104349

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-Phd
Location 426039..426586 Replicon chromosome
Accession NZ_CP028895
Organism Vibrio cholerae strain A1552

Toxin (Protein)


Gene name relE Uniprot ID Q9KM92
Locus tag A1552VC_RS16855 Protein ID WP_000229317.1
Coordinates 426284..426586 (+) Length 101 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID Q9KM93
Locus tag A1552VC_RS16850 Protein ID WP_000861987.1
Coordinates 426039..426296 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
A1552VC_RS16795 421068..421523 + 456 WP_001245327.1 GNAT family N-acetyltransferase -
A1552VC_RS16800 421845..421997 + 153 WP_001884520.1 DUF645 family protein -
A1552VC_RS16810 422199..422696 - 498 WP_000982260.1 GNAT family N-acetyltransferase -
A1552VC_RS16815 422693..422965 - 273 WP_000246253.1 DUF1778 domain-containing protein -
A1552VC_RS16820 423196..423864 + 669 WP_000043871.1 hypothetical protein -
A1552VC_RS16825 424016..424303 + 288 WP_000426470.1 hypothetical protein -
A1552VC_RS16830 424444..424815 + 372 WP_001164080.1 nucleotide pyrophosphohydrolase -
A1552VC_RS16835 424882..425307 + 426 WP_001882332.1 DUF1778 domain-containing protein -
A1552VC_RS16840 425304..425837 + 534 WP_000118351.1 GNAT family N-acetyltransferase -
A1552VC_RS16850 426039..426296 + 258 WP_000861987.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
A1552VC_RS16855 426284..426586 + 303 WP_000229317.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
A1552VC_RS16860 426820..427737 + 918 WP_000186333.1 alpha/beta hydrolase -
A1552VC_RS16865 427894..428283 + 390 WP_001081302.1 hypothetical protein -
A1552VC_RS16870 428419..428628 + 210 Protein_465 GNAT family N-acetyltransferase -
A1552VC_RS16875 428747..429184 + 438 WP_000503169.1 IS200/IS605-like element IS1004 family transposase -
A1552VC_RS16880 429248..429466 + 219 WP_071908318.1 GNAT family N-acetyltransferase -
A1552VC_RS16885 429641..430513 + 873 WP_000254716.1 DUF3800 domain-containing protein -
A1552VC_RS16890 430663..431262 + 600 WP_001891245.1 glutathione S-transferase N-terminal domain-containing protein -
A1552VC_RS16895 431319..431423 + 105 WP_099607150.1 acetyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island catB9 - 306914..436175 129261
inside Integron - - 311994..435799 123805
flank IS/Tn - - 428747..429184 437


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-87)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-69)


Sequences

Toxin        


Download         Length: 101 a.a.        Molecular weight: 11726.68 Da        Isoelectric Point: 5.1972

>T104349 WP_000229317.1 NZ_CP028895:426284-426586 [Vibrio cholerae]
MVEIIWTELALSDLNDIAEYIALENVVAAKQLVQTVFTKVERLADFPESGRVPPELEHLNYREVVVSPCRVFYKYDDAKV
RILFVMRAERDLRRLMLTKQ

Download         Length: 303 bp

>T104349 NZ_CP028895:426284-426586 [Vibrio cholerae]
ATGGTTGAAATAATTTGGACGGAGCTGGCTCTATCCGACTTGAATGATATTGCTGAATACATCGCGCTTGAAAATGTCGT
GGCTGCTAAACAACTGGTGCAAACCGTTTTTACAAAAGTTGAACGTTTGGCCGATTTTCCAGAGTCTGGGCGCGTCCCTC
CAGAACTAGAACACCTCAATTATCGTGAAGTCGTTGTAAGTCCGTGTCGTGTTTTCTACAAGTATGATGATGCAAAGGTT
CGTATTCTTTTTGTTATGCGTGCGGAGCGAGATTTGCGTCGGTTAATGCTTACGAAACAGTAG

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9647.15 Da        Isoelectric Point: 7.3178

>AT104349 WP_000861987.1 NZ_CP028895:426039-426296 [Vibrio cholerae]
MKVELVTSLKRQATKILADLHDTKEPVLITEHGKPSAYLIDVDDYEFMQNRLAILEGIARGERALADGKVVSHQDAKDRM
SKWLK

Download         Length: 258 bp

>AT104349 NZ_CP028895:426039-426296 [Vibrio cholerae]
ATGAAAGTAGAACTTGTGACGTCACTAAAACGTCAGGCCACTAAGATCCTTGCCGATCTTCATGATACGAAAGAGCCAGT
ATTGATAACTGAGCACGGAAAACCGTCAGCTTACCTTATTGATGTAGACGACTATGAATTTATGCAAAATCGTTTAGCGA
TCCTGGAAGGTATTGCTCGCGGAGAGCGAGCTTTAGCGGATGGTAAAGTGGTCAGCCATCAAGATGCTAAGGACAGAATG
TCAAAATGGTTGAAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB Q9KM92

Antitoxin

Source ID Structure
AlphaFold DB A0A1T4SLM9

References