Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) DhiAT/-
Location 337476..338260 Replicon chromosome
Accession NZ_CP013314
Organism Vibrio cholerae strain E9120

Toxin (Protein)


Gene name dhiT Uniprot ID A0A086SLD6
Locus tag ASZ79_RS15785 Protein ID WP_001114075.1
Coordinates 337476..337745 (+) Length 90 a.a.

Antitoxin (Protein)


Gene name dhiA Uniprot ID C3LUY7
Locus tag ASZ79_RS15790 Protein ID WP_000921692.1
Coordinates 337739..338260 (+) Length 174 a.a.

Genomic Context

ASZ79_RS15740ASZ79_RS20905ASZ79_RS20985ASZ79_RS20480ASZ79_RS15765ASZ79_RS15775ASZ79_RS15785ASZ79_RS15790ASZ79_RS20500ASZ79_RS15795ASZ79_RS15800ASZ79_RS20505ASZ79_RS15805ASZ79_RS15815ASZ79_RS15820ASZ79_RS15825ASZ79_RS15830ASZ79_RS15725ASZ79_RS15730
Location: 333843..333920 (78 bp)
Type: Others
Protein ID: WP_071908337.1
Location: 333924..333950 (27 bp)
Type: Others
Protein ID: Protein_298
Location: 334536..334679 (144 bp)
Type: Others
Protein ID: WP_001900215.1
Location: 334773..334952 (180 bp)
Type: Others
Protein ID: Protein_300
Location: 335170..335598 (429 bp)
Type: Others
Protein ID: WP_000620002.1
Location: 336186..336668 (483 bp)
Type: Others
Protein ID: WP_000422940.1
Location: 337476..337745 (270 bp)
Type: Toxin
Protein ID: WP_001114075.1
Location: 337739..338260 (522 bp)
Type: Antitoxin
Protein ID: WP_000921692.1
Location: 338317..338430 (114 bp)
Type: Others
Protein ID: WP_001894981.1
Location: 338399..339235 (837 bp)
Type: Others
Protein ID: WP_000242986.1
Location: 339400..340038 (639 bp)
Type: Others
Protein ID: WP_000230118.1
Location: 340128..340288 (161 bp)
Type: Others
Protein ID: Protein_308
Location: 340309..340530 (222 bp)
Type: Others
Protein ID: WP_012705854.1
Location: 340850..341170 (321 bp)
Type: Others
Protein ID: WP_001909340.1
Location: 341167..341700 (534 bp)
Type: Others
Protein ID: WP_000118351.1
Location: 341938..342216 (279 bp)
Type: Others
Protein ID: WP_000280324.1
Location: 342617..342841 (225 bp)
Type: Others
Protein ID: WP_001894423.1
Location: 332886..333185 (300 bp)
Type: Others
Protein ID: WP_000802136.1
Location: 333182..333424 (243 bp)
Type: Others
Protein ID: WP_001107719.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
ASZ79_RS15725332886..333185-300WP_000802136.1type II toxin-antitoxin system RelE/ParE family toxin-
ASZ79_RS15730333182..333424-243WP_001107719.1type II toxin-antitoxin system ParD family antitoxin-
ASZ79_RS15740333843..333920+78WP_071908337.1DUF645 family protein-
ASZ79_RS20905333924..333950+27Protein_298hypothetical protein-
ASZ79_RS20985334536..334679+144WP_001900215.1hypothetical protein-
ASZ79_RS20480334773..334952+180Protein_300DUF645 family protein-
ASZ79_RS15765335170..335598+429WP_000620002.1N-acetyltransferase-
ASZ79_RS15775336186..336668+483WP_000422940.1GNAT family N-acetyltransferase-
ASZ79_RS15785337476..337745+270WP_001114075.1DUF4160 domain-containing proteinToxin
ASZ79_RS15790337739..338260+522WP_000921692.1DUF2442 domain-containing proteinAntitoxin
ASZ79_RS20500338317..338430+114WP_001894981.1hypothetical protein-
ASZ79_RS15795338399..339235+837WP_000242986.1hypothetical protein-
ASZ79_RS15800339400..340038+639WP_000230118.1HD domain-containing protein-
ASZ79_RS20505340128..340288+161Protein_308DUF3709 domain-containing protein-
ASZ79_RS15805340309..340530+222WP_012705854.1DUF3709 domain-containing protein-
ASZ79_RS15815340850..341170+321WP_001909340.1DUF1778 domain-containing protein-
ASZ79_RS15820341167..341700+534WP_000118351.1GNAT family N-acetyltransferase-
ASZ79_RS15825341938..342216+279WP_000280324.1DUF3709 domain-containing protein-
ASZ79_RS15830342617..342841+225WP_001894423.1DUF3709 domain-containing protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideGenomic islandcatB9-304700..468464163764
insideIntegron--309780..468088158308


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Protein of unknown function DUF4160

(9-74)

Antitoxin

Protein of unknown function DUF2442

(4-59)


Sequences

Toxin        


Download         Length: 90 a.a.        Molecular weight: 10310.94 Da        Isoelectric Point: 6.6303

>T58351 WP_001114075.1 NZ_CP013314:337476-337745 [Vibrio cholerae]
MPEIDALLGLSFCLYFFDNKQHKLPHIHVKYGSYELIIAIETGECLEGYLPNKQRKRAENHILEHREQLMVMWNKAVNGE
NPGKLGDLC

Download         Length: 270 bp

>T58351 NZ_CP013314:337476-337745 [Vibrio cholerae]
ATGCCAGAGATTGATGCCCTATTAGGCCTTTCATTTTGCTTGTACTTCTTTGATAACAAGCAGCATAAATTGCCTCATAT
TCACGTTAAGTACGGTAGTTACGAGCTAATTATTGCTATTGAAACAGGTGAGTGTTTAGAGGGTTACTTACCCAATAAAC
AACGAAAACGTGCTGAAAACCATATTCTTGAACATCGAGAGCAATTGATGGTGATGTGGAATAAAGCGGTGAATGGTGAA
AATCCAGGTAAGTTAGGTGATTTATGTTGA

Antitoxin


Download         Length: 174 a.a.        Molecular weight: 19439.04 Da        Isoelectric Point: 6.7342

>AT58351 WP_000921692.1 NZ_CP013314:337739-338260 [Vibrio cholerae]
MLKVIDVDFVSDHTLELTFNDGYQGYADLSVYFKKTPFSEIKDFKRFSLTRDGSLNWDGNELTAATLRDITKGSQKSVEL
SFNVQEMEAVIKQASWESMMEGRPDILQAAIRSYVEQFGHGQVIAKAGIKSRTSAYRSLKPETTPNFGTLVQLGHAVIEL
AKDRTVANKEPRI

Download         Length: 522 bp

>AT58351 NZ_CP013314:337739-338260 [Vibrio cholerae]
ATGTTGAAAGTCATAGATGTTGATTTTGTCTCAGACCATACATTAGAACTGACGTTCAATGATGGTTACCAAGGCTATGC
CGACTTGTCGGTATACTTTAAAAAAACACCGTTTTCAGAAATTAAGGACTTTAAACGCTTTTCCTTGACTCGTGATGGCT
CGTTAAATTGGGATGGTAATGAGTTAACGGCCGCGACACTCCGTGACATAACCAAGGGCTCACAAAAGTCGGTGGAGTTA
AGTTTTAATGTTCAAGAAATGGAAGCCGTCATCAAACAGGCCTCATGGGAATCGATGATGGAGGGGCGTCCCGACATCTT
GCAAGCGGCTATTCGTTCTTACGTAGAGCAGTTTGGTCATGGTCAAGTTATTGCAAAGGCGGGTATAAAAAGTCGTACGA
GTGCTTATCGCTCCTTGAAGCCAGAAACAACGCCAAACTTTGGCACACTAGTTCAGTTAGGGCACGCCGTCATCGAACTA
GCGAAAGATAGAACAGTGGCAAACAAGGAACCACGCATATAA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A086SLD6

Antitoxin

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Source
ID
Structure
AlphaFold DBC3LUY7

References