230518

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /BrnT(toxin)
Location 332541..333039 Replicon chromosome
Accession NZ_CP090379
Organism Vibrio cholerae strain BY369

Toxin (Protein)


Gene name - Uniprot ID Q9KMK7
Locus tag LVJ30_RS15365 Protein ID WP_000589156.1
Coordinates 332541..332807 (+) Length 89 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID Q9KMK6
Locus tag LVJ30_RS15370 Protein ID WP_000643598.1
Coordinates 332794..333039 (+) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LVJ30_RS15300 (LVJ30_15305) 328070..328168 + 99 WP_223225486.1 DUF3709 domain-containing protein -
LVJ30_RS15305 (LVJ30_15310) 328368..328469 + 102 WP_001921603.1 hypothetical protein -
LVJ30_RS15310 (LVJ30_15315) 328459..328845 + 387 WP_000703163.1 VOC family protein -
LVJ30_RS15315 (LVJ30_15320) 329040..329291 + 252 WP_001890111.1 TIGR03643 family protein -
LVJ30_RS15320 (LVJ30_15325) 329264..329413 + 150 WP_071908333.1 DUF3265 domain-containing protein -
LVJ30_RS15325 (LVJ30_15330) 329505..329747 + 243 WP_000107461.1 hypothetical protein -
LVJ30_RS15330 (LVJ30_15335) 329999..330277 + 279 WP_000280324.1 DUF3709 domain-containing protein -
LVJ30_RS15335 (LVJ30_15340) 330709..330752 + 44 Protein_300 hypothetical protein -
LVJ30_RS15340 (LVJ30_15345) 330734..330827 + 94 Protein_301 ggdef family protein -
LVJ30_RS15345 (LVJ30_15350) 330796..330927 + 132 WP_001883067.1 hypothetical protein -
LVJ30_RS15350 (LVJ30_15355) 331099..331566 + 468 WP_001289288.1 OsmC family protein -
LVJ30_RS15355 (LVJ30_15360) 331694..332356 + 663 WP_000960654.1 hypothetical protein -
LVJ30_RS15360 (LVJ30_15365) 332346..332474 + 129 WP_088124358.1 DUF3265 domain-containing protein -
LVJ30_RS15365 (LVJ30_15370) 332541..332807 + 267 WP_000589156.1 BrnT family toxin Toxin
LVJ30_RS15370 (LVJ30_15375) 332794..333039 + 246 WP_000643598.1 hypothetical protein Antitoxin
LVJ30_RS15375 (LVJ30_15380) 333135..333929 + 795 WP_001911581.1 hypothetical protein -
LVJ30_RS15380 (LVJ30_15385) 333926..334042 + 117 WP_086010881.1 DUF3265 domain-containing protein -
LVJ30_RS15385 (LVJ30_15390) 334032..334160 + 129 WP_071908338.1 general secretion pathway protein GspI -
LVJ30_RS15390 (LVJ30_15395) 334221..334403 + 183 WP_000923182.1 DUF645 family protein -
LVJ30_RS15395 (LVJ30_15400) 334603..335076 + 474 WP_001161076.1 GrpB family protein -
LVJ30_RS15400 (LVJ30_15405) 335091..335183 + 93 WP_014378730.1 DUF3265 domain-containing protein -
LVJ30_RS15405 (LVJ30_15410) 335225..335851 + 627 WP_000365424.1 LysE family translocator -
LVJ30_RS15410 (LVJ30_15415) 335974..336672 + 699 WP_001890502.1 hypothetical protein -
LVJ30_RS15415 (LVJ30_15420) 336703..336792 + 90 WP_072606010.1 DUF3265 domain-containing protein -
LVJ30_RS15420 (LVJ30_15425) 337370..337549 + 180 WP_001883058.1 DUF645 family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island catB9 - 304645..399892 95247
inside Integron - - 309725..399516 89791


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Ribonuclease toxin, BrnT, of type II toxin-antitoxin system

(6-81)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10092.34 Da        Isoelectric Point: 7.3171

>T230518 WP_000589156.1 NZ_CP090379:332541-332807 [Vibrio cholerae]
MIKFEFDENKSRSNLEKHGIDFHTAQGLWNDSDLIEIPANTSDEPRYLVVGLLNGKHWSGVITYRGTNIRIISVRRSRKA
EVSLYESA

Download         Length: 267 bp

>T230518 NZ_CP124916:c2657768-2657667 [Enterococcus faecalis]
TTGTCAATCGAAGCGGCATTGGAATTGATGATTAGTTTTGCAGCGTTTGTTGCACTACTGATTTTCGGTATCCTTGAAGC
AACGAAAAACAATAAAAAATAA

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 9478.77 Da        Isoelectric Point: 6.4832

>AT230518 WP_000643598.1 NZ_CP090379:332794-333039 [Vibrio cholerae]
MKAHEFDAKFESDDDDIVMDLDLSQAKRPMHKQKRVNVDFPAWMLESLDREASRIGVTRQSIIKIWLAERLESVSHHSSV
R

Download         Length: 246 bp

>AT230518 NZ_CP124916:2657548-2657722 [Enterococcus faecalis]
AAAAGAGAGGTATGCGGGTACATACCTCTCCTTTTATACCAACACCAGTTATAAGAACTGGTGGCTTACTGAGTTAAGTT
TTGAATCTTAACCGTTCGGCCTACGAAGCTTGTGAACGGTTATTTTTTATTGTTTTTCGTTGCTTCAAGGATACCGAAAA
TCAGTAGTGCAACAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A271VMP7

Antitoxin

Source ID Structure
AlphaFold DB A0A271VME2

References