Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-Phd
Location 427937..428484 Replicon chromosome
Accession NZ_CP028828
Organism Vibrio cholerae strain N16961

Toxin (Protein)


Gene name relE Uniprot ID Q9KM92
Locus tag N16961_RS16635 Protein ID WP_000229317.1
Coordinates 428182..428484 (+) Length 101 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID Q9KM93
Locus tag N16961_RS16630 Protein ID WP_000861987.1
Coordinates 427937..428194 (+) Length 86 a.a.

Genomic Context

N16961_RS16575N16961_RS16580N16961_RS16600N16961_RS16605N16961_RS16610N16961_RS16615N16961_RS16620N16961_RS16630N16961_RS16635N16961_RS16640N16961_RS16645N16961_RS16650N16961_RS16655N16961_RS16660N16961_RS16665N16961_RS16670N16961_RS16675N16961_RS16590N16961_RS16595
Location: 422966..423421 (456 bp)
Type: Others
Protein ID: WP_001245327.1
Location: 423743..423895 (153 bp)
Type: Others
Protein ID: WP_001884520.1
Location: 425094..425762 (669 bp)
Type: Others
Protein ID: WP_000043871.1
Location: 425914..426201 (288 bp)
Type: Others
Protein ID: WP_000426470.1
Location: 426342..426713 (372 bp)
Type: Others
Protein ID: WP_001164080.1
Location: 426780..427205 (426 bp)
Type: Others
Protein ID: WP_001882332.1
Location: 427202..427735 (534 bp)
Type: Others
Protein ID: WP_000118351.1
Location: 427937..428194 (258 bp)
Type: Antitoxin
Protein ID: WP_000861987.1
Location: 428182..428484 (303 bp)
Type: Toxin
Protein ID: WP_000229317.1
Location: 428718..429635 (918 bp)
Type: Others
Protein ID: WP_000186333.1
Location: 429792..430181 (390 bp)
Type: Others
Protein ID: WP_001081302.1
Location: 430317..430526 (210 bp)
Type: Others
Protein ID: Protein_468
Location: 430645..431082 (438 bp)
Type: Others
Protein ID: WP_000503169.1
Location: 431146..431364 (219 bp)
Type: Others
Protein ID: WP_071908318.1
Location: 431539..432411 (873 bp)
Type: Others
Protein ID: WP_000254716.1
Location: 432561..433160 (600 bp)
Type: Others
Protein ID: WP_001891245.1
Location: 433217..433321 (105 bp)
Type: Others
Protein ID: WP_099607150.1
Location: 424097..424594 (498 bp)
Type: Others
Protein ID: WP_000982260.1
Location: 424591..424863 (273 bp)
Type: Others
Protein ID: WP_000246253.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
N16961_RS16575422966..423421+456WP_001245327.1GNAT family N-acetyltransferase-
N16961_RS16580423743..423895+153WP_001884520.1DUF645 family protein-
N16961_RS16590424097..424594-498WP_000982260.1GNAT family N-acetyltransferase-
N16961_RS16595424591..424863-273WP_000246253.1DUF1778 domain-containing protein-
N16961_RS16600425094..425762+669WP_000043871.1hypothetical protein-
N16961_RS16605425914..426201+288WP_000426470.1hypothetical protein-
N16961_RS16610426342..426713+372WP_001164080.1nucleotide pyrophosphohydrolase-
N16961_RS16615426780..427205+426WP_001882332.1DUF1778 domain-containing protein-
N16961_RS16620427202..427735+534WP_000118351.1GNAT family N-acetyltransferase-
N16961_RS16630427937..428194+258WP_000861987.1type II toxin-antitoxin system Phd/YefM family antitoxinAntitoxin
N16961_RS16635428182..428484+303WP_000229317.1type II toxin-antitoxin system RelE/ParE family toxinToxin
N16961_RS16640428718..429635+918WP_000186333.1alpha/beta hydrolase-
N16961_RS16645429792..430181+390WP_001081302.1hypothetical protein-
N16961_RS16650430317..430526+210Protein_468GNAT family N-acetyltransferase-
N16961_RS16655430645..431082+438WP_000503169.1IS200/IS605-like element IS1004 family transposase-
N16961_RS16660431146..431364+219WP_071908318.1GNAT family N-acetyltransferase-
N16961_RS16665431539..432411+873WP_000254716.1DUF3800 domain-containing protein-
N16961_RS16670432561..433160+600WP_001891245.1glutathione S-transferase N-terminal domain-containing protein-
N16961_RS16675433217..433321+105WP_099607150.1acetyltransferase-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideGenomic islandcatB9-306977..438073131096
insideIntegron--312057..437697125640
flankIS/Tn--430645..431082437


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-87)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-69)


Sequences

Toxin        


Download         Length: 101 a.a.        Molecular weight: 11726.68 Da        Isoelectric Point: 5.1972

>T104261 WP_000229317.1 NZ_CP028828:428182-428484 [Vibrio cholerae]
MVEIIWTELALSDLNDIAEYIALENVVAAKQLVQTVFTKVERLADFPESGRVPPELEHLNYREVVVSPCRVFYKYDDAKV
RILFVMRAERDLRRLMLTKQ

Download         Length: 303 bp

>T104261 NZ_CP028828:428182-428484 [Vibrio cholerae]
ATGGTTGAAATAATTTGGACGGAGCTGGCTCTATCCGACTTGAATGATATTGCTGAATACATCGCGCTTGAAAATGTCGT
GGCTGCTAAACAACTGGTGCAAACCGTTTTTACAAAAGTTGAACGTTTGGCCGATTTTCCAGAGTCTGGGCGCGTCCCTC
CAGAACTAGAACACCTCAATTATCGTGAAGTCGTTGTAAGTCCGTGTCGTGTTTTCTACAAGTATGATGATGCAAAGGTT
CGTATTCTTTTTGTTATGCGTGCGGAGCGAGATTTGCGTCGGTTAATGCTTACGAAACAGTAG

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9647.15 Da        Isoelectric Point: 7.3178

>AT104261 WP_000861987.1 NZ_CP028828:427937-428194 [Vibrio cholerae]
MKVELVTSLKRQATKILADLHDTKEPVLITEHGKPSAYLIDVDDYEFMQNRLAILEGIARGERALADGKVVSHQDAKDRM
SKWLK

Download         Length: 258 bp

>AT104261 NZ_CP028828:427937-428194 [Vibrio cholerae]
ATGAAAGTAGAACTTGTGACGTCACTAAAACGTCAGGCCACTAAGATCCTTGCCGATCTTCATGATACGAAAGAGCCAGT
ATTGATAACTGAGCACGGAAAACCGTCAGCTTACCTTATTGATGTAGACGACTATGAATTTATGCAAAATCGTTTAGCGA
TCCTGGAAGGTATTGCTCGCGGAGAGCGAGCTTTAGCGGATGGTAAAGTGGTCAGCCATCAAGATGCTAAGGACAGAATG
TCAAAATGGTTGAAATAA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBQ9KM92

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A1T4SLM9

References