Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/ParE-Phd
Location 363532..364110 Replicon chromosome
Accession NZ_CP024163
Organism Vibrio cholerae strain E7946

Toxin (Protein)


Gene name parE Uniprot ID O68848
Locus tag CSW01_RS16085 Protein ID WP_001180243.1
Coordinates 363532..363849 (-) Length 106 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID Q7DCR7
Locus tag CSW01_RS16090 Protein ID WP_000557292.1
Coordinates 363868..364110 (-) Length 81 a.a.

Genomic Context

CSW01_RS16035CSW01_RS16040CSW01_RS16050CSW01_RS16055CSW01_RS16060CSW01_RS16065CSW01_RS16070CSW01_RS19835CSW01_RS19960CSW01_RS16095CSW01_RS16100CSW01_RS16105CSW01_RS16110CSW01_RS16115CSW01_RS16125CSW01_RS16130CSW01_RS19965CSW01_RS16145CSW01_RS19840CSW01_RS16085CSW01_RS16090
Location: 358723..359118 (396 bp)
Type: Others
Protein ID: WP_000046952.1
Location: 359421..359602 (182 bp)
Type: Others
Protein ID: Protein_346
Location: 359779..360174 (396 bp)
Type: Others
Protein ID: WP_000046953.1
Location: 360318..360854 (537 bp)
Type: Others
Protein ID: WP_000644491.1
Location: 361151..361330 (180 bp)
Type: Others
Protein ID: WP_001883039.1
Location: 361526..361951 (426 bp)
Type: Others
Protein ID: WP_000403014.1
Location: 362100..362447 (348 bp)
Type: Others
Protein ID: WP_000933409.1
Location: 362594..362887 (294 bp)
Type: Others
Protein ID: WP_125460920.1
Location: 363243..363338 (96 bp)
Type: Others
Protein ID: WP_001907607.1
Location: 364352..364861 (510 bp)
Type: Others
Protein ID: WP_000409153.1
Location: 364918..365571 (654 bp)
Type: Others
Protein ID: WP_000226874.1
Location: 365881..366099 (219 bp)
Type: Others
Protein ID: WP_001917086.1
Location: 366502..366735 (234 bp)
Type: Others
Protein ID: WP_032482776.1
Location: 367160..367340 (181 bp)
Type: Others
Protein ID: Protein_360
Location: 367607..367894 (288 bp)
Type: Others
Protein ID: WP_001162670.1
Location: 367905..368222 (318 bp)
Type: Others
Protein ID: WP_001232701.1
Location: 368219..368329 (111 bp)
Type: Others
Protein ID: WP_134814058.1
Location: 368506..368631 (126 bp)
Type: Others
Protein ID: WP_001944767.1
Location: 368647..368685 (39 bp)
Type: Others
Protein ID: WP_106019119.1
Location: 363532..363849 (318 bp)
Type: Toxin
Protein ID: WP_001180243.1
Location: 363868..364110 (243 bp)
Type: Antitoxin
Protein ID: WP_000557292.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
CSW01_RS16035358723..359118+396WP_000046952.1hypothetical protein-
CSW01_RS16040359421..359602+182Protein_346DUF645 family protein-
CSW01_RS16050359779..360174+396WP_000046953.1hypothetical protein-
CSW01_RS16055360318..360854+537WP_000644491.1nucleotidyltransferase family protein-
CSW01_RS16060361151..361330+180WP_001883039.1DUF645 family protein-
CSW01_RS16065361526..361951+426WP_000403014.1GNAT family N-acetyltransferase-
CSW01_RS16070362100..362447+348WP_000933409.1hypothetical protein-
CSW01_RS19835362594..362887+294WP_125460920.1hypothetical protein-
CSW01_RS19960363243..363338+96WP_001907607.1DUF645 family protein-
CSW01_RS16085363532..363849-318WP_001180243.1type II toxin-antitoxin system RelE/ParE family toxinToxin
CSW01_RS16090363868..364110-243WP_000557292.1type II toxin-antitoxin system Phd/YefM family antitoxinAntitoxin
CSW01_RS16095364352..364861+510WP_000409153.1GNAT family N-acetyltransferase-
CSW01_RS16100364918..365571+654WP_000226874.1hypothetical protein-
CSW01_RS16105365881..366099+219WP_001917086.1DUF3709 domain-containing protein-
CSW01_RS16110366502..366735+234WP_032482776.1DUF3709 domain-containing protein-
CSW01_RS16115367160..367340+181Protein_360DUF645 family protein-
CSW01_RS16125367607..367894+288WP_001162670.1type II toxin-antitoxin system RelE/ParE family toxin-
CSW01_RS16130367905..368222+318WP_001232701.1HigA family addiction module antidote protein-
CSW01_RS19965368219..368329+111WP_134814058.1DUF3265 domain-containing protein-
CSW01_RS16145368506..368631+126WP_001944767.1DUF645 family protein-
CSW01_RS19840368647..368685+39WP_106019119.1hypothetical protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideGenomic islandcatB9-304226..433944129718
insideIntegron--309306..433568124262


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-93)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-71)


Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 12158.97 Da        Isoelectric Point: 9.7495

>T87022 WP_001180243.1 NZ_CP024163:c363849-363532 [Vibrio cholerae]
MQNKQYKLSQLAQEHLLKIKHYTIENFAEAQWQKYKSTLLSGFQTLADNPGLGKSCEDIYQNGFYFPVGKHMAYYTKEAN
FILIVAVLGQSQLPQKHLKQSRFVS

Download         Length: 318 bp

>T87022 NZ_CP024163:c363849-363532 [Vibrio cholerae]
ATGCAAAATAAACAATATAAGCTCAGCCAATTAGCCCAAGAGCACTTACTCAAGATTAAACACTACACCATTGAAAATTT
CGCTGAAGCGCAGTGGCAAAAATATAAGTCGACCTTGCTTTCAGGTTTCCAAACTCTTGCGGATAACCCAGGACTAGGAA
AAAGCTGTGAAGATATTTACCAAAATGGTTTTTACTTTCCAGTGGGGAAACACATGGCTTATTACACCAAAGAAGCAAAC
TTCATTCTCATTGTTGCGGTATTAGGGCAATCACAACTGCCCCAAAAGCATCTCAAACAGTCACGCTTTGTTTCTTAG

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8961.25 Da        Isoelectric Point: 5.6630

>AT87022 WP_000557292.1 NZ_CP024163:c364110-363868 [Vibrio cholerae]
MHTLTANDAKRNFGELLLSAQREPVIISKNSKNTVVVMSIKDFEELEAMKLDYLKHCFESAQKDLDSGKTVDGATFLNTL

Download         Length: 243 bp

>AT87022 NZ_CP024163:c364110-363868 [Vibrio cholerae]
ATGCACACACTAACAGCAAATGATGCTAAACGAAATTTTGGTGAACTTCTTCTAAGCGCACAACGCGAACCTGTCATCAT
CAGCAAAAACAGTAAGAATACTGTCGTTGTCATGTCCATTAAGGACTTTGAAGAACTTGAAGCAATGAAACTCGATTATC
TCAAACACTGCTTTGAGTCTGCTCAGAAAGACTTAGATAGTGGCAAAACCGTTGATGGTGCCACTTTTCTAAACACCCTT
TGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A0K9UJR8

Antitoxin

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Source
ID
Structure
AlphaFold DBQ7DCR7

References