Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/ParE-Phd
Location 108966..109544 Replicon chromosome
Accession NZ_CP013316
Organism Vibrio cholerae strain M2140

Toxin (Protein)


Gene name parE Uniprot ID O68848
Locus tag ASZ83_RS14485 Protein ID WP_001180243.1
Coordinates 108966..109283 (-) Length 106 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID Q7DCR7
Locus tag ASZ83_RS14490 Protein ID WP_000557292.1
Coordinates 109302..109544 (-) Length 81 a.a.

Genomic Context

ASZ83_RS14455ASZ83_RS14460ASZ83_RS14465ASZ83_RS14470ASZ83_RS14475ASZ83_RS14480ASZ83_RS14495ASZ83_RS14500ASZ83_RS14505ASZ83_RS14515ASZ83_RS14520ASZ83_RS19990ASZ83_RS19995ASZ83_RS14540ASZ83_RS14485ASZ83_RS14490ASZ83_RS14525ASZ83_RS14530
Location: 104490..104672 (183 bp)
Type: Others
Protein ID: WP_000923340.1
Location: 105026..105208 (183 bp)
Type: Others
Protein ID: WP_000923153.1
Location: 105403..106080 (678 bp)
Type: Others
Protein ID: WP_000254617.1
Location: 106242..107450 (1209 bp)
Type: Others
Protein ID: WP_000272282.1
Location: 107612..108316 (705 bp)
Type: Others
Protein ID: WP_000087610.1
Location: 108474..108812 (339 bp)
Type: Others
Protein ID: WP_000713853.1
Location: 109788..110174 (387 bp)
Type: Others
Protein ID: WP_001015867.1
Location: 110231..110344 (114 bp)
Type: Others
Protein ID: WP_001900214.1
Location: 110293..110574 (282 bp)
Type: Others
Protein ID: WP_001894429.1
Location: 110832..111368 (537 bp)
Type: Others
Protein ID: WP_000469482.1
Location: 111505..112020 (516 bp)
Type: Others
Protein ID: WP_001201509.1
Location: 113329..113454 (126 bp)
Type: Others
Protein ID: WP_001900195.1
Location: 113470..113508 (39 bp)
Type: Others
Protein ID: WP_106019118.1
Location: 113704..114150 (447 bp)
Type: Others
Protein ID: WP_000006157.1
Location: 108966..109283 (318 bp)
Type: Toxin
Protein ID: WP_001180243.1
Location: 109302..109544 (243 bp)
Type: Antitoxin
Protein ID: WP_000557292.1
Location: 112170..112667 (498 bp)
Type: Others
Protein ID: WP_000982260.1
Location: 112664..112936 (273 bp)
Type: Others
Protein ID: WP_000246253.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
ASZ83_RS14455104490..104672+183WP_000923340.1DUF645 family protein-
ASZ83_RS14460105026..105208+183WP_000923153.1DUF645 family protein-
ASZ83_RS14465105403..106080+678WP_000254617.1HNH endonuclease-
ASZ83_RS14470106242..107450+1209WP_000272282.1deoxyguanosinetriphosphate triphosphohydrolase family protein-
ASZ83_RS14475107612..108316+705WP_000087610.1HNH endonuclease-
ASZ83_RS14480108474..108812+339WP_000713853.1hypothetical protein-
ASZ83_RS14485108966..109283-318WP_001180243.1type II toxin-antitoxin system RelE/ParE family toxinToxin
ASZ83_RS14490109302..109544-243WP_000557292.1type II toxin-antitoxin system Phd/YefM family antitoxinAntitoxin
ASZ83_RS14495109788..110174+387WP_001015867.1NUDIX hydrolase-
ASZ83_RS14500110231..110344+114WP_001900214.1hypothetical protein-
ASZ83_RS14505110293..110574+282WP_001894429.1DUF1289 domain-containing protein-
ASZ83_RS14515110832..111368+537WP_000469482.1GNAT family N-acetyltransferase-
ASZ83_RS14520111505..112020+516WP_001201509.1lipocalin family protein-
ASZ83_RS14525112170..112667-498WP_000982260.1GNAT family N-acetyltransferase-
ASZ83_RS14530112664..112936-273WP_000246253.1DUF1778 domain-containing protein-
ASZ83_RS19990113329..113454+126WP_001900195.1DUF645 family protein-
ASZ83_RS19995113470..113508+39WP_106019118.1hypothetical protein-
ASZ83_RS14540113704..114150+447WP_000006157.1hypothetical protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideGenomic island--87981..224211136230
insideIntegron--93061..221594128533


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-93)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-71)


Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 12158.97 Da        Isoelectric Point: 9.7495

>T58372 WP_001180243.1 NZ_CP013316:c109283-108966 [Vibrio cholerae]
MQNKQYKLSQLAQEHLLKIKHYTIENFAEAQWQKYKSTLLSGFQTLADNPGLGKSCEDIYQNGFYFPVGKHMAYYTKEAN
FILIVAVLGQSQLPQKHLKQSRFVS

Download         Length: 318 bp

>T58372 NZ_CP013316:c109283-108966 [Vibrio cholerae]
ATGCAAAATAAACAATATAAGCTCAGCCAATTAGCCCAAGAGCACTTACTCAAGATTAAACACTACACCATTGAAAATTT
CGCTGAAGCGCAGTGGCAAAAATATAAGTCGACCTTGCTTTCAGGTTTCCAAACTCTTGCGGATAACCCAGGACTAGGAA
AAAGCTGTGAAGATATTTACCAAAATGGTTTTTACTTTCCAGTGGGGAAACACATGGCTTATTACACCAAAGAAGCAAAC
TTCATTCTCATTGTTGCGGTATTAGGGCAATCACAACTGCCCCAAAAGCATCTCAAACAGTCACGCTTTGTTTCTTAG

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8961.25 Da        Isoelectric Point: 5.6630

>AT58372 WP_000557292.1 NZ_CP013316:c109544-109302 [Vibrio cholerae]
MHTLTANDAKRNFGELLLSAQREPVIISKNSKNTVVVMSIKDFEELEAMKLDYLKHCFESAQKDLDSGKTVDGATFLNTL

Download         Length: 243 bp

>AT58372 NZ_CP013316:c109544-109302 [Vibrio cholerae]
ATGCACACACTAACAGCAAATGATGCTAAACGAAATTTTGGTGAACTTCTTCTAAGCGCACAACGCGAACCTGTCATCAT
CAGCAAAAACAGTAAGAATACTGTCGTTGTCATGTCCATTAAGGACTTTGAAGAACTTGAAGCAATGAAACTCGATTATC
TCAAACACTGCTTTGAGTCTGCTCAGAAAGACTTAGATAGTGGCAAAACCGTTGATGGTGCCACTTTTCTAAACACCCTT
TGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A0K9UJR8

Antitoxin

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Source
ID
Structure
AlphaFold DBQ7DCR7

References