Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /GNAT-DUF1778
Location 359457..360223 Replicon chromosome
Accession NZ_CP013306
Organism Vibrio cholerae strain CRC1106

Toxin (Protein)


Gene name - Uniprot ID Q9K2P7
Locus tag ASZ81_RS16065 Protein ID WP_000982260.1
Coordinates 359457..359954 (-) Length 166 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID -
Locus tag ASZ81_RS16070 Protein ID WP_000246254.1
Coordinates 359951..360223 (-) Length 91 a.a.

Genomic Context

ASZ81_RS16015ASZ81_RS16020ASZ81_RS16035ASZ81_RS16040ASZ81_RS16045ASZ81_RS16055ASZ81_RS16060ASZ81_RS20490ASZ81_RS20495ASZ81_RS16080ASZ81_RS16095ASZ81_RS20510ASZ81_RS20515ASZ81_RS16100ASZ81_RS16105ASZ81_RS16110ASZ81_RS16115ASZ81_RS16025ASZ81_RS16030ASZ81_RS16065ASZ81_RS16070ASZ81_RS16085ASZ81_RS16090
Location: 354899..355603 (705 bp)
Type: Others
Protein ID: WP_000087610.1
Location: 355761..356099 (339 bp)
Type: Others
Protein ID: WP_000713853.1
Location: 357075..357461 (387 bp)
Type: Others
Protein ID: WP_001015867.1
Location: 357518..357631 (114 bp)
Type: Others
Protein ID: WP_001900214.1
Location: 357580..357861 (282 bp)
Type: Others
Protein ID: WP_001894429.1
Location: 358119..358655 (537 bp)
Type: Others
Protein ID: WP_000469482.1
Location: 358792..359307 (516 bp)
Type: Others
Protein ID: WP_001201509.1
Location: 360616..360741 (126 bp)
Type: Others
Protein ID: WP_001900195.1
Location: 360757..360795 (39 bp)
Type: Others
Protein ID: WP_106019118.1
Location: 360991..361437 (447 bp)
Type: Others
Protein ID: WP_000006157.1
Location: 362411..362689 (279 bp)
Type: Others
Protein ID: WP_001921601.1
Location: 362941..363147 (207 bp)
Type: Others
Protein ID: Protein_347
Location: 363347..363448 (102 bp)
Type: Others
Protein ID: WP_001921603.1
Location: 363438..363824 (387 bp)
Type: Others
Protein ID: WP_000703163.1
Location: 364019..364270 (252 bp)
Type: Others
Protein ID: WP_001890111.1
Location: 364243..364392 (150 bp)
Type: Others
Protein ID: WP_071908333.1
Location: 364484..364726 (243 bp)
Type: Others
Protein ID: WP_000107461.1
Location: 356253..356570 (318 bp)
Type: Others
Protein ID: WP_001180243.1
Location: 356589..356831 (243 bp)
Type: Others
Protein ID: WP_000557292.1
Location: 359457..359954 (498 bp)
Type: Toxin
Protein ID: WP_000982260.1
Location: 359951..360223 (273 bp)
Type: Antitoxin
Protein ID: WP_000246254.1
Location: 361585..361854 (270 bp)
Type: Others
Protein ID: WP_000277238.1
Location: 361847..362125 (279 bp)
Type: Others
Protein ID: WP_001258569.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
ASZ81_RS16015354899..355603+705WP_000087610.1HNH endonuclease-
ASZ81_RS16020355761..356099+339WP_000713853.1hypothetical protein-
ASZ81_RS16025356253..356570-318WP_001180243.1type II toxin-antitoxin system RelE/ParE family toxin-
ASZ81_RS16030356589..356831-243WP_000557292.1type II toxin-antitoxin system Phd/YefM family antitoxin-
ASZ81_RS16035357075..357461+387WP_001015867.1NUDIX hydrolase-
ASZ81_RS16040357518..357631+114WP_001900214.1hypothetical protein-
ASZ81_RS16045357580..357861+282WP_001894429.1DUF1289 domain-containing protein-
ASZ81_RS16055358119..358655+537WP_000469482.1GNAT family N-acetyltransferase-
ASZ81_RS16060358792..359307+516WP_001201509.1lipocalin family protein-
ASZ81_RS16065359457..359954-498WP_000982260.1GNAT family N-acetyltransferaseToxin
ASZ81_RS16070359951..360223-273WP_000246254.1DUF1778 domain-containing proteinAntitoxin
ASZ81_RS20490360616..360741+126WP_001900195.1DUF645 family protein-
ASZ81_RS20495360757..360795+39WP_106019118.1hypothetical protein-
ASZ81_RS16080360991..361437+447WP_000006157.1hypothetical protein-
ASZ81_RS16085361585..361854-270WP_000277238.1type II toxin-antitoxin system YafQ family toxin-
ASZ81_RS16090361847..362125-279WP_001258569.1type II toxin-antitoxin system RelB/DinJ family antitoxin-
ASZ81_RS16095362411..362689+279WP_001921601.1DUF3709 domain-containing protein-
ASZ81_RS20510362941..363147+207Protein_347DUF3709 domain-containing protein-
ASZ81_RS20515363347..363448+102WP_001921603.1hypothetical protein-
ASZ81_RS16100363438..363824+387WP_000703163.1VOC family protein-
ASZ81_RS16105364019..364270+252WP_001890111.1TIGR03643 family protein-
ASZ81_RS16110364243..364392+150WP_071908333.1DUF3265 domain-containing protein-
ASZ81_RS16115364484..364726+243WP_000107461.1hypothetical protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideGenomic islandcatB9-304741..463550158809
insideIntegron--309821..463174153353


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(86-152)

Antitoxin

Vibrio phage ICP1, Orf50

(2-89)


Sequences

Toxin        


Download         Length: 166 a.a.        Molecular weight: 18527.18 Da        Isoelectric Point: 8.7753

>T58264 WP_000982260.1 NZ_CP013306:c359954-359457 [Vibrio cholerae]
MMNTVLLDKDKHDRNRFNCGTEALNNYLKVMASQQAKKDNTRTFVLEDDNNSAYIIGFYTLTMTPIDLKALPDKLQKKHQ
SSTSGGLIARLAVDDRYKGKGFGEWLLIDALRKLLAASDSVAFPVVIVDAKDGAKHFYERYGFQAFQDAENKLFITIADI
RASLG

Download         Length: 498 bp

>T58264 NZ_CP013306:c359954-359457 [Vibrio cholerae]
ATGATGAATACGGTACTTCTCGATAAAGATAAGCACGATAGGAACCGTTTCAATTGTGGCACTGAAGCACTCAACAATTA
CTTAAAAGTAATGGCGAGTCAGCAAGCCAAAAAAGACAACACCAGAACCTTCGTTTTGGAAGATGACAATAACAGTGCTT
ATATCATCGGCTTTTACACTCTGACTATGACGCCCATTGATTTGAAAGCCTTGCCCGACAAGTTACAAAAGAAGCACCAA
TCCTCAACCTCTGGAGGGCTCATTGCTCGTTTAGCTGTCGACGATAGATACAAAGGAAAAGGTTTTGGTGAGTGGCTACT
CATTGACGCTCTCAGAAAGCTACTCGCAGCCAGTGACAGTGTAGCGTTCCCTGTTGTCATTGTTGATGCCAAAGATGGTG
CAAAACATTTCTATGAGCGCTATGGGTTTCAAGCGTTTCAAGATGCCGAAAACAAACTCTTCATCACCATTGCTGATATC
AGAGCAAGCTTAGGCTAG

Antitoxin


Download         Length: 91 a.a.        Molecular weight: 9685.19 Da        Isoelectric Point: 6.2988

>AT58264 WP_000246254.1 NZ_CP013306:c360223-359951 [Vibrio cholerae]
MATTLPRITARVDVDTQDLLTKAAALAGMSSINSFVLNAAIEKAKQVIEREQALKLSQADAVLLMEALDNPAVANAKLKL
ASERYESKTQ

Download         Length: 273 bp

>AT58264 NZ_CP013306:c360223-359951 [Vibrio cholerae]
ATGGCAACGACTTTGCCTCGCATCACCGCTAGAGTTGATGTCGATACTCAAGATTTACTCACTAAGGCTGCTGCTCTTGC
TGGCATGTCTAGTATTAACTCATTTGTTTTGAATGCGGCAATTGAAAAAGCAAAACAAGTCATTGAACGTGAGCAAGCTC
TAAAGCTTAGCCAAGCTGATGCCGTATTGCTGATGGAAGCTCTTGATAATCCAGCGGTAGCAAATGCAAAGCTCAAATTG
GCATCCGAACGTTATGAGAGCAAAACTCAATGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A0Q0KGB1

Antitoxin

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Source
ID
Structure
No matching records found

References