Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /DUF1778(antitoxin)
Location 845981..846780 Replicon chromosome
Accession NZ_CP090400
Organism Vibrio cholerae strain PanChol

Toxin (Protein)


Gene name - Uniprot ID Q9KM94
Locus tag LZM82_RS17305 Protein ID WP_000118351.1
Coordinates 845981..846514 (-) Length 178 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID A0A0K9UER4
Locus tag LZM82_RS17310 Protein ID WP_000179600.1
Coordinates 846511..846780 (-) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LZM82_RS17260 (LZM82_17260) 841305..842177 - 873 WP_000254716.1 DUF3800 domain-containing protein -
LZM82_RS17265 (LZM82_17265) 842352..842573 - 222 Protein_720 GNAT family N-acetyltransferase -
LZM82_RS17270 (LZM82_17270) 842634..843071 - 438 WP_000503164.1 IS200/IS605-like element IS1004 family transposase -
LZM82_RS17275 (LZM82_17275) 843190..843399 - 210 Protein_722 GNAT family N-acetyltransferase -
LZM82_RS17280 (LZM82_17280) 843535..843924 - 390 WP_001081302.1 hypothetical protein -
LZM82_RS17285 (LZM82_17285) 844081..844998 - 918 WP_000186333.1 alpha/beta hydrolase -
LZM82_RS17290 (LZM82_17290) 845232..845534 - 303 WP_000229317.1 type II toxin-antitoxin system RelE/ParE family toxin -
LZM82_RS17295 (LZM82_17295) 845522..845779 - 258 WP_000861987.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
LZM82_RS17300 (LZM82_17300) 845861..845971 - 111 WP_086010065.1 DUF3265 domain-containing protein -
LZM82_RS17305 (LZM82_17305) 845981..846514 - 534 WP_000118351.1 GNAT family N-acetyltransferase Toxin
LZM82_RS17310 (LZM82_17310) 846511..846780 - 270 WP_000179600.1 DUF1778 domain-containing protein Antitoxin
LZM82_RS17315 (LZM82_17315) 847003..847374 - 372 WP_001164080.1 MazG nucleotide pyrophosphohydrolase domain-containing protein -
LZM82_RS17320 (LZM82_17320) 847515..847802 - 288 WP_000426470.1 hypothetical protein -
LZM82_RS17325 (LZM82_17325) 847954..848622 - 669 WP_000043871.1 hypothetical protein -
LZM82_RS17330 (LZM82_17330) 848639..848701 - 63 Protein_733 acetyltransferase -
LZM82_RS17335 (LZM82_17335) 848853..849125 + 273 WP_000246253.1 DUF1778 domain-containing protein -
LZM82_RS17340 (LZM82_17340) 849122..849619 + 498 WP_000982260.1 GNAT family N-acetyltransferase -
LZM82_RS17345 (LZM82_17345) 849636..849704 - 69 Protein_736 acetyltransferase -
LZM82_RS17350 (LZM82_17350) 849821..849925 - 105 WP_228840819.1 DUF645 family protein -
LZM82_RS17360 (LZM82_17360) 850116..850238 - 123 Protein_738 acetyltransferase -
LZM82_RS17365 (LZM82_17365) 850295..850750 - 456 WP_001245327.1 GNAT family N-acetyltransferase -
LZM82_RS17370 (LZM82_17370) 850878..851165 - 288 WP_000221354.1 type II toxin-antitoxin system RelE/ParE family toxin -
LZM82_RS17375 (LZM82_17375) 851155..851406 - 252 WP_001250179.1 type II toxin-antitoxin system Phd/YefM family antitoxin -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island catB9 - 835643..943910 108267
inside Integron - - 836019..937068 101049
flank IS/Tn - - 842634..843071 437


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(97-153)

Antitoxin

Vibrio phage ICP1, Orf50

(5-81)


Sequences

Toxin        


Download         Length: 178 a.a.        Molecular weight: 20171.46 Da        Isoelectric Point: 9.1432

>T230638 WP_000118351.1 NZ_CP090400:c846514-845981 [Vibrio cholerae]
VSWGKEFVELSKSKHDRDSFDCGEQELNTFIKTQAAKHMQAGISRTMVLPSAHPLLNQKFAICAFYSVAPSSISRETLPA
QLAKKLPRYPIPVFLLAQLAVHKEFHGSGLGKVSLIRALKYLWEVNHHMRAYAIVVDCLTDSAQAFYTKFGFEVLCEHNE
RIRMFLPMKTVEQLFNQ

Download         Length: 534 bp

>T230638 NZ_CP125220:c4179801-4179310 [Salmonella enterica subsp. enterica serovar Enteritidis]
ATGATCTCCACCCCTGAGCCGCTTCATGCCGGACATATTCTTACTCCGTTTTGCTGCGGTGTGGATTCTATAGATAACTG
GCTGAAACAGCGGGCGATGAAAAATCAGACCACTGGCGCGTCCCGTACCTTTGTGTGTTGTGGCAGCGATTCGAACGTAC
TGGCCTATTACTCGCTGGCGTCCAGCGCGGTCACGACGAATACCTCCCCCGGTCGCTTTCGTCGCAATATGCCTGACCCG
ATTCCGGTTGTGGTATTGGGGCGTCTGGCGGTGGATAAATCGCTTCATGGGCAGGGCGTCGCTCGGGCGCTGGTACGCGA
CGCAGGGCTGCGGGTTATTCAGGTGGCGGAGACTATCGGCATTCGTGGGATGCTGGTTCACGCCCTGTCGGATGAAGCGC
GGGAATTTTATCAGCGGGTGGGGTTTGTACCGTCGCCGATGGATCCGATGATGTTGATGGTGACGTTGGGGGATTTGGTG
GAGAGTGTTTAA

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 9924.49 Da        Isoelectric Point: 4.9107

>AT230638 WP_000179600.1 NZ_CP090400:c846780-846511 [Vibrio cholerae]
MATARLDIRLDEEIKAKAEKASALLGLKSLTEYVVRLMDEDATHVIEEHESIMVKDSVFDEFMAACNKVKAPNQALLEAV
KFTEKSGIK

Download         Length: 270 bp

>AT230638 NZ_CP125220:c4180091-4179798 [Salmonella enterica subsp. enterica serovar Enteritidis]
ATGCCAGCCGCAAACAGTATGGCGATGAAACGCGAAACCCTGAACCTGCGTATCAAACCCGCCGAGCGCGATCTTATTGA
TCGAGCGGCGAAAGCCAGAGGGAAAAACCGCACTGACTTTGTGCTGGAAGCTGCCCGTGCTGCCGCCGAGGAAGCGCTGA
TCGAACAACGCATCATTATGGCCGATCCAGAGGCTTATCAGGAGTTTCTCGTTCGTTTGGATCAAACACCTTCACCTAAT
GCCGCACTGCGTAAAACCATGCAGACCCCTGCGCCGTGGGAGCAGGAAAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB Q9KM94

Antitoxin

Source ID Structure
AlphaFold DB A0A0K9UER4

References