89001

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-Phd
Location 423842..424389 Replicon chromosome
Accession NZ_CP024868
Organism Vibrio cholerae strain A1552

Toxin (Protein)


Gene name relE Uniprot ID Q9KM92
Locus tag VCA1552_RS16845 Protein ID WP_000229317.1
Coordinates 424087..424389 (+) Length 101 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID Q9KM93
Locus tag VCA1552_RS16840 Protein ID WP_000861987.1
Coordinates 423842..424099 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
VCA1552_RS16785 418871..419326 + 456 WP_001245327.1 GNAT family N-acetyltransferase -
VCA1552_RS16790 419648..419800 + 153 WP_001884520.1 DUF645 family protein -
VCA1552_RS16800 420002..420499 - 498 WP_000982260.1 GNAT family N-acetyltransferase -
VCA1552_RS16805 420496..420768 - 273 WP_000246253.1 DUF1778 domain-containing protein -
VCA1552_RS16810 420999..421667 + 669 WP_000043871.1 hypothetical protein -
VCA1552_RS16815 421819..422106 + 288 WP_000426470.1 hypothetical protein -
VCA1552_RS16820 422247..422618 + 372 WP_001164080.1 nucleotide pyrophosphohydrolase -
VCA1552_RS20040 422685..423110 + 426 WP_001882332.1 DUF1778 domain-containing protein -
VCA1552_RS16830 423107..423640 + 534 WP_000118351.1 GNAT family N-acetyltransferase -
VCA1552_RS16840 423842..424099 + 258 WP_000861987.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
VCA1552_RS16845 424087..424389 + 303 WP_000229317.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
VCA1552_RS16850 424623..425540 + 918 WP_000186333.1 alpha/beta hydrolase -
VCA1552_RS16855 425697..426086 + 390 WP_001081302.1 hypothetical protein -
VCA1552_RS16860 426222..426431 + 210 Protein_463 GNAT family N-acetyltransferase -
VCA1552_RS16865 426550..426987 + 438 WP_000503169.1 IS200/IS605-like element IS1004 family transposase -
VCA1552_RS16870 427051..427269 + 219 WP_071908318.1 GNAT family N-acetyltransferase -
VCA1552_RS16875 427444..428316 + 873 WP_000254716.1 DUF3800 domain-containing protein -
VCA1552_RS16880 428466..429065 + 600 WP_001891245.1 glutathione S-transferase N-terminal domain-containing protein -
VCA1552_RS16885 429122..429226 + 105 WP_099607150.1 acetyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island catB9 - 304717..433978 129261
inside Integron - - 309797..433602 123805
flank IS/Tn - - 426550..426987 437


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-87)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-69)


Sequences

Toxin        


Download         Length: 101 a.a.        Molecular weight: 11726.68 Da        Isoelectric Point: 5.1972

>T89001 WP_000229317.1 NZ_CP024868:424087-424389 [Vibrio cholerae]
MVEIIWTELALSDLNDIAEYIALENVVAAKQLVQTVFTKVERLADFPESGRVPPELEHLNYREVVVSPCRVFYKYDDAKV
RILFVMRAERDLRRLMLTKQ

Download         Length: 303 bp

>T89001 NZ_CP024868:424087-424389 [Vibrio cholerae]
ATGGTTGAAATAATTTGGACGGAGCTGGCTCTATCCGACTTGAATGATATTGCTGAATACATCGCGCTTGAAAATGTCGT
GGCTGCTAAACAACTGGTGCAAACCGTTTTTACAAAAGTTGAACGTTTGGCCGATTTTCCAGAGTCTGGGCGCGTCCCTC
CAGAACTAGAACACCTCAATTATCGTGAAGTCGTTGTAAGTCCGTGTCGTGTTTTCTACAAGTATGATGATGCAAAGGTT
CGTATTCTTTTTGTTATGCGTGCGGAGCGAGATTTGCGTCGGTTAATGCTTACGAAACAGTAG

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9647.15 Da        Isoelectric Point: 7.3178

>AT89001 WP_000861987.1 NZ_CP024868:423842-424099 [Vibrio cholerae]
MKVELVTSLKRQATKILADLHDTKEPVLITEHGKPSAYLIDVDDYEFMQNRLAILEGIARGERALADGKVVSHQDAKDRM
SKWLK

Download         Length: 258 bp

>AT89001 NZ_CP024868:423842-424099 [Vibrio cholerae]
ATGAAAGTAGAACTTGTGACGTCACTAAAACGTCAGGCCACTAAGATCCTTGCCGATCTTCATGATACGAAAGAGCCAGT
ATTGATAACTGAGCACGGAAAACCGTCAGCTTACCTTATTGATGTAGACGACTATGAATTTATGCAAAATCGTTTAGCGA
TCCTGGAAGGTATTGCTCGCGGAGAGCGAGCTTTAGCGGATGGTAAAGTGGTCAGCCATCAAGATGCTAAGGACAGAATG
TCAAAATGGTTGAAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB Q9KM92

Antitoxin

Source ID Structure
AlphaFold DB A0A1T4SLM9

References