Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-YafN
Location 968620..969148 Replicon chromosome
Accession NZ_CP080466
Organism Vibrio cholerae strain ICDC-VC3741

Toxin (Protein)


Gene name relE Uniprot ID H9L4R3
Locus tag K1T75_RS18085 Protein ID WP_000221352.1
Coordinates 968858..969148 (+) Length 97 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID H9L4T4
Locus tag K1T75_RS18080 Protein ID WP_000213183.1
Coordinates 968620..968868 (+) Length 83 a.a.

Genomic Context

K1T75_RS18045K1T75_RS18080K1T75_RS18085K1T75_RS18050K1T75_RS18055K1T75_RS18060K1T75_RS18065K1T75_RS18070K1T75_RS18075K1T75_RS18090K1T75_RS18095K1T75_RS18885K1T75_RS18100K1T75_RS18105K1T75_RS18110K1T75_RS18890K1T75_RS18120K1T75_RS18895K1T75_RS18900
Location: 963659..964123 (465 bp)
Type: Others
Protein ID: WP_000140244.1
Location: 968620..968868 (249 bp)
Type: Antitoxin
Protein ID: WP_000213183.1
Location: 968858..969148 (291 bp)
Type: Toxin
Protein ID: WP_000221352.1
Location: 964223..964621 (399 bp)
Type: Others
Protein ID: WP_001882293.1
Location: 964777..965277 (501 bp)
Type: Others
Protein ID: WP_000789723.1
Location: 965415..965945 (531 bp)
Type: Others
Protein ID: WP_000415563.1
Location: 966096..966491 (396 bp)
Type: Others
Protein ID: WP_000649527.1
Location: 966699..967124 (426 bp)
Type: Others
Protein ID: WP_000415748.1
Location: 967396..968049 (654 bp)
Type: Others
Protein ID: WP_000036957.1
Location: 969284..969745 (462 bp)
Type: Others
Protein ID: WP_001911752.1
Location: 969936..970412 (477 bp)
Type: Others
Protein ID: WP_001047180.1
Location: 970440..970550 (111 bp)
Type: Others
Protein ID: WP_071917832.1
Location: 970547..971476 (930 bp)
Type: Others
Protein ID: WP_000335802.1
Location: 971596..972042 (447 bp)
Type: Others
Protein ID: WP_000128977.1
Location: 972195..973199 (1005 bp)
Type: Others
Protein ID: WP_000964925.1
Location: 973387..973503 (117 bp)
Type: Others
Protein ID: WP_001889170.1
Location: 973466..973591 (126 bp)
Type: Others
Protein ID: WP_001944767.1
Location: 973619..973729 (111 bp)
Type: Others
Protein ID: Protein_877
Location: 973768..973878 (111 bp)
Type: Others
Protein ID: WP_134814058.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
K1T75_RS18045963659..964123+465WP_000140244.1hypothetical protein-
K1T75_RS18050964223..964621-399WP_001882293.1hypothetical protein-
K1T75_RS18055964777..965277-501WP_000789723.1hypothetical protein-
K1T75_RS18060965415..965945-531WP_000415563.1hypothetical protein-
K1T75_RS18065966096..966491-396WP_000649527.1DUF3465 domain-containing protein-
K1T75_RS18070966699..967124-426WP_000415748.1hypothetical protein-
K1T75_RS18075967396..968049-654WP_000036957.1site-specific DNA-methyltransferase-
K1T75_RS18080968620..968868+249WP_000213183.1type II toxin-antitoxin system Phd/YefM family antitoxinAntitoxin
K1T75_RS18085968858..969148+291WP_000221352.1type II toxin-antitoxin system RelE/ParE family toxinToxin
K1T75_RS18090969284..969745-462WP_001911752.1lipocalin family protein-
K1T75_RS18095969936..970412-477WP_001047180.1GNAT family N-acetyltransferase-
K1T75_RS18885970440..970550-111WP_071917832.1DUF3265 domain-containing protein-
K1T75_RS18100970547..971476-930WP_000335802.1hypothetical protein-
K1T75_RS18105971596..972042-447WP_000128977.1hypothetical protein-
K1T75_RS18110972195..973199-1005WP_000964925.1LD-carboxypeptidase-
K1T75_RS18890973387..973503-117WP_001889170.1hypothetical protein-
K1T75_RS18120973466..973591-126WP_001944767.1DUF645 family protein-
K1T75_RS18895973619..973729-111Protein_877acetyltransferase-
K1T75_RS18900973768..973878-111WP_134814058.1DUF3265 domain-containing protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideGenomic islandcatB9-932680..1039634106954
insideIntegron--933056..103279299736


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-86)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 97 a.a.        Molecular weight: 11247.23 Da        Isoelectric Point: 10.4678

>T211914 WP_000221352.1 NZ_CP080466:968858-969148 [Vibrio cholerae]
MTYKLEFKKSALKEWKKLAVPLQQQFKKKLIERLENPHVPSAKLSGAENIYKIKLRQSGYRLVYQVENDIIVVTVLAVGK
RERSEVYTKALQRLDD

Download         Length: 291 bp

>T211914 NZ_CP106839:164024-164506 [Klebsiella michiganensis]
ATGGGAATGAGGACTCCGGAACCTCTTACCCCTGAACACAACATTGCTGAGTTTTGTTGTCAGGATCAGGTTCTTTCTGA
GTGGTTGAAGAAAAAGGCGCTGAAGAACCACAGAACGGGCATTTCAAGAGTTTTCGTCGTCTGTGCTGAAAACACGAATA
GGGTAATTGCGTACTACTGTTTGGCATCCGGAAGCGTGCACAGAAACACCGTACCTGGAGCATACCGTCGTAATGCACCA
GAGGCTTTACCGGTCATTGTTCTGGGAAGGCTTGCGGTTGACGCTGCCTGGGCAAGAAAAGGGCTGGGAGCTGCGCTGCT
TAAGGATGCGATATACCGAACAGAACATATTGCAATACAGGTTGGTGTTAGGGCGCTTCTTGTTCACGCCTTAAATGATG
AAGTTAGGGAATTTTACACAAAGTTTGGATTCGAGCCCTCCATTGCCAATGCGCTGACATTATTATTTCCGATCAAAACA
TGA

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 8937.28 Da        Isoelectric Point: 4.1079

>AT211914 WP_000213183.1 NZ_CP080466:968620-968868 [Vibrio cholerae]
MTTRILADVAASITEFKANPMKVATSAFGAPVAVLNRNEPAFYCVPASTYEIMMDKLEDLELLAIAKERLSEDSVSVNID
DL

Download         Length: 249 bp

>AT211914 NZ_CP106839:163755-164033 [Klebsiella michiganensis]
ATGAAACCAGACATTCGTGAGGCTCCGATAAACATCCGGGCGAAAACATCTCAACGCGATCTTATCGACATGGCCGCAAA
TCTTGTATCTAAATCGCGTACTGATTTTATGCTGGAAGTGGCCTGCCGCGAAGCGCAGGACATCTTGTTAGATCAGCGCT
TGTTTCTGTTGGATGATAATCAGTTTAACGCGTTTGTCGAAGAGCTTGACGCCCCTATGACCCCAGAGCGTCAGGCGCGT
ATTGATAACCTGATGAGCCGCAAATCGCCATGGGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBH9L4R3

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A366A3W8

References