Detailed information of TA system TA058266

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): /BrnT(toxin)
• Location: 367520..368018
• Replicon: chromosome
• Accession: NZ_CP013306
• Organism: Vibrio cholerae strain CRC1106

Toxin (Protein)

• Gene name: -
• Uniprot ID: Q9KMK7
• Locus tag: ASZ81_RS16145
• Protein ID: WP_000589156.1
• Coordinates: 367520..367786 (+)
• Length: 89 a.a.

Antitoxin (Protein)

• Gene name: -
• Uniprot ID: Q9KMK6
• Locus tag: ASZ81_RS16150
• Protein ID: WP_000643598.1
• Coordinates: 367773..368018 (+)
• Length: 82 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
ASZ81_RS20510	362941..363147	+	207	Protein_347	DUF3709 domain-containing protein	-
ASZ81_RS20515	363347..363448	+	102	WP_001921603.1	hypothetical protein	-
ASZ81_RS16100	363438..363824	+	387	WP_000703163.1	VOC family protein	-
ASZ81_RS16105	364019..364270	+	252	WP_001890111.1	TIGR03643 family protein	-
ASZ81_RS16110	364243..364392	+	150	WP_071908333.1	DUF3265 domain-containing protein	-
ASZ81_RS16115	364484..364726	+	243	WP_000107461.1	hypothetical protein	-
ASZ81_RS16120	364978..365256	+	279	WP_000280324.1	DUF3709 domain-containing protein	-
ASZ81_RS20920	365631..365774	+	144	Protein_354	DUF645 family protein	-
ASZ81_RS20925	365828..365866	+	39	WP_082798268.1	hypothetical protein	-
ASZ81_RS16135	366078..366545	+	468	WP_001289288.1	OsmC family protein	-
ASZ81_RS16140	366673..367335	+	663	WP_000960654.1	hypothetical protein	-
ASZ81_RS16145	367520..367786	+	267	WP_000589156.1	BrnT family toxin	Toxin
ASZ81_RS16150	367773..368018	+	246	WP_000643598.1	hypothetical protein	Antitoxin
ASZ81_RS16155	368114..368908	+	795	WP_001911581.1	hypothetical protein	-
ASZ81_RS20930	369011..369139	+	129	WP_071908338.1	general secretion pathway protein GspI	-
ASZ81_RS16170	369200..369382	+	183	WP_000923182.1	DUF645 family protein	-
ASZ81_RS16175	369598..370602	+	1005	WP_000964920.1	LD-carboxypeptidase	-
ASZ81_RS16180	370755..371114	+	360	WP_001071541.1	VOC family protein	-
ASZ81_RS16185	371387..371620	+	234	WP_001890112.1	DUF3709 domain-containing protein	-
ASZ81_RS16190	371888..372394	+	507	WP_000393074.1	hypothetical protein	-
ASZ81_RS16195	372551..372937	+	387	WP_000703163.1	VOC family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	catB9	-	304741..463550	158809
	Similar MGE(s) Similar MGE(s) is defined as other TA-related MGE(s) with Mash distance < 0.01 to this MGE. Detail Genome accession Organism MGE type Related TA Coordinates Mash distance View NC_002506 Vibrio cholerae O1 biovar El Tor str. N16961 Integron TA000164, TA000169, TA000166, TA000167, TA000179, TA000170, TA000171, TA000172, TA000173, TA000174, TA000175, TA000176, TA000177, TA000178, TA000168, TA000165, TA010030, TA010035 309750..435387 0.006	inside	Integron	-	-	309821..463174	153353

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Ribonuclease toxin, BrnT, of type II toxin-antitoxin system (6-81)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 89 a.a.
• Molecular weight: 10092.34 Da
• Isoelectric Point: 7.3171

>T58266 WP_000589156.1 NZ_CP013306:367520-367786 [Vibrio cholerae]
MIKFEFDENKSRSNLEKHGIDFHTAQGLWNDSDLIEIPANTSDEPRYLVVGLLNGKHWSGVITYRGTNIRIISVRRSRKA
EVSLYESA

Nucleotide

• Length: 267 bp

>T58266 NZ_CP013306:367520-367786 [Vibrio cholerae]
ATGATTAAATTTGAATTTGATGAAAACAAAAGCAGAAGTAATCTCGAAAAGCACGGTATTGATTTTCATACAGCTCAAGG
ATTGTGGAATGATTCAGATCTTATCGAGATCCCTGCTAACACGAGTGATGAGCCCAGATATTTGGTTGTCGGCTTACTAA
ACGGTAAGCATTGGTCAGGAGTAATTACCTACCGAGGTACGAATATCAGGATCATCTCAGTTCGGCGTTCACGGAAAGCG
GAGGTAAGCCTTTATGAAAGCGCATGA

Antitoxin

Protein

• Length: 82 a.a.
• Molecular weight: 9478.77 Da
• Isoelectric Point: 6.4832

>AT58266 WP_000643598.1 NZ_CP013306:367773-368018 [Vibrio cholerae]
MKAHEFDAKFESDDDDIVMDLDLSQAKRPMHKQKRVNVDFPAWMLESLDREASRIGVTRQSIIKIWLAERLESVSHHSSV
R

Nucleotide

• Length: 246 bp

>AT58266 NZ_CP013306:367773-368018 [Vibrio cholerae]
ATGAAAGCGCATGAATTTGATGCCAAGTTTGAAAGTGACGACGATGATATCGTAATGGACTTGGATCTATCGCAAGCTAA
AAGACCGATGCATAAGCAAAAACGAGTCAATGTAGATTTTCCAGCCTGGATGCTTGAGTCCTTGGACAGAGAAGCGAGTC
GTATTGGTGTAACACGTCAATCAATCATTAAAATTTGGCTGGCAGAAAGGTTAGAGAGCGTGTCTCATCATTCAAGTGTG
AGATAA

Structures

Toxin

• AlphaFold DB: A0A271VMP7

Antitoxin

• AlphaFold DB: A0A271VME2