230530

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-RelB
Location 397164..397723 Replicon chromosome
Accession NZ_CP090379
Organism Vibrio cholerae strain BY369

Toxin (Protein)


Gene name relE Uniprot ID Q9K2M8
Locus tag LVJ30_RS16020 Protein ID WP_000578476.1
Coordinates 397164..397442 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID Q9L991
Locus tag LVJ30_RS16025 Protein ID WP_000381183.1
Coordinates 397439..397723 (-) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LVJ30_RS15975 (LVJ30_15975) 392464..392901 + 438 WP_000503169.1 IS200/IS605-like element IS1004 family transposase -
LVJ30_RS15980 (LVJ30_15980) 392962..393183 + 222 Protein_429 GNAT family N-acetyltransferase -
LVJ30_RS15985 (LVJ30_15985) 393358..394230 + 873 WP_000254716.1 DUF3800 domain-containing protein -
LVJ30_RS15990 (LVJ30_15990) 394380..394979 + 600 WP_001891245.1 glutathione S-transferase N-terminal domain-containing protein -
LVJ30_RS15995 (LVJ30_15995) 395036..395104 + 69 Protein_432 acetyltransferase -
LVJ30_RS16000 (LVJ30_16000) 395171..395440 + 270 WP_001114075.1 DUF4160 domain-containing protein -
LVJ30_RS16005 (LVJ30_16005) 395434..395955 + 522 WP_000921691.1 DUF2442 domain-containing protein -
LVJ30_RS16010 (LVJ30_16010) 396254..396379 + 126 WP_001905700.1 DUF645 family protein -
LVJ30_RS16015 (LVJ30_16015) 396630..397025 + 396 WP_001000867.1 hypothetical protein -
LVJ30_RS16020 (LVJ30_16020) 397164..397442 - 279 WP_000578476.1 type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family Toxin
LVJ30_RS16025 (LVJ30_16025) 397439..397723 - 285 WP_000381183.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
LVJ30_RS16030 (LVJ30_16030) 397917..398432 + 516 WP_000343779.1 GNAT family protein -
LVJ30_RS16035 (LVJ30_16035) 398616..399029 + 414 WP_000049420.1 VOC family protein -
LVJ30_RS16040 (LVJ30_16040) 399584..400761 + 1178 WP_086010879.1 IS3-like element ISVch4 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island catB9 - 304645..399892 95247
inside Integron - - 309725..399516 89791
flank IS/Tn - - 392464..392901 437


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(2-89)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(5-70)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10819.59 Da        Isoelectric Point: 5.1651

>T230530 WP_000578476.1 NZ_CP090379:c397442-397164 [Vibrio cholerae]
MIFWEEASLNDREKIFEFLYDFNPAAAKKTDELIEAKVENLLEQPLIGVQRDGIRGRLLIIPEISMIVSYWVDGSKIRIM
RVLHQKQKFPND

Download         Length: 279 bp

>T230530 NZ_CP124918:2806828-2806971 [Enterococcus faecalis]
ATGAATGTAAGTACTAAAATCTATGAAAGGAGAGGCCTTTTGTCAGCATATGAAACAATTCAGACAATTCTTGGGTTTGG
TATGTTTACCATTGCTTTGATTGCGCTGATTGTGAAATTGCTTAAAAATGACAAGAAAAAATAA

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10901.25 Da        Isoelectric Point: 8.0775

>AT230530 WP_000381183.1 NZ_CP090379:c397723-397439 [Vibrio cholerae]
MDTRIQFRVDEETKRLAQQMAESQGRTLSDACRELTEQLAEQQRKALSHDAWLTEQVNQAFEKFDSGKAVFIEHDIAKAR
MAERKAKIRNRGHA

Download         Length: 285 bp

>AT230530 NZ_CP124918:c2807088-2806904 [Enterococcus faecalis]
TGCTACAATAGAGACGAAAAGAGAGGTATGCTCTAACATACCTCTCTAGTGTAGAGCCGTTTAAGACGGTGACCTTTTTA
GTTACAAAAAATAACCGTACTCAGTCAAAGTAGACGGTTATTTTTTCTTGTCATTTTTAAGCAATTTCACAATCAGCGCA
ATCAAAGCAATGGTAAACATACCAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB Q9K2M8

Antitoxin

Source ID Structure
AlphaFold DB A0A067BL33

References