38617

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/ParE-Phd
Location 23538..24116 Replicon chromosome
Accession NZ_AP024548
Organism Vibrio cholerae strain BCH-01536

Toxin (Protein)


Gene name parE Uniprot ID O68848
Locus tag K6J77_RS13995 Protein ID WP_001180243.1
Coordinates 23538..23855 (-) Length 106 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID Q7DCR7
Locus tag K6J77_RS14000 Protein ID WP_000557292.1
Coordinates 23874..24116 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K6J77_RS13965 19062..19244 + 183 WP_000923340.1 DUF645 family protein -
K6J77_RS18935 19364..19426 + 63 Protein_27 acetyltransferase -
K6J77_RS13970 19598..19780 + 183 WP_000923153.1 DUF645 family protein -
K6J77_RS13975 19975..20652 + 678 WP_000254617.1 HNH endonuclease signature motif containing protein -
K6J77_RS13980 20814..22022 + 1209 WP_000272282.1 deoxyguanosinetriphosphate triphosphohydrolase family protein -
K6J77_RS13985 22184..22888 + 705 WP_000087610.1 HNH endonuclease -
K6J77_RS13990 23046..23384 + 339 WP_000713853.1 hypothetical protein -
K6J77_RS13995 23538..23855 - 318 WP_001180243.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
K6J77_RS14000 23874..24116 - 243 WP_000557292.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
K6J77_RS14005 24360..24746 + 387 WP_001015867.1 NUDIX hydrolase -
K6J77_RS14010 24803..24916 + 114 WP_001900214.1 hypothetical protein -
K6J77_RS14015 24925..25146 + 222 WP_032467793.1 DUF1289 domain-containing protein -
K6J77_RS14020 25404..25940 + 537 WP_000469482.1 GNAT family protein -
K6J77_RS14025 26131..26592 + 462 WP_001903091.1 lipocalin family protein -
K6J77_RS18940 26657..26725 + 69 Protein_40 acetyltransferase -
K6J77_RS14030 26742..27238 - 497 Protein_41 GNAT family N-acetyltransferase -
K6J77_RS14035 27235..27507 - 273 WP_000246253.1 DUF1778 domain-containing protein -
K6J77_RS14040 27900..28025 + 126 WP_001900195.1 DUF645 family protein -
K6J77_RS14050 28275..28721 + 447 WP_000006157.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Integron - - 11978..113648 101670
- flank IS/Tn - - 28784..29995 1211


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-93)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-71)


Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 12158.97 Da        Isoelectric Point: 9.7495

>T38617 WP_001180243.1 NZ_AP024548:c23855-23538 [Vibrio cholerae]
MQNKQYKLSQLAQEHLLKIKHYTIENFAEAQWQKYKSTLLSGFQTLADNPGLGKSCEDIYQNGFYFPVGKHMAYYTKEAN
FILIVAVLGQSQLPQKHLKQSRFVS

Download         Length: 318 bp

>T38617 NZ_AP024548:c23855-23538 [Vibrio cholerae]
ATGCAAAATAAACAATATAAGCTCAGCCAATTAGCCCAAGAGCACTTACTCAAGATTAAACACTACACCATTGAAAATTT
CGCTGAAGCGCAGTGGCAAAAATATAAGTCGACCTTGCTTTCAGGTTTCCAAACTCTTGCGGATAACCCAGGACTAGGAA
AAAGCTGTGAAGATATTTACCAAAATGGTTTTTACTTTCCAGTGGGGAAACACATGGCTTATTACACCAAAGAAGCAAAC
TTCATTCTCATTGTTGCGGTATTAGGGCAATCACAACTGCCCCAAAAGCATCTCAAACAGTCACGCTTTGTTTCTTAG

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8961.25 Da        Isoelectric Point: 5.6630

>AT38617 WP_000557292.1 NZ_AP024548:c24116-23874 [Vibrio cholerae]
MHTLTANDAKRNFGELLLSAQREPVIISKNSKNTVVVMSIKDFEELEAMKLDYLKHCFESAQKDLDSGKTVDGATFLNTL

Download         Length: 243 bp

>AT38617 NZ_AP024548:c24116-23874 [Vibrio cholerae]
ATGCACACACTAACAGCAAATGATGCTAAACGAAATTTTGGTGAACTTCTTCTAAGCGCACAACGCGAACCTGTCATCAT
CAGCAAAAACAGTAAGAATACTGTCGTTGTCATGTCCATTAAGGACTTTGAAGAACTTGAAGCAATGAAACTCGATTATC
TCAAACACTGCTTTGAGTCTGCTCAGAAAGACTTAGATAGTGGCAAAACCGTTGATGGTGCCACTTTTCTAAACACCCTT
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0K9UJR8

Antitoxin

Source ID Structure
AlphaFold DB Q7DCR7

References