Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 167958..168573 Replicon chromosome
Accession NZ_CP033513
Organism Vibrio cholerae strain E4

Toxin (Protein)


Gene name higB Uniprot ID Q9KMG5
Locus tag EEL44_RS00995 Protein ID WP_001162670.1
Coordinates 168286..168573 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag EEL44_RS00990 Protein ID WP_001232701.1
Coordinates 167958..168275 (-) Length 106 a.a.

Genomic Context

EEL44_RS01025EEL44_RS01030EEL44_RS00940EEL44_RS00945EEL44_RS00950EEL44_RS00955EEL44_RS00960EEL44_RS00965EEL44_RS00970EEL44_RS00975EEL44_RS21145EEL44_RS00990EEL44_RS00995EEL44_RS01000EEL44_RS01005EEL44_RS01010EEL44_RS01015EEL44_RS01020EEL44_RS21150
Location: 172070..172312 (243 bp)
Type: Others
Protein ID: WP_000557292.1
Location: 172331..172648 (318 bp)
Type: Others
Protein ID: WP_001180243.1
Location: 163367..163882 (516 bp)
Type: Others
Protein ID: WP_001201528.1
Location: 164019..164495 (477 bp)
Type: Others
Protein ID: WP_001047180.1
Location: 164523..164633 (111 bp)
Type: Others
Protein ID: WP_071917832.1
Location: 164630..165559 (930 bp)
Type: Others
Protein ID: WP_000335802.1
Location: 165679..166125 (447 bp)
Type: Others
Protein ID: WP_000128977.1
Location: 166278..167282 (1005 bp)
Type: Others
Protein ID: WP_000964925.1
Location: 167495..167533 (39 bp)
Type: Others
Protein ID: WP_106019119.1
Location: 167549..167674 (126 bp)
Type: Others
Protein ID: WP_001944767.1
Location: 167851..167961 (111 bp)
Type: Others
Protein ID: WP_134814058.1
Location: 167958..168275 (318 bp)
Type: Antitoxin
Protein ID: WP_001232701.1
Location: 168286..168573 (288 bp)
Type: Toxin
Protein ID: WP_001162670.1
Location: 168840..169020 (181 bp)
Type: Others
Protein ID: Protein_181
Location: 169445..169678 (234 bp)
Type: Others
Protein ID: WP_032482776.1
Location: 170081..170299 (219 bp)
Type: Others
Protein ID: WP_001917086.1
Location: 170609..171262 (654 bp)
Type: Others
Protein ID: WP_000226874.1
Location: 171319..171828 (510 bp)
Type: Others
Protein ID: WP_000405987.1
Location: 172842..172937 (96 bp)
Type: Others
Protein ID: WP_001907607.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
EEL44_RS00940163367..163882-516WP_001201528.1lipocalin family protein-
EEL44_RS00945164019..164495-477WP_001047180.1GNAT family N-acetyltransferase-
EEL44_RS00950164523..164633-111WP_071917832.1DUF3265 domain-containing protein-
EEL44_RS00955164630..165559-930WP_000335802.1hypothetical protein-
EEL44_RS00960165679..166125-447WP_000128977.1hypothetical protein-
EEL44_RS00965166278..167282-1005WP_000964925.1LD-carboxypeptidase-
EEL44_RS00970167495..167533-39WP_106019119.1hypothetical protein-
EEL44_RS00975167549..167674-126WP_001944767.1DUF645 family protein-
EEL44_RS21145167851..167961-111WP_134814058.1DUF3265 domain-containing protein-
EEL44_RS00990167958..168275-318WP_001232701.1HigA family addiction module antidote proteinAntitoxin
EEL44_RS00995168286..168573-288WP_001162670.1type II toxin-antitoxin system RelE/ParE family toxinToxin
EEL44_RS01000168840..169020-181Protein_181DUF645 family protein-
EEL44_RS01005169445..169678-234WP_032482776.1DUF3709 domain-containing protein-
EEL44_RS01010170081..170299-219WP_001917086.1DUF3709 domain-containing protein-
EEL44_RS01015170609..171262-654WP_000226874.1hypothetical protein-
EEL44_RS01020171319..171828-510WP_000405987.1GNAT family N-acetyltransferase-
EEL44_RS01025172070..172312+243WP_000557292.1type II toxin-antitoxin system Phd/YefM family antitoxin-
EEL44_RS01030172331..172648+318WP_001180243.1type II toxin-antitoxin system RelE/ParE family toxin-
EEL44_RS21150172842..172937-96WP_001907607.1DUF645 family protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideGenomic islandcatB9-126763..233717106954
insideIntegron--127139..22687599736


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(2-95)

Antitoxin

Cro/C1-type helix-turn-helix domain

(12-69)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11349.95 Da        Isoelectric Point: 6.7187

>T113804 WP_001162670.1 NZ_CP033513:c168573-168286 [Vibrio cholerae]
MALEFKDKWLEQFYEDDKRHRLIPSSIENALFRKLEILDAAQAESDLRIPPGNRFEHLEGNLKGWCSIRVNKQYRLIFQW
VDGVALNTYLDPHKY

Download         Length: 288 bp

>T113804 NZ_CP033513:c168573-168286 [Vibrio cholerae]
ATGGCATTAGAATTTAAAGATAAGTGGTTAGAGCAGTTTTACGAGGATGATAAACGACATCGTTTAATTCCAAGTAGCAT
AGAGAATGCTCTATTTCGGAAGCTGGAAATCTTAGATGCAGCTCAAGCTGAATCAGACTTAAGAATTCCACCGGGTAATC
GTTTTGAACATCTTGAAGGAAATCTTAAAGGTTGGTGTTCAATTCGAGTGAACAAACAGTATCGTTTGATTTTTCAGTGG
GTTGATGGTGTTGCACTAAATACTTACTTAGACCCACATAAGTATTGA

Antitoxin


Download         Length: 106 a.a.        Molecular weight: 11705.63 Da        Isoelectric Point: 10.4711

>AT113804 WP_001232701.1 NZ_CP033513:c168275-167958 [Vibrio cholerae]
MRKTKRRPVSVGEMLKVEFLEPMGITSKALAEAMGVHRNTVSNLINGGVLTAPVAIKLAAALGNTPEFWLNIQHAVDLWD
TRNRYQEEAKFVKPLFVSLEQSART

Download         Length: 318 bp

>AT113804 NZ_CP033513:c168275-167958 [Vibrio cholerae]
ATGCGTAAGACAAAACGTCGTCCAGTTAGCGTTGGGGAAATGTTAAAAGTTGAATTTCTTGAACCAATGGGCATCACATC
AAAAGCGCTCGCTGAAGCGATGGGCGTACACAGAAATACGGTCAGTAATTTAATTAATGGTGGTGTGTTAACAGCTCCGG
TAGCAATCAAGTTAGCCGCGGCATTAGGTAACACACCAGAATTTTGGCTTAACATTCAACATGCAGTTGATCTTTGGGAT
ACGAGAAATCGTTATCAAGAAGAAGCAAAGTTTGTAAAGCCGTTGTTTGTTTCGCTGGAACAAAGCGCACGTACATAA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A0F2HI36

Antitoxin

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Source
ID
Structure
No matching records found

References