Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /DUF1778(antitoxin)
Location 491171..492126 Replicon chromosome
Accession NZ_CP064351
Organism Vibrio cholerae C6706

Toxin (Protein)


Gene name - Uniprot ID Q9KM94
Locus tag IT766_RS16320 Protein ID WP_000118351.1
Coordinates 491593..492126 (+) Length 178 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID -
Locus tag IT766_RS16315 Protein ID WP_001882332.1
Coordinates 491171..491596 (+) Length 142 a.a.

Genomic Context

IT766_RS16270IT766_RS16275IT766_RS16280IT766_RS16285IT766_RS16300IT766_RS16305IT766_RS16310IT766_RS16315IT766_RS16320IT766_RS16325IT766_RS16330IT766_RS16335IT766_RS16340IT766_RS16345IT766_RS16350IT766_RS16355IT766_RS16360IT766_RS16290IT766_RS16295
Location: 486701..486952 (252 bp)
Type: Others
Protein ID: WP_001250179.1
Location: 486942..487229 (288 bp)
Type: Others
Protein ID: WP_000221354.1
Location: 487357..487812 (456 bp)
Type: Others
Protein ID: WP_001245327.1
Location: 488134..488286 (153 bp)
Type: Others
Protein ID: WP_001884520.1
Location: 489485..490153 (669 bp)
Type: Others
Protein ID: WP_000043871.1
Location: 490305..490592 (288 bp)
Type: Others
Protein ID: WP_000426470.1
Location: 490733..491104 (372 bp)
Type: Others
Protein ID: WP_001164080.1
Location: 491171..491596 (426 bp)
Type: Antitoxin
Protein ID: WP_001882332.1
Location: 491593..492126 (534 bp)
Type: Toxin
Protein ID: WP_000118351.1
Location: 492328..492585 (258 bp)
Type: Others
Protein ID: WP_000861987.1
Location: 492573..492875 (303 bp)
Type: Others
Protein ID: WP_000229317.1
Location: 493109..494026 (918 bp)
Type: Others
Protein ID: WP_000186333.1
Location: 494183..494572 (390 bp)
Type: Others
Protein ID: WP_001081302.1
Location: 494708..494917 (210 bp)
Type: Others
Protein ID: Protein_519
Location: 495036..495473 (438 bp)
Type: Others
Protein ID: WP_000503169.1
Location: 495537..495755 (219 bp)
Type: Others
Protein ID: WP_071908318.1
Location: 495930..496802 (873 bp)
Type: Others
Protein ID: WP_000254716.1
Location: 488488..488985 (498 bp)
Type: Others
Protein ID: WP_000982260.1
Location: 488982..489254 (273 bp)
Type: Others
Protein ID: WP_000246253.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
IT766_RS16270486701..486952+252WP_001250179.1type II toxin-antitoxin system Phd/YefM family antitoxin-
IT766_RS16275486942..487229+288WP_000221354.1type II toxin-antitoxin system RelE/ParE family toxin-
IT766_RS16280487357..487812+456WP_001245327.1GNAT family N-acetyltransferase-
IT766_RS16285488134..488286+153WP_001884520.1DUF645 family protein-
IT766_RS16290488488..488985-498WP_000982260.1GNAT family N-acetyltransferase-
IT766_RS16295488982..489254-273WP_000246253.1DUF1778 domain-containing protein-
IT766_RS16300489485..490153+669WP_000043871.1hypothetical protein-
IT766_RS16305490305..490592+288WP_000426470.1hypothetical protein-
IT766_RS16310490733..491104+372WP_001164080.1nucleotide pyrophosphohydrolase-
IT766_RS16315491171..491596+426WP_001882332.1DUF1778 domain-containing proteinAntitoxin
IT766_RS16320491593..492126+534WP_000118351.1GNAT family N-acetyltransferaseToxin
IT766_RS16325492328..492585+258WP_000861987.1type II toxin-antitoxin system Phd/YefM family antitoxin-
IT766_RS16330492573..492875+303WP_000229317.1type II toxin-antitoxin system RelE/ParE family toxin-
IT766_RS16335493109..494026+918WP_000186333.1alpha/beta hydrolase-
IT766_RS16340494183..494572+390WP_001081302.1hypothetical protein-
IT766_RS16345494708..494917+210Protein_519GNAT family N-acetyltransferase-
IT766_RS16350495036..495473+438WP_000503169.1IS200/IS605-like element IS1004 family transposase-
IT766_RS16355495537..495755+219WP_071908318.1GNAT family N-acetyltransferase-
IT766_RS16360495930..496802+873WP_000254716.1DUF3800 domain-containing protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideGenomic islandcatB9-373204..502464129260
insideIntegron--378284..502088123804
flankIS/Tn--495036..495473437


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(97-153)

Antitoxin

Vibrio phage ICP1, Orf50

(57-133)


Sequences

Toxin        


Download         Length: 178 a.a.        Molecular weight: 20171.46 Da        Isoelectric Point: 9.1432

>T180878 WP_000118351.1 NZ_CP064351:491593-492126 [Vibrio cholerae C6706]
VSWGKEFVELSKSKHDRDSFDCGEQELNTFIKTQAAKHMQAGISRTMVLPSAHPLLNQKFAICAFYSVAPSSISRETLPA
QLAKKLPRYPIPVFLLAQLAVHKEFHGSGLGKVSLIRALKYLWEVNHHMRAYAIVVDCLTDSAQAFYTKFGFEVLCEHNE
RIRMFLPMKTVEQLFNQ

Download         Length: 534 bp

>T180878 NZ_CP085767:c3533589-3533116 [Enterobacter hormaechei]
ATGATTTTTTATCGTCTGGTAACAGGACGTTTTGCCAGCGAAGCGTGGAGTGGAAGTGGTGCAAACCAGTATGGAGGACG
CTGGAATCATAAAGGCCATCCTGCCGTGTATGTCTCCACCTCCATCTCGCTGGCTTCACTGGAAATTCTGGTGCACGTCA
GAAAAGACACCGTGCTGAACCAGTACCAGCTTTTCAGCATTAATATCCCGGATGATCAGATTGATTACCTGGATAAAGCG
TGGCTGCCCGAGGACTGGCAGGAAAATCCGGCGCCGGTATCAACGATGGATCTGGGTACCGGTTGGTTGCAGGCTAACAG
CGCTCTCGCACTCATCTTACCCTCCTGCATCATTCCCTATGAAAACAACGCCATACTTAATCCATTGCATCCGGCATTCC
GCAAAGCACTCAATTCTGTTGAATTACTGCCTTTTGATTTTGATACCCGTCTCGCAGAAAAAACCGCACCCTGA

Antitoxin


Download         Length: 142 a.a.        Molecular weight: 15714.41 Da        Isoelectric Point: 7.6659

>AT180878 WP_001882332.1 NZ_CP064351:491171-491596 [Vibrio cholerae C6706]
MLCLSLVVMRCQPLRRALYSPSPRKLSVRIECALSLAYNRSTDGMYPYAGGVMATARLDIRLDEEIKAKAEKASALLGLK
SLTEYVVRLMDEDATHVIEEHESIMVKDSVFDEFMAACNKVKAPNQALLEAVKFTEKSGIK

Download         Length: 426 bp

>AT180878 NZ_CP085767:c3534029-3533586 [Enterobacter hormaechei]
ATGAGAACATGGGTTCCTGCGCAAAGGTCGGCTGATAACACGCTGTGGCGCTACGCCGGTTTACCTGCAAGCAGAGGCAT
GCGGTTGATTGAATATCTCAATCAAGGATTACCCGTCAGCGTCCTCGACAATATTCACGAGTGGACGGACATGTCGAAAG
CGGAGATTTTACGCGTCACGGGAATTAACGAGCGTAACGTTGCCCGCCGCAAAAGTACGGGCCGGACGCTGACGCCCGAC
GAGAGCGAACGTGTGGCGCGTTTCGTTCGGGTACTGGATGCGGCCGTCGATTATTTCGGCAGTAAAGAAGAGGCATGGAA
CTGGTTGCAGTTACCGGTACGTGGGCTTGGCAATGTTGCACCTGTCGATCTGATTGCCACGGAAACCGGTGCGCTGGAAG
TTACCGATTTGATTGGTCGGCTGGAGCACGGAGTGTTCGCATGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBQ9KM94

Antitoxin

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Source
ID
Structure
No matching records found

References