Detailed information of TA system TA180878

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): /DUF1778(antitoxin)
• Location: 491171..492126
• Replicon: chromosome
• Accession: NZ_CP064351
• Organism: Vibrio cholerae C6706

Toxin (Protein)

• Gene name: -
• Uniprot ID: Q9KM94
• Locus tag: IT766_RS16320
• Protein ID: WP_000118351.1
• Coordinates: 491593..492126 (+)
• Length: 178 a.a.

Antitoxin (Protein)

• Gene name: -
• Uniprot ID: -
• Locus tag: IT766_RS16315
• Protein ID: WP_001882332.1
• Coordinates: 491171..491596 (+)
• Length: 142 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IT766_RS16270	486701..486952	+	252	WP_001250179.1	type II toxin-antitoxin system Phd/YefM family antitoxin	-
IT766_RS16275	486942..487229	+	288	WP_000221354.1	type II toxin-antitoxin system RelE/ParE family toxin	-
IT766_RS16280	487357..487812	+	456	WP_001245327.1	GNAT family N-acetyltransferase	-
IT766_RS16285	488134..488286	+	153	WP_001884520.1	DUF645 family protein	-
IT766_RS16290	488488..488985	-	498	WP_000982260.1	GNAT family N-acetyltransferase	-
IT766_RS16295	488982..489254	-	273	WP_000246253.1	DUF1778 domain-containing protein	-
IT766_RS16300	489485..490153	+	669	WP_000043871.1	hypothetical protein	-
IT766_RS16305	490305..490592	+	288	WP_000426470.1	hypothetical protein	-
IT766_RS16310	490733..491104	+	372	WP_001164080.1	nucleotide pyrophosphohydrolase	-
IT766_RS16315	491171..491596	+	426	WP_001882332.1	DUF1778 domain-containing protein	Antitoxin
IT766_RS16320	491593..492126	+	534	WP_000118351.1	GNAT family N-acetyltransferase	Toxin
IT766_RS16325	492328..492585	+	258	WP_000861987.1	type II toxin-antitoxin system Phd/YefM family antitoxin	-
IT766_RS16330	492573..492875	+	303	WP_000229317.1	type II toxin-antitoxin system RelE/ParE family toxin	-
IT766_RS16335	493109..494026	+	918	WP_000186333.1	alpha/beta hydrolase	-
IT766_RS16340	494183..494572	+	390	WP_001081302.1	hypothetical protein	-
IT766_RS16345	494708..494917	+	210	Protein_519	GNAT family N-acetyltransferase	-
IT766_RS16350	495036..495473	+	438	WP_000503169.1	IS200/IS605-like element IS1004 family transposase	-
IT766_RS16355	495537..495755	+	219	WP_071908318.1	GNAT family N-acetyltransferase	-
IT766_RS16360	495930..496802	+	873	WP_000254716.1	DUF3800 domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	catB9	-	373204..502464	129260
	Similar MGE(s) Similar MGE(s) is defined as other TA-related MGE(s) with Mash distance < 0.01 to this MGE. Detail Genome accession Organism MGE type Related TA Coordinates Mash distance View NC_002506 Vibrio cholerae O1 biovar El Tor str. N16961 Integron TA000164, TA000169, TA000166, TA000167, TA000179, TA000170, TA000171, TA000172, TA000173, TA000174, TA000175, TA000176, TA000177, TA000178, TA000168, TA000165, TA010030, TA010035 309750..435387 0	inside	Integron	-	-	378284..502088	123804
	Similar MGE(s) Similar MGE(s) is defined as other TA-related MGE(s) with Mash distance < 0.01 to this MGE. Detail Genome accession Organism MGE type Related TA Coordinates Mash distance View NC_002506 Vibrio cholerae O1 biovar El Tor str. N16961 IS/Tn TA000179, TA000177, TA000178, TA010035 428335..428772 0	flank	IS/Tn	-	-	495036..495473	437

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• GNAT domain (97-153)

Antitoxin

• Vibrio phage ICP1, Orf50 (57-133)

Sequences

Toxin

Protein

• Length: 178 a.a.
• Molecular weight: 20171.46 Da
• Isoelectric Point: 9.1432

>T180878 WP_000118351.1 NZ_CP064351:491593-492126 [Vibrio cholerae C6706]
VSWGKEFVELSKSKHDRDSFDCGEQELNTFIKTQAAKHMQAGISRTMVLPSAHPLLNQKFAICAFYSVAPSSISRETLPA
QLAKKLPRYPIPVFLLAQLAVHKEFHGSGLGKVSLIRALKYLWEVNHHMRAYAIVVDCLTDSAQAFYTKFGFEVLCEHNE
RIRMFLPMKTVEQLFNQ

Nucleotide

• Length: 534 bp

>T180878 NZ_CP085767:c3533589-3533116 [Enterobacter hormaechei]
ATGATTTTTTATCGTCTGGTAACAGGACGTTTTGCCAGCGAAGCGTGGAGTGGAAGTGGTGCAAACCAGTATGGAGGACG
CTGGAATCATAAAGGCCATCCTGCCGTGTATGTCTCCACCTCCATCTCGCTGGCTTCACTGGAAATTCTGGTGCACGTCA
GAAAAGACACCGTGCTGAACCAGTACCAGCTTTTCAGCATTAATATCCCGGATGATCAGATTGATTACCTGGATAAAGCG
TGGCTGCCCGAGGACTGGCAGGAAAATCCGGCGCCGGTATCAACGATGGATCTGGGTACCGGTTGGTTGCAGGCTAACAG
CGCTCTCGCACTCATCTTACCCTCCTGCATCATTCCCTATGAAAACAACGCCATACTTAATCCATTGCATCCGGCATTCC
GCAAAGCACTCAATTCTGTTGAATTACTGCCTTTTGATTTTGATACCCGTCTCGCAGAAAAAACCGCACCCTGA

Antitoxin

Protein

• Length: 142 a.a.
• Molecular weight: 15714.41 Da
• Isoelectric Point: 7.6659

>AT180878 WP_001882332.1 NZ_CP064351:491171-491596 [Vibrio cholerae C6706]
MLCLSLVVMRCQPLRRALYSPSPRKLSVRIECALSLAYNRSTDGMYPYAGGVMATARLDIRLDEEIKAKAEKASALLGLK
SLTEYVVRLMDEDATHVIEEHESIMVKDSVFDEFMAACNKVKAPNQALLEAVKFTEKSGIK

Nucleotide

• Length: 426 bp

>AT180878 NZ_CP085767:c3534029-3533586 [Enterobacter hormaechei]
ATGAGAACATGGGTTCCTGCGCAAAGGTCGGCTGATAACACGCTGTGGCGCTACGCCGGTTTACCTGCAAGCAGAGGCAT
GCGGTTGATTGAATATCTCAATCAAGGATTACCCGTCAGCGTCCTCGACAATATTCACGAGTGGACGGACATGTCGAAAG
CGGAGATTTTACGCGTCACGGGAATTAACGAGCGTAACGTTGCCCGCCGCAAAAGTACGGGCCGGACGCTGACGCCCGAC
GAGAGCGAACGTGTGGCGCGTTTCGTTCGGGTACTGGATGCGGCCGTCGATTATTTCGGCAGTAAAGAAGAGGCATGGAA
CTGGTTGCAGTTACCGGTACGTGGGCTTGGCAATGTTGCACCTGTCGATCTGATTGCCACGGAAACCGGTGCGCTGGAAG
TTACCGATTTGATTGGTCGGCTGGAGCACGGAGTGTTCGCATGA

Structures

Toxin

• AlphaFold DB: Q9KM94