294382

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/YafQ-RelB
Location 452077..452617 Replicon chromosome
Accession NZ_LT992489
Organism Vibrio cholerae strain 4295STDY6534232

Toxin (Protein)


Gene name relE Uniprot ID A0A151JGK8
Locus tag DG176_RS16800 Protein ID WP_000277238.1
Coordinates 452348..452617 (+) Length 90 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID Q9KML3
Locus tag DG176_RS16795 Protein ID WP_001258569.1
Coordinates 452077..452355 (+) Length 93 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DG176_RS16730 447657..448124 - 468 WP_001289288.1 OsmC family protein -
DG176_RS19835 448336..448374 - 39 WP_082798268.1 hypothetical protein -
DG176_RS19840 448428..448571 - 144 Protein_439 DUF645 family protein -
DG176_RS16750 448946..449224 - 279 WP_000280324.1 DUF3709 domain-containing protein -
DG176_RS16755 449476..449718 - 243 WP_000107461.1 hypothetical protein -
DG176_RS16760 449810..449959 - 150 WP_071908333.1 DUF3265 domain-containing protein -
DG176_RS16765 449932..450183 - 252 WP_001890111.1 TIGR03643 family protein -
DG176_RS16770 450378..450764 - 387 WP_000703163.1 VOC family protein -
DG176_RS16775 450754..450855 - 102 WP_001921603.1 hypothetical protein -
DG176_RS16780 451055..451261 - 207 Protein_446 DUF3709 domain-containing protein -
DG176_RS16785 451513..451791 - 279 WP_001921601.1 DUF3709 domain-containing protein -
DG176_RS16795 452077..452355 + 279 WP_001258569.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
DG176_RS16800 452348..452617 + 270 WP_000277238.1 type II toxin-antitoxin system YafQ family toxin Toxin
DG176_RS16805 452765..453211 - 447 WP_000006157.1 hypothetical protein -
DG176_RS16815 453407..453445 - 39 WP_106019118.1 hypothetical protein -
DG176_RS16820 453461..453586 - 126 WP_001900195.1 DUF645 family protein -
DG176_RS16825 453979..454251 + 273 WP_000246253.1 DUF1778 domain-containing protein -
DG176_RS16830 454248..454745 + 498 WP_000982260.1 GNAT family N-acetyltransferase -
DG176_RS16835 454895..455410 - 516 WP_001201509.1 lipocalin family protein -
DG176_RS16840 455547..456083 - 537 WP_000469482.1 GNAT family N-acetyltransferase -
DG176_RS16855 456341..456622 - 282 WP_001894429.1 DUF1289 domain-containing protein -
DG176_RS16860 456571..456684 - 114 WP_001900214.1 hypothetical protein -
DG176_RS16865 456741..457127 - 387 WP_001015867.1 NUDIX hydrolase -
DG176_RS16870 457371..457613 + 243 WP_000557292.1 type II toxin-antitoxin system Phd/YefM family antitoxin -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island catB9 - 379325..476297 96972
inside Integron catB9 - 379701..469509 89808


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(2-89)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-85)


Sequences

Toxin        


Download         Length: 90 a.a.        Molecular weight: 10406.11 Da        Isoelectric Point: 9.5084

>T294382 WP_000277238.1 NZ_LT992489:452348-452617 [Vibrio cholerae]
MYKLEYSTQFKKDFKKITKMPISDIIEVGNVISKLQRGEKLEPKNVDHPLTGNWVGFRDCHIKPDLVLIYRVFNDQLQLA
RIGSHSDLF

Download         Length: 270 bp

Antitoxin


Download         Length: 93 a.a.        Molecular weight: 10088.58 Da        Isoelectric Point: 6.0728

>AT294382 WP_001258569.1 NZ_LT992489:452077-452355 [Vibrio cholerae]
MRTEMLSTRIDHDTKIAFTNVCDEMGLSTSQAIKLFAKAVINHGGIPFELRVPQPNEVTASAIQELVEGKGHKAESVEAM
LNELTEGKVKHV

Download         Length: 279 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A151JGK8

Antitoxin

Source ID Structure
AlphaFold DB A0A151KTP9

References