Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /GNAT-DUF1778
Location 482857..483623 Replicon chromosome
Accession NZ_CP013318
Organism Vibrio cholerae strain NCTC5395

Toxin (Protein)


Gene name - Uniprot ID Q9K2P7
Locus tag ASZ85_RS17095 Protein ID WP_000982260.1
Coordinates 482857..483354 (-) Length 166 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID Q9K2J6
Locus tag ASZ85_RS17100 Protein ID WP_000246253.1
Coordinates 483351..483623 (-) Length 91 a.a.

Genomic Context

ASZ85_RS17045ASZ85_RS17050ASZ85_RS17055ASZ85_RS21215ASZ85_RS17065ASZ85_RS17070ASZ85_RS17075ASZ85_RS17080ASZ85_RS17090ASZ85_RS17105ASZ85_RS17110ASZ85_RS17115ASZ85_RS17120ASZ85_RS17125ASZ85_RS17130ASZ85_RS17135ASZ85_RS17140ASZ85_RS17095ASZ85_RS17100
Location: 478719..479025 (307 bp)
Type: Others
Protein ID: Protein_529
Location: 479162..479854 (693 bp)
Type: Others
Protein ID: WP_001047169.1
Location: 479854..480255 (402 bp)
Type: Others
Protein ID: WP_000351248.1
Location: 480225..480368 (144 bp)
Type: Others
Protein ID: WP_071908341.1
Location: 480443..480856 (414 bp)
Type: Others
Protein ID: WP_000049417.1
Location: 481070..481321 (252 bp)
Type: Others
Protein ID: WP_001250179.1
Location: 481311..481598 (288 bp)
Type: Others
Protein ID: WP_000221354.1
Location: 481726..482181 (456 bp)
Type: Others
Protein ID: WP_001245327.1
Location: 482503..482655 (153 bp)
Type: Others
Protein ID: WP_001884520.1
Location: 483854..484522 (669 bp)
Type: Others
Protein ID: WP_000043871.1
Location: 484674..484961 (288 bp)
Type: Others
Protein ID: WP_000426470.1
Location: 485102..485473 (372 bp)
Type: Others
Protein ID: WP_001164080.1
Location: 485540..485965 (426 bp)
Type: Others
Protein ID: WP_001882332.1
Location: 485962..486495 (534 bp)
Type: Others
Protein ID: WP_000118351.1
Location: 486697..486954 (258 bp)
Type: Others
Protein ID: WP_000861987.1
Location: 486942..487244 (303 bp)
Type: Others
Protein ID: WP_000229317.1
Location: 487478..488395 (918 bp)
Type: Others
Protein ID: WP_000186333.1
Location: 482857..483354 (498 bp)
Type: Toxin
Protein ID: WP_000982260.1
Location: 483351..483623 (273 bp)
Type: Antitoxin
Protein ID: WP_000246253.1
ToxinAntitoxinOther genes
Loading, please wait
Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
ASZ85_RS17045478719..479025+307Protein_529CatB-related O-acetyltransferase-
ASZ85_RS17050479162..479854+693WP_001047169.1GNAT family N-acetyltransferase-
ASZ85_RS17055479854..480255+402WP_000351248.1type II toxin-antitoxin system death-on-curing family toxin-
ASZ85_RS21215480225..480368+144WP_071908341.1DUF3265 domain-containing protein-
ASZ85_RS17065480443..480856+414WP_000049417.1VOC family protein-
ASZ85_RS17070481070..481321+252WP_001250179.1type II toxin-antitoxin system Phd/YefM family antitoxin-
ASZ85_RS17075481311..481598+288WP_000221354.1type II toxin-antitoxin system RelE/ParE family toxin-
ASZ85_RS17080481726..482181+456WP_001245327.1GNAT family N-acetyltransferase-
ASZ85_RS17090482503..482655+153WP_001884520.1DUF645 family protein-
ASZ85_RS17095482857..483354-498WP_000982260.1GNAT family N-acetyltransferaseToxin
ASZ85_RS17100483351..483623-273WP_000246253.1DUF1778 domain-containing proteinAntitoxin
ASZ85_RS17105483854..484522+669WP_000043871.1hypothetical protein-
ASZ85_RS17110484674..484961+288WP_000426470.1hypothetical protein-
ASZ85_RS17115485102..485473+372WP_001164080.1nucleotide pyrophosphohydrolase-
ASZ85_RS17120485540..485965+426WP_001882332.1DUF1778 domain-containing protein-
ASZ85_RS17125485962..486495+534WP_000118351.1GNAT family N-acetyltransferase-
ASZ85_RS17130486697..486954+258WP_000861987.1type II toxin-antitoxin system Phd/YefM family antitoxin-
ASZ85_RS17135486942..487244+303WP_000229317.1type II toxin-antitoxin system RelE/ParE family toxin-
ASZ85_RS17140487478..488395+918WP_000186333.1alpha/beta hydrolase-

Associated MGEs

Loading, please wait
MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideGenomic island--338285..496833158548
insideIntegron--343365..496457153092
flankIS/Tn--477671..478651980


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(86-152)

Antitoxin

Vibrio phage ICP1, Orf50

(7-86)


Sequences

Toxin        


Download         Length: 166 a.a.        Molecular weight: 18527.18 Da        Isoelectric Point: 8.7753

>T58406 WP_000982260.1 NZ_CP013318:c483354-482857 [Vibrio cholerae]
MMNTVLLDKDKHDRNRFNCGTEALNNYLKVMASQQAKKDNTRTFVLEDDNNSAYIIGFYTLTMTPIDLKALPDKLQKKHQ
SSTSGGLIARLAVDDRYKGKGFGEWLLIDALRKLLAASDSVAFPVVIVDAKDGAKHFYERYGFQAFQDAENKLFITIADI
RASLG

Download         Length: 498 bp

>T58406 NZ_CP013318:c483354-482857 [Vibrio cholerae]
ATGATGAATACGGTACTTCTCGATAAAGATAAGCACGATAGGAACCGTTTCAATTGTGGCACTGAAGCACTCAACAATTA
CTTAAAAGTAATGGCGAGTCAGCAAGCCAAAAAAGACAACACCAGAACCTTCGTTTTGGAAGATGACAATAACAGTGCTT
ATATCATCGGCTTTTACACTCTGACTATGACGCCCATTGATTTGAAAGCCTTGCCCGACAAGTTACAAAAGAAGCACCAA
TCCTCAACCTCTGGAGGGCTCATTGCTCGTTTAGCTGTCGACGATAGATACAAAGGAAAAGGTTTTGGTGAGTGGCTACT
CATTGACGCTCTCAGAAAGCTACTCGCAGCCAGTGACAGTGTAGCGTTCCCTGTTGTCATTGTTGATGCCAAAGATGGTG
CAAAACATTTCTATGAGCGCTATGGGTTTCAAGCGTTTCAAGATGCCGAAAACAAACTCTTCATCACCATTGCTGATATC
AGAGCAAGCTTAGGCTAG

Antitoxin


Download         Length: 91 a.a.        Molecular weight: 9683.22 Da        Isoelectric Point: 6.2988

>AT58406 WP_000246253.1 NZ_CP013318:c483623-483351 [Vibrio cholerae]
MATTLPRITARVDVDTQDLLAKAAALAGMSSINSFVLNAAIEKAKQVIEREQALKLSQADAVLLMEALDNPAVVNAKLKL
ASERYESKTQ

Download         Length: 273 bp

>AT58406 NZ_CP013318:c483623-483351 [Vibrio cholerae]
ATGGCAACGACTTTGCCTCGCATCACCGCTAGAGTTGATGTCGATACTCAAGATTTACTCGCTAAGGCTGCTGCTCTTGC
TGGTATGTCTAGTATTAACTCATTTGTTTTGAATGCAGCAATCGAAAAAGCAAAACAAGTCATTGAACGTGAGCAAGCTC
TAAAGCTTAGCCAAGCTGATGCCGTATTGCTGATGGAAGCTCTTGATAATCCAGCTGTAGTAAATGCAAAGCTCAAATTG
GCATCCGAACGTTATGAGAGCAAAACTCAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Loading, please wait
Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
Loading, please wait
Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

Loading, please wait
Source
ID
Structure
AlphaFold DBA0A0Q0KGB1

Antitoxin

Loading, please wait
Source
ID
Structure
PDB1Y9B
AlphaFold DBA0A0F2IC79

References