104261

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-Phd
Location 427937..428484 Replicon chromosome
Accession NZ_CP028828
Organism Vibrio cholerae strain N16961

Toxin (Protein)


Gene name relE Uniprot ID Q9KM92
Locus tag N16961_RS16635 Protein ID WP_000229317.1
Coordinates 428182..428484 (+) Length 101 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID Q9KM93
Locus tag N16961_RS16630 Protein ID WP_000861987.1
Coordinates 427937..428194 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N16961_RS16575 422966..423421 + 456 WP_001245327.1 GNAT family N-acetyltransferase -
N16961_RS16580 423743..423895 + 153 WP_001884520.1 DUF645 family protein -
N16961_RS16590 424097..424594 - 498 WP_000982260.1 GNAT family N-acetyltransferase -
N16961_RS16595 424591..424863 - 273 WP_000246253.1 DUF1778 domain-containing protein -
N16961_RS16600 425094..425762 + 669 WP_000043871.1 hypothetical protein -
N16961_RS16605 425914..426201 + 288 WP_000426470.1 hypothetical protein -
N16961_RS16610 426342..426713 + 372 WP_001164080.1 nucleotide pyrophosphohydrolase -
N16961_RS16615 426780..427205 + 426 WP_001882332.1 DUF1778 domain-containing protein -
N16961_RS16620 427202..427735 + 534 WP_000118351.1 GNAT family N-acetyltransferase -
N16961_RS16630 427937..428194 + 258 WP_000861987.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
N16961_RS16635 428182..428484 + 303 WP_000229317.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
N16961_RS16640 428718..429635 + 918 WP_000186333.1 alpha/beta hydrolase -
N16961_RS16645 429792..430181 + 390 WP_001081302.1 hypothetical protein -
N16961_RS16650 430317..430526 + 210 Protein_468 GNAT family N-acetyltransferase -
N16961_RS16655 430645..431082 + 438 WP_000503169.1 IS200/IS605-like element IS1004 family transposase -
N16961_RS16660 431146..431364 + 219 WP_071908318.1 GNAT family N-acetyltransferase -
N16961_RS16665 431539..432411 + 873 WP_000254716.1 DUF3800 domain-containing protein -
N16961_RS16670 432561..433160 + 600 WP_001891245.1 glutathione S-transferase N-terminal domain-containing protein -
N16961_RS16675 433217..433321 + 105 WP_099607150.1 acetyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island catB9 - 306977..438073 131096
inside Integron - - 312057..437697 125640
flank IS/Tn - - 430645..431082 437


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-87)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-69)


Sequences

Toxin        


Download         Length: 101 a.a.        Molecular weight: 11726.68 Da        Isoelectric Point: 5.1972

>T104261 WP_000229317.1 NZ_CP028828:428182-428484 [Vibrio cholerae]
MVEIIWTELALSDLNDIAEYIALENVVAAKQLVQTVFTKVERLADFPESGRVPPELEHLNYREVVVSPCRVFYKYDDAKV
RILFVMRAERDLRRLMLTKQ

Download         Length: 303 bp

>T104261 NZ_CP028828:428182-428484 [Vibrio cholerae]
ATGGTTGAAATAATTTGGACGGAGCTGGCTCTATCCGACTTGAATGATATTGCTGAATACATCGCGCTTGAAAATGTCGT
GGCTGCTAAACAACTGGTGCAAACCGTTTTTACAAAAGTTGAACGTTTGGCCGATTTTCCAGAGTCTGGGCGCGTCCCTC
CAGAACTAGAACACCTCAATTATCGTGAAGTCGTTGTAAGTCCGTGTCGTGTTTTCTACAAGTATGATGATGCAAAGGTT
CGTATTCTTTTTGTTATGCGTGCGGAGCGAGATTTGCGTCGGTTAATGCTTACGAAACAGTAG

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9647.15 Da        Isoelectric Point: 7.3178

>AT104261 WP_000861987.1 NZ_CP028828:427937-428194 [Vibrio cholerae]
MKVELVTSLKRQATKILADLHDTKEPVLITEHGKPSAYLIDVDDYEFMQNRLAILEGIARGERALADGKVVSHQDAKDRM
SKWLK

Download         Length: 258 bp

>AT104261 NZ_CP028828:427937-428194 [Vibrio cholerae]
ATGAAAGTAGAACTTGTGACGTCACTAAAACGTCAGGCCACTAAGATCCTTGCCGATCTTCATGATACGAAAGAGCCAGT
ATTGATAACTGAGCACGGAAAACCGTCAGCTTACCTTATTGATGTAGACGACTATGAATTTATGCAAAATCGTTTAGCGA
TCCTGGAAGGTATTGCTCGCGGAGAGCGAGCTTTAGCGGATGGTAAAGTGGTCAGCCATCAAGATGCTAAGGACAGAATG
TCAAAATGGTTGAAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB Q9KM92

Antitoxin

Source ID Structure
AlphaFold DB A0A1T4SLM9

References