Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-Phd
Location 399756..400303 Replicon chromosome
Accession NZ_CP009041
Organism Vibrio cholerae O1 biovar El Tor strain FJ147

Toxin (Protein)


Gene name relE Uniprot ID Q9KM92
Locus tag IR04_RS02045 Protein ID WP_000229317.1
Coordinates 400001..400303 (+) Length 101 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID Q9KM93
Locus tag IR04_RS02040 Protein ID WP_000861987.1
Coordinates 399756..400013 (+) Length 86 a.a.

Genomic Context

IR04_RS01995IR04_RS02000IR04_RS02015IR04_RS02020IR04_RS02025IR04_RS02030IR04_RS02035IR04_RS02040IR04_RS02045IR04_RS02050IR04_RS02055IR04_RS02060IR04_RS02065IR04_RS02070IR04_RS02075IR04_RS02080IR04_RS20045IR04_RS02005IR04_RS02010
Location: 394785..395240 (456 bp)
Type: Others
Protein ID: WP_001245327.1
Location: 395562..395714 (153 bp)
Type: Others
Protein ID: WP_001884520.1
Location: 396913..397581 (669 bp)
Type: Others
Protein ID: WP_000043871.1
Location: 397733..398020 (288 bp)
Type: Others
Protein ID: WP_000426470.1
Location: 398161..398532 (372 bp)
Type: Others
Protein ID: WP_001164080.1
Location: 398599..399024 (426 bp)
Type: Others
Protein ID: WP_001882332.1
Location: 399021..399554 (534 bp)
Type: Others
Protein ID: WP_000118351.1
Location: 399756..400013 (258 bp)
Type: Antitoxin
Protein ID: WP_000861987.1
Location: 400001..400303 (303 bp)
Type: Toxin
Protein ID: WP_000229317.1
Location: 400537..401454 (918 bp)
Type: Others
Protein ID: WP_000186333.1
Location: 401611..402000 (390 bp)
Type: Others
Protein ID: WP_001081302.1
Location: 402136..402345 (210 bp)
Type: Others
Protein ID: Protein_424
Location: 402464..402901 (438 bp)
Type: Others
Protein ID: WP_000503169.1
Location: 402965..403183 (219 bp)
Type: Others
Protein ID: WP_071908318.1
Location: 403358..404230 (873 bp)
Type: Others
Protein ID: WP_000254716.1
Location: 404380..404979 (600 bp)
Type: Others
Protein ID: WP_001891245.1
Location: 405036..405140 (105 bp)
Type: Others
Protein ID: WP_099607150.1
Location: 395916..396413 (498 bp)
Type: Others
Protein ID: WP_000982260.1
Location: 396410..396682 (273 bp)
Type: Others
Protein ID: WP_000246253.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
IR04_RS01995394785..395240+456WP_001245327.1GNAT family N-acetyltransferase-
IR04_RS02000395562..395714+153WP_001884520.1DUF645 family protein-
IR04_RS02005395916..396413-498WP_000982260.1GNAT family N-acetyltransferase-
IR04_RS02010396410..396682-273WP_000246253.1DUF1778 domain-containing protein-
IR04_RS02015396913..397581+669WP_000043871.1hypothetical protein-
IR04_RS02020397733..398020+288WP_000426470.1hypothetical protein-
IR04_RS02025398161..398532+372WP_001164080.1nucleotide pyrophosphohydrolase-
IR04_RS02030398599..399024+426WP_001882332.1DUF1778 domain-containing protein-
IR04_RS02035399021..399554+534WP_000118351.1GNAT family N-acetyltransferase-
IR04_RS02040399756..400013+258WP_000861987.1type II toxin-antitoxin system Phd/YefM family antitoxinAntitoxin
IR04_RS02045400001..400303+303WP_000229317.1type II toxin-antitoxin system RelE/ParE family toxinToxin
IR04_RS02050400537..401454+918WP_000186333.1alpha/beta hydrolase-
IR04_RS02055401611..402000+390WP_001081302.1hypothetical protein-
IR04_RS02060402136..402345+210Protein_424GNAT family N-acetyltransferase-
IR04_RS02065402464..402901+438WP_000503169.1IS200/IS605-like element IS1004 family transposase-
IR04_RS02070402965..403183+219WP_071908318.1GNAT family N-acetyltransferase-
IR04_RS02075403358..404230+873WP_000254716.1DUF3800 domain-containing protein-
IR04_RS02080404380..404979+600WP_001891245.1glutathione S-transferase N-terminal domain-containing protein-
IR04_RS20045405036..405140+105WP_099607150.1acetyltransferase-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideGenomic islandcatB9-304700..409892105192
insideIntegron--309780..40951699736
flankIS/Tn--402464..402901437


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-87)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-69)


Sequences

Toxin        


Download         Length: 101 a.a.        Molecular weight: 11726.68 Da        Isoelectric Point: 5.1972

>T48159 WP_000229317.1 NZ_CP009041:400001-400303 [Vibrio cholerae O1 biovar El Tor]
MVEIIWTELALSDLNDIAEYIALENVVAAKQLVQTVFTKVERLADFPESGRVPPELEHLNYREVVVSPCRVFYKYDDAKV
RILFVMRAERDLRRLMLTKQ

Download         Length: 303 bp

>T48159 NZ_CP009041:400001-400303 [Vibrio cholerae O1 biovar El Tor]
ATGGTTGAAATAATTTGGACGGAGCTGGCTCTATCCGACTTGAATGATATTGCTGAATACATCGCGCTTGAAAATGTCGT
GGCTGCTAAACAACTGGTGCAAACCGTTTTTACAAAAGTTGAACGTTTGGCCGATTTTCCAGAGTCTGGGCGCGTCCCTC
CAGAACTAGAACACCTCAATTATCGTGAAGTCGTTGTAAGTCCGTGTCGTGTTTTCTACAAGTATGATGATGCAAAGGTT
CGTATTCTTTTTGTTATGCGTGCGGAGCGAGATTTGCGTCGGTTAATGCTTACGAAACAGTAG

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9647.15 Da        Isoelectric Point: 7.3178

>AT48159 WP_000861987.1 NZ_CP009041:399756-400013 [Vibrio cholerae O1 biovar El Tor]
MKVELVTSLKRQATKILADLHDTKEPVLITEHGKPSAYLIDVDDYEFMQNRLAILEGIARGERALADGKVVSHQDAKDRM
SKWLK

Download         Length: 258 bp

>AT48159 NZ_CP009041:399756-400013 [Vibrio cholerae O1 biovar El Tor]
ATGAAAGTAGAACTTGTGACGTCACTAAAACGTCAGGCCACTAAGATCCTTGCCGATCTTCATGATACGAAAGAGCCAGT
ATTGATAACTGAGCACGGAAAACCGTCAGCTTACCTTATTGATGTAGACGACTATGAATTTATGCAAAATCGTTTAGCGA
TCCTGGAAGGTATTGCTCGCGGAGAGCGAGCTTTAGCGGATGGTAAAGTGGTCAGCCATCAAGATGCTAAGGACAGAATG
TCAAAATGGTTGAAATAA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBQ9KM92

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A1T4SLM9

References