23784

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-YafN
Location 965719..966247 Replicon chromosome
Accession NC_012667
Organism Vibrio cholerae MJ-1236

Toxin (Protein)


Gene name relE Uniprot ID A0A0X1KZS6
Locus tag VCD_RS18965 Protein ID WP_000221354.1
Coordinates 965719..966006 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A0X1KZS8
Locus tag VCD_RS18970 Protein ID WP_001250179.1
Coordinates 965996..966247 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
VCD_RS18920 960822..961355 - 534 WP_000118351.1 GNAT family N-acetyltransferase -
VCD_RS21060 961352..961777 - 426 WP_001882332.1 DUF1778 domain-containing protein -
VCD_RS18930 961844..962215 - 372 WP_001164080.1 nucleotide pyrophosphohydrolase -
VCD_RS18935 962356..962643 - 288 WP_000426470.1 hypothetical protein -
VCD_RS18940 962795..963463 - 669 WP_000043871.1 hypothetical protein -
VCD_RS18945 963694..963966 + 273 WP_000246253.1 DUF1778 domain-containing protein -
VCD_RS18950 963963..964460 + 498 WP_000982260.1 GNAT family N-acetyltransferase -
VCD_RS18955 964662..964814 - 153 WP_001884520.1 DUF645 family protein -
VCD_RS18960 965136..965591 - 456 WP_001245327.1 GNAT family N-acetyltransferase -
VCD_RS18965 965719..966006 - 288 WP_000221354.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
VCD_RS18970 965996..966247 - 252 WP_001250179.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
VCD_RS18975 966461..966874 - 414 WP_000049417.1 VOC family protein -
VCD_RS20710 966949..967092 - 144 WP_071908341.1 DUF3265 domain-containing protein -
VCD_RS18980 967062..967463 - 402 WP_000351248.1 type II toxin-antitoxin system death-on-curing family toxin -
VCD_RS18985 967463..968155 - 693 WP_001047169.1 GNAT family N-acetyltransferase -
VCD_RS18990 968292..968598 - 307 Protein_849 CatB-related O-acetyltransferase -
VCD_RS18995 968666..969646 + 981 WP_000019370.1 IS5-like element ISVch5 family transposase -
VCD_RS19000 969771..969926 - 156 WP_000751734.1 hypothetical protein -
VCD_RS19005 970094..970528 - 435 WP_000256036.1 GNAT family N-acetyltransferase -
VCD_RS19010 970665..970979 - 315 WP_000071008.1 DNA-binding transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island catB9 - 932253..1057432 125179
inside Integron - - 958376..1050596 92220
flank IS/Tn - - 968666..969646 980


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(11-71)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 10991.96 Da        Isoelectric Point: 10.4934

>T23784 WP_000221354.1 NC_012667:c966006-965719 [Vibrio cholerae MJ-1236]
MTYKLKFLPAAQKEWSKLAPTIQSQFKKKLKERLENPHVPSAKLRGYDAVYKIKLRTAGYRLAYEVIDDEIVVYVLAVGK
RDKDAVYKKLASRFG

Download         Length: 288 bp

>T23784 NC_012667:c966006-965719 [Vibrio cholerae MJ-1236]
ATGACCTATAAGTTAAAGTTTCTGCCGGCTGCGCAAAAGGAATGGAGTAAGTTAGCTCCGACAATTCAGAGTCAGTTCAA
GAAGAAGTTAAAGGAACGATTAGAAAATCCGCACGTCCCTTCGGCTAAGCTTCGAGGATACGACGCTGTTTACAAGATTA
AACTTCGTACGGCGGGTTATCGTTTAGCTTATGAGGTTATTGACGATGAGATAGTTGTCTATGTCCTTGCTGTCGGTAAA
CGTGACAAAGATGCTGTCTATAAAAAACTGGCTTCACGCTTCGGTTAG

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9136.29 Da        Isoelectric Point: 4.0197

>AT23784 WP_001250179.1 NC_012667:c966247-965996 [Vibrio cholerae MJ-1236]
MRQVLANCSASISELKKNPTALLNEADGSAIAILNHNKPAAYLVPAETYEYLIDMLDDYELSQIVDSRRADLAQAVEVNI
DDL

Download         Length: 252 bp

>AT23784 NC_012667:c966247-965996 [Vibrio cholerae MJ-1236]
ATGAGACAAGTTTTAGCGAATTGCTCTGCAAGTATTTCAGAGTTAAAGAAGAACCCAACAGCTTTGTTGAATGAGGCTGA
TGGGTCTGCAATTGCAATTTTAAACCACAACAAGCCAGCGGCTTACCTTGTGCCAGCGGAAACGTATGAGTATCTCATCG
ATATGCTCGATGATTATGAGCTTTCCCAAATTGTCGATAGTCGCCGAGCTGACTTAGCACAAGCTGTGGAAGTAAATATT
GATGACCTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0X1KZS6

Antitoxin

Source ID Structure
AlphaFold DB A0A0X1KZS8

References