45817

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) dhiT-phd/-
Location 406281..406685 Replicon chromosome
Accession NZ_CP006948
Organism Vibrio cholerae O1 str. KW3

Toxin (Protein)


Gene name dhiT Uniprot ID A0A086SLD6
Locus tag N900_RS16125 Protein ID WP_001114075.1
Coordinates 406416..406685 (+) Length 90 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID -
Locus tag N900_RS20070 Protein ID WP_099607150.1
Coordinates 406281..406385 (+) Length 35 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N900_RS16090 401783..402699 + 917 Protein_421 alpha/beta hydrolase -
N900_RS16095 402856..403245 + 390 WP_001081302.1 hypothetical protein -
N900_RS16100 403381..403590 + 210 Protein_423 GNAT family N-acetyltransferase -
N900_RS16105 403709..404146 + 438 WP_000503169.1 IS200/IS605-like element IS1004 family transposase -
N900_RS16110 404210..404428 + 219 WP_071908318.1 GNAT family N-acetyltransferase -
N900_RS16115 404603..405475 + 873 WP_000254716.1 DUF3800 domain-containing protein -
N900_RS16120 405625..406224 + 600 WP_001891245.1 glutathione S-transferase N-terminal domain-containing protein -
N900_RS20070 406281..406385 + 105 WP_099607150.1 acetyltransferase Antitoxin
N900_RS16125 406416..406685 + 270 WP_001114075.1 DUF4160 domain-containing protein Toxin
N900_RS16130 406679..407200 + 522 WP_000921691.1 DUF2442 domain-containing protein -
N900_RS20075 407499..407624 + 126 WP_001905700.1 DUF645 family protein -
N900_RS16135 407875..408270 + 396 WP_001000867.1 hypothetical protein -
N900_RS16140 408409..408687 - 279 WP_000578476.1 type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family -
N900_RS16145 408684..408968 - 285 WP_000381183.1 type II toxin-antitoxin system RelB/DinJ family antitoxin -
N900_RS16150 409161..409676 + 516 WP_000343779.1 GNAT family N-acetyltransferase -
N900_RS16155 409860..410273 + 414 WP_000049420.1 VOC family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island catB9 - 304645..411088 106443
inside Integron - - 309725..410760 101035
flank IS/Tn - - 403709..404146 437


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Protein of unknown function DUF4160

(9-74)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 90 a.a.        Molecular weight: 10310.94 Da        Isoelectric Point: 6.6303

>T45817 WP_001114075.1 NZ_CP006948:406416-406685 [Vibrio cholerae O1 str. KW3]
MPEIDALLGLSFCLYFFDNKQHKLPHIHVKYGSYELIIAIETGECLEGYLPNKQRKRAENHILEHREQLMVMWNKAVNGE
NPGKLGDLC

Download         Length: 270 bp

>T45817 NZ_CP006948:406416-406685 [Vibrio cholerae O1 str. KW3]
ATGCCAGAGATTGATGCCCTATTAGGTCTTTCATTTTGCTTGTACTTCTTTGATAACAAGCAGCATAAATTACCTCATAT
TCACGTTAAGTACGGTAGTTACGAGCTAATTATTGCTATTGAAACAGGTGAGTGTTTAGAGGGTTACTTACCCAATAAGC
AACGAAAACGTGCTGAAAACCATATTCTTGAACATCGAGAGCAATTGATGGTGATGTGGAATAAAGCGGTGAATGGTGAA
AATCCAGGTAAGTTAGGTGATTTATGTTGA

Antitoxin


Download         Length: 35 a.a.        Molecular weight: 3991.79 Da        Isoelectric Point: 9.2853

>AT45817 WP_099607150.1 NZ_CP006948:406281-406385 [Vibrio cholerae O1 str. KW3]
VVSVVVFEFSSMRCQPLRRALYAYRNCLLKDTLL

Download         Length: 105 bp

>AT45817 NZ_CP006948:406281-406385 [Vibrio cholerae O1 str. KW3]
GTGGTTTCGGTTGTTGTGTTTGAGTTTAGTAGTATGCGCTGCCAGCCCCTTAGGCGGGCGTTATATGCTTATAGGAATTG
TCTCCTAAAGGATACGCTGCTATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A086SLD6

Antitoxin

Source ID Structure

References