58350

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/ParE-RHH
Location 332886..333424 Replicon chromosome
Accession NZ_CP013314
Organism Vibrio cholerae strain E9120

Toxin (Protein)


Gene name parE Uniprot ID Q9KMJ0
Locus tag ASZ79_RS15725 Protein ID WP_000802136.1
Coordinates 332886..333185 (-) Length 100 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID P58093
Locus tag ASZ79_RS15730 Protein ID WP_001107719.1
Coordinates 333182..333424 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ASZ79_RS15665 328091..328273 + 183 WP_000923340.1 DUF645 family protein -
ASZ79_RS15670 328488..329027 + 540 WP_000099372.1 hypothetical protein -
ASZ79_RS15675 329150..329665 + 516 WP_000090011.1 hypothetical protein -
ASZ79_RS15680 329800..330336 + 537 WP_000644491.1 nucleotidyltransferase family protein -
ASZ79_RS15685 330805..330915 + 111 WP_071908335.1 DUF3265 domain-containing protein -
ASZ79_RS15695 331128..331280 + 153 WP_001884520.1 DUF645 family protein -
ASZ79_RS15700 331564..332007 + 444 WP_000803902.1 hypothetical protein -
ASZ79_RS15705 332011..332121 + 111 WP_071908336.1 DUF3265 domain-containing protein -
ASZ79_RS15710 332151..332429 - 279 WP_000578476.1 type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family -
ASZ79_RS15715 332426..332710 - 285 WP_000381183.1 type II toxin-antitoxin system RelB/DinJ family antitoxin -
ASZ79_RS15725 332886..333185 - 300 WP_000802136.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
ASZ79_RS15730 333182..333424 - 243 WP_001107719.1 type II toxin-antitoxin system ParD family antitoxin Antitoxin
ASZ79_RS15740 333843..333920 + 78 WP_071908337.1 DUF645 family protein -
ASZ79_RS20905 333924..333950 + 27 Protein_298 hypothetical protein -
ASZ79_RS20985 334536..334679 + 144 WP_001900215.1 hypothetical protein -
ASZ79_RS20480 334773..334952 + 180 Protein_300 DUF645 family protein -
ASZ79_RS15765 335170..335598 + 429 WP_000620002.1 N-acetyltransferase -
ASZ79_RS15775 336186..336668 + 483 WP_000422940.1 GNAT family N-acetyltransferase -
ASZ79_RS15785 337476..337745 + 270 WP_001114075.1 DUF4160 domain-containing protein -
ASZ79_RS15790 337739..338260 + 522 WP_000921692.1 DUF2442 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island catB9 - 304700..468464 163764
inside Integron - - 309780..468088 158308


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-92)

Antitoxin

Antitoxin ParD

(1-79)


Sequences

Toxin        


Download         Length: 100 a.a.        Molecular weight: 11589.29 Da        Isoelectric Point: 9.9232

>T58350 WP_000802136.1 NZ_CP013314:c333185-332886 [Vibrio cholerae]
MKPFNLTVAAKADLRDIALFTQRRWGKEQRNVYLKQFDDSFWLLAENPDIGKSCDEIREGYRKFPQGSHVIFYQQTGSQQ
IRVIRILHKSMDVNPIFGA

Download         Length: 300 bp

>T58350 NZ_CP013314:c333185-332886 [Vibrio cholerae]
ATGAAACCATTTAATCTTACCGTCGCCGCCAAAGCCGATTTACGTGATATTGCTTTATTCACTCAACGACGCTGGGGAAA
AGAGCAGCGAAATGTTTATTTAAAGCAATTCGATGATTCCTTTTGGCTTTTAGCGGAAAATCCCGACATTGGTAAATCAT
GCGATGAAATCCGAGAGGGATACAGAAAATTTCCCCAAGGGAGTCACGTCATCTTTTATCAGCAAACCGGCAGCCAACAA
ATCCGGGTGATCCGAATTCTTCATAAGAGCATGGATGTGAACCCAATATTCGGCGCATAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8964.84 Da        Isoelectric Point: 4.1677

>AT58350 WP_001107719.1 NZ_CP013314:c333424-333182 [Vibrio cholerae]
MAKNTSITLGEHFDGFITSQIQSGRYGSASEVIRSALRLLENQETKLQSLRQLLIEGEQSGDADYDLDSFINELDSENIR

Download         Length: 243 bp

>AT58350 NZ_CP013314:c333424-333182 [Vibrio cholerae]
ATGGCTAAAAATACAAGTATCACTCTTGGTGAACACTTCGATGGCTTTATTACAAGCCAAATACAAAGTGGGCGTTACGG
CTCAGCAAGTGAAGTCATTCGCTCTGCGCTACGTCTACTCGAAAACCAAGAAACCAAACTACAGTCACTCCGTCAACTAC
TTATTGAAGGAGAGCAAAGTGGTGACGCTGATTATGACCTTGATAGCTTCATCAATGAACTCGATAGTGAAAACATTCGA
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7R5A

Antitoxin

Source ID Structure
AlphaFold DB A0A151JFU4

References