Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-Phd
Location 423842..424389 Replicon chromosome
Accession NZ_CP024868
Organism Vibrio cholerae strain A1552

Toxin (Protein)


Gene name relE Uniprot ID Q9KM92
Locus tag VCA1552_RS16845 Protein ID WP_000229317.1
Coordinates 424087..424389 (+) Length 101 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID Q9KM93
Locus tag VCA1552_RS16840 Protein ID WP_000861987.1
Coordinates 423842..424099 (+) Length 86 a.a.

Genomic Context

VCA1552_RS16785VCA1552_RS16790VCA1552_RS16810VCA1552_RS16815VCA1552_RS16820VCA1552_RS20040VCA1552_RS16830VCA1552_RS16840VCA1552_RS16845VCA1552_RS16850VCA1552_RS16855VCA1552_RS16860VCA1552_RS16865VCA1552_RS16870VCA1552_RS16875VCA1552_RS16880VCA1552_RS16885VCA1552_RS16800VCA1552_RS16805
Location: 418871..419326 (456 bp)
Type: Others
Protein ID: WP_001245327.1
Location: 419648..419800 (153 bp)
Type: Others
Protein ID: WP_001884520.1
Location: 420999..421667 (669 bp)
Type: Others
Protein ID: WP_000043871.1
Location: 421819..422106 (288 bp)
Type: Others
Protein ID: WP_000426470.1
Location: 422247..422618 (372 bp)
Type: Others
Protein ID: WP_001164080.1
Location: 422685..423110 (426 bp)
Type: Others
Protein ID: WP_001882332.1
Location: 423107..423640 (534 bp)
Type: Others
Protein ID: WP_000118351.1
Location: 423842..424099 (258 bp)
Type: Antitoxin
Protein ID: WP_000861987.1
Location: 424087..424389 (303 bp)
Type: Toxin
Protein ID: WP_000229317.1
Location: 424623..425540 (918 bp)
Type: Others
Protein ID: WP_000186333.1
Location: 425697..426086 (390 bp)
Type: Others
Protein ID: WP_001081302.1
Location: 426222..426431 (210 bp)
Type: Others
Protein ID: Protein_463
Location: 426550..426987 (438 bp)
Type: Others
Protein ID: WP_000503169.1
Location: 427051..427269 (219 bp)
Type: Others
Protein ID: WP_071908318.1
Location: 427444..428316 (873 bp)
Type: Others
Protein ID: WP_000254716.1
Location: 428466..429065 (600 bp)
Type: Others
Protein ID: WP_001891245.1
Location: 429122..429226 (105 bp)
Type: Others
Protein ID: WP_099607150.1
Location: 420002..420499 (498 bp)
Type: Others
Protein ID: WP_000982260.1
Location: 420496..420768 (273 bp)
Type: Others
Protein ID: WP_000246253.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
VCA1552_RS16785418871..419326+456WP_001245327.1GNAT family N-acetyltransferase-
VCA1552_RS16790419648..419800+153WP_001884520.1DUF645 family protein-
VCA1552_RS16800420002..420499-498WP_000982260.1GNAT family N-acetyltransferase-
VCA1552_RS16805420496..420768-273WP_000246253.1DUF1778 domain-containing protein-
VCA1552_RS16810420999..421667+669WP_000043871.1hypothetical protein-
VCA1552_RS16815421819..422106+288WP_000426470.1hypothetical protein-
VCA1552_RS16820422247..422618+372WP_001164080.1nucleotide pyrophosphohydrolase-
VCA1552_RS20040422685..423110+426WP_001882332.1DUF1778 domain-containing protein-
VCA1552_RS16830423107..423640+534WP_000118351.1GNAT family N-acetyltransferase-
VCA1552_RS16840423842..424099+258WP_000861987.1type II toxin-antitoxin system Phd/YefM family antitoxinAntitoxin
VCA1552_RS16845424087..424389+303WP_000229317.1type II toxin-antitoxin system RelE/ParE family toxinToxin
VCA1552_RS16850424623..425540+918WP_000186333.1alpha/beta hydrolase-
VCA1552_RS16855425697..426086+390WP_001081302.1hypothetical protein-
VCA1552_RS16860426222..426431+210Protein_463GNAT family N-acetyltransferase-
VCA1552_RS16865426550..426987+438WP_000503169.1IS200/IS605-like element IS1004 family transposase-
VCA1552_RS16870427051..427269+219WP_071908318.1GNAT family N-acetyltransferase-
VCA1552_RS16875427444..428316+873WP_000254716.1DUF3800 domain-containing protein-
VCA1552_RS16880428466..429065+600WP_001891245.1glutathione S-transferase N-terminal domain-containing protein-
VCA1552_RS16885429122..429226+105WP_099607150.1acetyltransferase-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideGenomic islandcatB9-304717..433978129261
insideIntegron--309797..433602123805
flankIS/Tn--426550..426987437


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-87)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-69)


Sequences

Toxin        


Download         Length: 101 a.a.        Molecular weight: 11726.68 Da        Isoelectric Point: 5.1972

>T89001 WP_000229317.1 NZ_CP024868:424087-424389 [Vibrio cholerae]
MVEIIWTELALSDLNDIAEYIALENVVAAKQLVQTVFTKVERLADFPESGRVPPELEHLNYREVVVSPCRVFYKYDDAKV
RILFVMRAERDLRRLMLTKQ

Download         Length: 303 bp

>T89001 NZ_CP024868:424087-424389 [Vibrio cholerae]
ATGGTTGAAATAATTTGGACGGAGCTGGCTCTATCCGACTTGAATGATATTGCTGAATACATCGCGCTTGAAAATGTCGT
GGCTGCTAAACAACTGGTGCAAACCGTTTTTACAAAAGTTGAACGTTTGGCCGATTTTCCAGAGTCTGGGCGCGTCCCTC
CAGAACTAGAACACCTCAATTATCGTGAAGTCGTTGTAAGTCCGTGTCGTGTTTTCTACAAGTATGATGATGCAAAGGTT
CGTATTCTTTTTGTTATGCGTGCGGAGCGAGATTTGCGTCGGTTAATGCTTACGAAACAGTAG

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9647.15 Da        Isoelectric Point: 7.3178

>AT89001 WP_000861987.1 NZ_CP024868:423842-424099 [Vibrio cholerae]
MKVELVTSLKRQATKILADLHDTKEPVLITEHGKPSAYLIDVDDYEFMQNRLAILEGIARGERALADGKVVSHQDAKDRM
SKWLK

Download         Length: 258 bp

>AT89001 NZ_CP024868:423842-424099 [Vibrio cholerae]
ATGAAAGTAGAACTTGTGACGTCACTAAAACGTCAGGCCACTAAGATCCTTGCCGATCTTCATGATACGAAAGAGCCAGT
ATTGATAACTGAGCACGGAAAACCGTCAGCTTACCTTATTGATGTAGACGACTATGAATTTATGCAAAATCGTTTAGCGA
TCCTGGAAGGTATTGCTCGCGGAGAGCGAGCTTTAGCGGATGGTAAAGTGGTCAGCCATCAAGATGCTAAGGACAGAATG
TCAAAATGGTTGAAATAA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBQ9KM92

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A1T4SLM9

References