Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-RelB
Location 69547..70106 Replicon chromosome
Accession NZ_CP007635
Organism Vibrio cholerae strain 2012EL-2176

Toxin (Protein)


Gene name relE Uniprot ID Q9K2M8
Locus tag EN18_RS14560 Protein ID WP_000578476.1
Coordinates 69547..69825 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID Q9L991
Locus tag EN18_RS14565 Protein ID WP_000381183.1
Coordinates 69822..70106 (-) Length 95 a.a.

Genomic Context

EN18_RS14520EN18_RS14525EN18_RS14530EN18_RS14535EN18_RS20560EN18_RS14540EN18_RS14545EN18_RS14550EN18_RS14555EN18_RS14570EN18_RS14575EN18_RS14580EN18_RS14585EN18_RS20575EN18_RS14590EN18_RS14595EN18_RS20580EN18_RS14560EN18_RS14565
Location: 64625..65131 (507 bp)
Type: Others
Protein ID: WP_000393074.1
Location: 65288..65674 (387 bp)
Type: Others
Protein ID: WP_000703163.1
Location: 65931..66134 (204 bp)
Type: Others
Protein ID: WP_001911580.1
Location: 66329..66580 (252 bp)
Type: Others
Protein ID: WP_001890111.1
Location: 66553..66702 (150 bp)
Type: Others
Protein ID: WP_071908333.1
Location: 66849..67274 (426 bp)
Type: Others
Protein ID: WP_000415750.1
Location: 67480..68103 (624 bp)
Type: Others
Protein ID: WP_000247070.1
Location: 68316..68795 (480 bp)
Type: Others
Protein ID: WP_000009888.1
Location: 68983..69396 (414 bp)
Type: Others
Protein ID: WP_000049420.1
Location: 70301..70816 (516 bp)
Type: Others
Protein ID: WP_001201520.1
Location: 70881..71477 (597 bp)
Type: Others
Protein ID: WP_000255434.1
Location: 71869..72051 (183 bp)
Type: Others
Protein ID: WP_000923182.1
Location: 72251..72724 (474 bp)
Type: Others
Protein ID: WP_001161076.1
Location: 72739..72831 (93 bp)
Type: Others
Protein ID: WP_014378730.1
Location: 72873..73499 (627 bp)
Type: Others
Protein ID: WP_000365424.1
Location: 73622..74320 (699 bp)
Type: Others
Protein ID: WP_001890502.1
Location: 74330..74440 (111 bp)
Type: Others
Protein ID: WP_079857360.1
Location: 69547..69825 (279 bp)
Type: Toxin
Protein ID: WP_000578476.1
Location: 69822..70106 (285 bp)
Type: Antitoxin
Protein ID: WP_000381183.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
EN18_RS1452064625..65131+507WP_000393074.1hypothetical protein-
EN18_RS1452565288..65674+387WP_000703163.1VOC family protein-
EN18_RS1453065931..66134+204WP_001911580.1hypothetical protein-
EN18_RS1453566329..66580+252WP_001890111.1TIGR03643 family protein-
EN18_RS2056066553..66702+150WP_071908333.1DUF3265 domain-containing protein-
EN18_RS1454066849..67274+426WP_000415750.1hypothetical protein-
EN18_RS1454567480..68103+624WP_000247070.1DUF1349 domain-containing protein-
EN18_RS1455068316..68795+480WP_000009888.1lecithin retinol acyltransferase family protein-
EN18_RS1455568983..69396+414WP_000049420.1VOC family protein-
EN18_RS1456069547..69825-279WP_000578476.1type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE familyToxin
EN18_RS1456569822..70106-285WP_000381183.1type II toxin-antitoxin system RelB/DinJ family antitoxinAntitoxin
EN18_RS1457070301..70816+516WP_001201520.1lipocalin family protein-
EN18_RS1457570881..71477+597WP_000255434.1hypothetical protein-
EN18_RS1458071869..72051+183WP_000923182.1DUF645 family protein-
EN18_RS1458572251..72724+474WP_001161076.1GrpB family protein-
EN18_RS2057572739..72831+93WP_014378730.1DUF3265 domain-containing protein-
EN18_RS1459072873..73499+627WP_000365424.1LysE family translocator-
EN18_RS1459573622..74320+699WP_001890502.1hypothetical protein-
EN18_RS2058074330..74440+111WP_079857360.1DUF3265 domain-containing protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideGenomic islandcatB9-31037..137542106505
insideIntegron--36117..137166101049


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(2-89)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(5-70)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10819.59 Da        Isoelectric Point: 5.1651

>T46753 WP_000578476.1 NZ_CP007635:c69825-69547 [Vibrio cholerae]
MIFWEEASLNDREKIFEFLYDFNPAAAKKTDELIEAKVENLLEQPLIGVQRDGIRGRLLIIPEISMIVSYWVDGSKIRIM
RVLHQKQKFPND

Download         Length: 279 bp

>T46753 NZ_CP007635:c69825-69547 [Vibrio cholerae]
ATGATTTTCTGGGAAGAAGCATCTCTCAATGATCGTGAGAAAATTTTCGAATTTCTCTACGACTTTAACCCAGCAGCGGC
TAAAAAAACGGATGAGCTCATAGAAGCCAAAGTCGAAAATTTGCTTGAGCAACCACTAATCGGTGTTCAGCGTGATGGCA
TTAGAGGCAGATTGCTTATTATCCCTGAGATATCAATGATTGTTTCGTATTGGGTTGATGGTTCTAAAATTCGAATAATG
CGTGTACTACATCAGAAACAAAAATTTCCAAACGACTGA

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10901.25 Da        Isoelectric Point: 8.0775

>AT46753 WP_000381183.1 NZ_CP007635:c70106-69822 [Vibrio cholerae]
MDTRIQFRVDEETKRLAQQMAESQGRTLSDACRELTEQLAEQQRKALSHDAWLTEQVNQAFEKFDSGKAVFIEHDIAKAR
MAERKAKIRNRGHA

Download         Length: 285 bp

>AT46753 NZ_CP007635:c70106-69822 [Vibrio cholerae]
ATGGATACTAGAATTCAATTTCGTGTAGACGAAGAAACAAAACGTTTAGCTCAACAAATGGCTGAAAGCCAAGGTCGAAC
TCTTAGCGATGCTTGCCGTGAACTCACTGAACAATTAGCTGAGCAGCAACGCAAGGCATTATCTCACGATGCATGGCTAA
CTGAACAAGTGAATCAAGCATTTGAGAAGTTCGACTCAGGAAAAGCAGTATTCATTGAACATGACATCGCCAAAGCACGA
ATGGCTGAACGTAAAGCTAAAATCCGAAATCGAGGCCACGCATGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBQ9K2M8

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A067BL33

References