Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/ParE-Phd
Location 321357..321935 Replicon chromosome
Accession NZ_CP024868
Organism Vibrio cholerae strain A1552

Toxin (Protein)


Gene name parE Uniprot ID O68848
Locus tag VCA1552_RS15710 Protein ID WP_001180243.1
Coordinates 321357..321674 (-) Length 106 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID Q7DCR7
Locus tag VCA1552_RS15715 Protein ID WP_000557292.1
Coordinates 321693..321935 (-) Length 81 a.a.

Genomic Context

VCA1552_RS15670VCA1552_RS15675VCA1552_RS15685VCA1552_RS15690VCA1552_RS15695VCA1552_RS15700VCA1552_RS15720VCA1552_RS15725VCA1552_RS15730VCA1552_RS15745VCA1552_RS15750VCA1552_RS15765VCA1552_RS15770VCA1552_RS15780VCA1552_RS15710VCA1552_RS15715VCA1552_RS15755VCA1552_RS15760
Location: 316881..317063 (183 bp)
Type: Others
Protein ID: WP_000923340.1
Location: 317417..317599 (183 bp)
Type: Others
Protein ID: WP_000923153.1
Location: 317794..318471 (678 bp)
Type: Others
Protein ID: WP_000254617.1
Location: 318633..319841 (1209 bp)
Type: Others
Protein ID: WP_000272282.1
Location: 320003..320707 (705 bp)
Type: Others
Protein ID: WP_000087610.1
Location: 320865..321203 (339 bp)
Type: Others
Protein ID: WP_000713853.1
Location: 322179..322565 (387 bp)
Type: Others
Protein ID: WP_001015867.1
Location: 322622..322735 (114 bp)
Type: Others
Protein ID: WP_001900214.1
Location: 322684..322965 (282 bp)
Type: Others
Protein ID: WP_001894429.1
Location: 323223..323759 (537 bp)
Type: Others
Protein ID: WP_000469482.1
Location: 323896..324411 (516 bp)
Type: Others
Protein ID: WP_001201509.1
Location: 325720..325845 (126 bp)
Type: Others
Protein ID: WP_001900195.1
Location: 325861..325899 (39 bp)
Type: Others
Protein ID: WP_106019118.1
Location: 326095..326541 (447 bp)
Type: Others
Protein ID: WP_000006157.1
Location: 321357..321674 (318 bp)
Type: Toxin
Protein ID: WP_001180243.1
Location: 321693..321935 (243 bp)
Type: Antitoxin
Protein ID: WP_000557292.1
Location: 324561..325058 (498 bp)
Type: Others
Protein ID: WP_000982260.1
Location: 325055..325327 (273 bp)
Type: Others
Protein ID: WP_000246253.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
VCA1552_RS15670316881..317063+183WP_000923340.1DUF645 family protein-
VCA1552_RS15675317417..317599+183WP_000923153.1DUF645 family protein-
VCA1552_RS15685317794..318471+678WP_000254617.1HNH endonuclease-
VCA1552_RS15690318633..319841+1209WP_000272282.1deoxyguanosinetriphosphate triphosphohydrolase family protein-
VCA1552_RS15695320003..320707+705WP_000087610.1HNH endonuclease-
VCA1552_RS15700320865..321203+339WP_000713853.1hypothetical protein-
VCA1552_RS15710321357..321674-318WP_001180243.1type II toxin-antitoxin system RelE/ParE family toxinToxin
VCA1552_RS15715321693..321935-243WP_000557292.1type II toxin-antitoxin system Phd/YefM family antitoxinAntitoxin
VCA1552_RS15720322179..322565+387WP_001015867.1NUDIX hydrolase-
VCA1552_RS15725322622..322735+114WP_001900214.1hypothetical protein-
VCA1552_RS15730322684..322965+282WP_001894429.1DUF1289 domain-containing protein-
VCA1552_RS15745323223..323759+537WP_000469482.1GNAT family N-acetyltransferase-
VCA1552_RS15750323896..324411+516WP_001201509.1lipocalin family protein-
VCA1552_RS15755324561..325058-498WP_000982260.1GNAT family N-acetyltransferase-
VCA1552_RS15760325055..325327-273WP_000246253.1DUF1778 domain-containing protein-
VCA1552_RS15765325720..325845+126WP_001900195.1DUF645 family protein-
VCA1552_RS15770325861..325899+39WP_106019118.1hypothetical protein-
VCA1552_RS15780326095..326541+447WP_000006157.1hypothetical protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideGenomic islandcatB9-304717..433978129261
insideIntegron--309797..433602123805


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-93)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-71)


Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 12158.97 Da        Isoelectric Point: 9.7495

>T88987 WP_001180243.1 NZ_CP024868:c321674-321357 [Vibrio cholerae]
MQNKQYKLSQLAQEHLLKIKHYTIENFAEAQWQKYKSTLLSGFQTLADNPGLGKSCEDIYQNGFYFPVGKHMAYYTKEAN
FILIVAVLGQSQLPQKHLKQSRFVS

Download         Length: 318 bp

>T88987 NZ_CP024868:c321674-321357 [Vibrio cholerae]
ATGCAAAATAAACAATATAAGCTCAGCCAATTAGCCCAAGAGCACTTACTCAAGATTAAACACTACACCATTGAAAATTT
CGCTGAAGCGCAGTGGCAAAAATATAAGTCGACCTTGCTTTCAGGTTTCCAAACTCTTGCGGATAACCCAGGACTAGGAA
AAAGCTGTGAAGATATTTACCAAAATGGTTTTTACTTTCCAGTGGGGAAACACATGGCTTATTACACCAAAGAAGCAAAC
TTCATTCTCATTGTTGCGGTATTAGGGCAATCACAACTGCCCCAAAAGCATCTCAAACAGTCACGCTTTGTTTCTTAG

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8961.25 Da        Isoelectric Point: 5.6630

>AT88987 WP_000557292.1 NZ_CP024868:c321935-321693 [Vibrio cholerae]
MHTLTANDAKRNFGELLLSAQREPVIISKNSKNTVVVMSIKDFEELEAMKLDYLKHCFESAQKDLDSGKTVDGATFLNTL

Download         Length: 243 bp

>AT88987 NZ_CP024868:c321935-321693 [Vibrio cholerae]
ATGCACACACTAACAGCAAATGATGCTAAACGAAATTTTGGTGAACTTCTTCTAAGCGCACAACGCGAACCTGTCATCAT
CAGCAAAAACAGTAAGAATACTGTCGTTGTCATGTCCATTAAGGACTTTGAAGAACTTGAAGCAATGAAACTCGATTATC
TCAAACACTGCTTTGAGTCTGCTCAGAAAGACTTAGATAGTGGCAAAACCGTTGATGGTGCCACTTTTCTAAACACCCTT
TGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A0K9UJR8

Antitoxin

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Source
ID
Structure
AlphaFold DBQ7DCR7

References