Detailed information of TA system TA058351

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): DhiAT/-
• Location: 337476..338260
• Replicon: chromosome
• Accession: NZ_CP013314
• Organism: Vibrio cholerae strain E9120

Toxin (Protein)

• Gene name: dhiT
• Uniprot ID: A0A086SLD6
• Locus tag: ASZ79_RS15785
• Protein ID: WP_001114075.1
• Coordinates: 337476..337745 (+)
• Length: 90 a.a.

Antitoxin (Protein)

• Gene name: dhiA
• Uniprot ID: C3LUY7
• Locus tag: ASZ79_RS15790
• Protein ID: WP_000921692.1
• Coordinates: 337739..338260 (+)
• Length: 174 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
ASZ79_RS15725	332886..333185	-	300	WP_000802136.1	type II toxin-antitoxin system RelE/ParE family toxin	-
ASZ79_RS15730	333182..333424	-	243	WP_001107719.1	type II toxin-antitoxin system ParD family antitoxin	-
ASZ79_RS15740	333843..333920	+	78	WP_071908337.1	DUF645 family protein	-
ASZ79_RS20905	333924..333950	+	27	Protein_298	hypothetical protein	-
ASZ79_RS20985	334536..334679	+	144	WP_001900215.1	hypothetical protein	-
ASZ79_RS20480	334773..334952	+	180	Protein_300	DUF645 family protein	-
ASZ79_RS15765	335170..335598	+	429	WP_000620002.1	N-acetyltransferase	-
ASZ79_RS15775	336186..336668	+	483	WP_000422940.1	GNAT family N-acetyltransferase	-
ASZ79_RS15785	337476..337745	+	270	WP_001114075.1	DUF4160 domain-containing protein	Toxin
ASZ79_RS15790	337739..338260	+	522	WP_000921692.1	DUF2442 domain-containing protein	Antitoxin
ASZ79_RS20500	338317..338430	+	114	WP_001894981.1	hypothetical protein	-
ASZ79_RS15795	338399..339235	+	837	WP_000242986.1	hypothetical protein	-
ASZ79_RS15800	339400..340038	+	639	WP_000230118.1	HD domain-containing protein	-
ASZ79_RS20505	340128..340288	+	161	Protein_308	DUF3709 domain-containing protein	-
ASZ79_RS15805	340309..340530	+	222	WP_012705854.1	DUF3709 domain-containing protein	-
ASZ79_RS15815	340850..341170	+	321	WP_001909340.1	DUF1778 domain-containing protein	-
ASZ79_RS15820	341167..341700	+	534	WP_000118351.1	GNAT family N-acetyltransferase	-
ASZ79_RS15825	341938..342216	+	279	WP_000280324.1	DUF3709 domain-containing protein	-
ASZ79_RS15830	342617..342841	+	225	WP_001894423.1	DUF3709 domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	catB9	-	304700..468464	163764
	Similar MGE(s) Similar MGE(s) is defined as other TA-related MGE(s) with Mash distance < 0.01 to this MGE. Detail Genome accession Organism MGE type Related TA Coordinates Mash distance View NC_002506 Vibrio cholerae O1 biovar El Tor str. N16961 Integron TA000164, TA000169, TA000166, TA000167, TA000179, TA000170, TA000171, TA000172, TA000173, TA000174, TA000175, TA000176, TA000177, TA000178, TA000168, TA000165, TA010030, TA010035 309750..435387 0.005	inside	Integron	-	-	309780..468088	158308

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Protein of unknown function DUF4160 (9-74)

Antitoxin

• Protein of unknown function DUF2442 (4-59)

Sequences

Toxin

Protein

• Length: 90 a.a.
• Molecular weight: 10310.94 Da
• Isoelectric Point: 6.6303

>T58351 WP_001114075.1 NZ_CP013314:337476-337745 [Vibrio cholerae]
MPEIDALLGLSFCLYFFDNKQHKLPHIHVKYGSYELIIAIETGECLEGYLPNKQRKRAENHILEHREQLMVMWNKAVNGE
NPGKLGDLC

Nucleotide

• Length: 270 bp

>T58351 NZ_CP013314:337476-337745 [Vibrio cholerae]
ATGCCAGAGATTGATGCCCTATTAGGCCTTTCATTTTGCTTGTACTTCTTTGATAACAAGCAGCATAAATTGCCTCATAT
TCACGTTAAGTACGGTAGTTACGAGCTAATTATTGCTATTGAAACAGGTGAGTGTTTAGAGGGTTACTTACCCAATAAAC
AACGAAAACGTGCTGAAAACCATATTCTTGAACATCGAGAGCAATTGATGGTGATGTGGAATAAAGCGGTGAATGGTGAA
AATCCAGGTAAGTTAGGTGATTTATGTTGA

Antitoxin

Protein

• Length: 174 a.a.
• Molecular weight: 19439.04 Da
• Isoelectric Point: 6.7342

>AT58351 WP_000921692.1 NZ_CP013314:337739-338260 [Vibrio cholerae]
MLKVIDVDFVSDHTLELTFNDGYQGYADLSVYFKKTPFSEIKDFKRFSLTRDGSLNWDGNELTAATLRDITKGSQKSVEL
SFNVQEMEAVIKQASWESMMEGRPDILQAAIRSYVEQFGHGQVIAKAGIKSRTSAYRSLKPETTPNFGTLVQLGHAVIEL
AKDRTVANKEPRI

Nucleotide

• Length: 522 bp

>AT58351 NZ_CP013314:337739-338260 [Vibrio cholerae]
ATGTTGAAAGTCATAGATGTTGATTTTGTCTCAGACCATACATTAGAACTGACGTTCAATGATGGTTACCAAGGCTATGC
CGACTTGTCGGTATACTTTAAAAAAACACCGTTTTCAGAAATTAAGGACTTTAAACGCTTTTCCTTGACTCGTGATGGCT
CGTTAAATTGGGATGGTAATGAGTTAACGGCCGCGACACTCCGTGACATAACCAAGGGCTCACAAAAGTCGGTGGAGTTA
AGTTTTAATGTTCAAGAAATGGAAGCCGTCATCAAACAGGCCTCATGGGAATCGATGATGGAGGGGCGTCCCGACATCTT
GCAAGCGGCTATTCGTTCTTACGTAGAGCAGTTTGGTCATGGTCAAGTTATTGCAAAGGCGGGTATAAAAAGTCGTACGA
GTGCTTATCGCTCCTTGAAGCCAGAAACAACGCCAAACTTTGGCACACTAGTTCAGTTAGGGCACGCCGTCATCGAACTA
GCGAAAGATAGAACAGTGGCAAACAAGGAACCACGCATATAA

Structures

Toxin

• AlphaFold DB: A0A086SLD6

Antitoxin

• AlphaFold DB: C3LUY7