Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 369824..370439 Replicon chromosome
Accession NZ_CP047298
Organism Vibrio cholerae O1 biovar El Tor strain C6709

Toxin (Protein)


Gene name higB Uniprot ID Q9KMG5
Locus tag GTF73_RS15615 Protein ID WP_001162670.1
Coordinates 369824..370111 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag GTF73_RS15620 Protein ID WP_001232701.1
Coordinates 370122..370439 (+) Length 106 a.a.

Genomic Context

GTF73_RS15575GTF73_RS15590GTF73_RS15595GTF73_RS15600GTF73_RS15605GTF73_RS15610GTF73_RS15615GTF73_RS15620GTF73_RS15625GTF73_RS15630GTF73_RS15635GTF73_RS15640GTF73_RS15645GTF73_RS15650GTF73_RS15655GTF73_RS15660GTF73_RS15580GTF73_RS15585
Location: 365460..365555 (96 bp)
Type: Others
Protein ID: WP_001907607.1
Location: 366569..367078 (510 bp)
Type: Others
Protein ID: WP_000405987.1
Location: 367135..367788 (654 bp)
Type: Others
Protein ID: WP_000226874.1
Location: 368098..368316 (219 bp)
Type: Others
Protein ID: WP_001917086.1
Location: 368719..368952 (234 bp)
Type: Others
Protein ID: WP_032482776.1
Location: 369377..369557 (181 bp)
Type: Others
Protein ID: Protein_365
Location: 369824..370111 (288 bp)
Type: Toxin
Protein ID: WP_001162670.1
Location: 370122..370439 (318 bp)
Type: Antitoxin
Protein ID: WP_001232701.1
Location: 370436..370546 (111 bp)
Type: Others
Protein ID: WP_134814058.1
Location: 370723..370848 (126 bp)
Type: Others
Protein ID: WP_001944767.1
Location: 370864..370902 (39 bp)
Type: Others
Protein ID: WP_106019119.1
Location: 371126..371866 (741 bp)
Type: Others
Protein ID: WP_000469836.1
Location: 372071..372901 (831 bp)
Type: Others
Protein ID: WP_000056616.1
Location: 372958..373440 (483 bp)
Type: Others
Protein ID: WP_001895003.1
Location: 373887..374762 (876 bp)
Type: Others
Protein ID: WP_000259044.1
Location: 374892..375347 (456 bp)
Type: Others
Protein ID: WP_001245327.1
Location: 365749..366066 (318 bp)
Type: Others
Protein ID: WP_001180243.1
Location: 366085..366327 (243 bp)
Type: Others
Protein ID: WP_000557292.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
GTF73_RS15575365460..365555+96WP_001907607.1DUF645 family protein-
GTF73_RS15580365749..366066-318WP_001180243.1type II toxin-antitoxin system RelE/ParE family toxin-
GTF73_RS15585366085..366327-243WP_000557292.1type II toxin-antitoxin system Phd/YefM family antitoxin-
GTF73_RS15590366569..367078+510WP_000405987.1GNAT family N-acetyltransferase-
GTF73_RS15595367135..367788+654WP_000226874.1hypothetical protein-
GTF73_RS15600368098..368316+219WP_001917086.1DUF3709 domain-containing protein-
GTF73_RS15605368719..368952+234WP_032482776.1DUF3709 domain-containing protein-
GTF73_RS15610369377..369557+181Protein_365DUF645 family protein-
GTF73_RS15615369824..370111+288WP_001162670.1type II toxin-antitoxin system RelE/ParE family toxinToxin
GTF73_RS15620370122..370439+318WP_001232701.1HigA family addiction module antidote proteinAntitoxin
GTF73_RS15625370436..370546+111WP_134814058.1DUF3265 domain-containing protein-
GTF73_RS15630370723..370848+126WP_001944767.1DUF645 family protein-
GTF73_RS15635370864..370902+39WP_106019119.1hypothetical protein-
GTF73_RS15640371126..371866+741WP_000469836.1PhzF family phenazine biosynthesis protein-
GTF73_RS15645372071..372901+831WP_000056616.1abortive infection family protein-
GTF73_RS15650372958..373440+483WP_001895003.1hypothetical protein-
GTF73_RS15655373887..374762+876WP_000259044.1hypothetical protein-
GTF73_RS15660374892..375347+456WP_001245327.1GNAT family N-acetyltransferase-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideGenomic islandcatB9-306901..436162129261
insideIntegron--311981..435786123805


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(2-95)

Antitoxin

Cro/C1-type helix-turn-helix domain

(12-69)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11349.95 Da        Isoelectric Point: 6.7187

>T145830 WP_001162670.1 NZ_CP047298:369824-370111 [Vibrio cholerae O1 biovar El Tor]
MALEFKDKWLEQFYEDDKRHRLIPSSIENALFRKLEILDAAQAESDLRIPPGNRFEHLEGNLKGWCSIRVNKQYRLIFQW
VDGVALNTYLDPHKY

Download         Length: 288 bp

>T145830 NZ_CP062701:69659-69817 [Escherichia coli O157:H7]
ATGAAACTACCACGCAGCTCTCTTGTCTGGTGTGTGTTGATAGTGTGTCTCACACTGTTGATATTCACTTATCTGACACG
AAAATCGCTGTGCGAGATTCGTTACAGAGACGGATACAGGGAGGTGGCGGCTTTCATGGCTTACGAATCCGGTAAGTAG

Antitoxin


Download         Length: 106 a.a.        Molecular weight: 11705.63 Da        Isoelectric Point: 10.4711

>AT145830 WP_001232701.1 NZ_CP047298:370122-370439 [Vibrio cholerae O1 biovar El Tor]
MRKTKRRPVSVGEMLKVEFLEPMGITSKALAEAMGVHRNTVSNLINGGVLTAPVAIKLAAALGNTPEFWLNIQHAVDLWD
TRNRYQEEAKFVKPLFVSLEQSART

Download         Length: 318 bp

>AT145830 NZ_CP062701:69396-69594 [Escherichia coli O157:H7]
TCACACGGATTGCCCGTAAACAGCCTGAATGAGCGGGTTATTTTCAGGAAAAGTGAATGTGGTCAGCGTGCTGGTATATG
GGCTATGATGTGCCCGGCGCTTGAGGCTTTCTGCCTCATGACGTGAAGGTGGTTTGTTACCGTGTTGTGTGGCAGAAGGA
CAAAAGCCCCGTAGTTAATTTTTCATTAACCCACGAGGC

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A0F2HI36

Antitoxin

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Source
ID
Structure
No matching records found

References