88987

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/ParE-Phd
Location 321357..321935 Replicon chromosome
Accession NZ_CP024868
Organism Vibrio cholerae strain A1552

Toxin (Protein)


Gene name parE Uniprot ID O68848
Locus tag VCA1552_RS15710 Protein ID WP_001180243.1
Coordinates 321357..321674 (-) Length 106 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID Q7DCR7
Locus tag VCA1552_RS15715 Protein ID WP_000557292.1
Coordinates 321693..321935 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
VCA1552_RS15670 316881..317063 + 183 WP_000923340.1 DUF645 family protein -
VCA1552_RS15675 317417..317599 + 183 WP_000923153.1 DUF645 family protein -
VCA1552_RS15685 317794..318471 + 678 WP_000254617.1 HNH endonuclease -
VCA1552_RS15690 318633..319841 + 1209 WP_000272282.1 deoxyguanosinetriphosphate triphosphohydrolase family protein -
VCA1552_RS15695 320003..320707 + 705 WP_000087610.1 HNH endonuclease -
VCA1552_RS15700 320865..321203 + 339 WP_000713853.1 hypothetical protein -
VCA1552_RS15710 321357..321674 - 318 WP_001180243.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
VCA1552_RS15715 321693..321935 - 243 WP_000557292.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
VCA1552_RS15720 322179..322565 + 387 WP_001015867.1 NUDIX hydrolase -
VCA1552_RS15725 322622..322735 + 114 WP_001900214.1 hypothetical protein -
VCA1552_RS15730 322684..322965 + 282 WP_001894429.1 DUF1289 domain-containing protein -
VCA1552_RS15745 323223..323759 + 537 WP_000469482.1 GNAT family N-acetyltransferase -
VCA1552_RS15750 323896..324411 + 516 WP_001201509.1 lipocalin family protein -
VCA1552_RS15755 324561..325058 - 498 WP_000982260.1 GNAT family N-acetyltransferase -
VCA1552_RS15760 325055..325327 - 273 WP_000246253.1 DUF1778 domain-containing protein -
VCA1552_RS15765 325720..325845 + 126 WP_001900195.1 DUF645 family protein -
VCA1552_RS15770 325861..325899 + 39 WP_106019118.1 hypothetical protein -
VCA1552_RS15780 326095..326541 + 447 WP_000006157.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island catB9 - 304717..433978 129261
inside Integron - - 309797..433602 123805


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-93)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-71)


Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 12158.97 Da        Isoelectric Point: 9.7495

>T88987 WP_001180243.1 NZ_CP024868:c321674-321357 [Vibrio cholerae]
MQNKQYKLSQLAQEHLLKIKHYTIENFAEAQWQKYKSTLLSGFQTLADNPGLGKSCEDIYQNGFYFPVGKHMAYYTKEAN
FILIVAVLGQSQLPQKHLKQSRFVS

Download         Length: 318 bp

>T88987 NZ_CP024868:c321674-321357 [Vibrio cholerae]
ATGCAAAATAAACAATATAAGCTCAGCCAATTAGCCCAAGAGCACTTACTCAAGATTAAACACTACACCATTGAAAATTT
CGCTGAAGCGCAGTGGCAAAAATATAAGTCGACCTTGCTTTCAGGTTTCCAAACTCTTGCGGATAACCCAGGACTAGGAA
AAAGCTGTGAAGATATTTACCAAAATGGTTTTTACTTTCCAGTGGGGAAACACATGGCTTATTACACCAAAGAAGCAAAC
TTCATTCTCATTGTTGCGGTATTAGGGCAATCACAACTGCCCCAAAAGCATCTCAAACAGTCACGCTTTGTTTCTTAG

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8961.25 Da        Isoelectric Point: 5.6630

>AT88987 WP_000557292.1 NZ_CP024868:c321935-321693 [Vibrio cholerae]
MHTLTANDAKRNFGELLLSAQREPVIISKNSKNTVVVMSIKDFEELEAMKLDYLKHCFESAQKDLDSGKTVDGATFLNTL

Download         Length: 243 bp

>AT88987 NZ_CP024868:c321935-321693 [Vibrio cholerae]
ATGCACACACTAACAGCAAATGATGCTAAACGAAATTTTGGTGAACTTCTTCTAAGCGCACAACGCGAACCTGTCATCAT
CAGCAAAAACAGTAAGAATACTGTCGTTGTCATGTCCATTAAGGACTTTGAAGAACTTGAAGCAATGAAACTCGATTATC
TCAAACACTGCTTTGAGTCTGCTCAGAAAGACTTAGATAGTGGCAAAACCGTTGATGGTGCCACTTTTCTAAACACCCTT
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0K9UJR8

Antitoxin

Source ID Structure
AlphaFold DB Q7DCR7

References