Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/RelE-MqsA
Location 115420..116053 Replicon chromosome
Accession NZ_CP026648
Organism Vibrio cholerae O1 biovar El Tor strain HC1037

Toxin (Protein)


Gene name higB Uniprot ID Q9KMA6
Locus tag C4E16_RS15125 Protein ID WP_000843587.1
Coordinates 115420..115752 (+) Length 111 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag C4E16_RS15130 Protein ID WP_000071008.1
Coordinates 115739..116053 (+) Length 105 a.a.

Genomic Context

C4E16_RS19575C4E16_RS15060C4E16_RS15065C4E16_RS15070C4E16_RS15075C4E16_RS15080C4E16_RS15085C4E16_RS19580C4E16_RS15090C4E16_RS15105C4E16_RS15110C4E16_RS15125C4E16_RS15130C4E16_RS15135C4E16_RS19445C4E16_RS15145C4E16_RS15150C4E16_RS15155C4E16_RS15160C4E16_RS15165C4E16_RS15170C4E16_RS15175C4E16_RS15140
Location: 110861..111064 (204 bp)
Type: Others
Protein ID: WP_001911745.1
Location: 111345..111518 (174 bp)
Type: Others
Protein ID: WP_001882305.1
Location: 111878..112147 (270 bp)
Type: Others
Protein ID: WP_001198131.1
Location: 112465..112636 (172 bp)
Type: Others
Protein ID: Protein_169
Location: 112845..113231 (387 bp)
Type: Others
Protein ID: WP_000703163.1
Location: 113433..113675 (243 bp)
Type: Others
Protein ID: WP_000107461.1
Location: 113846..114223 (378 bp)
Type: Others
Protein ID: WP_000411109.1
Location: 114280..114394 (115 bp)
Type: Others
Protein ID: Protein_173
Location: 114343..114624 (282 bp)
Type: Others
Protein ID: WP_001894453.1
Location: 114790..114903 (114 bp)
Type: Others
Protein ID: WP_001889158.1
Location: 114852..115079 (228 bp)
Type: Others
Protein ID: WP_073426587.1
Location: 115420..115752 (333 bp)
Type: Toxin
Protein ID: WP_000843587.1
Location: 115739..116053 (315 bp)
Type: Antitoxin
Protein ID: WP_000071008.1
Location: 116190..116624 (435 bp)
Type: Others
Protein ID: WP_000256036.1
Location: 116792..116947 (156 bp)
Type: Others
Protein ID: WP_000751734.1
Location: 118120..118426 (307 bp)
Type: Others
Protein ID: Protein_182
Location: 118563..119255 (693 bp)
Type: Others
Protein ID: WP_001047169.1
Location: 119255..119656 (402 bp)
Type: Others
Protein ID: WP_000351248.1
Location: 119626..119769 (144 bp)
Type: Others
Protein ID: WP_071908341.1
Location: 119844..120257 (414 bp)
Type: Others
Protein ID: WP_000049417.1
Location: 120471..120722 (252 bp)
Type: Others
Protein ID: WP_001250179.1
Location: 120712..120999 (288 bp)
Type: Others
Protein ID: WP_000221354.1
Location: 117072..118052 (981 bp)
Type: Others
Protein ID: WP_000019370.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
C4E16_RS19575110861..111064+204WP_001911745.1hypothetical protein-
C4E16_RS15060111345..111518+174WP_001882305.1DUF3709 domain-containing protein-
C4E16_RS15065111878..112147+270WP_001198131.1hypothetical protein-
C4E16_RS15070112465..112636+172Protein_169DUF645 family protein-
C4E16_RS15075112845..113231+387WP_000703163.1VOC family protein-
C4E16_RS15080113433..113675+243WP_000107461.1hypothetical protein-
C4E16_RS15085113846..114223+378WP_000411109.1hypothetical protein-
C4E16_RS19580114280..114394+115Protein_173acetyltransferase-
C4E16_RS15090114343..114624+282WP_001894453.1DUF1289 domain-containing protein-
C4E16_RS15105114790..114903+114WP_001889158.1hypothetical protein-
C4E16_RS15110114852..115079+228WP_073426587.1DUF1289 domain-containing protein-
C4E16_RS15125115420..115752+333WP_000843587.1type II toxin-antitoxin system RelE/ParE family toxinToxin
C4E16_RS15130115739..116053+315WP_000071008.1DNA-binding transcriptional regulatorAntitoxin
C4E16_RS15135116190..116624+435WP_000256036.1GNAT family N-acetyltransferase-
C4E16_RS19445116792..116947+156WP_000751734.1hypothetical protein-
C4E16_RS15140117072..118052-981WP_000019370.1IS5-like element ISVch5 family transposase-
C4E16_RS15145118120..118426+307Protein_182CatB-related O-acetyltransferase-
C4E16_RS15150118563..119255+693WP_001047169.1GNAT family N-acetyltransferase-
C4E16_RS15155119255..119656+402WP_000351248.1type II toxin-antitoxin system death-on-curing family toxin-
C4E16_RS15160119626..119769+144WP_071908341.1DUF3265 domain-containing protein-
C4E16_RS15165119844..120257+414WP_000049417.1VOC family protein-
C4E16_RS15170120471..120722+252WP_001250179.1type II toxin-antitoxin system Phd/YefM family antitoxin-
C4E16_RS15175120712..120999+288WP_000221354.1type II toxin-antitoxin system RelE/ParE family toxin-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideGenomic islandcatB9-31043..136234105191
insideIntegron--36123..13585899735
flankIS/Tn--117072..118052980


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-2

(4-100)

Antitoxin

Cro/C1-type helix-turn-helix domain

(43-92)


Sequences

Toxin        


Download         Length: 111 a.a.        Molecular weight: 13005.95 Da        Isoelectric Point: 9.9244

>T95384 WP_000843587.1 NZ_CP026648:115420-115752 [Vibrio cholerae O1 biovar El Tor]
MKSVFVESTIFEKYRDEYLSDEEYRLFQAELMLNPKLGDVIQGTGGLRKIRVASKGKGKRGGSRIIYYFLDEKRRFYLLT
IYGKNEMSDLNANQRKQLMAFMEAWRNEQS

Download         Length: 333 bp

>T95384 NZ_CP026648:115420-115752 [Vibrio cholerae O1 biovar El Tor]
ATGAAAAGTGTATTTGTCGAATCAACAATTTTTGAAAAGTACCGAGATGAATATCTCAGTGATGAGGAGTATAGGCTCTT
TCAAGCAGAGCTAATGCTAAACCCCAAGCTGGGTGATGTGATTCAAGGTACTGGCGGTTTGCGAAAAATTCGAGTTGCGA
GTAAAGGCAAGGGAAAGCGTGGTGGTTCACGGATTATCTATTACTTTCTCGATGAAAAGAGGCGTTTCTATTTGCTAACC
ATTTACGGCAAAAATGAAATGTCTGACTTGAATGCAAATCAAAGGAAACAACTAATGGCTTTTATGGAGGCGTGGCGCAA
TGAGCAATCGTGA

Antitoxin


Download         Length: 105 a.a.        Molecular weight: 11696.20 Da        Isoelectric Point: 6.7600

>AT95384 WP_000071008.1 NZ_CP026648:115739-116053 [Vibrio cholerae O1 biovar El Tor]
MSNRDLFAELSSALVEAKQHSEGKLTLKTHHVNDVGELNISPDEIVSIREQFNMSRGVFARLLHTSSRTLENWEQGRSVP
NGQAVTLLKLVQRHPETLSHIAEL

Download         Length: 315 bp

>AT95384 NZ_CP026648:115739-116053 [Vibrio cholerae O1 biovar El Tor]
ATGAGCAATCGTGATTTATTTGCAGAGTTAAGCTCAGCTCTTGTTGAGGCTAAGCAGCATTCAGAAGGTAAGCTTACTCT
GAAAACACATCATGTGAATGATGTGGGTGAGTTGAACATCTCACCGGATGAAATCGTGAGTATTCGCGAGCAGTTCAATA
TGTCCCGCGGAGTCTTCGCGCGGTTACTTCATACGTCTTCGCGCACATTAGAAAACTGGGAACAAGGTCGTAGTGTGCCA
AATGGTCAAGCGGTCACTCTTTTAAAGTTAGTACAGCGTCATCCAGAAACGTTGTCACACATAGCCGAGCTATAA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
PDB5JA9
PDB8A0X
PDB5MJE
PDB5JA8
PDB5JAA

Antitoxin

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Source
ID
Structure
No matching records found

References