113794

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-RelB
Location 128932..129491 Replicon chromosome
Accession NZ_CP033513
Organism Vibrio cholerae strain E4

Toxin (Protein)


Gene name relE Uniprot ID Q9K2M8
Locus tag EEL44_RS00580 Protein ID WP_000578476.1
Coordinates 129213..129491 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID Q9L991
Locus tag EEL44_RS00575 Protein ID WP_000381183.1
Coordinates 128932..129216 (+) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EEL44_RS00560 127626..128039 - 414 WP_000049420.1 VOC family protein -
EEL44_RS00570 128223..128738 - 516 WP_000343779.1 GNAT family N-acetyltransferase -
EEL44_RS00575 128932..129216 + 285 WP_000381183.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
EEL44_RS00580 129213..129491 + 279 WP_000578476.1 type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family Toxin
EEL44_RS00585 129630..130025 - 396 WP_001000867.1 hypothetical protein -
EEL44_RS00595 130276..130401 - 126 WP_001905700.1 DUF645 family protein -
EEL44_RS00600 130700..131221 - 522 WP_000921691.1 DUF2442 domain-containing protein -
EEL44_RS00605 131215..131484 - 270 WP_001114075.1 DUF4160 domain-containing protein -
EEL44_RS00610 131515..131619 - 105 WP_099607150.1 acetyltransferase -
EEL44_RS00615 131676..132275 - 600 WP_001891245.1 glutathione S-transferase N-terminal domain-containing protein -
EEL44_RS00620 132425..133297 - 873 WP_000254716.1 DUF3800 domain-containing protein -
EEL44_RS00625 133472..133690 - 219 WP_071908318.1 GNAT family N-acetyltransferase -
EEL44_RS00630 133754..134191 - 438 WP_000503169.1 IS200/IS605-like element IS1004 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island catB9 - 126763..233717 106954
inside Integron - - 127139..226875 99736
flank IS/Tn - - 133754..134191 437


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(2-89)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(5-70)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10819.59 Da        Isoelectric Point: 5.1651

>T113794 WP_000578476.1 NZ_CP033513:129213-129491 [Vibrio cholerae]
MIFWEEASLNDREKIFEFLYDFNPAAAKKTDELIEAKVENLLEQPLIGVQRDGIRGRLLIIPEISMIVSYWVDGSKIRIM
RVLHQKQKFPND

Download         Length: 279 bp

>T113794 NZ_CP033513:129213-129491 [Vibrio cholerae]
ATGATTTTCTGGGAAGAAGCATCTCTCAATGATCGTGAGAAAATTTTCGAATTTCTCTACGACTTTAACCCAGCAGCGGC
TAAAAAAACGGATGAGCTCATAGAAGCCAAAGTCGAAAATTTGCTTGAGCAACCACTAATCGGTGTTCAGCGTGATGGCA
TTAGAGGCAGATTGCTTATTATCCCTGAGATATCAATGATTGTTTCGTATTGGGTTGATGGTTCTAAAATTCGAATAATG
CGTGTACTACATCAGAAACAAAAATTTCCAAACGACTGA

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10901.25 Da        Isoelectric Point: 8.0775

>AT113794 WP_000381183.1 NZ_CP033513:128932-129216 [Vibrio cholerae]
MDTRIQFRVDEETKRLAQQMAESQGRTLSDACRELTEQLAEQQRKALSHDAWLTEQVNQAFEKFDSGKAVFIEHDIAKAR
MAERKAKIRNRGHA

Download         Length: 285 bp

>AT113794 NZ_CP033513:128932-129216 [Vibrio cholerae]
ATGGATACTAGAATTCAATTTCGTGTAGACGAAGAAACAAAACGTTTAGCTCAACAAATGGCTGAAAGCCAAGGTCGAAC
TCTTAGCGATGCTTGCCGTGAACTCACTGAACAATTAGCTGAGCAGCAACGCAAGGCATTATCTCACGATGCATGGCTAA
CTGAACAAGTGAATCAAGCATTTGAGAAGTTCGACTCAGGAAAAGCAGTATTCATTGAACATGACATCGCCAAAGCACGA
ATGGCTGAACGTAAAGCTAAAATCCGAAATCGAGGCCACGCATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB Q9K2M8

Antitoxin

Source ID Structure
AlphaFold DB A0A067BL33

References