87022

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/ParE-Phd
Location 363532..364110 Replicon chromosome
Accession NZ_CP024163
Organism Vibrio cholerae strain E7946

Toxin (Protein)


Gene name parE Uniprot ID O68848
Locus tag CSW01_RS16085 Protein ID WP_001180243.1
Coordinates 363532..363849 (-) Length 106 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID Q7DCR7
Locus tag CSW01_RS16090 Protein ID WP_000557292.1
Coordinates 363868..364110 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CSW01_RS16035 358723..359118 + 396 WP_000046952.1 hypothetical protein -
CSW01_RS16040 359421..359602 + 182 Protein_346 DUF645 family protein -
CSW01_RS16050 359779..360174 + 396 WP_000046953.1 hypothetical protein -
CSW01_RS16055 360318..360854 + 537 WP_000644491.1 nucleotidyltransferase family protein -
CSW01_RS16060 361151..361330 + 180 WP_001883039.1 DUF645 family protein -
CSW01_RS16065 361526..361951 + 426 WP_000403014.1 GNAT family N-acetyltransferase -
CSW01_RS16070 362100..362447 + 348 WP_000933409.1 hypothetical protein -
CSW01_RS19835 362594..362887 + 294 WP_125460920.1 hypothetical protein -
CSW01_RS19960 363243..363338 + 96 WP_001907607.1 DUF645 family protein -
CSW01_RS16085 363532..363849 - 318 WP_001180243.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
CSW01_RS16090 363868..364110 - 243 WP_000557292.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
CSW01_RS16095 364352..364861 + 510 WP_000409153.1 GNAT family N-acetyltransferase -
CSW01_RS16100 364918..365571 + 654 WP_000226874.1 hypothetical protein -
CSW01_RS16105 365881..366099 + 219 WP_001917086.1 DUF3709 domain-containing protein -
CSW01_RS16110 366502..366735 + 234 WP_032482776.1 DUF3709 domain-containing protein -
CSW01_RS16115 367160..367340 + 181 Protein_360 DUF645 family protein -
CSW01_RS16125 367607..367894 + 288 WP_001162670.1 type II toxin-antitoxin system RelE/ParE family toxin -
CSW01_RS16130 367905..368222 + 318 WP_001232701.1 HigA family addiction module antidote protein -
CSW01_RS19965 368219..368329 + 111 WP_134814058.1 DUF3265 domain-containing protein -
CSW01_RS16145 368506..368631 + 126 WP_001944767.1 DUF645 family protein -
CSW01_RS19840 368647..368685 + 39 WP_106019119.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island catB9 - 304226..433944 129718
inside Integron - - 309306..433568 124262


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-93)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-71)


Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 12158.97 Da        Isoelectric Point: 9.7495

>T87022 WP_001180243.1 NZ_CP024163:c363849-363532 [Vibrio cholerae]
MQNKQYKLSQLAQEHLLKIKHYTIENFAEAQWQKYKSTLLSGFQTLADNPGLGKSCEDIYQNGFYFPVGKHMAYYTKEAN
FILIVAVLGQSQLPQKHLKQSRFVS

Download         Length: 318 bp

>T87022 NZ_CP024163:c363849-363532 [Vibrio cholerae]
ATGCAAAATAAACAATATAAGCTCAGCCAATTAGCCCAAGAGCACTTACTCAAGATTAAACACTACACCATTGAAAATTT
CGCTGAAGCGCAGTGGCAAAAATATAAGTCGACCTTGCTTTCAGGTTTCCAAACTCTTGCGGATAACCCAGGACTAGGAA
AAAGCTGTGAAGATATTTACCAAAATGGTTTTTACTTTCCAGTGGGGAAACACATGGCTTATTACACCAAAGAAGCAAAC
TTCATTCTCATTGTTGCGGTATTAGGGCAATCACAACTGCCCCAAAAGCATCTCAAACAGTCACGCTTTGTTTCTTAG

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8961.25 Da        Isoelectric Point: 5.6630

>AT87022 WP_000557292.1 NZ_CP024163:c364110-363868 [Vibrio cholerae]
MHTLTANDAKRNFGELLLSAQREPVIISKNSKNTVVVMSIKDFEELEAMKLDYLKHCFESAQKDLDSGKTVDGATFLNTL

Download         Length: 243 bp

>AT87022 NZ_CP024163:c364110-363868 [Vibrio cholerae]
ATGCACACACTAACAGCAAATGATGCTAAACGAAATTTTGGTGAACTTCTTCTAAGCGCACAACGCGAACCTGTCATCAT
CAGCAAAAACAGTAAGAATACTGTCGTTGTCATGTCCATTAAGGACTTTGAAGAACTTGAAGCAATGAAACTCGATTATC
TCAAACACTGCTTTGAGTCTGCTCAGAAAGACTTAGATAGTGGCAAAACCGTTGATGGTGCCACTTTTCTAAACACCCTT
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0K9UJR8

Antitoxin

Source ID Structure
AlphaFold DB Q7DCR7

References