46753

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-RelB
Location 69547..70106 Replicon chromosome
Accession NZ_CP007635
Organism Vibrio cholerae strain 2012EL-2176

Toxin (Protein)


Gene name relE Uniprot ID Q9K2M8
Locus tag EN18_RS14560 Protein ID WP_000578476.1
Coordinates 69547..69825 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID Q9L991
Locus tag EN18_RS14565 Protein ID WP_000381183.1
Coordinates 69822..70106 (-) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EN18_RS14520 64625..65131 + 507 WP_000393074.1 hypothetical protein -
EN18_RS14525 65288..65674 + 387 WP_000703163.1 VOC family protein -
EN18_RS14530 65931..66134 + 204 WP_001911580.1 hypothetical protein -
EN18_RS14535 66329..66580 + 252 WP_001890111.1 TIGR03643 family protein -
EN18_RS20560 66553..66702 + 150 WP_071908333.1 DUF3265 domain-containing protein -
EN18_RS14540 66849..67274 + 426 WP_000415750.1 hypothetical protein -
EN18_RS14545 67480..68103 + 624 WP_000247070.1 DUF1349 domain-containing protein -
EN18_RS14550 68316..68795 + 480 WP_000009888.1 lecithin retinol acyltransferase family protein -
EN18_RS14555 68983..69396 + 414 WP_000049420.1 VOC family protein -
EN18_RS14560 69547..69825 - 279 WP_000578476.1 type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family Toxin
EN18_RS14565 69822..70106 - 285 WP_000381183.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
EN18_RS14570 70301..70816 + 516 WP_001201520.1 lipocalin family protein -
EN18_RS14575 70881..71477 + 597 WP_000255434.1 hypothetical protein -
EN18_RS14580 71869..72051 + 183 WP_000923182.1 DUF645 family protein -
EN18_RS14585 72251..72724 + 474 WP_001161076.1 GrpB family protein -
EN18_RS20575 72739..72831 + 93 WP_014378730.1 DUF3265 domain-containing protein -
EN18_RS14590 72873..73499 + 627 WP_000365424.1 LysE family translocator -
EN18_RS14595 73622..74320 + 699 WP_001890502.1 hypothetical protein -
EN18_RS20580 74330..74440 + 111 WP_079857360.1 DUF3265 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island catB9 - 31037..137542 106505
inside Integron - - 36117..137166 101049


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(2-89)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(5-70)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10819.59 Da        Isoelectric Point: 5.1651

>T46753 WP_000578476.1 NZ_CP007635:c69825-69547 [Vibrio cholerae]
MIFWEEASLNDREKIFEFLYDFNPAAAKKTDELIEAKVENLLEQPLIGVQRDGIRGRLLIIPEISMIVSYWVDGSKIRIM
RVLHQKQKFPND

Download         Length: 279 bp

>T46753 NZ_CP007635:c69825-69547 [Vibrio cholerae]
ATGATTTTCTGGGAAGAAGCATCTCTCAATGATCGTGAGAAAATTTTCGAATTTCTCTACGACTTTAACCCAGCAGCGGC
TAAAAAAACGGATGAGCTCATAGAAGCCAAAGTCGAAAATTTGCTTGAGCAACCACTAATCGGTGTTCAGCGTGATGGCA
TTAGAGGCAGATTGCTTATTATCCCTGAGATATCAATGATTGTTTCGTATTGGGTTGATGGTTCTAAAATTCGAATAATG
CGTGTACTACATCAGAAACAAAAATTTCCAAACGACTGA

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10901.25 Da        Isoelectric Point: 8.0775

>AT46753 WP_000381183.1 NZ_CP007635:c70106-69822 [Vibrio cholerae]
MDTRIQFRVDEETKRLAQQMAESQGRTLSDACRELTEQLAEQQRKALSHDAWLTEQVNQAFEKFDSGKAVFIEHDIAKAR
MAERKAKIRNRGHA

Download         Length: 285 bp

>AT46753 NZ_CP007635:c70106-69822 [Vibrio cholerae]
ATGGATACTAGAATTCAATTTCGTGTAGACGAAGAAACAAAACGTTTAGCTCAACAAATGGCTGAAAGCCAAGGTCGAAC
TCTTAGCGATGCTTGCCGTGAACTCACTGAACAATTAGCTGAGCAGCAACGCAAGGCATTATCTCACGATGCATGGCTAA
CTGAACAAGTGAATCAAGCATTTGAGAAGTTCGACTCAGGAAAAGCAGTATTCATTGAACATGACATCGCCAAAGCACGA
ATGGCTGAACGTAAAGCTAAAATCCGAAATCGAGGCCACGCATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB Q9K2M8

Antitoxin

Source ID Structure
AlphaFold DB A0A067BL33

References