58302

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-RelB
Location 462985..463544 Replicon chromosome
Accession NZ_CP013310
Organism Vibrio cholerae strain E1162

Toxin (Protein)


Gene name relE Uniprot ID Q9K2M8
Locus tag ASZ87_RS16495 Protein ID WP_000578476.1
Coordinates 462985..463263 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID Q9L991
Locus tag ASZ87_RS16500 Protein ID WP_000381183.1
Coordinates 463260..463544 (-) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ASZ87_RS16450 458925..459107 + 183 WP_000923340.1 DUF645 family protein -
ASZ87_RS16455 459322..459861 + 540 WP_000099372.1 hypothetical protein -
ASZ87_RS16460 459984..460499 + 516 WP_000090011.1 hypothetical protein -
ASZ87_RS16465 460634..461170 + 537 WP_000644491.1 nucleotidyltransferase family protein -
ASZ87_RS16470 461639..461749 + 111 WP_071908335.1 DUF3265 domain-containing protein -
ASZ87_RS16480 461962..462114 + 153 WP_001884520.1 DUF645 family protein -
ASZ87_RS16485 462398..462841 + 444 WP_000803902.1 hypothetical protein -
ASZ87_RS16490 462845..462955 + 111 WP_071908336.1 DUF3265 domain-containing protein -
ASZ87_RS16495 462985..463263 - 279 WP_000578476.1 type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family Toxin
ASZ87_RS16500 463260..463544 - 285 WP_000381183.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
ASZ87_RS16510 463720..464019 - 300 WP_000802136.1 type II toxin-antitoxin system RelE/ParE family toxin -
ASZ87_RS16515 464016..464258 - 243 WP_001107719.1 type II toxin-antitoxin system ParD family antitoxin -
ASZ87_RS16525 464677..464754 + 78 WP_071908337.1 DUF645 family protein -
ASZ87_RS20990 464758..464784 + 27 Protein_414 hypothetical protein -
ASZ87_RS21065 465370..465513 + 144 WP_001900215.1 hypothetical protein -
ASZ87_RS20560 465607..465786 + 180 Protein_416 DUF645 family protein -
ASZ87_RS16550 466004..466432 + 429 WP_000620002.1 N-acetyltransferase -
ASZ87_RS16560 467020..467502 + 483 WP_000422940.1 GNAT family N-acetyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island catB9 - 435534..596659 161125
inside Integron - - 440614..596283 155669


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(2-89)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(5-70)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10819.59 Da        Isoelectric Point: 5.1651

>T58302 WP_000578476.1 NZ_CP013310:c463263-462985 [Vibrio cholerae]
MIFWEEASLNDREKIFEFLYDFNPAAAKKTDELIEAKVENLLEQPLIGVQRDGIRGRLLIIPEISMIVSYWVDGSKIRIM
RVLHQKQKFPND

Download         Length: 279 bp

>T58302 NZ_CP013310:c463263-462985 [Vibrio cholerae]
ATGATTTTCTGGGAAGAAGCATCTCTCAATGATCGTGAGAAAATTTTCGAATTTCTCTACGACTTTAACCCAGCAGCGGC
TAAAAAAACGGATGAGCTCATAGAAGCCAAAGTCGAAAATTTGCTTGAGCAACCACTAATCGGTGTTCAGCGTGATGGCA
TTAGAGGCAGATTGCTTATTATCCCTGAGATATCAATGATTGTTTCGTATTGGGTTGATGGTTCTAAAATTCGAATAATG
CGTGTACTACATCAGAAACAAAAATTTCCAAACGACTGA

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10901.25 Da        Isoelectric Point: 8.0775

>AT58302 WP_000381183.1 NZ_CP013310:c463544-463260 [Vibrio cholerae]
MDTRIQFRVDEETKRLAQQMAESQGRTLSDACRELTEQLAEQQRKALSHDAWLTEQVNQAFEKFDSGKAVFIEHDIAKAR
MAERKAKIRNRGHA

Download         Length: 285 bp

>AT58302 NZ_CP013310:c463544-463260 [Vibrio cholerae]
ATGGATACTAGAATTCAATTTCGTGTAGACGAAGAAACAAAACGTTTAGCTCAACAAATGGCTGAAAGCCAAGGTCGAAC
TCTTAGCGATGCTTGCCGTGAACTCACTGAACAATTAGCTGAGCAGCAACGCAAGGCATTATCTCACGATGCATGGCTAA
CTGAACAAGTGAATCAAGCATTTGAGAAGTTCGACTCAGGAAAAGCAGTATTCATTGAACATGACATCGCCAAAGCACGA
ATGGCTGAACGTAAAGCTAAAATCCGAAATCGAGGCCACGCATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB Q9K2M8

Antitoxin

Source ID Structure
AlphaFold DB A0A067BL33

References