element ISVch5 family transposase -
DG176_RS19665 398612..398767 - 156 WP_000751734.1 hypothetical protein -
DG176_RS16215 398935..399369 - 435 WP_000256036.1 GNAT family N-acetyltransferase -
DG176_RS16220 399506..399820 - 315 WP_000071008.1 DNA-binding transcriptional regulator Antitoxin
DG176_RS16225 399807..400139 - 333 WP_000843587.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
DG176_RS16235 400480..400707 - 228 WP_001894457.1 DUF1289 domain-containing protein -
DG176_RS19790 400656..400769 - 114 WP_001889158.1 hypothetical protein -
DG176_RS16255 400935..401216 - 282 WP_001894453.1 DUF1289 domain-containing protein -
DG176_RS19795 401165..401279 - 115 Protein_358 acetyltransferase -
DG176_RS16260 401336..401713 - 378 WP_000411109.1 hypothetical protein -
DG176_RS16265 401884..402126 - 243 WP_000107461.1 hypothetical protein -
DG176_RS16270 402328..402714 - 387 WP_000703163.1 VOC family protein -
DG176_RS19865 402923..403094 - 172 Protein_362 DUF645 family protein -
DG176_RS16280 403412..403681 - 270 WP_001198131.1 hypothetical protein -
DG176_RS16285 404041..404214 - 174 WP_001882305.1 DUF3709 domain-containing protein -
DG176_RS19715 404495..404698 - 204 WP_001911745.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island catB9 - 379325..476297 96972
flank IS/Tn - - 397507..398487 980
inside Integron catB9 - 379701..469509 89808


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-2

(4-100)

Antitoxin

Cro/C1-type helix-turn-helix domain

(43-92)


Sequences

Toxin        


Download         Length: 111 a.a.        Molecular weight: 13005.95 Da        Isoelectric Point: 9.9244

>T294376 WP_000843587.1 NZ_LT992489:c400139-399807 [Vibrio cholerae]
MKSVFVESTIFEKYRDEYLSDEEYRLFQAELMLNPKLGDVIQGTGGLRKIRVASKGKGKRGGSRIIYYFLDEKRRFYLLT
IYGKNEMSDLNANQRKQLMAFMEAWRNEQS

Download         Length: 333 bp

Antitoxin


Download         Length: 105 a.a.        Molecular weight: 11696.20 Da        Isoelectric Point: 6.7600

>AT294376 WP_000071008.1 NZ_LT992489:c399820-399506 [Vibrio cholerae]
MSNRDLFAELSSALVEAKQHSEGKLTLKTHHVNDVGELNISPDEIVSIREQFNMSRGVFARLLHTSSRTLENWEQGRSVP
NGQAVTLLKLVQRHPETLSHIAEL

Download         Length: 315 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 5JA9
PDB 8A0X
PDB 5MJE
PDB 5JA8
PDB 5JAA

Antitoxin

Source ID Structure

References