211914

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-YafN
Location 968620..969148 Replicon chromosome
Accession NZ_CP080466
Organism Vibrio cholerae strain ICDC-VC3741

Toxin (Protein)


Gene name relE Uniprot ID H9L4R3
Locus tag K1T75_RS18085 Protein ID WP_000221352.1
Coordinates 968858..969148 (+) Length 97 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID H9L4T4
Locus tag K1T75_RS18080 Protein ID WP_000213183.1
Coordinates 968620..968868 (+) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K1T75_RS18045 963659..964123 + 465 WP_000140244.1 hypothetical protein -
K1T75_RS18050 964223..964621 - 399 WP_001882293.1 hypothetical protein -
K1T75_RS18055 964777..965277 - 501 WP_000789723.1 hypothetical protein -
K1T75_RS18060 965415..965945 - 531 WP_000415563.1 hypothetical protein -
K1T75_RS18065 966096..966491 - 396 WP_000649527.1 DUF3465 domain-containing protein -
K1T75_RS18070 966699..967124 - 426 WP_000415748.1 hypothetical protein -
K1T75_RS18075 967396..968049 - 654 WP_000036957.1 site-specific DNA-methyltransferase -
K1T75_RS18080 968620..968868 + 249 WP_000213183.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
K1T75_RS18085 968858..969148 + 291 WP_000221352.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
K1T75_RS18090 969284..969745 - 462 WP_001911752.1 lipocalin family protein -
K1T75_RS18095 969936..970412 - 477 WP_001047180.1 GNAT family N-acetyltransferase -
K1T75_RS18885 970440..970550 - 111 WP_071917832.1 DUF3265 domain-containing protein -
K1T75_RS18100 970547..971476 - 930 WP_000335802.1 hypothetical protein -
K1T75_RS18105 971596..972042 - 447 WP_000128977.1 hypothetical protein -
K1T75_RS18110 972195..973199 - 1005 WP_000964925.1 LD-carboxypeptidase -
K1T75_RS18890 973387..973503 - 117 WP_001889170.1 hypothetical protein -
K1T75_RS18120 973466..973591 - 126 WP_001944767.1 DUF645 family protein -
K1T75_RS18895 973619..973729 - 111 Protein_877 acetyltransferase -
K1T75_RS18900 973768..973878 - 111 WP_134814058.1 DUF3265 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island catB9 - 932680..1039634 106954
inside Integron - - 933056..1032792 99736


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-86)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 97 a.a.        Molecular weight: 11247.23 Da        Isoelectric Point: 10.4678

>T211914 WP_000221352.1 NZ_CP080466:968858-969148 [Vibrio cholerae]
MTYKLEFKKSALKEWKKLAVPLQQQFKKKLIERLENPHVPSAKLSGAENIYKIKLRQSGYRLVYQVENDIIVVTVLAVGK
RERSEVYTKALQRLDD

Download         Length: 291 bp

>T211914 NZ_CP106839:164024-164506 [Klebsiella michiganensis]
ATGGGAATGAGGACTCCGGAACCTCTTACCCCTGAACACAACATTGCTGAGTTTTGTTGTCAGGATCAGGTTCTTTCTGA
GTGGTTGAAGAAAAAGGCGCTGAAGAACCACAGAACGGGCATTTCAAGAGTTTTCGTCGTCTGTGCTGAAAACACGAATA
GGGTAATTGCGTACTACTGTTTGGCATCCGGAAGCGTGCACAGAAACACCGTACCTGGAGCATACCGTCGTAATGCACCA
GAGGCTTTACCGGTCATTGTTCTGGGAAGGCTTGCGGTTGACGCTGCCTGGGCAAGAAAAGGGCTGGGAGCTGCGCTGCT
TAAGGATGCGATATACCGAACAGAACATATTGCAATACAGGTTGGTGTTAGGGCGCTTCTTGTTCACGCCTTAAATGATG
AAGTTAGGGAATTTTACACAAAGTTTGGATTCGAGCCCTCCATTGCCAATGCGCTGACATTATTATTTCCGATCAAAACA
TGA

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 8937.28 Da        Isoelectric Point: 4.1079

>AT211914 WP_000213183.1 NZ_CP080466:968620-968868 [Vibrio cholerae]
MTTRILADVAASITEFKANPMKVATSAFGAPVAVLNRNEPAFYCVPASTYEIMMDKLEDLELLAIAKERLSEDSVSVNID
DL

Download         Length: 249 bp

>AT211914 NZ_CP106839:163755-164033 [Klebsiella michiganensis]
ATGAAACCAGACATTCGTGAGGCTCCGATAAACATCCGGGCGAAAACATCTCAACGCGATCTTATCGACATGGCCGCAAA
TCTTGTATCTAAATCGCGTACTGATTTTATGCTGGAAGTGGCCTGCCGCGAAGCGCAGGACATCTTGTTAGATCAGCGCT
TGTTTCTGTTGGATGATAATCAGTTTAACGCGTTTGTCGAAGAGCTTGACGCCCCTATGACCCCAGAGCGTCAGGCGCGT
ATTGATAACCTGATGAGCCGCAAATCGCCATGGGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB H9L4R3

Antitoxin

Source ID Structure
AlphaFold DB A0A366A3W8

References