Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-RelB
Location 128932..129491 Replicon chromosome
Accession NZ_CP033513
Organism Vibrio cholerae strain E4

Toxin (Protein)


Gene name relE Uniprot ID Q9K2M8
Locus tag EEL44_RS00580 Protein ID WP_000578476.1
Coordinates 129213..129491 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID Q9L991
Locus tag EEL44_RS00575 Protein ID WP_000381183.1
Coordinates 128932..129216 (+) Length 95 a.a.

Genomic Context

EEL44_RS00575EEL44_RS00580EEL44_RS00560EEL44_RS00570EEL44_RS00585EEL44_RS00595EEL44_RS00600EEL44_RS00605EEL44_RS00610EEL44_RS00615EEL44_RS00620EEL44_RS00625EEL44_RS00630
Location: 128932..129216 (285 bp)
Type: Antitoxin
Protein ID: WP_000381183.1
Location: 129213..129491 (279 bp)
Type: Toxin
Protein ID: WP_000578476.1
Location: 127626..128039 (414 bp)
Type: Others
Protein ID: WP_000049420.1
Location: 128223..128738 (516 bp)
Type: Others
Protein ID: WP_000343779.1
Location: 129630..130025 (396 bp)
Type: Others
Protein ID: WP_001000867.1
Location: 130276..130401 (126 bp)
Type: Others
Protein ID: WP_001905700.1
Location: 130700..131221 (522 bp)
Type: Others
Protein ID: WP_000921691.1
Location: 131215..131484 (270 bp)
Type: Others
Protein ID: WP_001114075.1
Location: 131515..131619 (105 bp)
Type: Others
Protein ID: WP_099607150.1
Location: 131676..132275 (600 bp)
Type: Others
Protein ID: WP_001891245.1
Location: 132425..133297 (873 bp)
Type: Others
Protein ID: WP_000254716.1
Location: 133472..133690 (219 bp)
Type: Others
Protein ID: WP_071908318.1
Location: 133754..134191 (438 bp)
Type: Others
Protein ID: WP_000503169.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
EEL44_RS00560127626..128039-414WP_000049420.1VOC family protein-
EEL44_RS00570128223..128738-516WP_000343779.1GNAT family N-acetyltransferase-
EEL44_RS00575128932..129216+285WP_000381183.1type II toxin-antitoxin system RelB/DinJ family antitoxinAntitoxin
EEL44_RS00580129213..129491+279WP_000578476.1type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE familyToxin
EEL44_RS00585129630..130025-396WP_001000867.1hypothetical protein-
EEL44_RS00595130276..130401-126WP_001905700.1DUF645 family protein-
EEL44_RS00600130700..131221-522WP_000921691.1DUF2442 domain-containing protein-
EEL44_RS00605131215..131484-270WP_001114075.1DUF4160 domain-containing protein-
EEL44_RS00610131515..131619-105WP_099607150.1acetyltransferase-
EEL44_RS00615131676..132275-600WP_001891245.1glutathione S-transferase N-terminal domain-containing protein-
EEL44_RS00620132425..133297-873WP_000254716.1DUF3800 domain-containing protein-
EEL44_RS00625133472..133690-219WP_071908318.1GNAT family N-acetyltransferase-
EEL44_RS00630133754..134191-438WP_000503169.1IS200/IS605-like element IS1004 family transposase-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideGenomic islandcatB9-126763..233717106954
insideIntegron--127139..22687599736
flankIS/Tn--133754..134191437


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(2-89)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(5-70)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10819.59 Da        Isoelectric Point: 5.1651

>T113794 WP_000578476.1 NZ_CP033513:129213-129491 [Vibrio cholerae]
MIFWEEASLNDREKIFEFLYDFNPAAAKKTDELIEAKVENLLEQPLIGVQRDGIRGRLLIIPEISMIVSYWVDGSKIRIM
RVLHQKQKFPND

Download         Length: 279 bp

>T113794 NZ_CP033513:129213-129491 [Vibrio cholerae]
ATGATTTTCTGGGAAGAAGCATCTCTCAATGATCGTGAGAAAATTTTCGAATTTCTCTACGACTTTAACCCAGCAGCGGC
TAAAAAAACGGATGAGCTCATAGAAGCCAAAGTCGAAAATTTGCTTGAGCAACCACTAATCGGTGTTCAGCGTGATGGCA
TTAGAGGCAGATTGCTTATTATCCCTGAGATATCAATGATTGTTTCGTATTGGGTTGATGGTTCTAAAATTCGAATAATG
CGTGTACTACATCAGAAACAAAAATTTCCAAACGACTGA

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10901.25 Da        Isoelectric Point: 8.0775

>AT113794 WP_000381183.1 NZ_CP033513:128932-129216 [Vibrio cholerae]
MDTRIQFRVDEETKRLAQQMAESQGRTLSDACRELTEQLAEQQRKALSHDAWLTEQVNQAFEKFDSGKAVFIEHDIAKAR
MAERKAKIRNRGHA

Download         Length: 285 bp

>AT113794 NZ_CP033513:128932-129216 [Vibrio cholerae]
ATGGATACTAGAATTCAATTTCGTGTAGACGAAGAAACAAAACGTTTAGCTCAACAAATGGCTGAAAGCCAAGGTCGAAC
TCTTAGCGATGCTTGCCGTGAACTCACTGAACAATTAGCTGAGCAGCAACGCAAGGCATTATCTCACGATGCATGGCTAA
CTGAACAAGTGAATCAAGCATTTGAGAAGTTCGACTCAGGAAAAGCAGTATTCATTGAACATGACATCGCCAAAGCACGA
ATGGCTGAACGTAAAGCTAAAATCCGAAATCGAGGCCACGCATGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBQ9K2M8

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A067BL33

References