Detailed information of TA system TA058264

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): /GNAT-DUF1778
• Location: 359457..360223
• Replicon: chromosome
• Accession: NZ_CP013306
• Organism: Vibrio cholerae strain CRC1106

Toxin (Protein)

• Gene name: -
• Uniprot ID: Q9K2P7
• Locus tag: ASZ81_RS16065
• Protein ID: WP_000982260.1
• Coordinates: 359457..359954 (-)
• Length: 166 a.a.

Antitoxin (Protein)

• Gene name: -
• Uniprot ID: -
• Locus tag: ASZ81_RS16070
• Protein ID: WP_000246254.1
• Coordinates: 359951..360223 (-)
• Length: 91 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
ASZ81_RS16015	354899..355603	+	705	WP_000087610.1	HNH endonuclease	-
ASZ81_RS16020	355761..356099	+	339	WP_000713853.1	hypothetical protein	-
ASZ81_RS16025	356253..356570	-	318	WP_001180243.1	type II toxin-antitoxin system RelE/ParE family toxin	-
ASZ81_RS16030	356589..356831	-	243	WP_000557292.1	type II toxin-antitoxin system Phd/YefM family antitoxin	-
ASZ81_RS16035	357075..357461	+	387	WP_001015867.1	NUDIX hydrolase	-
ASZ81_RS16040	357518..357631	+	114	WP_001900214.1	hypothetical protein	-
ASZ81_RS16045	357580..357861	+	282	WP_001894429.1	DUF1289 domain-containing protein	-
ASZ81_RS16055	358119..358655	+	537	WP_000469482.1	GNAT family N-acetyltransferase	-
ASZ81_RS16060	358792..359307	+	516	WP_001201509.1	lipocalin family protein	-
ASZ81_RS16065	359457..359954	-	498	WP_000982260.1	GNAT family N-acetyltransferase	Toxin
ASZ81_RS16070	359951..360223	-	273	WP_000246254.1	DUF1778 domain-containing protein	Antitoxin
ASZ81_RS20490	360616..360741	+	126	WP_001900195.1	DUF645 family protein	-
ASZ81_RS20495	360757..360795	+	39	WP_106019118.1	hypothetical protein	-
ASZ81_RS16080	360991..361437	+	447	WP_000006157.1	hypothetical protein	-
ASZ81_RS16085	361585..361854	-	270	WP_000277238.1	type II toxin-antitoxin system YafQ family toxin	-
ASZ81_RS16090	361847..362125	-	279	WP_001258569.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	-
ASZ81_RS16095	362411..362689	+	279	WP_001921601.1	DUF3709 domain-containing protein	-
ASZ81_RS20510	362941..363147	+	207	Protein_347	DUF3709 domain-containing protein	-
ASZ81_RS20515	363347..363448	+	102	WP_001921603.1	hypothetical protein	-
ASZ81_RS16100	363438..363824	+	387	WP_000703163.1	VOC family protein	-
ASZ81_RS16105	364019..364270	+	252	WP_001890111.1	TIGR03643 family protein	-
ASZ81_RS16110	364243..364392	+	150	WP_071908333.1	DUF3265 domain-containing protein	-
ASZ81_RS16115	364484..364726	+	243	WP_000107461.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	catB9	-	304741..463550	158809
	Similar MGE(s) Similar MGE(s) is defined as other TA-related MGE(s) with Mash distance < 0.01 to this MGE. Detail Genome accession Organism MGE type Related TA Coordinates Mash distance View NC_002506 Vibrio cholerae O1 biovar El Tor str. N16961 Integron TA000164, TA000169, TA000166, TA000167, TA000179, TA000170, TA000171, TA000172, TA000173, TA000174, TA000175, TA000176, TA000177, TA000178, TA000168, TA000165, TA010030, TA010035 309750..435387 0.006	inside	Integron	-	-	309821..463174	153353

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• GNAT domain (86-152)

Antitoxin

• Vibrio phage ICP1, Orf50 (2-89)

Sequences

Toxin

Protein

• Length: 166 a.a.
• Molecular weight: 18527.18 Da
• Isoelectric Point: 8.7753

>T58264 WP_000982260.1 NZ_CP013306:c359954-359457 [Vibrio cholerae]
MMNTVLLDKDKHDRNRFNCGTEALNNYLKVMASQQAKKDNTRTFVLEDDNNSAYIIGFYTLTMTPIDLKALPDKLQKKHQ
SSTSGGLIARLAVDDRYKGKGFGEWLLIDALRKLLAASDSVAFPVVIVDAKDGAKHFYERYGFQAFQDAENKLFITIADI
RASLG

Nucleotide

• Length: 498 bp

>T58264 NZ_CP013306:c359954-359457 [Vibrio cholerae]
ATGATGAATACGGTACTTCTCGATAAAGATAAGCACGATAGGAACCGTTTCAATTGTGGCACTGAAGCACTCAACAATTA
CTTAAAAGTAATGGCGAGTCAGCAAGCCAAAAAAGACAACACCAGAACCTTCGTTTTGGAAGATGACAATAACAGTGCTT
ATATCATCGGCTTTTACACTCTGACTATGACGCCCATTGATTTGAAAGCCTTGCCCGACAAGTTACAAAAGAAGCACCAA
TCCTCAACCTCTGGAGGGCTCATTGCTCGTTTAGCTGTCGACGATAGATACAAAGGAAAAGGTTTTGGTGAGTGGCTACT
CATTGACGCTCTCAGAAAGCTACTCGCAGCCAGTGACAGTGTAGCGTTCCCTGTTGTCATTGTTGATGCCAAAGATGGTG
CAAAACATTTCTATGAGCGCTATGGGTTTCAAGCGTTTCAAGATGCCGAAAACAAACTCTTCATCACCATTGCTGATATC
AGAGCAAGCTTAGGCTAG

Antitoxin

Protein

• Length: 91 a.a.
• Molecular weight: 9685.19 Da
• Isoelectric Point: 6.2988

>AT58264 WP_000246254.1 NZ_CP013306:c360223-359951 [Vibrio cholerae]
MATTLPRITARVDVDTQDLLTKAAALAGMSSINSFVLNAAIEKAKQVIEREQALKLSQADAVLLMEALDNPAVANAKLKL
ASERYESKTQ

Nucleotide

• Length: 273 bp

>AT58264 NZ_CP013306:c360223-359951 [Vibrio cholerae]
ATGGCAACGACTTTGCCTCGCATCACCGCTAGAGTTGATGTCGATACTCAAGATTTACTCACTAAGGCTGCTGCTCTTGC
TGGCATGTCTAGTATTAACTCATTTGTTTTGAATGCGGCAATTGAAAAAGCAAAACAAGTCATTGAACGTGAGCAAGCTC
TAAAGCTTAGCCAAGCTGATGCCGTATTGCTGATGGAAGCTCTTGATAATCCAGCGGTAGCAAATGCAAAGCTCAAATTG
GCATCCGAACGTTATGAGAGCAAAACTCAATGA

Structures

Toxin

• AlphaFold DB: A0A0Q0KGB1