Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-RelB
Location 462985..463544 Replicon chromosome
Accession NZ_CP013310
Organism Vibrio cholerae strain E1162

Toxin (Protein)


Gene name relE Uniprot ID Q9K2M8
Locus tag ASZ87_RS16495 Protein ID WP_000578476.1
Coordinates 462985..463263 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID Q9L991
Locus tag ASZ87_RS16500 Protein ID WP_000381183.1
Coordinates 463260..463544 (-) Length 95 a.a.

Genomic Context

ASZ87_RS16450ASZ87_RS16455ASZ87_RS16460ASZ87_RS16465ASZ87_RS16470ASZ87_RS16480ASZ87_RS16485ASZ87_RS16490ASZ87_RS16525ASZ87_RS20990ASZ87_RS21065ASZ87_RS20560ASZ87_RS16550ASZ87_RS16560ASZ87_RS16495ASZ87_RS16500ASZ87_RS16510ASZ87_RS16515
Location: 458925..459107 (183 bp)
Type: Others
Protein ID: WP_000923340.1
Location: 459322..459861 (540 bp)
Type: Others
Protein ID: WP_000099372.1
Location: 459984..460499 (516 bp)
Type: Others
Protein ID: WP_000090011.1
Location: 460634..461170 (537 bp)
Type: Others
Protein ID: WP_000644491.1
Location: 461639..461749 (111 bp)
Type: Others
Protein ID: WP_071908335.1
Location: 461962..462114 (153 bp)
Type: Others
Protein ID: WP_001884520.1
Location: 462398..462841 (444 bp)
Type: Others
Protein ID: WP_000803902.1
Location: 462845..462955 (111 bp)
Type: Others
Protein ID: WP_071908336.1
Location: 464677..464754 (78 bp)
Type: Others
Protein ID: WP_071908337.1
Location: 464758..464784 (27 bp)
Type: Others
Protein ID: Protein_414
Location: 465370..465513 (144 bp)
Type: Others
Protein ID: WP_001900215.1
Location: 465607..465786 (180 bp)
Type: Others
Protein ID: Protein_416
Location: 466004..466432 (429 bp)
Type: Others
Protein ID: WP_000620002.1
Location: 467020..467502 (483 bp)
Type: Others
Protein ID: WP_000422940.1
Location: 462985..463263 (279 bp)
Type: Toxin
Protein ID: WP_000578476.1
Location: 463260..463544 (285 bp)
Type: Antitoxin
Protein ID: WP_000381183.1
Location: 463720..464019 (300 bp)
Type: Others
Protein ID: WP_000802136.1
Location: 464016..464258 (243 bp)
Type: Others
Protein ID: WP_001107719.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
ASZ87_RS16450458925..459107+183WP_000923340.1DUF645 family protein-
ASZ87_RS16455459322..459861+540WP_000099372.1hypothetical protein-
ASZ87_RS16460459984..460499+516WP_000090011.1hypothetical protein-
ASZ87_RS16465460634..461170+537WP_000644491.1nucleotidyltransferase family protein-
ASZ87_RS16470461639..461749+111WP_071908335.1DUF3265 domain-containing protein-
ASZ87_RS16480461962..462114+153WP_001884520.1DUF645 family protein-
ASZ87_RS16485462398..462841+444WP_000803902.1hypothetical protein-
ASZ87_RS16490462845..462955+111WP_071908336.1DUF3265 domain-containing protein-
ASZ87_RS16495462985..463263-279WP_000578476.1type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE familyToxin
ASZ87_RS16500463260..463544-285WP_000381183.1type II toxin-antitoxin system RelB/DinJ family antitoxinAntitoxin
ASZ87_RS16510463720..464019-300WP_000802136.1type II toxin-antitoxin system RelE/ParE family toxin-
ASZ87_RS16515464016..464258-243WP_001107719.1type II toxin-antitoxin system ParD family antitoxin-
ASZ87_RS16525464677..464754+78WP_071908337.1DUF645 family protein-
ASZ87_RS20990464758..464784+27Protein_414hypothetical protein-
ASZ87_RS21065465370..465513+144WP_001900215.1hypothetical protein-
ASZ87_RS20560465607..465786+180Protein_416DUF645 family protein-
ASZ87_RS16550466004..466432+429WP_000620002.1N-acetyltransferase-
ASZ87_RS16560467020..467502+483WP_000422940.1GNAT family N-acetyltransferase-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideGenomic islandcatB9-435534..596659161125
insideIntegron--440614..596283155669


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(2-89)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(5-70)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10819.59 Da        Isoelectric Point: 5.1651

>T58302 WP_000578476.1 NZ_CP013310:c463263-462985 [Vibrio cholerae]
MIFWEEASLNDREKIFEFLYDFNPAAAKKTDELIEAKVENLLEQPLIGVQRDGIRGRLLIIPEISMIVSYWVDGSKIRIM
RVLHQKQKFPND

Download         Length: 279 bp

>T58302 NZ_CP013310:c463263-462985 [Vibrio cholerae]
ATGATTTTCTGGGAAGAAGCATCTCTCAATGATCGTGAGAAAATTTTCGAATTTCTCTACGACTTTAACCCAGCAGCGGC
TAAAAAAACGGATGAGCTCATAGAAGCCAAAGTCGAAAATTTGCTTGAGCAACCACTAATCGGTGTTCAGCGTGATGGCA
TTAGAGGCAGATTGCTTATTATCCCTGAGATATCAATGATTGTTTCGTATTGGGTTGATGGTTCTAAAATTCGAATAATG
CGTGTACTACATCAGAAACAAAAATTTCCAAACGACTGA

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10901.25 Da        Isoelectric Point: 8.0775

>AT58302 WP_000381183.1 NZ_CP013310:c463544-463260 [Vibrio cholerae]
MDTRIQFRVDEETKRLAQQMAESQGRTLSDACRELTEQLAEQQRKALSHDAWLTEQVNQAFEKFDSGKAVFIEHDIAKAR
MAERKAKIRNRGHA

Download         Length: 285 bp

>AT58302 NZ_CP013310:c463544-463260 [Vibrio cholerae]
ATGGATACTAGAATTCAATTTCGTGTAGACGAAGAAACAAAACGTTTAGCTCAACAAATGGCTGAAAGCCAAGGTCGAAC
TCTTAGCGATGCTTGCCGTGAACTCACTGAACAATTAGCTGAGCAGCAACGCAAGGCATTATCTCACGATGCATGGCTAA
CTGAACAAGTGAATCAAGCATTTGAGAAGTTCGACTCAGGAAAAGCAGTATTCATTGAACATGACATCGCCAAAGCACGA
ATGGCTGAACGTAAAGCTAAAATCCGAAATCGAGGCCACGCATGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBQ9K2M8

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A067BL33

References