38682

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/YafQ-RelB
Location 295424..295964 Replicon chromosome
Accession NZ_AP024554
Organism Vibrio cholerae strain IDH-03329

Toxin (Protein)


Gene name relE Uniprot ID A0A151JGK8
Locus tag K6J80_RS15510 Protein ID WP_000277238.1
Coordinates 295695..295964 (+) Length 90 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID Q9KML3
Locus tag K6J80_RS15505 Protein ID WP_001258569.1
Coordinates 295424..295702 (+) Length 93 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K6J80_RS15455 291004..291471 - 468 WP_001289288.1 OsmC family protein -
K6J80_RS19080 291643..291774 - 132 WP_001883067.1 hypothetical protein -
K6J80_RS15470 292293..292571 - 279 WP_000280324.1 DUF3709 domain-containing protein -
K6J80_RS15475 292823..293065 - 243 WP_000107461.1 hypothetical protein -
K6J80_RS19085 293157..293306 - 150 WP_071908333.1 DUF3265 domain-containing protein -
K6J80_RS15480 293279..293530 - 252 WP_001890111.1 TIGR03643 family protein -
K6J80_RS15485 293725..294111 - 387 WP_000703163.1 VOC family protein -
K6J80_RS15490 294101..294202 - 102 WP_001921603.1 hypothetical protein -
K6J80_RS19090 294402..294500 - 99 WP_223225486.1 DUF3709 domain-containing protein -
K6J80_RS15500 294860..295138 - 279 WP_001921601.1 DUF3709 domain-containing protein -
K6J80_RS19095 295256..295373 - 118 Protein_348 DUF3265 domain-containing protein -
K6J80_RS15505 295424..295702 + 279 WP_001258569.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
K6J80_RS15510 295695..295964 + 270 WP_000277238.1 type II toxin-antitoxin system YafQ family toxin Toxin
K6J80_RS15515 296112..296558 - 447 WP_000006157.1 hypothetical protein -
K6J80_RS15525 296808..296933 - 126 WP_001900195.1 DUF645 family protein -
K6J80_RS15530 297326..297598 + 273 WP_000246253.1 DUF1778 domain-containing protein -
K6J80_RS15535 297595..298092 + 498 WP_000982260.1 GNAT family N-acetyltransferase -
K6J80_RS19100 298109..298177 - 69 Protein_355 acetyltransferase -
K6J80_RS15540 298242..298703 - 462 WP_001903091.1 lipocalin family protein -
K6J80_RS15545 298894..299430 - 537 WP_000469482.1 GNAT family protein -
K6J80_RS15550 299688..299909 - 222 WP_032467793.1 DUF1289 domain-containing protein -
K6J80_RS15555 299918..300031 - 114 WP_001900214.1 hypothetical protein -
K6J80_RS15560 300088..300474 - 387 WP_001015867.1 NUDIX hydrolase -
K6J80_RS15565 300718..300960 + 243 WP_000557292.1 type II toxin-antitoxin system Phd/YefM family antitoxin -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island catB9 - 213119..319686 106567
inside Integron - - 213119..312856 99737


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(2-89)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-85)


Sequences

Toxin        


Download         Length: 90 a.a.        Molecular weight: 10406.11 Da        Isoelectric Point: 9.5084

>T38682 WP_000277238.1 NZ_AP024554:295695-295964 [Vibrio cholerae]
MYKLEYSTQFKKDFKKITKMPISDIIEVGNVISKLQRGEKLEPKNVDHPLTGNWVGFRDCHIKPDLVLIYRVFNDQLQLA
RIGSHSDLF

Download         Length: 270 bp

>T38682 NZ_AP024554:295695-295964 [Vibrio cholerae]
ATGTATAAACTCGAATACTCCACACAGTTTAAGAAAGATTTCAAAAAGATAACTAAGATGCCGATTTCAGACATCATTGA
AGTCGGCAATGTTATTTCTAAGCTGCAACGCGGCGAAAAGCTTGAACCCAAGAATGTTGACCATCCGTTAACTGGAAATT
GGGTTGGATTTCGAGACTGCCACATTAAACCCGACCTAGTGTTAATCTATCGAGTTTTTAACGATCAACTACAACTAGCG
CGCATTGGTTCACATAGTGATTTATTCTAA

Antitoxin


Download         Length: 93 a.a.        Molecular weight: 10088.58 Da        Isoelectric Point: 6.0728

>AT38682 WP_001258569.1 NZ_AP024554:295424-295702 [Vibrio cholerae]
MRTEMLSTRIDHDTKIAFTNVCDEMGLSTSQAIKLFAKAVINHGGIPFELRVPQPNEVTASAIQELVEGKGHKAESVEAM
LNELTEGKVKHV

Download         Length: 279 bp

>AT38682 NZ_AP024554:295424-295702 [Vibrio cholerae]
ATGAGAACAGAAATGCTGAGCACGCGCATTGACCACGACACGAAAATTGCGTTCACAAACGTCTGCGATGAGATGGGTCT
AAGTACATCACAGGCCATAAAGTTATTTGCAAAAGCGGTTATTAATCATGGTGGAATCCCTTTTGAGCTGCGAGTTCCAC
AGCCTAATGAGGTTACTGCATCTGCAATTCAAGAGCTCGTTGAAGGAAAAGGACATAAAGCTGAATCCGTTGAAGCTATG
CTGAATGAGCTTACTGAAGGCAAAGTTAAGCATGTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A151JGK8

Antitoxin

Source ID Structure
AlphaFold DB A0A151KTP9

References