Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/Doc-GNAT
Location 338634..339727 Replicon chromosome
Accession NZ_CP046841
Organism Vibrio cholerae strain F9993

Toxin (Protein)


Gene name doc Uniprot ID Q9KMA2
Locus tag GPY07_RS15880 Protein ID WP_000351248.1
Coordinates 338634..339035 (-) Length 134 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID -
Locus tag GPY07_RS15885 Protein ID WP_001047169.1
Coordinates 339035..339727 (-) Length 231 a.a.

Genomic Context

GPY07_RS15835GPY07_RS15840GPY07_RS15895GPY07_RS15825GPY07_RS15830GPY07_RS15850GPY07_RS15855GPY07_RS15860GPY07_RS15865GPY07_RS15870GPY07_RS15875GPY07_RS15880GPY07_RS15885GPY07_RS15890GPY07_RS15900GPY07_RS15905GPY07_RS15910GPY07_RS15915GPY07_RS15925GPY07_RS15930GPY07_RS15940GPY07_RS19435GPY07_RS15945
Location: 335266..335538 (273 bp)
Type: Others
Protein ID: WP_000246253.1
Location: 335535..336032 (498 bp)
Type: Others
Protein ID: WP_000982260.1
Location: 340238..341218 (981 bp)
Type: Others
Protein ID: WP_000019370.1
Location: 333928..334215 (288 bp)
Type: Others
Protein ID: WP_000426470.1
Location: 334367..335035 (669 bp)
Type: Others
Protein ID: WP_000043871.1
Location: 336234..336386 (153 bp)
Type: Others
Protein ID: WP_001884520.1
Location: 336708..337163 (456 bp)
Type: Others
Protein ID: WP_001245327.1
Location: 337291..337578 (288 bp)
Type: Others
Protein ID: WP_000221354.1
Location: 337568..337819 (252 bp)
Type: Others
Protein ID: WP_001250179.1
Location: 338033..338446 (414 bp)
Type: Others
Protein ID: WP_000049417.1
Location: 338521..338664 (144 bp)
Type: Others
Protein ID: WP_071908341.1
Location: 338634..339035 (402 bp)
Type: Toxin
Protein ID: WP_000351248.1
Location: 339035..339727 (693 bp)
Type: Antitoxin
Protein ID: WP_001047169.1
Location: 339864..340170 (307 bp)
Type: Others
Protein ID: Protein_310
Location: 341343..341498 (156 bp)
Type: Others
Protein ID: WP_000751734.1
Location: 341666..342100 (435 bp)
Type: Others
Protein ID: WP_000256036.1
Location: 342237..342551 (315 bp)
Type: Others
Protein ID: WP_000071008.1
Location: 342538..342870 (333 bp)
Type: Others
Protein ID: WP_000843587.1
Location: 343211..343438 (228 bp)
Type: Others
Protein ID: WP_001894457.1
Location: 343387..343500 (114 bp)
Type: Others
Protein ID: WP_001889158.1
Location: 343666..343947 (282 bp)
Type: Others
Protein ID: WP_001894453.1
Location: 343896..344010 (115 bp)
Type: Others
Protein ID: Protein_319
Location: 344067..344444 (378 bp)
Type: Others
Protein ID: WP_000411109.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
GPY07_RS15825333928..334215-288WP_000426470.1hypothetical protein-
GPY07_RS15830334367..335035-669WP_000043871.1hypothetical protein-
GPY07_RS15835335266..335538+273WP_000246253.1DUF1778 domain-containing protein-
GPY07_RS15840335535..336032+498WP_000982260.1GNAT family N-acetyltransferase-
GPY07_RS15850336234..336386-153WP_001884520.1DUF645 family protein-
GPY07_RS15855336708..337163-456WP_001245327.1GNAT family N-acetyltransferase-
GPY07_RS15860337291..337578-288WP_000221354.1type II toxin-antitoxin system RelE/ParE family toxin-
GPY07_RS15865337568..337819-252WP_001250179.1type II toxin-antitoxin system Phd/YefM family antitoxin-
GPY07_RS15870338033..338446-414WP_000049417.1VOC family protein-
GPY07_RS15875338521..338664-144WP_071908341.1DUF3265 domain-containing protein-
GPY07_RS15880338634..339035-402WP_000351248.1type II toxin-antitoxin system death-on-curing family toxinToxin
GPY07_RS15885339035..339727-693WP_001047169.1GNAT family N-acetyltransferaseAntitoxin
GPY07_RS15890339864..340170-307Protein_310CatB-related O-acetyltransferase-
GPY07_RS15895340238..341218+981WP_000019370.1IS5-like element ISVch5 family transposase-
GPY07_RS15900341343..341498-156WP_000751734.1hypothetical protein-
GPY07_RS15905341666..342100-435WP_000256036.1GNAT family N-acetyltransferase-
GPY07_RS15910342237..342551-315WP_000071008.1DNA-binding transcriptional regulator-
GPY07_RS15915342538..342870-333WP_000843587.1type II toxin-antitoxin system RelE/ParE family toxin-
GPY07_RS15925343211..343438-228WP_001894457.1DUF1289 domain-containing protein-
GPY07_RS15930343387..343500-114WP_001889158.1hypothetical protein-
GPY07_RS15940343666..343947-282WP_001894453.1DUF1289 domain-containing protein-
GPY07_RS19435343896..344010-115Protein_319acetyltransferase-
GPY07_RS15945344067..344444-378WP_000411109.1hypothetical protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideGenomic islandcatB9-322056..41902496968
insideIntegron--322432..41223689804
flankIS/Tn--340238..341218980


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Death on curing protein

(1-132)

Antitoxin

GNAT domain

(36-153)


Sequences

Toxin        


Download         Length: 134 a.a.        Molecular weight: 14608.71 Da        Isoelectric Point: 4.0128

>T145063 WP_000351248.1 NZ_CP046841:c339035-338634 [Vibrio cholerae]
MDIICFPFERVIEINAFILKTEPGMKGAVDIPKLQGALGRIDNAIVYEGLDDVFEIAAKYTACIAVSHALPDANKRTGLA
VALEYLSLNDFELTQENDLLADAVRDLVIGIINETDFADILYAQYAKEQNSAL

Download         Length: 402 bp

>T145063 NZ_CP062252:3758813-3759097 [Pseudomonas allokribbensis]
CTGCTGCTTGAATGGAGCGATCAAGCTCTGAACGATCTGGCTGACATTATTGATTACATTGAACAATACAACTCAAACGC
TTCAGTTGCTCTGCAACACAAGGTTGGTGCAGCAACGAAAAGGCTTTCATCAATCCCCTATGGTTACCGGTCCGGTCGAG
TGCCAAGCACTCGGGAAATGGTGATCAATCCAAACTATCTGCTGGTCTATCGGGTGAACGGGCGCATCAGAATACTGACG
TTAGTCCACACCCGACGACAATACCCACGGACCTCATCGCCATAA

Antitoxin


Download         Length: 231 a.a.        Molecular weight: 26352.73 Da        Isoelectric Point: 8.5633

>AT145063 WP_001047169.1 NZ_CP046841:c339727-339035 [Vibrio cholerae]
MNLEEFQESDFDLLIKWIDSDELNYLWGCPAYVFPLTYEQIHSHCSKAEVFPYLLKVKGRHAGFVELYKVTDEQYRICRV
FISNAYRGQGLSKSMLMLLIDKARLDFSATKLSLGVFEQNTVARKCYESLGFEVVMVVVIEFGGMRCQPLRRALCFLSRF
GAIIGLTFIDSRCDMNRKVEAYGVDAVERPKIKASKKLDLTGDAGRQIVKSETKLALRTHQKTFTKLADM

Download         Length: 693 bp

>AT145063 NZ_CP062252:3758629-3758823 [Pseudomonas allokribbensis]
ATGAGCATATTGCATTCCCCGTTTTACTCTGACTTCGAATCCGAAGAAGAGGCAGAGAGCTACGATCGCTGGTTTCGTGC
CAAGGTGCAGGAGGCACTCGATGACCCCAGCCCCGGCATTCCACATGATGAAGCTATGGCAATGCTCGACCAGATGCTGG
AAGAGATGCGCAGGAAGCGCCGCGCTGCTGCTTGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A0Q0PN34

Antitoxin

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Source
ID
Structure
No matching records found

References