Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 397213..397828 Replicon chromosome
Accession NZ_CP013306
Organism Vibrio cholerae strain CRC1106

Toxin (Protein)


Gene name higB Uniprot ID Q9KMG5
Locus tag ASZ81_RS16460 Protein ID WP_001162670.1
Coordinates 397213..397500 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag ASZ81_RS16465 Protein ID WP_001232701.1
Coordinates 397511..397828 (+) Length 106 a.a.

Genomic Context

ASZ81_RS20935ASZ81_RS16430ASZ81_RS16435ASZ81_RS16440ASZ81_RS16450ASZ81_RS16455ASZ81_RS16460ASZ81_RS16465ASZ81_RS20940ASZ81_RS20945ASZ81_RS20950ASZ81_RS16485ASZ81_RS16490ASZ81_RS16495ASZ81_RS16505ASZ81_RS16510ASZ81_RS16420ASZ81_RS16425
Location: 392849..392944 (96 bp)
Type: Others
Protein ID: WP_001907607.1
Location: 393958..394467 (510 bp)
Type: Others
Protein ID: WP_000405987.1
Location: 394524..395177 (654 bp)
Type: Others
Protein ID: WP_000226874.1
Location: 395487..395705 (219 bp)
Type: Others
Protein ID: WP_001917086.1
Location: 396108..396341 (234 bp)
Type: Others
Protein ID: WP_032482776.1
Location: 396766..396946 (181 bp)
Type: Others
Protein ID: Protein_411
Location: 397213..397500 (288 bp)
Type: Toxin
Protein ID: WP_001162670.1
Location: 397511..397828 (318 bp)
Type: Antitoxin
Protein ID: WP_001232701.1
Location: 397825..397935 (111 bp)
Type: Others
Protein ID: WP_134814058.1
Location: 398112..398237 (126 bp)
Type: Others
Protein ID: WP_001944767.1
Location: 398253..398291 (39 bp)
Type: Others
Protein ID: WP_106019119.1
Location: 398515..399255 (741 bp)
Type: Others
Protein ID: WP_000469836.1
Location: 399460..400290 (831 bp)
Type: Others
Protein ID: WP_000056616.1
Location: 400347..400829 (483 bp)
Type: Others
Protein ID: WP_001895003.1
Location: 401276..402151 (876 bp)
Type: Others
Protein ID: WP_000259044.1
Location: 402281..402736 (456 bp)
Type: Others
Protein ID: WP_001245327.1
Location: 393138..393455 (318 bp)
Type: Others
Protein ID: WP_001180243.1
Location: 393474..393716 (243 bp)
Type: Others
Protein ID: WP_000557292.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
ASZ81_RS20935392849..392944+96WP_001907607.1DUF645 family protein-
ASZ81_RS16420393138..393455-318WP_001180243.1type II toxin-antitoxin system RelE/ParE family toxin-
ASZ81_RS16425393474..393716-243WP_000557292.1type II toxin-antitoxin system Phd/YefM family antitoxin-
ASZ81_RS16430393958..394467+510WP_000405987.1GNAT family N-acetyltransferase-
ASZ81_RS16435394524..395177+654WP_000226874.1hypothetical protein-
ASZ81_RS16440395487..395705+219WP_001917086.1DUF3709 domain-containing protein-
ASZ81_RS16450396108..396341+234WP_032482776.1DUF3709 domain-containing protein-
ASZ81_RS16455396766..396946+181Protein_411DUF645 family protein-
ASZ81_RS16460397213..397500+288WP_001162670.1type II toxin-antitoxin system RelE/ParE family toxinToxin
ASZ81_RS16465397511..397828+318WP_001232701.1HigA family addiction module antidote proteinAntitoxin
ASZ81_RS20940397825..397935+111WP_134814058.1DUF3265 domain-containing protein-
ASZ81_RS20945398112..398237+126WP_001944767.1DUF645 family protein-
ASZ81_RS20950398253..398291+39WP_106019119.1hypothetical protein-
ASZ81_RS16485398515..399255+741WP_000469836.1PhzF family phenazine biosynthesis protein-
ASZ81_RS16490399460..400290+831WP_000056616.1abortive infection family protein-
ASZ81_RS16495400347..400829+483WP_001895003.1hypothetical protein-
ASZ81_RS16505401276..402151+876WP_000259044.1hypothetical protein-
ASZ81_RS16510402281..402736+456WP_001245327.1GNAT family N-acetyltransferase-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideGenomic islandcatB9-304741..463550158809
insideIntegron--309821..463174153353


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(2-95)

Antitoxin

Cro/C1-type helix-turn-helix domain

(12-69)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11349.95 Da        Isoelectric Point: 6.7187

>T58270 WP_001162670.1 NZ_CP013306:397213-397500 [Vibrio cholerae]
MALEFKDKWLEQFYEDDKRHRLIPSSIENALFRKLEILDAAQAESDLRIPPGNRFEHLEGNLKGWCSIRVNKQYRLIFQW
VDGVALNTYLDPHKY

Download         Length: 288 bp

>T58270 NZ_CP013306:397213-397500 [Vibrio cholerae]
ATGGCATTAGAATTTAAAGATAAGTGGTTAGAGCAGTTTTACGAGGATGATAAACGACATCGTTTAATTCCAAGTAGCAT
AGAGAATGCTCTATTTCGGAAGCTGGAAATCTTAGATGCAGCTCAAGCTGAATCAGACTTAAGAATTCCACCGGGTAATC
GTTTTGAACATCTTGAAGGAAATCTTAAAGGTTGGTGTTCAATTCGAGTGAACAAACAGTATCGTTTGATTTTTCAGTGG
GTTGATGGTGTTGCACTAAATACTTACTTAGACCCACATAAGTATTGA

Antitoxin


Download         Length: 106 a.a.        Molecular weight: 11705.63 Da        Isoelectric Point: 10.4711

>AT58270 WP_001232701.1 NZ_CP013306:397511-397828 [Vibrio cholerae]
MRKTKRRPVSVGEMLKVEFLEPMGITSKALAEAMGVHRNTVSNLINGGVLTAPVAIKLAAALGNTPEFWLNIQHAVDLWD
TRNRYQEEAKFVKPLFVSLEQSART

Download         Length: 318 bp

>AT58270 NZ_CP013306:397511-397828 [Vibrio cholerae]
ATGCGTAAGACAAAACGTCGTCCAGTTAGCGTTGGGGAAATGTTAAAAGTTGAATTTCTTGAACCAATGGGCATCACATC
AAAAGCGCTCGCTGAAGCGATGGGCGTACACAGAAATACGGTCAGTAATTTAATTAATGGTGGTGTGTTAACAGCTCCGG
TAGCAATCAAGTTAGCCGCGGCATTAGGTAACACACCAGAATTTTGGCTTAACATTCAACATGCAGTTGATCTTTGGGAT
ACGAGAAATCGTTATCAAGAAGAAGCAAAGTTTGTAAAGCCGTTGTTTGTTTCGCTGGAACAAAGCGCACGTACATAA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A0F2HI36

Antitoxin

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Source
ID
Structure
No matching records found

References