Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /GNAT-DUF1778
Location 217612..218378 Replicon chromosome
Accession NZ_LT992493
Organism Vibrio cholerae strain 4295STDY6534248

Toxin (Protein)


Gene name - Uniprot ID Q9K2P7
Locus tag DG169_RS15430 Protein ID WP_000982260.1
Coordinates 217612..218109 (-) Length 166 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID Q9K2J6
Locus tag DG169_RS15435 Protein ID WP_000246253.1
Coordinates 218106..218378 (-) Length 91 a.a.

Genomic Context

DG169_RS15370DG169_RS15375DG169_RS15395DG169_RS15400DG169_RS15405DG169_RS15420DG169_RS15425DG169_RS15440DG169_RS15445DG169_RS15455DG169_RS15475DG169_RS15480DG169_RS15485DG169_RS15490DG169_RS15495DG169_RS15500DG169_RS15505DG169_RS15385DG169_RS15390DG169_RS15430DG169_RS15435DG169_RS15460DG169_RS15465
Location: 213054..213758 (705 bp)
Type: Others
Protein ID: WP_000087610.1
Location: 213916..214254 (339 bp)
Type: Others
Protein ID: WP_000713853.1
Location: 215230..215616 (387 bp)
Type: Others
Protein ID: WP_001015867.1
Location: 215673..215786 (114 bp)
Type: Others
Protein ID: WP_001900214.1
Location: 215735..216016 (282 bp)
Type: Others
Protein ID: WP_001894429.1
Location: 216274..216810 (537 bp)
Type: Others
Protein ID: WP_000469482.1
Location: 216947..217462 (516 bp)
Type: Others
Protein ID: WP_001201509.1
Location: 218771..218896 (126 bp)
Type: Others
Protein ID: WP_001900195.1
Location: 218912..218950 (39 bp)
Type: Others
Protein ID: WP_106019118.1
Location: 219146..219592 (447 bp)
Type: Others
Protein ID: WP_000006157.1
Location: 220566..220844 (279 bp)
Type: Others
Protein ID: WP_001921601.1
Location: 221096..221302 (207 bp)
Type: Others
Protein ID: Protein_208
Location: 221502..221603 (102 bp)
Type: Others
Protein ID: WP_001921603.1
Location: 221593..221979 (387 bp)
Type: Others
Protein ID: WP_000703163.1
Location: 222174..222425 (252 bp)
Type: Others
Protein ID: WP_001890111.1
Location: 222398..222547 (150 bp)
Type: Others
Protein ID: WP_071908333.1
Location: 222639..222881 (243 bp)
Type: Others
Protein ID: WP_000107461.1
Location: 214408..214725 (318 bp)
Type: Others
Protein ID: WP_001180243.1
Location: 214744..214986 (243 bp)
Type: Others
Protein ID: WP_000557292.1
Location: 217612..218109 (498 bp)
Type: Toxin
Protein ID: WP_000982260.1
Location: 218106..218378 (273 bp)
Type: Antitoxin
Protein ID: WP_000246253.1
Location: 219740..220009 (270 bp)
Type: Others
Protein ID: WP_000277238.1
Location: 220002..220280 (279 bp)
Type: Others
Protein ID: WP_001258569.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
DG169_RS15370213054..213758+705WP_000087610.1HNH endonuclease-
DG169_RS15375213916..214254+339WP_000713853.1hypothetical protein-
DG169_RS15385214408..214725-318WP_001180243.1type II toxin-antitoxin system RelE/ParE family toxin-
DG169_RS15390214744..214986-243WP_000557292.1type II toxin-antitoxin system Phd/YefM family antitoxin-
DG169_RS15395215230..215616+387WP_001015867.1NUDIX hydrolase-
DG169_RS15400215673..215786+114WP_001900214.1hypothetical protein-
DG169_RS15405215735..216016+282WP_001894429.1DUF1289 domain-containing protein-
DG169_RS15420216274..216810+537WP_000469482.1GNAT family N-acetyltransferase-
DG169_RS15425216947..217462+516WP_001201509.1lipocalin family protein-
DG169_RS15430217612..218109-498WP_000982260.1GNAT family N-acetyltransferaseToxin
DG169_RS15435218106..218378-273WP_000246253.1DUF1778 domain-containing proteinAntitoxin
DG169_RS15440218771..218896+126WP_001900195.1DUF645 family protein-
DG169_RS15445218912..218950+39WP_106019118.1hypothetical protein-
DG169_RS15455219146..219592+447WP_000006157.1hypothetical protein-
DG169_RS15460219740..220009-270WP_000277238.1type II toxin-antitoxin system YafQ family toxin-
DG169_RS15465220002..220280-279WP_001258569.1type II toxin-antitoxin system RelB/DinJ family antitoxin-
DG169_RS15475220566..220844+279WP_001921601.1DUF3709 domain-containing protein-
DG169_RS15480221096..221302+207Protein_208DUF3709 domain-containing protein-
DG169_RS15485221502..221603+102WP_001921603.1hypothetical protein-
DG169_RS15490221593..221979+387WP_000703163.1VOC family protein-
DG169_RS15495222174..222425+252WP_001890111.1TIGR03643 family protein-
DG169_RS15500222398..222547+150WP_071908333.1DUF3265 domain-containing protein-
DG169_RS15505222639..222881+243WP_000107461.1hypothetical protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideGenomic islandcatB9-197768..29303295264
insideIntegroncatB9-202848..29265689808


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(86-152)

Antitoxin

Vibrio phage ICP1, Orf50

(7-86)


Sequences

Toxin        


Download         Length: 166 a.a.        Molecular weight: 18527.18 Da        Isoelectric Point: 8.7753

>T294407 WP_000982260.1 NZ_LT992493:c218109-217612 [Vibrio cholerae]
MMNTVLLDKDKHDRNRFNCGTEALNNYLKVMASQQAKKDNTRTFVLEDDNNSAYIIGFYTLTMTPIDLKALPDKLQKKHQ
SSTSGGLIARLAVDDRYKGKGFGEWLLIDALRKLLAASDSVAFPVVIVDAKDGAKHFYERYGFQAFQDAENKLFITIADI
RASLG

Download         Length: 498 bp

Antitoxin


Download         Length: 91 a.a.        Molecular weight: 9683.22 Da        Isoelectric Point: 6.2988

>AT294407 WP_000246253.1 NZ_LT992493:c218378-218106 [Vibrio cholerae]
MATTLPRITARVDVDTQDLLAKAAALAGMSSINSFVLNAAIEKAKQVIEREQALKLSQADAVLLMEALDNPAVVNAKLKL
ASERYESKTQ

Download         Length: 273 bp


Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A0Q0KGB1

Antitoxin

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Source
ID
Structure
PDB1Y9B
AlphaFold DBA0A0F2IC79

References