Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /BrnT(toxin)
Location 367520..368018 Replicon chromosome
Accession NZ_CP013306
Organism Vibrio cholerae strain CRC1106

Toxin (Protein)


Gene name - Uniprot ID Q9KMK7
Locus tag ASZ81_RS16145 Protein ID WP_000589156.1
Coordinates 367520..367786 (+) Length 89 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID Q9KMK6
Locus tag ASZ81_RS16150 Protein ID WP_000643598.1
Coordinates 367773..368018 (+) Length 82 a.a.

Genomic Context

ASZ81_RS20510ASZ81_RS20515ASZ81_RS16100ASZ81_RS16105ASZ81_RS16110ASZ81_RS16115ASZ81_RS16120ASZ81_RS20920ASZ81_RS20925ASZ81_RS16135ASZ81_RS16140ASZ81_RS16145ASZ81_RS16150ASZ81_RS16155ASZ81_RS20930ASZ81_RS16170ASZ81_RS16175ASZ81_RS16180ASZ81_RS16185ASZ81_RS16190ASZ81_RS16195
Location: 362941..363147 (207 bp)
Type: Others
Protein ID: Protein_347
Location: 363347..363448 (102 bp)
Type: Others
Protein ID: WP_001921603.1
Location: 363438..363824 (387 bp)
Type: Others
Protein ID: WP_000703163.1
Location: 364019..364270 (252 bp)
Type: Others
Protein ID: WP_001890111.1
Location: 364243..364392 (150 bp)
Type: Others
Protein ID: WP_071908333.1
Location: 364484..364726 (243 bp)
Type: Others
Protein ID: WP_000107461.1
Location: 364978..365256 (279 bp)
Type: Others
Protein ID: WP_000280324.1
Location: 365631..365774 (144 bp)
Type: Others
Protein ID: Protein_354
Location: 365828..365866 (39 bp)
Type: Others
Protein ID: WP_082798268.1
Location: 366078..366545 (468 bp)
Type: Others
Protein ID: WP_001289288.1
Location: 366673..367335 (663 bp)
Type: Others
Protein ID: WP_000960654.1
Location: 367520..367786 (267 bp)
Type: Toxin
Protein ID: WP_000589156.1
Location: 367773..368018 (246 bp)
Type: Antitoxin
Protein ID: WP_000643598.1
Location: 368114..368908 (795 bp)
Type: Others
Protein ID: WP_001911581.1
Location: 369011..369139 (129 bp)
Type: Others
Protein ID: WP_071908338.1
Location: 369200..369382 (183 bp)
Type: Others
Protein ID: WP_000923182.1
Location: 369598..370602 (1005 bp)
Type: Others
Protein ID: WP_000964920.1
Location: 370755..371114 (360 bp)
Type: Others
Protein ID: WP_001071541.1
Location: 371387..371620 (234 bp)
Type: Others
Protein ID: WP_001890112.1
Location: 371888..372394 (507 bp)
Type: Others
Protein ID: WP_000393074.1
Location: 372551..372937 (387 bp)
Type: Others
Protein ID: WP_000703163.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
ASZ81_RS20510362941..363147+207Protein_347DUF3709 domain-containing protein-
ASZ81_RS20515363347..363448+102WP_001921603.1hypothetical protein-
ASZ81_RS16100363438..363824+387WP_000703163.1VOC family protein-
ASZ81_RS16105364019..364270+252WP_001890111.1TIGR03643 family protein-
ASZ81_RS16110364243..364392+150WP_071908333.1DUF3265 domain-containing protein-
ASZ81_RS16115364484..364726+243WP_000107461.1hypothetical protein-
ASZ81_RS16120364978..365256+279WP_000280324.1DUF3709 domain-containing protein-
ASZ81_RS20920365631..365774+144Protein_354DUF645 family protein-
ASZ81_RS20925365828..365866+39WP_082798268.1hypothetical protein-
ASZ81_RS16135366078..366545+468WP_001289288.1OsmC family protein-
ASZ81_RS16140366673..367335+663WP_000960654.1hypothetical protein-
ASZ81_RS16145367520..367786+267WP_000589156.1BrnT family toxinToxin
ASZ81_RS16150367773..368018+246WP_000643598.1hypothetical proteinAntitoxin
ASZ81_RS16155368114..368908+795WP_001911581.1hypothetical protein-
ASZ81_RS20930369011..369139+129WP_071908338.1general secretion pathway protein GspI-
ASZ81_RS16170369200..369382+183WP_000923182.1DUF645 family protein-
ASZ81_RS16175369598..370602+1005WP_000964920.1LD-carboxypeptidase-
ASZ81_RS16180370755..371114+360WP_001071541.1VOC family protein-
ASZ81_RS16185371387..371620+234WP_001890112.1DUF3709 domain-containing protein-
ASZ81_RS16190371888..372394+507WP_000393074.1hypothetical protein-
ASZ81_RS16195372551..372937+387WP_000703163.1VOC family protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideGenomic islandcatB9-304741..463550158809
insideIntegron--309821..463174153353


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Ribonuclease toxin, BrnT, of type II toxin-antitoxin system

(6-81)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10092.34 Da        Isoelectric Point: 7.3171

>T58266 WP_000589156.1 NZ_CP013306:367520-367786 [Vibrio cholerae]
MIKFEFDENKSRSNLEKHGIDFHTAQGLWNDSDLIEIPANTSDEPRYLVVGLLNGKHWSGVITYRGTNIRIISVRRSRKA
EVSLYESA

Download         Length: 267 bp

>T58266 NZ_CP013306:367520-367786 [Vibrio cholerae]
ATGATTAAATTTGAATTTGATGAAAACAAAAGCAGAAGTAATCTCGAAAAGCACGGTATTGATTTTCATACAGCTCAAGG
ATTGTGGAATGATTCAGATCTTATCGAGATCCCTGCTAACACGAGTGATGAGCCCAGATATTTGGTTGTCGGCTTACTAA
ACGGTAAGCATTGGTCAGGAGTAATTACCTACCGAGGTACGAATATCAGGATCATCTCAGTTCGGCGTTCACGGAAAGCG
GAGGTAAGCCTTTATGAAAGCGCATGA

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 9478.77 Da        Isoelectric Point: 6.4832

>AT58266 WP_000643598.1 NZ_CP013306:367773-368018 [Vibrio cholerae]
MKAHEFDAKFESDDDDIVMDLDLSQAKRPMHKQKRVNVDFPAWMLESLDREASRIGVTRQSIIKIWLAERLESVSHHSSV
R

Download         Length: 246 bp

>AT58266 NZ_CP013306:367773-368018 [Vibrio cholerae]
ATGAAAGCGCATGAATTTGATGCCAAGTTTGAAAGTGACGACGATGATATCGTAATGGACTTGGATCTATCGCAAGCTAA
AAGACCGATGCATAAGCAAAAACGAGTCAATGTAGATTTTCCAGCCTGGATGCTTGAGTCCTTGGACAGAGAAGCGAGTC
GTATTGGTGTAACACGTCAATCAATCATTAAAATTTGGCTGGCAGAAAGGTTAGAGAGCGTGTCTCATCATTCAAGTGTG
AGATAA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A271VMP7

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A271VME2

References