87030

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-Phd
Location 423808..424355 Replicon chromosome
Accession NZ_CP024163
Organism Vibrio cholerae strain E7946

Toxin (Protein)


Gene name relE Uniprot ID Q9KM92
Locus tag CSW01_RS16785 Protein ID WP_000229317.1
Coordinates 424053..424355 (+) Length 101 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID Q9KM93
Locus tag CSW01_RS16780 Protein ID WP_000861987.1
Coordinates 423808..424065 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CSW01_RS16720 418837..419292 + 456 WP_001245327.1 GNAT family N-acetyltransferase -
CSW01_RS16725 419614..419766 + 153 WP_001884520.1 DUF645 family protein -
CSW01_RS16735 419968..420465 - 498 WP_000982260.1 GNAT family N-acetyltransferase -
CSW01_RS16740 420462..420734 - 273 WP_000246253.1 DUF1778 domain-containing protein -
CSW01_RS16750 420965..421633 + 669 WP_000043871.1 hypothetical protein -
CSW01_RS16755 421785..422072 + 288 WP_000426470.1 hypothetical protein -
CSW01_RS16760 422213..422584 + 372 WP_001164080.1 nucleotide pyrophosphohydrolase -
CSW01_RS20000 422651..423076 + 426 WP_001882332.1 DUF1778 domain-containing protein -
CSW01_RS16770 423073..423606 + 534 WP_000118351.1 GNAT family N-acetyltransferase -
CSW01_RS16780 423808..424065 + 258 WP_000861987.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
CSW01_RS16785 424053..424355 + 303 WP_000229317.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
CSW01_RS16790 424589..425506 + 918 WP_000186333.1 alpha/beta hydrolase -
CSW01_RS16795 425663..426052 + 390 WP_001081302.1 hypothetical protein -
CSW01_RS16800 426188..426397 + 210 Protein_463 GNAT family N-acetyltransferase -
CSW01_RS16805 426516..426953 + 438 WP_000503169.1 IS200/IS605-like element IS1004 family transposase -
CSW01_RS16810 427017..427235 + 219 WP_071908318.1 GNAT family N-acetyltransferase -
CSW01_RS16815 427410..428282 + 873 WP_000254716.1 DUF3800 domain-containing protein -
CSW01_RS16820 428432..429031 + 600 WP_001891245.1 glutathione S-transferase N-terminal domain-containing protein -
CSW01_RS16825 429088..429192 + 105 WP_099607150.1 acetyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island catB9 - 304226..433944 129718
inside Integron - - 309306..433568 124262
flank IS/Tn - - 426516..426953 437


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-87)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-69)


Sequences

Toxin        


Download         Length: 101 a.a.        Molecular weight: 11726.68 Da        Isoelectric Point: 5.1972

>T87030 WP_000229317.1 NZ_CP024163:424053-424355 [Vibrio cholerae]
MVEIIWTELALSDLNDIAEYIALENVVAAKQLVQTVFTKVERLADFPESGRVPPELEHLNYREVVVSPCRVFYKYDDAKV
RILFVMRAERDLRRLMLTKQ

Download         Length: 303 bp

>T87030 NZ_CP024163:424053-424355 [Vibrio cholerae]
ATGGTTGAAATAATTTGGACGGAGCTGGCTCTATCCGACTTGAATGATATTGCTGAATACATCGCGCTTGAAAATGTCGT
GGCTGCTAAACAACTGGTGCAAACCGTTTTTACAAAAGTTGAACGTTTGGCCGATTTTCCAGAGTCTGGGCGCGTCCCTC
CAGAACTAGAACACCTCAATTATCGTGAAGTCGTTGTAAGTCCGTGTCGTGTTTTCTACAAGTATGATGATGCAAAGGTT
CGTATTCTTTTTGTTATGCGTGCGGAGCGAGATTTGCGTCGGTTAATGCTTACGAAACAGTAG

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9647.15 Da        Isoelectric Point: 7.3178

>AT87030 WP_000861987.1 NZ_CP024163:423808-424065 [Vibrio cholerae]
MKVELVTSLKRQATKILADLHDTKEPVLITEHGKPSAYLIDVDDYEFMQNRLAILEGIARGERALADGKVVSHQDAKDRM
SKWLK

Download         Length: 258 bp

>AT87030 NZ_CP024163:423808-424065 [Vibrio cholerae]
ATGAAAGTAGAACTTGTGACGTCACTAAAACGTCAGGCCACTAAGATCCTTGCCGATCTTCATGATACGAAAGAGCCAGT
ATTGATAACTGAGCACGGAAAACCGTCAGCTTACCTTATTGATGTAGACGACTATGAATTTATGCAAAATCGTTTAGCGA
TCCTGGAAGGTATTGCTCGCGGAGAGCGAGCTTTAGCGGATGGTAAAGTGGTCAGCCATCAAGATGCTAAGGACAGAATG
TCAAAATGGTTGAAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB Q9KM92

Antitoxin

Source ID Structure
AlphaFold DB A0A1T4SLM9

References