Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /DUF1778(antitoxin)
Location 845981..846780 Replicon chromosome
Accession NZ_CP090400
Organism Vibrio cholerae strain PanChol

Toxin (Protein)


Gene name - Uniprot ID Q9KM94
Locus tag LZM82_RS17305 Protein ID WP_000118351.1
Coordinates 845981..846514 (-) Length 178 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID A0A0K9UER4
Locus tag LZM82_RS17310 Protein ID WP_000179600.1
Coordinates 846511..846780 (-) Length 90 a.a.

Genomic Context

LZM82_RS17335LZM82_RS17340LZM82_RS17260LZM82_RS17265LZM82_RS17270LZM82_RS17275LZM82_RS17280LZM82_RS17285LZM82_RS17290LZM82_RS17295LZM82_RS17300LZM82_RS17305LZM82_RS17310LZM82_RS17315LZM82_RS17320LZM82_RS17325LZM82_RS17330LZM82_RS17345LZM82_RS17350LZM82_RS17360LZM82_RS17365LZM82_RS17370LZM82_RS17375
Location: 848853..849125 (273 bp)
Type: Others
Protein ID: WP_000246253.1
Location: 849122..849619 (498 bp)
Type: Others
Protein ID: WP_000982260.1
Location: 841305..842177 (873 bp)
Type: Others
Protein ID: WP_000254716.1
Location: 842352..842573 (222 bp)
Type: Others
Protein ID: Protein_720
Location: 842634..843071 (438 bp)
Type: Others
Protein ID: WP_000503164.1
Location: 843190..843399 (210 bp)
Type: Others
Protein ID: Protein_722
Location: 843535..843924 (390 bp)
Type: Others
Protein ID: WP_001081302.1
Location: 844081..844998 (918 bp)
Type: Others
Protein ID: WP_000186333.1
Location: 845232..845534 (303 bp)
Type: Others
Protein ID: WP_000229317.1
Location: 845522..845779 (258 bp)
Type: Others
Protein ID: WP_000861987.1
Location: 845861..845971 (111 bp)
Type: Others
Protein ID: WP_086010065.1
Location: 845981..846514 (534 bp)
Type: Toxin
Protein ID: WP_000118351.1
Location: 846511..846780 (270 bp)
Type: Antitoxin
Protein ID: WP_000179600.1
Location: 847003..847374 (372 bp)
Type: Others
Protein ID: WP_001164080.1
Location: 847515..847802 (288 bp)
Type: Others
Protein ID: WP_000426470.1
Location: 847954..848622 (669 bp)
Type: Others
Protein ID: WP_000043871.1
Location: 848639..848701 (63 bp)
Type: Others
Protein ID: Protein_733
Location: 849636..849704 (69 bp)
Type: Others
Protein ID: Protein_736
Location: 849821..849925 (105 bp)
Type: Others
Protein ID: WP_228840819.1
Location: 850116..850238 (123 bp)
Type: Others
Protein ID: Protein_738
Location: 850295..850750 (456 bp)
Type: Others
Protein ID: WP_001245327.1
Location: 850878..851165 (288 bp)
Type: Others
Protein ID: WP_000221354.1
Location: 851155..851406 (252 bp)
Type: Others
Protein ID: WP_001250179.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
LZM82_RS17260 (LZM82_17260)841305..842177-873WP_000254716.1DUF3800 domain-containing protein-
LZM82_RS17265 (LZM82_17265)842352..842573-222Protein_720GNAT family N-acetyltransferase-
LZM82_RS17270 (LZM82_17270)842634..843071-438WP_000503164.1IS200/IS605-like element IS1004 family transposase-
LZM82_RS17275 (LZM82_17275)843190..843399-210Protein_722GNAT family N-acetyltransferase-
LZM82_RS17280 (LZM82_17280)843535..843924-390WP_001081302.1hypothetical protein-
LZM82_RS17285 (LZM82_17285)844081..844998-918WP_000186333.1alpha/beta hydrolase-
LZM82_RS17290 (LZM82_17290)845232..845534-303WP_000229317.1type II toxin-antitoxin system RelE/ParE family toxin-
LZM82_RS17295 (LZM82_17295)845522..845779-258WP_000861987.1type II toxin-antitoxin system Phd/YefM family antitoxin-
LZM82_RS17300 (LZM82_17300)845861..845971-111WP_086010065.1DUF3265 domain-containing protein-
LZM82_RS17305 (LZM82_17305)845981..846514-534WP_000118351.1GNAT family N-acetyltransferaseToxin
LZM82_RS17310 (LZM82_17310)846511..846780-270WP_000179600.1DUF1778 domain-containing proteinAntitoxin
LZM82_RS17315 (LZM82_17315)847003..847374-372WP_001164080.1MazG nucleotide pyrophosphohydrolase domain-containing protein-
LZM82_RS17320 (LZM82_17320)847515..847802-288WP_000426470.1hypothetical protein-
LZM82_RS17325 (LZM82_17325)847954..848622-669WP_000043871.1hypothetical protein-
LZM82_RS17330 (LZM82_17330)848639..848701-63Protein_733acetyltransferase-
LZM82_RS17335 (LZM82_17335)848853..849125+273WP_000246253.1DUF1778 domain-containing protein-
LZM82_RS17340 (LZM82_17340)849122..849619+498WP_000982260.1GNAT family N-acetyltransferase-
LZM82_RS17345 (LZM82_17345)849636..849704-69Protein_736acetyltransferase-
LZM82_RS17350 (LZM82_17350)849821..849925-105WP_228840819.1DUF645 family protein-
LZM82_RS17360 (LZM82_17360)850116..850238-123Protein_738acetyltransferase-
LZM82_RS17365 (LZM82_17365)850295..850750-456WP_001245327.1GNAT family N-acetyltransferase-
LZM82_RS17370 (LZM82_17370)850878..851165-288WP_000221354.1type II toxin-antitoxin system RelE/ParE family toxin-
LZM82_RS17375 (LZM82_17375)851155..851406-252WP_001250179.1type II toxin-antitoxin system Phd/YefM family antitoxin-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideGenomic islandcatB9-835643..943910108267
insideIntegron--836019..937068101049
flankIS/Tn--842634..843071437


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(97-153)

Antitoxin

Vibrio phage ICP1, Orf50

(5-81)


Sequences

Toxin        


Download         Length: 178 a.a.        Molecular weight: 20171.46 Da        Isoelectric Point: 9.1432

>T230638 WP_000118351.1 NZ_CP090400:c846514-845981 [Vibrio cholerae]
VSWGKEFVELSKSKHDRDSFDCGEQELNTFIKTQAAKHMQAGISRTMVLPSAHPLLNQKFAICAFYSVAPSSISRETLPA
QLAKKLPRYPIPVFLLAQLAVHKEFHGSGLGKVSLIRALKYLWEVNHHMRAYAIVVDCLTDSAQAFYTKFGFEVLCEHNE
RIRMFLPMKTVEQLFNQ

Download         Length: 534 bp

>T230638 NZ_CP125220:c4179801-4179310 [Salmonella enterica subsp. enterica serovar Enteritidis]
ATGATCTCCACCCCTGAGCCGCTTCATGCCGGACATATTCTTACTCCGTTTTGCTGCGGTGTGGATTCTATAGATAACTG
GCTGAAACAGCGGGCGATGAAAAATCAGACCACTGGCGCGTCCCGTACCTTTGTGTGTTGTGGCAGCGATTCGAACGTAC
TGGCCTATTACTCGCTGGCGTCCAGCGCGGTCACGACGAATACCTCCCCCGGTCGCTTTCGTCGCAATATGCCTGACCCG
ATTCCGGTTGTGGTATTGGGGCGTCTGGCGGTGGATAAATCGCTTCATGGGCAGGGCGTCGCTCGGGCGCTGGTACGCGA
CGCAGGGCTGCGGGTTATTCAGGTGGCGGAGACTATCGGCATTCGTGGGATGCTGGTTCACGCCCTGTCGGATGAAGCGC
GGGAATTTTATCAGCGGGTGGGGTTTGTACCGTCGCCGATGGATCCGATGATGTTGATGGTGACGTTGGGGGATTTGGTG
GAGAGTGTTTAA

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 9924.49 Da        Isoelectric Point: 4.9107

>AT230638 WP_000179600.1 NZ_CP090400:c846780-846511 [Vibrio cholerae]
MATARLDIRLDEEIKAKAEKASALLGLKSLTEYVVRLMDEDATHVIEEHESIMVKDSVFDEFMAACNKVKAPNQALLEAV
KFTEKSGIK

Download         Length: 270 bp

>AT230638 NZ_CP125220:c4180091-4179798 [Salmonella enterica subsp. enterica serovar Enteritidis]
ATGCCAGCCGCAAACAGTATGGCGATGAAACGCGAAACCCTGAACCTGCGTATCAAACCCGCCGAGCGCGATCTTATTGA
TCGAGCGGCGAAAGCCAGAGGGAAAAACCGCACTGACTTTGTGCTGGAAGCTGCCCGTGCTGCCGCCGAGGAAGCGCTGA
TCGAACAACGCATCATTATGGCCGATCCAGAGGCTTATCAGGAGTTTCTCGTTCGTTTGGATCAAACACCTTCACCTAAT
GCCGCACTGCGTAAAACCATGCAGACCCCTGCGCCGTGGGAGCAGGAAAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBQ9KM94

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A0K9UER4

References