Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/ParE-RHH
Location 332886..333424 Replicon chromosome
Accession NZ_CP013314
Organism Vibrio cholerae strain E9120

Toxin (Protein)


Gene name parE Uniprot ID Q9KMJ0
Locus tag ASZ79_RS15725 Protein ID WP_000802136.1
Coordinates 332886..333185 (-) Length 100 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID P58093
Locus tag ASZ79_RS15730 Protein ID WP_001107719.1
Coordinates 333182..333424 (-) Length 81 a.a.

Genomic Context

ASZ79_RS15665ASZ79_RS15670ASZ79_RS15675ASZ79_RS15680ASZ79_RS15685ASZ79_RS15695ASZ79_RS15700ASZ79_RS15705ASZ79_RS15740ASZ79_RS20905ASZ79_RS20985ASZ79_RS20480ASZ79_RS15765ASZ79_RS15775ASZ79_RS15785ASZ79_RS15790ASZ79_RS15710ASZ79_RS15715ASZ79_RS15725ASZ79_RS15730
Location: 328091..328273 (183 bp)
Type: Others
Protein ID: WP_000923340.1
Location: 328488..329027 (540 bp)
Type: Others
Protein ID: WP_000099372.1
Location: 329150..329665 (516 bp)
Type: Others
Protein ID: WP_000090011.1
Location: 329800..330336 (537 bp)
Type: Others
Protein ID: WP_000644491.1
Location: 330805..330915 (111 bp)
Type: Others
Protein ID: WP_071908335.1
Location: 331128..331280 (153 bp)
Type: Others
Protein ID: WP_001884520.1
Location: 331564..332007 (444 bp)
Type: Others
Protein ID: WP_000803902.1
Location: 332011..332121 (111 bp)
Type: Others
Protein ID: WP_071908336.1
Location: 333843..333920 (78 bp)
Type: Others
Protein ID: WP_071908337.1
Location: 333924..333950 (27 bp)
Type: Others
Protein ID: Protein_298
Location: 334536..334679 (144 bp)
Type: Others
Protein ID: WP_001900215.1
Location: 334773..334952 (180 bp)
Type: Others
Protein ID: Protein_300
Location: 335170..335598 (429 bp)
Type: Others
Protein ID: WP_000620002.1
Location: 336186..336668 (483 bp)
Type: Others
Protein ID: WP_000422940.1
Location: 337476..337745 (270 bp)
Type: Others
Protein ID: WP_001114075.1
Location: 337739..338260 (522 bp)
Type: Others
Protein ID: WP_000921692.1
Location: 332151..332429 (279 bp)
Type: Others
Protein ID: WP_000578476.1
Location: 332426..332710 (285 bp)
Type: Others
Protein ID: WP_000381183.1
Location: 332886..333185 (300 bp)
Type: Toxin
Protein ID: WP_000802136.1
Location: 333182..333424 (243 bp)
Type: Antitoxin
Protein ID: WP_001107719.1
ToxinAntitoxinOther genes
Loading, please wait
Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
ASZ79_RS15665328091..328273+183WP_000923340.1DUF645 family protein-
ASZ79_RS15670328488..329027+540WP_000099372.1hypothetical protein-
ASZ79_RS15675329150..329665+516WP_000090011.1hypothetical protein-
ASZ79_RS15680329800..330336+537WP_000644491.1nucleotidyltransferase family protein-
ASZ79_RS15685330805..330915+111WP_071908335.1DUF3265 domain-containing protein-
ASZ79_RS15695331128..331280+153WP_001884520.1DUF645 family protein-
ASZ79_RS15700331564..332007+444WP_000803902.1hypothetical protein-
ASZ79_RS15705332011..332121+111WP_071908336.1DUF3265 domain-containing protein-
ASZ79_RS15710332151..332429-279WP_000578476.1type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family-
ASZ79_RS15715332426..332710-285WP_000381183.1type II toxin-antitoxin system RelB/DinJ family antitoxin-
ASZ79_RS15725332886..333185-300WP_000802136.1type II toxin-antitoxin system RelE/ParE family toxinToxin
ASZ79_RS15730333182..333424-243WP_001107719.1type II toxin-antitoxin system ParD family antitoxinAntitoxin
ASZ79_RS15740333843..333920+78WP_071908337.1DUF645 family protein-
ASZ79_RS20905333924..333950+27Protein_298hypothetical protein-
ASZ79_RS20985334536..334679+144WP_001900215.1hypothetical protein-
ASZ79_RS20480334773..334952+180Protein_300DUF645 family protein-
ASZ79_RS15765335170..335598+429WP_000620002.1N-acetyltransferase-
ASZ79_RS15775336186..336668+483WP_000422940.1GNAT family N-acetyltransferase-
ASZ79_RS15785337476..337745+270WP_001114075.1DUF4160 domain-containing protein-
ASZ79_RS15790337739..338260+522WP_000921692.1DUF2442 domain-containing protein-

Associated MGEs

Loading, please wait
MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideGenomic islandcatB9-304700..468464163764
insideIntegron--309780..468088158308


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-92)

Antitoxin

Antitoxin ParD

(1-79)


Sequences

Toxin        


Download         Length: 100 a.a.        Molecular weight: 11589.29 Da        Isoelectric Point: 9.9232

>T58350 WP_000802136.1 NZ_CP013314:c333185-332886 [Vibrio cholerae]
MKPFNLTVAAKADLRDIALFTQRRWGKEQRNVYLKQFDDSFWLLAENPDIGKSCDEIREGYRKFPQGSHVIFYQQTGSQQ
IRVIRILHKSMDVNPIFGA

Download         Length: 300 bp

>T58350 NZ_CP013314:c333185-332886 [Vibrio cholerae]
ATGAAACCATTTAATCTTACCGTCGCCGCCAAAGCCGATTTACGTGATATTGCTTTATTCACTCAACGACGCTGGGGAAA
AGAGCAGCGAAATGTTTATTTAAAGCAATTCGATGATTCCTTTTGGCTTTTAGCGGAAAATCCCGACATTGGTAAATCAT
GCGATGAAATCCGAGAGGGATACAGAAAATTTCCCCAAGGGAGTCACGTCATCTTTTATCAGCAAACCGGCAGCCAACAA
ATCCGGGTGATCCGAATTCTTCATAAGAGCATGGATGTGAACCCAATATTCGGCGCATAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8964.84 Da        Isoelectric Point: 4.1677

>AT58350 WP_001107719.1 NZ_CP013314:c333424-333182 [Vibrio cholerae]
MAKNTSITLGEHFDGFITSQIQSGRYGSASEVIRSALRLLENQETKLQSLRQLLIEGEQSGDADYDLDSFINELDSENIR

Download         Length: 243 bp

>AT58350 NZ_CP013314:c333424-333182 [Vibrio cholerae]
ATGGCTAAAAATACAAGTATCACTCTTGGTGAACACTTCGATGGCTTTATTACAAGCCAAATACAAAGTGGGCGTTACGG
CTCAGCAAGTGAAGTCATTCGCTCTGCGCTACGTCTACTCGAAAACCAAGAAACCAAACTACAGTCACTCCGTCAACTAC
TTATTGAAGGAGAGCAAAGTGGTGACGCTGATTATGACCTTGATAGCTTCATCAATGAACTCGATAGTGAAAACATTCGA
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Loading, please wait
Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
Loading, please wait
Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

Loading, please wait
Source
ID
Structure
PDB7R5A

Antitoxin

Loading, please wait
Source
ID
Structure
PDB7R5A
PDB7B22
AlphaFold DBA0A151JFU4

References