125043

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-YafN
Location 941376..941904 Replicon chromosome
Accession NZ_CP040173
Organism Vibrio cholerae strain VC1374

Toxin (Protein)


Gene name relE Uniprot ID H9L4R3
Locus tag FDZ90_RS19045 Protein ID WP_000221352.1
Coordinates 941376..941666 (-) Length 97 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID H9L4T4
Locus tag FDZ90_RS19050 Protein ID WP_000213183.1
Coordinates 941656..941904 (-) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FDZ90_RS19000 936646..936756 + 111 WP_134814058.1 DUF3265 domain-containing protein -
FDZ90_RS19005 936933..937058 + 126 WP_001944767.1 DUF645 family protein -
FDZ90_RS19010 937074..937112 + 39 WP_106019119.1 hypothetical protein -
FDZ90_RS19015 937325..938329 + 1005 WP_000964925.1 LD-carboxypeptidase -
FDZ90_RS19020 938482..938928 + 447 WP_000128977.1 hypothetical protein -
FDZ90_RS19025 939048..939977 + 930 WP_000335802.1 hypothetical protein -
FDZ90_RS19030 939974..940084 + 111 WP_071917832.1 DUF3265 domain-containing protein -
FDZ90_RS19035 940112..940588 + 477 WP_001047180.1 GNAT family N-acetyltransferase -
FDZ90_RS19040 940725..941240 + 516 WP_001201528.1 lipocalin family protein -
FDZ90_RS19045 941376..941666 - 291 WP_000221352.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
FDZ90_RS19050 941656..941904 - 249 WP_000213183.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
FDZ90_RS19055 942475..943128 + 654 WP_000036957.1 site-specific DNA-methyltransferase -
FDZ90_RS19060 943400..943825 + 426 WP_000415748.1 hypothetical protein -
FDZ90_RS19065 944033..944428 + 396 WP_000649527.1 DUF3465 domain-containing protein -
FDZ90_RS19070 944579..945109 + 531 WP_000415563.1 hypothetical protein -
FDZ90_RS19075 945247..945747 + 501 WP_000789723.1 hypothetical protein -
FDZ90_RS19080 945903..946301 + 399 WP_001882293.1 hypothetical protein -
FDZ90_RS19085 946401..946865 - 465 WP_000140244.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island catB9 - 882589..977840 95251
inside Integron catB9 - 887669..977464 89795


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-86)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 97 a.a.        Molecular weight: 11247.23 Da        Isoelectric Point: 10.4678

>T125043 WP_000221352.1 NZ_CP040173:c941666-941376 [Vibrio cholerae]
MTYKLEFKKSALKEWKKLAVPLQQQFKKKLIERLENPHVPSAKLSGAENIYKIKLRQSGYRLVYQVENDIIVVTVLAVGK
RERSEVYTKALQRLDD

Download         Length: 291 bp

>T125043 NZ_CP040173:c941666-941376 [Vibrio cholerae]
ATGACCTATAAGCTTGAGTTCAAAAAGAGTGCTTTGAAGGAATGGAAAAAGTTAGCCGTTCCACTCCAACAGCAGTTCAA
GAAGAAACTAATAGAACGCCTTGAAAATCCACATGTTCCATCAGCCAAACTGTCTGGCGCTGAGAACATTTATAAAATAA
AACTTCGGCAGTCTGGTTATCGCTTAGTCTATCAAGTTGAAAATGACATCATCGTAGTTACTGTTTTAGCTGTCGGTAAA
CGAGAACGCAGCGAAGTTTACACTAAAGCGCTGCAACGGCTAGACGACTGA

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 8937.28 Da        Isoelectric Point: 4.1079

>AT125043 WP_000213183.1 NZ_CP040173:c941904-941656 [Vibrio cholerae]
MTTRILADVAASITEFKANPMKVATSAFGAPVAVLNRNEPAFYCVPASTYEIMMDKLEDLELLAIAKERLSEDSVSVNID
DL

Download         Length: 249 bp

>AT125043 NZ_CP040173:c941904-941656 [Vibrio cholerae]
ATGACCACTAGAATCCTAGCTGATGTTGCAGCAAGCATTACCGAATTTAAAGCAAACCCAATGAAAGTTGCAACTAGTGC
CTTCGGTGCTCCTGTTGCTGTACTCAACCGAAATGAGCCGGCTTTCTACTGCGTCCCTGCAAGCACCTACGAGATCATGA
TGGATAAGCTTGAAGATCTTGAGCTACTGGCTATTGCCAAAGAACGCTTAAGTGAAGACAGCGTATCGGTAAATATCGAT
GACCTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB H9L4R3

Antitoxin

Source ID Structure
AlphaFold DB A0A366A3W8

References