293830

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/RelE-MqsA
Location 414947..415580 Replicon chromosome
Accession NZ_LT907990
Organism Vibrio cholerae strain A19

Toxin (Protein)


Gene name higB Uniprot ID Q9KMA6
Locus tag ALC86_RS16390 Protein ID WP_000843587.1
Coordinates 414947..415279 (+) Length 111 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag ALC86_RS16395 Protein ID WP_000071008.1
Coordinates 415266..415580 (+) Length 105 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ALC86_RS19760 410388..410591 + 204 WP_001911745.1 hypothetical protein -
ALC86_RS19605 410872..411045 + 174 WP_001882305.1 DUF3709 domain-containing protein -
ALC86_RS16325 411405..411674 + 270 WP_001198131.1 hypothetical protein -
ALC86_RS19820 411992..412163 + 172 Protein_433 DUF645 family protein -
ALC86_RS16340 412372..412758 + 387 WP_000703163.1 VOC family protein -
ALC86_RS16345 412960..413202 + 243 WP_172625548.1 hypothetical protein -
ALC86_RS16350 413373..413750 + 378 WP_000411109.1 hypothetical protein -
ALC86_RS19775 413807..413921 + 115 Protein_437 acetyltransferase -
ALC86_RS16355 413870..414151 + 282 WP_001894453.1 DUF1289 domain-containing protein -
ALC86_RS16370 414317..414430 + 114 WP_001889158.1 hypothetical protein -
ALC86_RS16375 414379..414606 + 228 WP_001894457.1 DUF1289 domain-containing protein -
ALC86_RS16390 414947..415279 + 333 WP_000843587.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
ALC86_RS16395 415266..415580 + 315 WP_000071008.1 DNA-binding transcriptional regulator Antitoxin
ALC86_RS16400 415717..416151 + 435 WP_000256036.1 GNAT family N-acetyltransferase -
ALC86_RS19610 416319..416474 + 156 WP_000751734.1 hypothetical protein -
ALC86_RS16410 416599..417579 - 981 WP_000019370.1 IS5-like element ISVch5 family transposase -
ALC86_RS16415 417647..417953 + 307 Protein_446 CatB-related O-acetyltransferase -
ALC86_RS16420 418090..418782 + 693 WP_001047169.1 GNAT family N-acetyltransferase -
ALC86_RS16425 418782..419183 + 402 WP_000351248.1 type II toxin-antitoxin system death-on-curing family toxin -
ALC86_RS16430 419153..419296 + 144 WP_071908341.1 DUF3265 domain-containing protein -
ALC86_RS16435 419371..419784 + 414 WP_000049417.1 VOC family protein -
ALC86_RS16440 419998..420249 + 252 WP_001250179.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
ALC86_RS16445 420239..420526 + 288 WP_000221354.1 type II toxin-antitoxin system RelE/ParE family toxin -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island catB9 - 304666..435761 131095
inside Integron catB9 - 309746..435385 125639
flank IS/Tn - - 416599..417579 980


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-2

(4-100)

Antitoxin

Cro/C1-type helix-turn-helix domain

(43-92)


Sequences

Toxin        


Download         Length: 111 a.a.        Molecular weight: 13005.95 Da        Isoelectric Point: 9.9244

>T293830 WP_000843587.1 NZ_LT907990:414947-415279 [Vibrio cholerae]
MKSVFVESTIFEKYRDEYLSDEEYRLFQAELMLNPKLGDVIQGTGGLRKIRVASKGKGKRGGSRIIYYFLDEKRRFYLLT
IYGKNEMSDLNANQRKQLMAFMEAWRNEQS

Download         Length: 333 bp

Antitoxin


Download         Length: 105 a.a.        Molecular weight: 11696.20 Da        Isoelectric Point: 6.7600

>AT293830 WP_000071008.1 NZ_LT907990:415266-415580 [Vibrio cholerae]
MSNRDLFAELSSALVEAKQHSEGKLTLKTHHVNDVGELNISPDEIVSIREQFNMSRGVFARLLHTSSRTLENWEQGRSVP
NGQAVTLLKLVQRHPETLSHIAEL

Download         Length: 315 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 5JA9
PDB 8A0X
PDB 5MJE
PDB 5JA8
PDB 5JAA

Antitoxin

Source ID Structure

References