Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | phd-doc/Doc-GNAT |
| Location | 338634..339727 | Replicon | chromosome |
| Accession | NZ_CP046841 | ||
| Organism | Vibrio cholerae strain F9993 | ||
Toxin (Protein)
| Gene name | doc | Uniprot ID | Q9KMA2 |
| Locus tag | GPY07_RS15880 | Protein ID | WP_000351248.1 |
| Coordinates | 338634..339035 (-) | Length | 134 a.a. |
Antitoxin (Protein)
| Gene name | phd | Uniprot ID | - |
| Locus tag | GPY07_RS15885 | Protein ID | WP_001047169.1 |
| Coordinates | 339035..339727 (-) | Length | 231 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| GPY07_RS15825 | 333928..334215 | - | 288 | WP_000426470.1 | hypothetical protein | - |
| GPY07_RS15830 | 334367..335035 | - | 669 | WP_000043871.1 | hypothetical protein | - |
| GPY07_RS15835 | 335266..335538 | + | 273 | WP_000246253.1 | DUF1778 domain-containing protein | - |
| GPY07_RS15840 | 335535..336032 | + | 498 | WP_000982260.1 | GNAT family N-acetyltransferase | - |
| GPY07_RS15850 | 336234..336386 | - | 153 | WP_001884520.1 | DUF645 family protein | - |
| GPY07_RS15855 | 336708..337163 | - | 456 | WP_001245327.1 | GNAT family N-acetyltransferase | - |
| GPY07_RS15860 | 337291..337578 | - | 288 | WP_000221354.1 | type II toxin-antitoxin system RelE/ParE family toxin | - |
| GPY07_RS15865 | 337568..337819 | - | 252 | WP_001250179.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | - |
| GPY07_RS15870 | 338033..338446 | - | 414 | WP_000049417.1 | VOC family protein | - |
| GPY07_RS15875 | 338521..338664 | - | 144 | WP_071908341.1 | DUF3265 domain-containing protein | - |
| GPY07_RS15880 | 338634..339035 | - | 402 | WP_000351248.1 | type II toxin-antitoxin system death-on-curing family toxin | Toxin |
| GPY07_RS15885 | 339035..339727 | - | 693 | WP_001047169.1 | GNAT family N-acetyltransferase | Antitoxin |
| GPY07_RS15890 | 339864..340170 | - | 307 | Protein_310 | CatB-related O-acetyltransferase | - |
| GPY07_RS15895 | 340238..341218 | + | 981 | WP_000019370.1 | IS5-like element ISVch5 family transposase | - |
| GPY07_RS15900 | 341343..341498 | - | 156 | WP_000751734.1 | hypothetical protein | - |
| GPY07_RS15905 | 341666..342100 | - | 435 | WP_000256036.1 | GNAT family N-acetyltransferase | - |
| GPY07_RS15910 | 342237..342551 | - | 315 | WP_000071008.1 | DNA-binding transcriptional regulator | - |
| GPY07_RS15915 | 342538..342870 | - | 333 | WP_000843587.1 | type II toxin-antitoxin system RelE/ParE family toxin | - |
| GPY07_RS15925 | 343211..343438 | - | 228 | WP_001894457.1 | DUF1289 domain-containing protein | - |
| GPY07_RS15930 | 343387..343500 | - | 114 | WP_001889158.1 | hypothetical protein | - |
| GPY07_RS15940 | 343666..343947 | - | 282 | WP_001894453.1 | DUF1289 domain-containing protein | - |
| GPY07_RS19435 | 343896..344010 | - | 115 | Protein_319 | acetyltransferase | - |
| GPY07_RS15945 | 344067..344444 | - | 378 | WP_000411109.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Genomic island | catB9 | - | 322056..419024 | 96968 | |
| inside | Integron | - | - | 322432..412236 | 89804 | ||
| flank | IS/Tn | - | - | 340238..341218 | 980 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 134 a.a. Molecular weight: 14608.71 Da Isoelectric Point: 4.0128
>T145063 WP_000351248.1 NZ_CP046841:c339035-338634 [Vibrio cholerae]
MDIICFPFERVIEINAFILKTEPGMKGAVDIPKLQGALGRIDNAIVYEGLDDVFEIAAKYTACIAVSHALPDANKRTGLA
VALEYLSLNDFELTQENDLLADAVRDLVIGIINETDFADILYAQYAKEQNSAL
MDIICFPFERVIEINAFILKTEPGMKGAVDIPKLQGALGRIDNAIVYEGLDDVFEIAAKYTACIAVSHALPDANKRTGLA
VALEYLSLNDFELTQENDLLADAVRDLVIGIINETDFADILYAQYAKEQNSAL
Download Length: 402 bp
>T145063 NZ_CP062252:3758813-3759097 [Pseudomonas allokribbensis]
CTGCTGCTTGAATGGAGCGATCAAGCTCTGAACGATCTGGCTGACATTATTGATTACATTGAACAATACAACTCAAACGC
TTCAGTTGCTCTGCAACACAAGGTTGGTGCAGCAACGAAAAGGCTTTCATCAATCCCCTATGGTTACCGGTCCGGTCGAG
TGCCAAGCACTCGGGAAATGGTGATCAATCCAAACTATCTGCTGGTCTATCGGGTGAACGGGCGCATCAGAATACTGACG
TTAGTCCACACCCGACGACAATACCCACGGACCTCATCGCCATAA
CTGCTGCTTGAATGGAGCGATCAAGCTCTGAACGATCTGGCTGACATTATTGATTACATTGAACAATACAACTCAAACGC
TTCAGTTGCTCTGCAACACAAGGTTGGTGCAGCAACGAAAAGGCTTTCATCAATCCCCTATGGTTACCGGTCCGGTCGAG
TGCCAAGCACTCGGGAAATGGTGATCAATCCAAACTATCTGCTGGTCTATCGGGTGAACGGGCGCATCAGAATACTGACG
TTAGTCCACACCCGACGACAATACCCACGGACCTCATCGCCATAA
Antitoxin
Download Length: 231 a.a. Molecular weight: 26352.73 Da Isoelectric Point: 8.5633
>AT145063 WP_001047169.1 NZ_CP046841:c339727-339035 [Vibrio cholerae]
MNLEEFQESDFDLLIKWIDSDELNYLWGCPAYVFPLTYEQIHSHCSKAEVFPYLLKVKGRHAGFVELYKVTDEQYRICRV
FISNAYRGQGLSKSMLMLLIDKARLDFSATKLSLGVFEQNTVARKCYESLGFEVVMVVVIEFGGMRCQPLRRALCFLSRF
GAIIGLTFIDSRCDMNRKVEAYGVDAVERPKIKASKKLDLTGDAGRQIVKSETKLALRTHQKTFTKLADM
MNLEEFQESDFDLLIKWIDSDELNYLWGCPAYVFPLTYEQIHSHCSKAEVFPYLLKVKGRHAGFVELYKVTDEQYRICRV
FISNAYRGQGLSKSMLMLLIDKARLDFSATKLSLGVFEQNTVARKCYESLGFEVVMVVVIEFGGMRCQPLRRALCFLSRF
GAIIGLTFIDSRCDMNRKVEAYGVDAVERPKIKASKKLDLTGDAGRQIVKSETKLALRTHQKTFTKLADM
Download Length: 693 bp
>AT145063 NZ_CP062252:3758629-3758823 [Pseudomonas allokribbensis]
ATGAGCATATTGCATTCCCCGTTTTACTCTGACTTCGAATCCGAAGAAGAGGCAGAGAGCTACGATCGCTGGTTTCGTGC
CAAGGTGCAGGAGGCACTCGATGACCCCAGCCCCGGCATTCCACATGATGAAGCTATGGCAATGCTCGACCAGATGCTGG
AAGAGATGCGCAGGAAGCGCCGCGCTGCTGCTTGA
ATGAGCATATTGCATTCCCCGTTTTACTCTGACTTCGAATCCGAAGAAGAGGCAGAGAGCTACGATCGCTGGTTTCGTGC
CAAGGTGCAGGAGGCACTCGATGACCCCAGCCCCGGCATTCCACATGATGAAGCTATGGCAATGCTCGACCAGATGCTGG
AAGAGATGCGCAGGAAGCGCCGCGCTGCTGCTTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|