38620

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-RelB
Location 45408..45967 Replicon chromosome
Accession NZ_AP024548
Organism Vibrio cholerae strain BCH-01536

Toxin (Protein)


Gene name relE Uniprot ID Q9K2M8
Locus tag K6J77_RS14205 Protein ID WP_000578476.1
Coordinates 45408..45686 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID Q9L991
Locus tag K6J77_RS14210 Protein ID WP_000381183.1
Coordinates 45683..45967 (-) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K6J77_RS14165 40486..40992 + 507 WP_000393074.1 hypothetical protein -
K6J77_RS14170 41149..41535 + 387 WP_000703163.1 VOC family protein -
K6J77_RS14175 41792..41995 + 204 WP_001911580.1 hypothetical protein -
K6J77_RS14180 42190..42441 + 252 WP_001890111.1 TIGR03643 family protein -
K6J77_RS18995 42414..42563 + 150 WP_071908333.1 DUF3265 domain-containing protein -
K6J77_RS14185 42710..43135 + 426 WP_000415750.1 hypothetical protein -
K6J77_RS14190 43341..43964 + 624 WP_000247070.1 DUF1349 domain-containing protein -
K6J77_RS14195 44177..44656 + 480 WP_000009888.1 lecithin retinol acyltransferase family protein -
K6J77_RS19000 44653..44769 + 117 WP_086010882.1 DUF3265 domain-containing protein -
K6J77_RS14200 44844..45257 + 414 WP_000049420.1 VOC family protein -
K6J77_RS14205 45408..45686 - 279 WP_000578476.1 type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family Toxin
K6J77_RS14210 45683..45967 - 285 WP_000381183.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
K6J77_RS14215 46216..46677 + 462 WP_001911578.1 lipocalin family protein -
K6J77_RS14220 46742..47338 + 597 WP_000255434.1 hypothetical protein -
K6J77_RS19005 47532..47669 + 138 WP_001890145.1 hypothetical protein -
K6J77_RS14225 47730..47912 + 183 WP_000923182.1 DUF645 family protein -
K6J77_RS14230 48112..48585 + 474 WP_001161076.1 GrpB family protein -
K6J77_RS14235 48600..48692 + 93 WP_014378730.1 DUF3265 domain-containing protein -
K6J77_RS14240 48734..49360 + 627 WP_000365424.1 LysE family translocator -
K6J77_RS14245 49483..50181 + 699 WP_001890502.1 hypothetical protein -
K6J77_RS14250 50212..50301 + 90 WP_072606010.1 DUF3265 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Integron - - 11978..113648 101670


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(2-89)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(5-70)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10819.59 Da        Isoelectric Point: 5.1651

>T38620 WP_000578476.1 NZ_AP024548:c45686-45408 [Vibrio cholerae]
MIFWEEASLNDREKIFEFLYDFNPAAAKKTDELIEAKVENLLEQPLIGVQRDGIRGRLLIIPEISMIVSYWVDGSKIRIM
RVLHQKQKFPND

Download         Length: 279 bp

>T38620 NZ_AP024548:c45686-45408 [Vibrio cholerae]
ATGATTTTCTGGGAAGAAGCATCTCTCAATGATCGTGAGAAAATTTTCGAATTTCTCTACGACTTTAACCCAGCAGCGGC
TAAAAAAACGGATGAGCTCATAGAAGCCAAAGTCGAAAATTTGCTTGAGCAACCACTAATCGGTGTTCAGCGTGATGGCA
TTAGAGGCAGATTGCTTATTATCCCTGAGATATCAATGATTGTTTCGTATTGGGTTGATGGTTCTAAAATTCGAATAATG
CGTGTACTACATCAGAAACAAAAATTTCCAAACGACTGA

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10901.25 Da        Isoelectric Point: 8.0775

>AT38620 WP_000381183.1 NZ_AP024548:c45967-45683 [Vibrio cholerae]
MDTRIQFRVDEETKRLAQQMAESQGRTLSDACRELTEQLAEQQRKALSHDAWLTEQVNQAFEKFDSGKAVFIEHDIAKAR
MAERKAKIRNRGHA

Download         Length: 285 bp

>AT38620 NZ_AP024548:c45967-45683 [Vibrio cholerae]
ATGGATACTAGAATTCAATTTCGTGTAGACGAAGAAACAAAACGTTTAGCTCAACAAATGGCTGAAAGCCAAGGTCGAAC
TCTTAGCGATGCTTGCCGTGAACTCACTGAACAATTAGCTGAGCAGCAACGCAAGGCATTATCTCACGATGCATGGCTAA
CTGAACAAGTGAATCAAGCATTTGAGAAGTTCGACTCAGGAAAAGCAGTATTCATTGAACATGACATCGCCAAAGCACGA
ATGGCTGAACGTAAAGCTAAAATCCGAAATCGAGGCCACGCATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB Q9K2M8

Antitoxin

Source ID Structure
AlphaFold DB A0A067BL33

References