Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/RelE-MqsA
Location 414947..415580 Replicon chromosome
Accession NZ_LT907990
Organism Vibrio cholerae strain A19

Toxin (Protein)


Gene name higB Uniprot ID Q9KMA6
Locus tag ALC86_RS16390 Protein ID WP_000843587.1
Coordinates 414947..415279 (+) Length 111 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag ALC86_RS16395 Protein ID WP_000071008.1
Coordinates 415266..415580 (+) Length 105 a.a.

Genomic Context

ALC86_RS19760ALC86_RS19605ALC86_RS16325ALC86_RS19820ALC86_RS16340ALC86_RS16345ALC86_RS16350ALC86_RS19775ALC86_RS16355ALC86_RS16370ALC86_RS16375ALC86_RS16390ALC86_RS16395ALC86_RS16400ALC86_RS19610ALC86_RS16415ALC86_RS16420ALC86_RS16425ALC86_RS16430ALC86_RS16435ALC86_RS16440ALC86_RS16445ALC86_RS16410
Location: 410388..410591 (204 bp)
Type: Others
Protein ID: WP_001911745.1
Location: 410872..411045 (174 bp)
Type: Others
Protein ID: WP_001882305.1
Location: 411405..411674 (270 bp)
Type: Others
Protein ID: WP_001198131.1
Location: 411992..412163 (172 bp)
Type: Others
Protein ID: Protein_433
Location: 412372..412758 (387 bp)
Type: Others
Protein ID: WP_000703163.1
Location: 412960..413202 (243 bp)
Type: Others
Protein ID: WP_172625548.1
Location: 413373..413750 (378 bp)
Type: Others
Protein ID: WP_000411109.1
Location: 413807..413921 (115 bp)
Type: Others
Protein ID: Protein_437
Location: 413870..414151 (282 bp)
Type: Others
Protein ID: WP_001894453.1
Location: 414317..414430 (114 bp)
Type: Others
Protein ID: WP_001889158.1
Location: 414379..414606 (228 bp)
Type: Others
Protein ID: WP_001894457.1
Location: 414947..415279 (333 bp)
Type: Toxin
Protein ID: WP_000843587.1
Location: 415266..415580 (315 bp)
Type: Antitoxin
Protein ID: WP_000071008.1
Location: 415717..416151 (435 bp)
Type: Others
Protein ID: WP_000256036.1
Location: 416319..416474 (156 bp)
Type: Others
Protein ID: WP_000751734.1
Location: 417647..417953 (307 bp)
Type: Others
Protein ID: Protein_446
Location: 418090..418782 (693 bp)
Type: Others
Protein ID: WP_001047169.1
Location: 418782..419183 (402 bp)
Type: Others
Protein ID: WP_000351248.1
Location: 419153..419296 (144 bp)
Type: Others
Protein ID: WP_071908341.1
Location: 419371..419784 (414 bp)
Type: Others
Protein ID: WP_000049417.1
Location: 419998..420249 (252 bp)
Type: Others
Protein ID: WP_001250179.1
Location: 420239..420526 (288 bp)
Type: Others
Protein ID: WP_000221354.1
Location: 416599..417579 (981 bp)
Type: Others
Protein ID: WP_000019370.1
ToxinAntitoxinOther genes
Loading, please wait
Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
ALC86_RS19760410388..410591+204WP_001911745.1hypothetical protein-
ALC86_RS19605410872..411045+174WP_001882305.1DUF3709 domain-containing protein-
ALC86_RS16325411405..411674+270WP_001198131.1hypothetical protein-
ALC86_RS19820411992..412163+172Protein_433DUF645 family protein-
ALC86_RS16340412372..412758+387WP_000703163.1VOC family protein-
ALC86_RS16345412960..413202+243WP_172625548.1hypothetical protein-
ALC86_RS16350413373..413750+378WP_000411109.1hypothetical protein-
ALC86_RS19775413807..413921+115Protein_437acetyltransferase-
ALC86_RS16355413870..414151+282WP_001894453.1DUF1289 domain-containing protein-
ALC86_RS16370414317..414430+114WP_001889158.1hypothetical protein-
ALC86_RS16375414379..414606+228WP_001894457.1DUF1289 domain-containing protein-
ALC86_RS16390414947..415279+333WP_000843587.1type II toxin-antitoxin system RelE/ParE family toxinToxin
ALC86_RS16395415266..415580+315WP_000071008.1DNA-binding transcriptional regulatorAntitoxin
ALC86_RS16400415717..416151+435WP_000256036.1GNAT family N-acetyltransferase-
ALC86_RS19610416319..416474+156WP_000751734.1hypothetical protein-
ALC86_RS16410416599..417579-981WP_000019370.1IS5-like element ISVch5 family transposase-
ALC86_RS16415417647..417953+307Protein_446CatB-related O-acetyltransferase-
ALC86_RS16420418090..418782+693WP_001047169.1GNAT family N-acetyltransferase-
ALC86_RS16425418782..419183+402WP_000351248.1type II toxin-antitoxin system death-on-curing family toxin-
ALC86_RS16430419153..419296+144WP_071908341.1DUF3265 domain-containing protein-
ALC86_RS16435419371..419784+414WP_000049417.1VOC family protein-
ALC86_RS16440419998..420249+252WP_001250179.1type II toxin-antitoxin system Phd/YefM family antitoxin-
ALC86_RS16445420239..420526+288WP_000221354.1type II toxin-antitoxin system RelE/ParE family toxin-

Associated MGEs

Loading, please wait
MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideGenomic islandcatB9-304666..435761131095
insideIntegroncatB9-309746..435385125639
flankIS/Tn--416599..417579980


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-2

(4-100)

Antitoxin

Cro/C1-type helix-turn-helix domain

(43-92)


Sequences

Toxin        


Download         Length: 111 a.a.        Molecular weight: 13005.95 Da        Isoelectric Point: 9.9244

>T293830 WP_000843587.1 NZ_LT907990:414947-415279 [Vibrio cholerae]
MKSVFVESTIFEKYRDEYLSDEEYRLFQAELMLNPKLGDVIQGTGGLRKIRVASKGKGKRGGSRIIYYFLDEKRRFYLLT
IYGKNEMSDLNANQRKQLMAFMEAWRNEQS

Download         Length: 333 bp

Antitoxin


Download         Length: 105 a.a.        Molecular weight: 11696.20 Da        Isoelectric Point: 6.7600

>AT293830 WP_000071008.1 NZ_LT907990:415266-415580 [Vibrio cholerae]
MSNRDLFAELSSALVEAKQHSEGKLTLKTHHVNDVGELNISPDEIVSIREQFNMSRGVFARLLHTSSRTLENWEQGRSVP
NGQAVTLLKLVQRHPETLSHIAEL

Download         Length: 315 bp


Similar Proteins

Only experimentally validated proteins are listed.

Loading, please wait
Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
Loading, please wait
Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

Loading, please wait
Source
ID
Structure
PDB5JA9
PDB8A0X
PDB5MJE
PDB5JA8
PDB5JAA

Antitoxin

Loading, please wait
Source
ID
Structure
No matching records found

References