Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-RelB
Location 45408..45967 Replicon chromosome
Accession NZ_AP024548
Organism Vibrio cholerae strain BCH-01536

Toxin (Protein)


Gene name relE Uniprot ID Q9K2M8
Locus tag K6J77_RS14205 Protein ID WP_000578476.1
Coordinates 45408..45686 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID Q9L991
Locus tag K6J77_RS14210 Protein ID WP_000381183.1
Coordinates 45683..45967 (-) Length 95 a.a.

Genomic Context

K6J77_RS14165K6J77_RS14170K6J77_RS14175K6J77_RS14180K6J77_RS18995K6J77_RS14185K6J77_RS14190K6J77_RS14195K6J77_RS19000K6J77_RS14200K6J77_RS14215K6J77_RS14220K6J77_RS19005K6J77_RS14225K6J77_RS14230K6J77_RS14235K6J77_RS14240K6J77_RS14245K6J77_RS14250K6J77_RS14205K6J77_RS14210
Location: 40486..40992 (507 bp)
Type: Others
Protein ID: WP_000393074.1
Location: 41149..41535 (387 bp)
Type: Others
Protein ID: WP_000703163.1
Location: 41792..41995 (204 bp)
Type: Others
Protein ID: WP_001911580.1
Location: 42190..42441 (252 bp)
Type: Others
Protein ID: WP_001890111.1
Location: 42414..42563 (150 bp)
Type: Others
Protein ID: WP_071908333.1
Location: 42710..43135 (426 bp)
Type: Others
Protein ID: WP_000415750.1
Location: 43341..43964 (624 bp)
Type: Others
Protein ID: WP_000247070.1
Location: 44177..44656 (480 bp)
Type: Others
Protein ID: WP_000009888.1
Location: 44653..44769 (117 bp)
Type: Others
Protein ID: WP_086010882.1
Location: 44844..45257 (414 bp)
Type: Others
Protein ID: WP_000049420.1
Location: 46216..46677 (462 bp)
Type: Others
Protein ID: WP_001911578.1
Location: 46742..47338 (597 bp)
Type: Others
Protein ID: WP_000255434.1
Location: 47532..47669 (138 bp)
Type: Others
Protein ID: WP_001890145.1
Location: 47730..47912 (183 bp)
Type: Others
Protein ID: WP_000923182.1
Location: 48112..48585 (474 bp)
Type: Others
Protein ID: WP_001161076.1
Location: 48600..48692 (93 bp)
Type: Others
Protein ID: WP_014378730.1
Location: 48734..49360 (627 bp)
Type: Others
Protein ID: WP_000365424.1
Location: 49483..50181 (699 bp)
Type: Others
Protein ID: WP_001890502.1
Location: 50212..50301 (90 bp)
Type: Others
Protein ID: WP_072606010.1
Location: 45408..45686 (279 bp)
Type: Toxin
Protein ID: WP_000578476.1
Location: 45683..45967 (285 bp)
Type: Antitoxin
Protein ID: WP_000381183.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
K6J77_RS1416540486..40992+507WP_000393074.1hypothetical protein-
K6J77_RS1417041149..41535+387WP_000703163.1VOC family protein-
K6J77_RS1417541792..41995+204WP_001911580.1hypothetical protein-
K6J77_RS1418042190..42441+252WP_001890111.1TIGR03643 family protein-
K6J77_RS1899542414..42563+150WP_071908333.1DUF3265 domain-containing protein-
K6J77_RS1418542710..43135+426WP_000415750.1hypothetical protein-
K6J77_RS1419043341..43964+624WP_000247070.1DUF1349 domain-containing protein-
K6J77_RS1419544177..44656+480WP_000009888.1lecithin retinol acyltransferase family protein-
K6J77_RS1900044653..44769+117WP_086010882.1DUF3265 domain-containing protein-
K6J77_RS1420044844..45257+414WP_000049420.1VOC family protein-
K6J77_RS1420545408..45686-279WP_000578476.1type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE familyToxin
K6J77_RS1421045683..45967-285WP_000381183.1type II toxin-antitoxin system RelB/DinJ family antitoxinAntitoxin
K6J77_RS1421546216..46677+462WP_001911578.1lipocalin family protein-
K6J77_RS1422046742..47338+597WP_000255434.1hypothetical protein-
K6J77_RS1900547532..47669+138WP_001890145.1hypothetical protein-
K6J77_RS1422547730..47912+183WP_000923182.1DUF645 family protein-
K6J77_RS1423048112..48585+474WP_001161076.1GrpB family protein-
K6J77_RS1423548600..48692+93WP_014378730.1DUF3265 domain-containing protein-
K6J77_RS1424048734..49360+627WP_000365424.1LysE family translocator-
K6J77_RS1424549483..50181+699WP_001890502.1hypothetical protein-
K6J77_RS1425050212..50301+90WP_072606010.1DUF3265 domain-containing protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
insideIntegron--11978..113648101670


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(2-89)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(5-70)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10819.59 Da        Isoelectric Point: 5.1651

>T38620 WP_000578476.1 NZ_AP024548:c45686-45408 [Vibrio cholerae]
MIFWEEASLNDREKIFEFLYDFNPAAAKKTDELIEAKVENLLEQPLIGVQRDGIRGRLLIIPEISMIVSYWVDGSKIRIM
RVLHQKQKFPND

Download         Length: 279 bp

>T38620 NZ_AP024548:c45686-45408 [Vibrio cholerae]
ATGATTTTCTGGGAAGAAGCATCTCTCAATGATCGTGAGAAAATTTTCGAATTTCTCTACGACTTTAACCCAGCAGCGGC
TAAAAAAACGGATGAGCTCATAGAAGCCAAAGTCGAAAATTTGCTTGAGCAACCACTAATCGGTGTTCAGCGTGATGGCA
TTAGAGGCAGATTGCTTATTATCCCTGAGATATCAATGATTGTTTCGTATTGGGTTGATGGTTCTAAAATTCGAATAATG
CGTGTACTACATCAGAAACAAAAATTTCCAAACGACTGA

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10901.25 Da        Isoelectric Point: 8.0775

>AT38620 WP_000381183.1 NZ_AP024548:c45967-45683 [Vibrio cholerae]
MDTRIQFRVDEETKRLAQQMAESQGRTLSDACRELTEQLAEQQRKALSHDAWLTEQVNQAFEKFDSGKAVFIEHDIAKAR
MAERKAKIRNRGHA

Download         Length: 285 bp

>AT38620 NZ_AP024548:c45967-45683 [Vibrio cholerae]
ATGGATACTAGAATTCAATTTCGTGTAGACGAAGAAACAAAACGTTTAGCTCAACAAATGGCTGAAAGCCAAGGTCGAAC
TCTTAGCGATGCTTGCCGTGAACTCACTGAACAATTAGCTGAGCAGCAACGCAAGGCATTATCTCACGATGCATGGCTAA
CTGAACAAGTGAATCAAGCATTTGAGAAGTTCGACTCAGGAAAAGCAGTATTCATTGAACATGACATCGCCAAAGCACGA
ATGGCTGAACGTAAAGCTAAAATCCGAAATCGAGGCCACGCATGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBQ9K2M8

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A067BL33

References