Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-RelB
Location 397164..397723 Replicon chromosome
Accession NZ_CP090379
Organism Vibrio cholerae strain BY369

Toxin (Protein)


Gene name relE Uniprot ID Q9K2M8
Locus tag LVJ30_RS16020 Protein ID WP_000578476.1
Coordinates 397164..397442 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID Q9L991
Locus tag LVJ30_RS16025 Protein ID WP_000381183.1
Coordinates 397439..397723 (-) Length 95 a.a.

Genomic Context

LVJ30_RS15975LVJ30_RS15980LVJ30_RS15985LVJ30_RS15990LVJ30_RS15995LVJ30_RS16000LVJ30_RS16005LVJ30_RS16010LVJ30_RS16015LVJ30_RS16030LVJ30_RS16035LVJ30_RS16040LVJ30_RS16020LVJ30_RS16025
Location: 392464..392901 (438 bp)
Type: Others
Protein ID: WP_000503169.1
Location: 392962..393183 (222 bp)
Type: Others
Protein ID: Protein_429
Location: 393358..394230 (873 bp)
Type: Others
Protein ID: WP_000254716.1
Location: 394380..394979 (600 bp)
Type: Others
Protein ID: WP_001891245.1
Location: 395036..395104 (69 bp)
Type: Others
Protein ID: Protein_432
Location: 395171..395440 (270 bp)
Type: Others
Protein ID: WP_001114075.1
Location: 395434..395955 (522 bp)
Type: Others
Protein ID: WP_000921691.1
Location: 396254..396379 (126 bp)
Type: Others
Protein ID: WP_001905700.1
Location: 396630..397025 (396 bp)
Type: Others
Protein ID: WP_001000867.1
Location: 397917..398432 (516 bp)
Type: Others
Protein ID: WP_000343779.1
Location: 398616..399029 (414 bp)
Type: Others
Protein ID: WP_000049420.1
Location: 399584..400761 (1178 bp)
Type: Others
Protein ID: WP_086010879.1
Location: 397164..397442 (279 bp)
Type: Toxin
Protein ID: WP_000578476.1
Location: 397439..397723 (285 bp)
Type: Antitoxin
Protein ID: WP_000381183.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
LVJ30_RS15975 (LVJ30_15975)392464..392901+438WP_000503169.1IS200/IS605-like element IS1004 family transposase-
LVJ30_RS15980 (LVJ30_15980)392962..393183+222Protein_429GNAT family N-acetyltransferase-
LVJ30_RS15985 (LVJ30_15985)393358..394230+873WP_000254716.1DUF3800 domain-containing protein-
LVJ30_RS15990 (LVJ30_15990)394380..394979+600WP_001891245.1glutathione S-transferase N-terminal domain-containing protein-
LVJ30_RS15995 (LVJ30_15995)395036..395104+69Protein_432acetyltransferase-
LVJ30_RS16000 (LVJ30_16000)395171..395440+270WP_001114075.1DUF4160 domain-containing protein-
LVJ30_RS16005 (LVJ30_16005)395434..395955+522WP_000921691.1DUF2442 domain-containing protein-
LVJ30_RS16010 (LVJ30_16010)396254..396379+126WP_001905700.1DUF645 family protein-
LVJ30_RS16015 (LVJ30_16015)396630..397025+396WP_001000867.1hypothetical protein-
LVJ30_RS16020 (LVJ30_16020)397164..397442-279WP_000578476.1type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE familyToxin
LVJ30_RS16025 (LVJ30_16025)397439..397723-285WP_000381183.1type II toxin-antitoxin system RelB/DinJ family antitoxinAntitoxin
LVJ30_RS16030 (LVJ30_16030)397917..398432+516WP_000343779.1GNAT family protein-
LVJ30_RS16035 (LVJ30_16035)398616..399029+414WP_000049420.1VOC family protein-
LVJ30_RS16040 (LVJ30_16040)399584..400761+1178WP_086010879.1IS3-like element ISVch4 family transposase-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideGenomic islandcatB9-304645..39989295247
insideIntegron--309725..39951689791
flankIS/Tn--392464..392901437


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(2-89)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(5-70)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10819.59 Da        Isoelectric Point: 5.1651

>T230530 WP_000578476.1 NZ_CP090379:c397442-397164 [Vibrio cholerae]
MIFWEEASLNDREKIFEFLYDFNPAAAKKTDELIEAKVENLLEQPLIGVQRDGIRGRLLIIPEISMIVSYWVDGSKIRIM
RVLHQKQKFPND

Download         Length: 279 bp

>T230530 NZ_CP124918:2806828-2806971 [Enterococcus faecalis]
ATGAATGTAAGTACTAAAATCTATGAAAGGAGAGGCCTTTTGTCAGCATATGAAACAATTCAGACAATTCTTGGGTTTGG
TATGTTTACCATTGCTTTGATTGCGCTGATTGTGAAATTGCTTAAAAATGACAAGAAAAAATAA

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10901.25 Da        Isoelectric Point: 8.0775

>AT230530 WP_000381183.1 NZ_CP090379:c397723-397439 [Vibrio cholerae]
MDTRIQFRVDEETKRLAQQMAESQGRTLSDACRELTEQLAEQQRKALSHDAWLTEQVNQAFEKFDSGKAVFIEHDIAKAR
MAERKAKIRNRGHA

Download         Length: 285 bp

>AT230530 NZ_CP124918:c2807088-2806904 [Enterococcus faecalis]
TGCTACAATAGAGACGAAAAGAGAGGTATGCTCTAACATACCTCTCTAGTGTAGAGCCGTTTAAGACGGTGACCTTTTTA
GTTACAAAAAATAACCGTACTCAGTCAAAGTAGACGGTTATTTTTTCTTGTCATTTTTAAGCAATTTCACAATCAGCGCA
ATCAAAGCAATGGTAAACATACCAA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBQ9K2M8

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A067BL33

References