Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-YafN
Location 941376..941904 Replicon chromosome
Accession NZ_CP040173
Organism Vibrio cholerae strain VC1374

Toxin (Protein)


Gene name relE Uniprot ID H9L4R3
Locus tag FDZ90_RS19045 Protein ID WP_000221352.1
Coordinates 941376..941666 (-) Length 97 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID H9L4T4
Locus tag FDZ90_RS19050 Protein ID WP_000213183.1
Coordinates 941656..941904 (-) Length 83 a.a.

Genomic Context

FDZ90_RS19000FDZ90_RS19005FDZ90_RS19010FDZ90_RS19015FDZ90_RS19020FDZ90_RS19025FDZ90_RS19030FDZ90_RS19035FDZ90_RS19040FDZ90_RS19055FDZ90_RS19060FDZ90_RS19065FDZ90_RS19070FDZ90_RS19075FDZ90_RS19080FDZ90_RS19045FDZ90_RS19050FDZ90_RS19085
Location: 936646..936756 (111 bp)
Type: Others
Protein ID: WP_134814058.1
Location: 936933..937058 (126 bp)
Type: Others
Protein ID: WP_001944767.1
Location: 937074..937112 (39 bp)
Type: Others
Protein ID: WP_106019119.1
Location: 937325..938329 (1005 bp)
Type: Others
Protein ID: WP_000964925.1
Location: 938482..938928 (447 bp)
Type: Others
Protein ID: WP_000128977.1
Location: 939048..939977 (930 bp)
Type: Others
Protein ID: WP_000335802.1
Location: 939974..940084 (111 bp)
Type: Others
Protein ID: WP_071917832.1
Location: 940112..940588 (477 bp)
Type: Others
Protein ID: WP_001047180.1
Location: 940725..941240 (516 bp)
Type: Others
Protein ID: WP_001201528.1
Location: 942475..943128 (654 bp)
Type: Others
Protein ID: WP_000036957.1
Location: 943400..943825 (426 bp)
Type: Others
Protein ID: WP_000415748.1
Location: 944033..944428 (396 bp)
Type: Others
Protein ID: WP_000649527.1
Location: 944579..945109 (531 bp)
Type: Others
Protein ID: WP_000415563.1
Location: 945247..945747 (501 bp)
Type: Others
Protein ID: WP_000789723.1
Location: 945903..946301 (399 bp)
Type: Others
Protein ID: WP_001882293.1
Location: 941376..941666 (291 bp)
Type: Toxin
Protein ID: WP_000221352.1
Location: 941656..941904 (249 bp)
Type: Antitoxin
Protein ID: WP_000213183.1
Location: 946401..946865 (465 bp)
Type: Others
Protein ID: WP_000140244.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
FDZ90_RS19000936646..936756+111WP_134814058.1DUF3265 domain-containing protein-
FDZ90_RS19005936933..937058+126WP_001944767.1DUF645 family protein-
FDZ90_RS19010937074..937112+39WP_106019119.1hypothetical protein-
FDZ90_RS19015937325..938329+1005WP_000964925.1LD-carboxypeptidase-
FDZ90_RS19020938482..938928+447WP_000128977.1hypothetical protein-
FDZ90_RS19025939048..939977+930WP_000335802.1hypothetical protein-
FDZ90_RS19030939974..940084+111WP_071917832.1DUF3265 domain-containing protein-
FDZ90_RS19035940112..940588+477WP_001047180.1GNAT family N-acetyltransferase-
FDZ90_RS19040940725..941240+516WP_001201528.1lipocalin family protein-
FDZ90_RS19045941376..941666-291WP_000221352.1type II toxin-antitoxin system RelE/ParE family toxinToxin
FDZ90_RS19050941656..941904-249WP_000213183.1type II toxin-antitoxin system Phd/YefM family antitoxinAntitoxin
FDZ90_RS19055942475..943128+654WP_000036957.1site-specific DNA-methyltransferase-
FDZ90_RS19060943400..943825+426WP_000415748.1hypothetical protein-
FDZ90_RS19065944033..944428+396WP_000649527.1DUF3465 domain-containing protein-
FDZ90_RS19070944579..945109+531WP_000415563.1hypothetical protein-
FDZ90_RS19075945247..945747+501WP_000789723.1hypothetical protein-
FDZ90_RS19080945903..946301+399WP_001882293.1hypothetical protein-
FDZ90_RS19085946401..946865-465WP_000140244.1hypothetical protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideGenomic islandcatB9-882589..97784095251
insideIntegroncatB9-887669..97746489795


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-86)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 97 a.a.        Molecular weight: 11247.23 Da        Isoelectric Point: 10.4678

>T125043 WP_000221352.1 NZ_CP040173:c941666-941376 [Vibrio cholerae]
MTYKLEFKKSALKEWKKLAVPLQQQFKKKLIERLENPHVPSAKLSGAENIYKIKLRQSGYRLVYQVENDIIVVTVLAVGK
RERSEVYTKALQRLDD

Download         Length: 291 bp

>T125043 NZ_CP040173:c941666-941376 [Vibrio cholerae]
ATGACCTATAAGCTTGAGTTCAAAAAGAGTGCTTTGAAGGAATGGAAAAAGTTAGCCGTTCCACTCCAACAGCAGTTCAA
GAAGAAACTAATAGAACGCCTTGAAAATCCACATGTTCCATCAGCCAAACTGTCTGGCGCTGAGAACATTTATAAAATAA
AACTTCGGCAGTCTGGTTATCGCTTAGTCTATCAAGTTGAAAATGACATCATCGTAGTTACTGTTTTAGCTGTCGGTAAA
CGAGAACGCAGCGAAGTTTACACTAAAGCGCTGCAACGGCTAGACGACTGA

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 8937.28 Da        Isoelectric Point: 4.1079

>AT125043 WP_000213183.1 NZ_CP040173:c941904-941656 [Vibrio cholerae]
MTTRILADVAASITEFKANPMKVATSAFGAPVAVLNRNEPAFYCVPASTYEIMMDKLEDLELLAIAKERLSEDSVSVNID
DL

Download         Length: 249 bp

>AT125043 NZ_CP040173:c941904-941656 [Vibrio cholerae]
ATGACCACTAGAATCCTAGCTGATGTTGCAGCAAGCATTACCGAATTTAAAGCAAACCCAATGAAAGTTGCAACTAGTGC
CTTCGGTGCTCCTGTTGCTGTACTCAACCGAAATGAGCCGGCTTTCTACTGCGTCCCTGCAAGCACCTACGAGATCATGA
TGGATAAGCTTGAAGATCTTGAGCTACTGGCTATTGCCAAAGAACGCTTAAGTGAAGACAGCGTATCGGTAAATATCGAT
GACCTATAA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBH9L4R3

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A366A3W8

References