Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-YafN
Location 783889..784417 Replicon chromosome
Accession NZ_CP102928
Organism Vibrio cholerae strain N1252

Toxin (Protein)


Gene name relE Uniprot ID H9L4R3
Locus tag NW313_RS17655 Protein ID WP_000221352.1
Coordinates 783889..784179 (-) Length 97 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID H9L4T4
Locus tag NW313_RS17660 Protein ID WP_000213183.1
Coordinates 784169..784417 (-) Length 83 a.a.

Genomic Context

NW313_RS17605NW313_RS17610NW313_RS17615NW313_RS17620NW313_RS17625NW313_RS17630NW313_RS17635NW313_RS17640NW313_RS17645NW313_RS17650NW313_RS17665NW313_RS17670NW313_RS17675NW313_RS17680NW313_RS17685NW313_RS17690NW313_RS17655NW313_RS17660NW313_RS17695
Location: 779159..779269 (111 bp)
Type: Others
Protein ID: WP_134814058.1
Location: 779308..779418 (111 bp)
Type: Others
Protein ID: Protein_745
Location: 779446..779571 (126 bp)
Type: Others
Protein ID: WP_001944767.1
Location: 779534..779650 (117 bp)
Type: Others
Protein ID: WP_001889170.1
Location: 779838..780842 (1005 bp)
Type: Others
Protein ID: WP_000964925.1
Location: 780995..781441 (447 bp)
Type: Others
Protein ID: WP_000128977.1
Location: 781561..782490 (930 bp)
Type: Others
Protein ID: WP_000335802.1
Location: 782487..782597 (111 bp)
Type: Others
Protein ID: WP_071917832.1
Location: 782625..783101 (477 bp)
Type: Others
Protein ID: WP_001047171.1
Location: 783292..783753 (462 bp)
Type: Others
Protein ID: WP_001911752.1
Location: 784988..785641 (654 bp)
Type: Others
Protein ID: WP_000036957.1
Location: 785913..786338 (426 bp)
Type: Others
Protein ID: WP_000415748.1
Location: 786546..786941 (396 bp)
Type: Others
Protein ID: WP_000649527.1
Location: 787092..787622 (531 bp)
Type: Others
Protein ID: WP_000415563.1
Location: 787760..788260 (501 bp)
Type: Others
Protein ID: WP_000789723.1
Location: 788416..788814 (399 bp)
Type: Others
Protein ID: WP_001882293.1
Location: 783889..784179 (291 bp)
Type: Toxin
Protein ID: WP_000221352.1
Location: 784169..784417 (249 bp)
Type: Antitoxin
Protein ID: WP_000213183.1
Location: 788914..789378 (465 bp)
Type: Others
Protein ID: WP_000140244.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
NW313_RS17605779159..779269+111WP_134814058.1DUF3265 domain-containing protein-
NW313_RS17610779308..779418+111Protein_745acetyltransferase-
NW313_RS17615779446..779571+126WP_001944767.1DUF645 family protein-
NW313_RS17620779534..779650+117WP_001889170.1hypothetical protein-
NW313_RS17625779838..780842+1005WP_000964925.1LD-carboxypeptidase-
NW313_RS17630780995..781441+447WP_000128977.1hypothetical protein-
NW313_RS17635781561..782490+930WP_000335802.1hypothetical protein-
NW313_RS17640782487..782597+111WP_071917832.1DUF3265 domain-containing protein-
NW313_RS17645782625..783101+477WP_001047171.1GNAT family N-acetyltransferase-
NW313_RS17650783292..783753+462WP_001911752.1lipocalin family protein-
NW313_RS17655783889..784179-291WP_000221352.1type II toxin-antitoxin system RelE/ParE family toxinToxin
NW313_RS17660784169..784417-249WP_000213183.1type II toxin-antitoxin system Phd/YefM family antitoxinAntitoxin
NW313_RS17665784988..785641+654WP_000036957.1site-specific DNA-methyltransferase-
NW313_RS17670785913..786338+426WP_000415748.1hypothetical protein-
NW313_RS17675786546..786941+396WP_000649527.1DUF3465 domain-containing protein-
NW313_RS17680787092..787622+531WP_000415563.1hypothetical protein-
NW313_RS17685787760..788260+501WP_000789723.1hypothetical protein-
NW313_RS17690788416..788814+399WP_001882293.1hypothetical protein-
NW313_RS17695788914..789378-465WP_000140244.1hypothetical protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideGenomic islandcatB9-713852..820357106505
insideIntegroncatB9-718932..819981101049


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-86)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 97 a.a.        Molecular weight: 11247.23 Da        Isoelectric Point: 10.4678

>T254473 WP_000221352.1 NZ_CP102928:c784179-783889 [Vibrio cholerae]
MTYKLEFKKSALKEWKKLAVPLQQQFKKKLIERLENPHVPSAKLSGAENIYKIKLRQSGYRLVYQVENDIIVVTVLAVGK
RERSEVYTKALQRLDD

Download         Length: 291 bp

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 8937.28 Da        Isoelectric Point: 4.1079

>AT254473 WP_000213183.1 NZ_CP102928:c784417-784169 [Vibrio cholerae]
MTTRILADVAASITEFKANPMKVATSAFGAPVAVLNRNEPAFYCVPASTYEIMMDKLEDLELLAIAKERLSEDSVSVNID
DL

Download         Length: 249 bp


Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBH9L4R3

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A366A3W8

References