Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /BrnT(toxin)
Location 367473..367971 Replicon chromosome
Accession NZ_CP013302
Organism Vibrio cholerae strain C5

Toxin (Protein)


Gene name - Uniprot ID Q9KMK7
Locus tag ASZ80_RS16120 Protein ID WP_000589156.1
Coordinates 367473..367739 (+) Length 89 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID Q9KMK6
Locus tag ASZ80_RS16125 Protein ID WP_000643598.1
Coordinates 367726..367971 (+) Length 82 a.a.

Genomic Context

ASZ80_RS20515ASZ80_RS20520ASZ80_RS16075ASZ80_RS16080ASZ80_RS16085ASZ80_RS16090ASZ80_RS16095ASZ80_RS20950ASZ80_RS20955ASZ80_RS16110ASZ80_RS16115ASZ80_RS16120ASZ80_RS16125ASZ80_RS16130ASZ80_RS20960ASZ80_RS16145ASZ80_RS16150ASZ80_RS16155ASZ80_RS16160ASZ80_RS16165ASZ80_RS16170
Location: 362894..363100 (207 bp)
Type: Others
Protein ID: Protein_348
Location: 363300..363401 (102 bp)
Type: Others
Protein ID: WP_001921603.1
Location: 363391..363777 (387 bp)
Type: Others
Protein ID: WP_000703163.1
Location: 363972..364223 (252 bp)
Type: Others
Protein ID: WP_001890111.1
Location: 364196..364345 (150 bp)
Type: Others
Protein ID: WP_071908333.1
Location: 364437..364679 (243 bp)
Type: Others
Protein ID: WP_000107461.1
Location: 364931..365209 (279 bp)
Type: Others
Protein ID: WP_000280324.1
Location: 365584..365727 (144 bp)
Type: Others
Protein ID: Protein_355
Location: 365781..365819 (39 bp)
Type: Others
Protein ID: WP_082798268.1
Location: 366031..366498 (468 bp)
Type: Others
Protein ID: WP_001289288.1
Location: 366626..367288 (663 bp)
Type: Others
Protein ID: WP_000960654.1
Location: 367473..367739 (267 bp)
Type: Toxin
Protein ID: WP_000589156.1
Location: 367726..367971 (246 bp)
Type: Antitoxin
Protein ID: WP_000643598.1
Location: 368067..368861 (795 bp)
Type: Others
Protein ID: WP_001911581.1
Location: 368964..369092 (129 bp)
Type: Others
Protein ID: WP_071908338.1
Location: 369153..369335 (183 bp)
Type: Others
Protein ID: WP_000923182.1
Location: 369551..370555 (1005 bp)
Type: Others
Protein ID: WP_000964920.1
Location: 370708..371067 (360 bp)
Type: Others
Protein ID: WP_001071541.1
Location: 371340..371573 (234 bp)
Type: Others
Protein ID: WP_001890112.1
Location: 371841..372347 (507 bp)
Type: Others
Protein ID: WP_000393074.1
Location: 372504..372890 (387 bp)
Type: Others
Protein ID: WP_000703163.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
ASZ80_RS20515362894..363100+207Protein_348DUF3709 domain-containing protein-
ASZ80_RS20520363300..363401+102WP_001921603.1hypothetical protein-
ASZ80_RS16075363391..363777+387WP_000703163.1VOC family protein-
ASZ80_RS16080363972..364223+252WP_001890111.1TIGR03643 family protein-
ASZ80_RS16085364196..364345+150WP_071908333.1DUF3265 domain-containing protein-
ASZ80_RS16090364437..364679+243WP_000107461.1hypothetical protein-
ASZ80_RS16095364931..365209+279WP_000280324.1DUF3709 domain-containing protein-
ASZ80_RS20950365584..365727+144Protein_355DUF645 family protein-
ASZ80_RS20955365781..365819+39WP_082798268.1hypothetical protein-
ASZ80_RS16110366031..366498+468WP_001289288.1OsmC family protein-
ASZ80_RS16115366626..367288+663WP_000960654.1hypothetical protein-
ASZ80_RS16120367473..367739+267WP_000589156.1BrnT family toxinToxin
ASZ80_RS16125367726..367971+246WP_000643598.1hypothetical proteinAntitoxin
ASZ80_RS16130368067..368861+795WP_001911581.1hypothetical protein-
ASZ80_RS20960368964..369092+129WP_071908338.1general secretion pathway protein GspI-
ASZ80_RS16145369153..369335+183WP_000923182.1DUF645 family protein-
ASZ80_RS16150369551..370555+1005WP_000964920.1LD-carboxypeptidase-
ASZ80_RS16155370708..371067+360WP_001071541.1VOC family protein-
ASZ80_RS16160371340..371573+234WP_001890112.1DUF3709 domain-containing protein-
ASZ80_RS16165371841..372347+507WP_000393074.1hypothetical protein-
ASZ80_RS16170372504..372890+387WP_000703163.1VOC family protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideGenomic islandcatB9-304694..469286164592
insideIntegron--309774..468910159136


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Ribonuclease toxin, BrnT, of type II toxin-antitoxin system

(6-81)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10092.34 Da        Isoelectric Point: 7.3171

>T58221 WP_000589156.1 NZ_CP013302:367473-367739 [Vibrio cholerae]
MIKFEFDENKSRSNLEKHGIDFHTAQGLWNDSDLIEIPANTSDEPRYLVVGLLNGKHWSGVITYRGTNIRIISVRRSRKA
EVSLYESA

Download         Length: 267 bp

>T58221 NZ_CP013302:367473-367739 [Vibrio cholerae]
ATGATTAAATTTGAATTTGATGAAAACAAAAGCAGAAGTAATCTCGAAAAGCACGGTATTGATTTTCATACAGCTCAAGG
ATTGTGGAATGATTCAGATCTTATCGAGATCCCTGCTAACACGAGTGATGAGCCCAGATATTTGGTTGTCGGCTTACTAA
ACGGTAAGCATTGGTCAGGAGTAATTACCTACCGAGGTACGAATATCAGGATCATCTCAGTTCGGCGTTCACGGAAAGCG
GAGGTAAGCCTTTATGAAAGCGCATGA

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 9478.77 Da        Isoelectric Point: 6.4832

>AT58221 WP_000643598.1 NZ_CP013302:367726-367971 [Vibrio cholerae]
MKAHEFDAKFESDDDDIVMDLDLSQAKRPMHKQKRVNVDFPAWMLESLDREASRIGVTRQSIIKIWLAERLESVSHHSSV
R

Download         Length: 246 bp

>AT58221 NZ_CP013302:367726-367971 [Vibrio cholerae]
ATGAAAGCGCATGAATTTGATGCCAAGTTTGAAAGTGACGACGATGATATCGTAATGGACTTGGATCTATCGCAAGCTAA
AAGACCGATGCATAAGCAAAAACGAGTCAATGTAGATTTTCCAGCCTGGATGCTTGAGTCCTTGGACAGAGAAGCGAGTC
GTATTGGTGTAACACGTCAATCAATCATTAAAATTTGGCTGGCAGAAAGGTTAGAGAGCGTGTCTCATCATTCAAGTGTG
AGATAA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A271VMP7

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A271VME2

References