58214

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-RelB
Location 332145..332704 Replicon chromosome
Accession NZ_CP013302
Organism Vibrio cholerae strain C5

Toxin (Protein)


Gene name relE Uniprot ID Q9K2M8
Locus tag ASZ80_RS15775 Protein ID WP_000578476.1
Coordinates 332145..332423 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID Q9L991
Locus tag ASZ80_RS15780 Protein ID WP_000381183.1
Coordinates 332420..332704 (-) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ASZ80_RS15730 328085..328267 + 183 WP_000923340.1 DUF645 family protein -
ASZ80_RS15735 328482..329021 + 540 WP_000099372.1 hypothetical protein -
ASZ80_RS15740 329144..329659 + 516 WP_000090011.1 hypothetical protein -
ASZ80_RS15745 329794..330330 + 537 WP_000644491.1 nucleotidyltransferase family protein -
ASZ80_RS20940 330449..330610 + 162 WP_000481782.1 hypothetical protein -
ASZ80_RS15750 330799..330909 + 111 WP_071908335.1 DUF3265 domain-containing protein -
ASZ80_RS15760 331122..331274 + 153 WP_001884520.1 DUF645 family protein -
ASZ80_RS15765 331558..332001 + 444 WP_000803902.1 hypothetical protein -
ASZ80_RS15770 332005..332115 + 111 WP_071908336.1 DUF3265 domain-containing protein -
ASZ80_RS15775 332145..332423 - 279 WP_000578476.1 type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family Toxin
ASZ80_RS15780 332420..332704 - 285 WP_000381183.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
ASZ80_RS15790 332880..333179 - 300 WP_000802136.1 type II toxin-antitoxin system RelE/ParE family toxin -
ASZ80_RS15795 333176..333418 - 243 WP_001107719.1 type II toxin-antitoxin system ParD family antitoxin -
ASZ80_RS15805 333837..333914 + 78 WP_071908337.1 DUF645 family protein -
ASZ80_RS20860 333918..333944 + 27 Protein_299 hypothetical protein -
ASZ80_RS20945 334530..334673 + 144 WP_001900215.1 hypothetical protein -
ASZ80_RS20420 334767..334946 + 180 Protein_301 DUF645 family protein -
ASZ80_RS15830 335164..335592 + 429 WP_000620002.1 N-acetyltransferase -
ASZ80_RS15840 336180..336662 + 483 WP_000422940.1 GNAT family N-acetyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island catB9 - 304694..469286 164592
inside Integron - - 309774..468910 159136


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(2-89)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(5-70)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10819.59 Da        Isoelectric Point: 5.1651

>T58214 WP_000578476.1 NZ_CP013302:c332423-332145 [Vibrio cholerae]
MIFWEEASLNDREKIFEFLYDFNPAAAKKTDELIEAKVENLLEQPLIGVQRDGIRGRLLIIPEISMIVSYWVDGSKIRIM
RVLHQKQKFPND

Download         Length: 279 bp

>T58214 NZ_CP013302:c332423-332145 [Vibrio cholerae]
ATGATTTTCTGGGAAGAAGCATCTCTCAATGATCGTGAGAAAATTTTCGAATTTCTCTACGACTTTAACCCAGCAGCGGC
TAAAAAAACGGATGAGCTCATAGAAGCCAAAGTCGAAAATTTGCTTGAGCAACCACTAATCGGTGTTCAGCGTGATGGCA
TTAGAGGCAGATTGCTTATTATCCCTGAGATATCAATGATTGTTTCGTATTGGGTTGATGGTTCTAAAATTCGAATAATG
CGTGTACTACATCAGAAACAAAAATTTCCAAACGACTGA

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10901.25 Da        Isoelectric Point: 8.0775

>AT58214 WP_000381183.1 NZ_CP013302:c332704-332420 [Vibrio cholerae]
MDTRIQFRVDEETKRLAQQMAESQGRTLSDACRELTEQLAEQQRKALSHDAWLTEQVNQAFEKFDSGKAVFIEHDIAKAR
MAERKAKIRNRGHA

Download         Length: 285 bp

>AT58214 NZ_CP013302:c332704-332420 [Vibrio cholerae]
ATGGATACTAGAATTCAATTTCGTGTAGACGAAGAAACAAAACGTTTAGCTCAACAAATGGCTGAAAGCCAAGGTCGAAC
TCTTAGCGATGCTTGCCGTGAACTCACTGAACAATTAGCTGAGCAGCAACGCAAGGCATTATCTCACGATGCATGGCTAA
CTGAACAAGTGAATCAAGCATTTGAGAAGTTCGACTCAGGAAAAGCAGTATTCATTGAACATGACATCGCCAAAGCACGA
ATGGCTGAACGTAAAGCTAAAATCCGAAATCGAGGCCACGCATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB Q9K2M8

Antitoxin

Source ID Structure
AlphaFold DB A0A067BL33

References