56913

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/ParE-RHH
Location 338286..338824 Replicon chromosome
Accession NZ_CP012666
Organism Vibrio cholerae strain ICDC-VC661

Toxin (Protein)


Gene name parE Uniprot ID Q9KMJ0
Locus tag AN947_RS01730 Protein ID WP_000802136.1
Coordinates 338286..338585 (-) Length 100 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID P58093
Locus tag AN947_RS01735 Protein ID WP_001107719.1
Coordinates 338582..338824 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AN947_RS01675 334032..334160 + 129 WP_071908338.1 general secretion pathway protein GspI -
AN947_RS01680 334221..334403 + 183 WP_000923182.1 DUF645 family protein -
AN947_RS01685 334603..335076 + 474 WP_001161076.1 GrpB family protein -
AN947_RS01690 335091..335183 + 93 WP_014378730.1 DUF3265 domain-containing protein -
AN947_RS01695 335225..335851 + 627 WP_000365424.1 LysE family translocator -
AN947_RS01700 335974..336672 + 699 WP_001890502.1 hypothetical protein -
AN947_RS01705 336682..336792 + 111 WP_079857360.1 DUF3265 domain-containing protein -
AN947_RS01720 337370..337549 + 180 WP_001883058.1 DUF645 family protein -
AN947_RS01725 337763..338158 + 396 WP_000870857.1 DUF3465 domain-containing protein -
AN947_RS01730 338286..338585 - 300 WP_000802136.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
AN947_RS01735 338582..338824 - 243 WP_001107719.1 type II toxin-antitoxin system ParD family antitoxin Antitoxin
AN947_RS01740 339053..339631 + 579 WP_000110120.1 hypothetical protein -
AN947_RS01745 339653..339745 + 93 WP_014164112.1 DUF3265 domain-containing protein -
AN947_RS01755 340169..340852 + 684 WP_000877436.1 hypothetical protein -
AN947_RS01760 341066..341332 + 267 WP_000937852.1 hypothetical protein -
AN947_RS01770 341487..342086 + 600 WP_000429495.1 hypothetical protein -
AN947_RS01775 342367..343302 + 936 WP_000051985.1 restriction endonuclease -
AN947_RS01780 343268..343408 + 141 WP_001883049.1 DUF3265 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island catB9 - 304645..399892 95247
inside Integron - - 309725..399516 89791


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-92)

Antitoxin

Antitoxin ParD

(1-79)


Sequences

Toxin        


Download         Length: 100 a.a.        Molecular weight: 11589.29 Da        Isoelectric Point: 9.9232

>T56913 WP_000802136.1 NZ_CP012666:c338585-338286 [Vibrio cholerae]
MKPFNLTVAAKADLRDIALFTQRRWGKEQRNVYLKQFDDSFWLLAENPDIGKSCDEIREGYRKFPQGSHVIFYQQTGSQQ
IRVIRILHKSMDVNPIFGA

Download         Length: 300 bp

>T56913 NZ_CP012666:c338585-338286 [Vibrio cholerae]
ATGAAACCATTTAATCTTACCGTCGCCGCCAAAGCCGATTTACGTGATATTGCTTTATTCACTCAACGACGCTGGGGAAA
AGAGCAGCGAAATGTTTATTTAAAGCAATTCGATGATTCCTTTTGGCTTTTAGCGGAAAATCCCGACATTGGTAAATCAT
GCGATGAAATCCGAGAGGGATACAGAAAATTTCCCCAAGGGAGTCACGTCATCTTTTATCAGCAAACCGGCAGCCAACAA
ATCAGGGTGATCCGAATTCTTCATAAGAGCATGGATGTGAACCCAATATTCGGCGCATAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8964.84 Da        Isoelectric Point: 4.1677

>AT56913 WP_001107719.1 NZ_CP012666:c338824-338582 [Vibrio cholerae]
MAKNTSITLGEHFDGFITSQIQSGRYGSASEVIRSALRLLENQETKLQSLRQLLIEGEQSGDADYDLDSFINELDSENIR

Download         Length: 243 bp

>AT56913 NZ_CP012666:c338824-338582 [Vibrio cholerae]
ATGGCTAAAAATACAAGTATCACTCTTGGTGAACACTTCGATGGCTTTATTACAAGCCAAATACAAAGTGGGCGTTACGG
CTCAGCAAGTGAAGTCATTCGCTCTGCGCTACGTCTACTCGAAAACCAAGAAACCAAACTACAGTCACTCCGTCAACTAC
TTATTGAAGGAGAGCAAAGTGGTGACGCTGATTATGACCTTGATAGCTTCATCAATGAACTCGATAGTGAAAACATTCGA
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7R5A

Antitoxin

Source ID Structure
AlphaFold DB A0A151JFU4

References