Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /BrnT(toxin)
Location 333921..334419 Replicon chromosome II
Accession NC_016945
Organism Vibrio cholerae IEC224

Toxin (Protein)


Gene name - Uniprot ID Q9KMK7
Locus tag O3Y_RS15525 Protein ID WP_000589156.1
Coordinates 333921..334187 (+) Length 89 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID Q9KMK6
Locus tag O3Y_RS15530 Protein ID WP_000643598.1
Coordinates 334174..334419 (+) Length 82 a.a.

Genomic Context

O3Y_RS20160O3Y_RS20165O3Y_RS15490O3Y_RS15495O3Y_RS19635O3Y_RS15500O3Y_RS15505O3Y_RS20580O3Y_RS20585O3Y_RS15515O3Y_RS15520O3Y_RS15525O3Y_RS15530O3Y_RS15535O3Y_RS20590O3Y_RS15540O3Y_RS15545O3Y_RS15550O3Y_RS15555O3Y_RS15560O3Y_RS15565
Location: 329341..329547 (207 bp)
Type: Others
Protein ID: Protein_292
Location: 329747..329848 (102 bp)
Type: Others
Protein ID: WP_001921603.1
Location: 329838..330224 (387 bp)
Type: Others
Protein ID: WP_000703163.1
Location: 330419..330670 (252 bp)
Type: Others
Protein ID: WP_001890111.1
Location: 330643..330792 (150 bp)
Type: Others
Protein ID: WP_071908333.1
Location: 330884..331126 (243 bp)
Type: Others
Protein ID: WP_000107461.1
Location: 331378..331656 (279 bp)
Type: Others
Protein ID: WP_000280324.1
Location: 332031..332174 (144 bp)
Type: Others
Protein ID: Protein_299
Location: 332228..332266 (39 bp)
Type: Others
Protein ID: WP_082798268.1
Location: 332478..332945 (468 bp)
Type: Others
Protein ID: WP_001289288.1
Location: 333073..333736 (664 bp)
Type: Others
Protein ID: Protein_302
Location: 333921..334187 (267 bp)
Type: Toxin
Protein ID: WP_000589156.1
Location: 334174..334419 (246 bp)
Type: Antitoxin
Protein ID: WP_000643598.1
Location: 334515..335309 (795 bp)
Type: Others
Protein ID: WP_001911581.1
Location: 335412..335540 (129 bp)
Type: Others
Protein ID: WP_071908338.1
Location: 335601..335783 (183 bp)
Type: Others
Protein ID: WP_000923182.1
Location: 335999..337003 (1005 bp)
Type: Others
Protein ID: WP_000964920.1
Location: 337156..337515 (360 bp)
Type: Others
Protein ID: WP_001071541.1
Location: 337788..338021 (234 bp)
Type: Others
Protein ID: WP_001890112.1
Location: 338289..338795 (507 bp)
Type: Others
Protein ID: WP_000393074.1
Location: 338952..339338 (387 bp)
Type: Others
Protein ID: WP_000703163.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
O3Y_RS20160329341..329547+207Protein_292DUF3709 domain-containing protein-
O3Y_RS20165329747..329848+102WP_001921603.1hypothetical protein-
O3Y_RS15490329838..330224+387WP_000703163.1VOC family protein-
O3Y_RS15495330419..330670+252WP_001890111.1TIGR03643 family protein-
O3Y_RS19635330643..330792+150WP_071908333.1DUF3265 domain-containing protein-
O3Y_RS15500330884..331126+243WP_000107461.1hypothetical protein-
O3Y_RS15505331378..331656+279WP_000280324.1DUF3709 domain-containing protein-
O3Y_RS20580332031..332174+144Protein_299DUF645 family protein-
O3Y_RS20585332228..332266+39WP_082798268.1hypothetical protein-
O3Y_RS15515332478..332945+468WP_001289288.1OsmC family protein-
O3Y_RS15520333073..333736+664Protein_302hypothetical protein-
O3Y_RS15525333921..334187+267WP_000589156.1BrnT family toxinToxin
O3Y_RS15530334174..334419+246WP_000643598.1hypothetical proteinAntitoxin
O3Y_RS15535334515..335309+795WP_001911581.1hypothetical protein-
O3Y_RS20590335412..335540+129WP_071908338.1general secretion pathway protein GspI-
O3Y_RS15540335601..335783+183WP_000923182.1DUF645 family protein-
O3Y_RS15545335999..337003+1005WP_000964920.1LD-carboxypeptidase-
O3Y_RS15550337156..337515+360WP_001071541.1VOC family protein-
O3Y_RS15555337788..338021+234WP_001890112.1DUF3709 domain-containing protein-
O3Y_RS15560338289..338795+507WP_000393074.1hypothetical protein-
O3Y_RS15565338952..339338+387WP_000703163.1VOC family protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideGenomic islandcatB9-304637..435582130945
insideIntegron--309717..435206125489


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Ribonuclease toxin, BrnT, of type II toxin-antitoxin system

(6-81)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10092.34 Da        Isoelectric Point: 7.3171

>T26146 WP_000589156.1 NC_016945:333921-334187 [Vibrio cholerae IEC224]
MIKFEFDENKSRSNLEKHGIDFHTAQGLWNDSDLIEIPANTSDEPRYLVVGLLNGKHWSGVITYRGTNIRIISVRRSRKA
EVSLYESA

Download         Length: 267 bp

>T26146 NC_016945:333921-334187 [Vibrio cholerae IEC224]
ATGATTAAATTTGAATTTGATGAAAACAAAAGCAGAAGTAATCTCGAAAAGCACGGTATTGATTTTCATACAGCTCAAGG
ATTGTGGAATGATTCAGATCTTATCGAGATCCCTGCTAACACGAGTGATGAGCCCAGATATTTGGTTGTCGGCTTACTAA
ACGGTAAGCATTGGTCAGGAGTAATTACCTACCGAGGTACGAATATCAGGATCATCTCAGTTCGGCGTTCACGGAAAGCG
GAGGTAAGCCTTTATGAAAGCGCATGA

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 9478.77 Da        Isoelectric Point: 6.4832

>AT26146 WP_000643598.1 NC_016945:334174-334419 [Vibrio cholerae IEC224]
MKAHEFDAKFESDDDDIVMDLDLSQAKRPMHKQKRVNVDFPAWMLESLDREASRIGVTRQSIIKIWLAERLESVSHHSSV
R

Download         Length: 246 bp

>AT26146 NC_016945:334174-334419 [Vibrio cholerae IEC224]
ATGAAAGCGCATGAATTTGATGCCAAGTTTGAAAGTGACGACGATGATATCGTAATGGACTTGGATCTATCGCAAGCTAA
AAGACCGATGCATAAGCAAAAACGAGTCAATGTAGATTTTCCAGCCTGGATGCTTGAGTCCTTGGACAGAGAAGCGAGTC
GTATTGGTGTAACACGTCAATCAATCATTAAAATTTGGCTGGCAGAAAGGTTAGAGAGCGTGTCTCATCATTCAAGTGTG
AGATAA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A271VMP7

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A271VME2

References