125036

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/ParE-Phd
Location 899229..899807 Replicon chromosome
Accession NZ_CP040173
Organism Vibrio cholerae strain VC1374

Toxin (Protein)


Gene name parE Uniprot ID O68848
Locus tag FDZ90_RS18640 Protein ID WP_001180243.1
Coordinates 899229..899546 (-) Length 106 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID Q7DCR7
Locus tag FDZ90_RS18645 Protein ID WP_000557292.1
Coordinates 899565..899807 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FDZ90_RS18610 894753..894935 + 183 WP_000923340.1 DUF645 family protein -
FDZ90_RS18615 895289..895471 + 183 WP_000923153.1 DUF645 family protein -
FDZ90_RS18620 895666..896343 + 678 WP_000254617.1 HNH endonuclease -
FDZ90_RS18625 896505..897713 + 1209 WP_000272282.1 deoxyguanosinetriphosphate triphosphohydrolase family protein -
FDZ90_RS18630 897875..898579 + 705 WP_000087610.1 HNH endonuclease -
FDZ90_RS18635 898737..899075 + 339 WP_000713853.1 hypothetical protein -
FDZ90_RS18640 899229..899546 - 318 WP_001180243.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
FDZ90_RS18645 899565..899807 - 243 WP_000557292.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
FDZ90_RS18650 900051..900437 + 387 WP_001015867.1 NUDIX hydrolase -
FDZ90_RS18655 900494..900607 + 114 WP_001900214.1 hypothetical protein -
FDZ90_RS18660 900556..900837 + 282 WP_001894429.1 DUF1289 domain-containing protein -
FDZ90_RS18665 901095..901631 + 537 WP_000469482.1 GNAT family N-acetyltransferase -
FDZ90_RS18670 901768..902283 + 516 WP_001201509.1 lipocalin family protein -
FDZ90_RS18675 902433..902930 - 498 WP_000982260.1 GNAT family N-acetyltransferase -
FDZ90_RS18680 902927..903199 - 273 WP_000246253.1 DUF1778 domain-containing protein -
FDZ90_RS18685 903592..903717 + 126 WP_001900195.1 DUF645 family protein -
FDZ90_RS18690 903733..903771 + 39 WP_106019118.1 hypothetical protein -
FDZ90_RS18695 903966..904412 + 447 WP_000006157.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island catB9 - 882589..977840 95251
inside Integron catB9 - 887669..977464 89795


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-93)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-71)


Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 12158.97 Da        Isoelectric Point: 9.7495

>T125036 WP_001180243.1 NZ_CP040173:c899546-899229 [Vibrio cholerae]
MQNKQYKLSQLAQEHLLKIKHYTIENFAEAQWQKYKSTLLSGFQTLADNPGLGKSCEDIYQNGFYFPVGKHMAYYTKEAN
FILIVAVLGQSQLPQKHLKQSRFVS

Download         Length: 318 bp

>T125036 NZ_CP040173:c899546-899229 [Vibrio cholerae]
ATGCAAAATAAACAATATAAGCTCAGCCAATTAGCCCAAGAGCACTTACTCAAGATTAAACACTACACCATTGAAAATTT
CGCTGAAGCGCAGTGGCAAAAATATAAGTCGACCTTGCTTTCAGGTTTCCAAACTCTTGCGGATAACCCAGGACTAGGAA
AAAGCTGTGAAGATATTTACCAAAATGGTTTTTACTTTCCAGTGGGGAAACACATGGCTTATTACACCAAAGAAGCAAAC
TTCATTCTCATTGTTGCGGTATTAGGGCAATCACAACTGCCCCAAAAGCATCTCAAACAGTCACGCTTTGTTTCTTAG

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8961.25 Da        Isoelectric Point: 5.6630

>AT125036 WP_000557292.1 NZ_CP040173:c899807-899565 [Vibrio cholerae]
MHTLTANDAKRNFGELLLSAQREPVIISKNSKNTVVVMSIKDFEELEAMKLDYLKHCFESAQKDLDSGKTVDGATFLNTL

Download         Length: 243 bp

>AT125036 NZ_CP040173:c899807-899565 [Vibrio cholerae]
ATGCACACACTAACAGCAAATGATGCTAAACGAAATTTTGGTGAACTTCTTCTAAGCGCACAACGCGAACCTGTCATCAT
CAGCAAAAACAGTAAGAATACTGTCGTTGTCATGTCCATTAAGGACTTTGAAGAACTTGAAGCAATGAAACTCGATTATC
TCAAACACTGCTTTGAGTCTGCTCAGAAAGACTTAGATAGTGGCAAAACCGTTGATGGTGCCACTTTTCTAAACACCCTT
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0K9UJR8

Antitoxin

Source ID Structure
AlphaFold DB Q7DCR7

References