Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /GNAT-DUF1778
Location 420002..420768 Replicon chromosome
Accession NZ_CP024868
Organism Vibrio cholerae strain A1552

Toxin (Protein)


Gene name - Uniprot ID Q9K2P7
Locus tag VCA1552_RS16800 Protein ID WP_000982260.1
Coordinates 420002..420499 (-) Length 166 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID Q9K2J6
Locus tag VCA1552_RS16805 Protein ID WP_000246253.1
Coordinates 420496..420768 (-) Length 91 a.a.

Genomic Context

VCA1552_RS16750VCA1552_RS16755VCA1552_RS16760VCA1552_RS16765VCA1552_RS16770VCA1552_RS16775VCA1552_RS16780VCA1552_RS16785VCA1552_RS16790VCA1552_RS16810VCA1552_RS16815VCA1552_RS16820VCA1552_RS20040VCA1552_RS16830VCA1552_RS16840VCA1552_RS16845VCA1552_RS16850VCA1552_RS16800VCA1552_RS16805
Location: 415864..416136 (273 bp)
Type: Others
Protein ID: Protein_443
Location: 416307..416999 (693 bp)
Type: Others
Protein ID: WP_001047169.1
Location: 416999..417400 (402 bp)
Type: Others
Protein ID: WP_000351248.1
Location: 417370..417513 (144 bp)
Type: Others
Protein ID: WP_071908341.1
Location: 417588..418001 (414 bp)
Type: Others
Protein ID: WP_000049417.1
Location: 418215..418466 (252 bp)
Type: Others
Protein ID: WP_001250179.1
Location: 418456..418743 (288 bp)
Type: Others
Protein ID: WP_000221354.1
Location: 418871..419326 (456 bp)
Type: Others
Protein ID: WP_001245327.1
Location: 419648..419800 (153 bp)
Type: Others
Protein ID: WP_001884520.1
Location: 420999..421667 (669 bp)
Type: Others
Protein ID: WP_000043871.1
Location: 421819..422106 (288 bp)
Type: Others
Protein ID: WP_000426470.1
Location: 422247..422618 (372 bp)
Type: Others
Protein ID: WP_001164080.1
Location: 422685..423110 (426 bp)
Type: Others
Protein ID: WP_001882332.1
Location: 423107..423640 (534 bp)
Type: Others
Protein ID: WP_000118351.1
Location: 423842..424099 (258 bp)
Type: Others
Protein ID: WP_000861987.1
Location: 424087..424389 (303 bp)
Type: Others
Protein ID: WP_000229317.1
Location: 424623..425540 (918 bp)
Type: Others
Protein ID: WP_000186333.1
Location: 420002..420499 (498 bp)
Type: Toxin
Protein ID: WP_000982260.1
Location: 420496..420768 (273 bp)
Type: Antitoxin
Protein ID: WP_000246253.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
VCA1552_RS16750415864..416136+273Protein_443CatB-related O-acetyltransferase-
VCA1552_RS16755416307..416999+693WP_001047169.1GNAT family N-acetyltransferase-
VCA1552_RS16760416999..417400+402WP_000351248.1type II toxin-antitoxin system death-on-curing family toxin-
VCA1552_RS16765417370..417513+144WP_071908341.1DUF3265 domain-containing protein-
VCA1552_RS16770417588..418001+414WP_000049417.1VOC family protein-
VCA1552_RS16775418215..418466+252WP_001250179.1type II toxin-antitoxin system Phd/YefM family antitoxin-
VCA1552_RS16780418456..418743+288WP_000221354.1type II toxin-antitoxin system RelE/ParE family toxin-
VCA1552_RS16785418871..419326+456WP_001245327.1GNAT family N-acetyltransferase-
VCA1552_RS16790419648..419800+153WP_001884520.1DUF645 family protein-
VCA1552_RS16800420002..420499-498WP_000982260.1GNAT family N-acetyltransferaseToxin
VCA1552_RS16805420496..420768-273WP_000246253.1DUF1778 domain-containing proteinAntitoxin
VCA1552_RS16810420999..421667+669WP_000043871.1hypothetical protein-
VCA1552_RS16815421819..422106+288WP_000426470.1hypothetical protein-
VCA1552_RS16820422247..422618+372WP_001164080.1nucleotide pyrophosphohydrolase-
VCA1552_RS20040422685..423110+426WP_001882332.1DUF1778 domain-containing protein-
VCA1552_RS16830423107..423640+534WP_000118351.1GNAT family N-acetyltransferase-
VCA1552_RS16840423842..424099+258WP_000861987.1type II toxin-antitoxin system Phd/YefM family antitoxin-
VCA1552_RS16845424087..424389+303WP_000229317.1type II toxin-antitoxin system RelE/ParE family toxin-
VCA1552_RS16850424623..425540+918WP_000186333.1alpha/beta hydrolase-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideGenomic islandcatB9-304717..433978129261
insideIntegron--309797..433602123805
flankIS/Tn--414816..415796980


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(86-152)

Antitoxin

Vibrio phage ICP1, Orf50

(7-86)


Sequences

Toxin        


Download         Length: 166 a.a.        Molecular weight: 18527.18 Da        Isoelectric Point: 8.7753

>T88999 WP_000982260.1 NZ_CP024868:c420499-420002 [Vibrio cholerae]
MMNTVLLDKDKHDRNRFNCGTEALNNYLKVMASQQAKKDNTRTFVLEDDNNSAYIIGFYTLTMTPIDLKALPDKLQKKHQ
SSTSGGLIARLAVDDRYKGKGFGEWLLIDALRKLLAASDSVAFPVVIVDAKDGAKHFYERYGFQAFQDAENKLFITIADI
RASLG

Download         Length: 498 bp

>T88999 NZ_CP024868:c420499-420002 [Vibrio cholerae]
ATGATGAATACGGTACTTCTCGATAAAGATAAGCACGATAGGAACCGTTTCAATTGTGGCACTGAAGCACTCAACAATTA
CTTAAAAGTAATGGCGAGTCAGCAAGCCAAAAAAGACAACACCAGAACCTTCGTTTTGGAAGATGACAATAACAGTGCTT
ATATCATCGGCTTTTACACTCTGACTATGACGCCCATTGATTTGAAAGCCTTGCCCGACAAGTTACAAAAGAAGCACCAA
TCCTCAACCTCTGGAGGGCTCATTGCTCGTTTAGCTGTCGACGATAGATACAAAGGAAAAGGTTTTGGTGAGTGGCTACT
CATTGACGCTCTCAGAAAGCTACTCGCAGCCAGTGACAGTGTAGCGTTCCCTGTTGTCATTGTTGATGCCAAAGATGGTG
CAAAACATTTCTATGAGCGCTATGGGTTTCAAGCGTTTCAAGATGCCGAAAACAAACTCTTCATCACCATTGCTGATATC
AGAGCAAGCTTAGGCTAG

Antitoxin


Download         Length: 91 a.a.        Molecular weight: 9683.22 Da        Isoelectric Point: 6.2988

>AT88999 WP_000246253.1 NZ_CP024868:c420768-420496 [Vibrio cholerae]
MATTLPRITARVDVDTQDLLAKAAALAGMSSINSFVLNAAIEKAKQVIEREQALKLSQADAVLLMEALDNPAVVNAKLKL
ASERYESKTQ

Download         Length: 273 bp

>AT88999 NZ_CP024868:c420768-420496 [Vibrio cholerae]
ATGGCAACGACTTTGCCTCGCATCACCGCTAGAGTTGATGTCGATACTCAAGATTTACTCGCTAAGGCTGCTGCTCTTGC
TGGTATGTCTAGTATTAACTCATTTGTTTTGAATGCAGCAATCGAAAAAGCAAAACAAGTCATTGAACGTGAGCAAGCTC
TAAAGCTTAGCCAAGCTGATGCCGTATTGCTGATGGAAGCTCTTGATAATCCAGCTGTAGTAAATGCAAAGCTCAAATTG
GCATCCGAACGTTATGAGAGCAAAACTCAATGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A0Q0KGB1

Antitoxin

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Source
ID
Structure
PDB1Y9B
AlphaFold DBA0A0F2IC79

References