23788

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 991679..992294 Replicon chromosome
Accession NC_012667
Organism Vibrio cholerae MJ-1236

Toxin (Protein)


Gene name higB Uniprot ID Q9KMG5
Locus tag VCD_RS19165 Protein ID WP_001162670.1
Coordinates 992007..992294 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag VCD_RS19160 Protein ID WP_001232701.1
Coordinates 991679..991996 (-) Length 106 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
VCD_RS19130 987088..987603 - 516 WP_001201528.1 lipocalin family protein -
VCD_RS19135 987740..988216 - 477 WP_001047180.1 GNAT family N-acetyltransferase -
VCD_RS20725 988244..988354 - 111 WP_071917832.1 DUF3265 domain-containing protein -
VCD_RS19140 988351..989280 - 930 WP_000335802.1 hypothetical protein -
VCD_RS19145 989400..989846 - 447 WP_000128977.1 hypothetical protein -
VCD_RS19150 989999..991003 - 1005 WP_000964925.1 LD-carboxypeptidase -
VCD_RS20895 991216..991254 - 39 WP_106019119.1 hypothetical protein -
VCD_RS20430 991270..991395 - 126 WP_001944767.1 DUF645 family protein -
VCD_RS21075 991572..991682 - 111 WP_134814058.1 DUF3265 domain-containing protein -
VCD_RS19160 991679..991996 - 318 WP_001232701.1 HigA family addiction module antidote protein Antitoxin
VCD_RS19165 992007..992294 - 288 WP_001162670.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
VCD_RS19170 992561..992741 - 181 Protein_892 DUF645 family protein -
VCD_RS20440 993166..993399 - 234 WP_032482776.1 DUF3709 domain-containing protein -
VCD_RS19175 993802..994020 - 219 WP_001917086.1 DUF3709 domain-containing protein -
VCD_RS19180 994330..994983 - 654 WP_000226874.1 hypothetical protein -
VCD_RS19185 995040..995549 - 510 WP_000405987.1 GNAT family N-acetyltransferase -
VCD_RS19190 995791..996033 + 243 WP_000557292.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
VCD_RS19195 996052..996369 + 318 WP_001180243.1 type II toxin-antitoxin system RelE/ParE family toxin -
VCD_RS21080 996563..996658 - 96 WP_001907607.1 DUF645 family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island catB9 - 932253..1057432 125179
inside Integron - - 958376..1050596 92220


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(2-95)

Antitoxin

Cro/C1-type helix-turn-helix domain

(12-69)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11349.95 Da        Isoelectric Point: 6.7187

>T23788 WP_001162670.1 NC_012667:c992294-992007 [Vibrio cholerae MJ-1236]
MALEFKDKWLEQFYEDDKRHRLIPSSIENALFRKLEILDAAQAESDLRIPPGNRFEHLEGNLKGWCSIRVNKQYRLIFQW
VDGVALNTYLDPHKY

Download         Length: 288 bp

>T23788 NC_012667:c992294-992007 [Vibrio cholerae MJ-1236]
ATGGCATTAGAATTTAAAGATAAGTGGTTAGAGCAGTTTTACGAGGATGATAAACGACATCGTTTAATTCCAAGTAGCAT
AGAGAATGCTCTATTTCGGAAGCTGGAAATCTTAGATGCAGCTCAAGCTGAATCAGACTTAAGAATTCCACCGGGTAATC
GTTTTGAACATCTTGAAGGAAATCTTAAAGGTTGGTGTTCAATTCGAGTGAACAAACAGTATCGTTTGATTTTTCAGTGG
GTTGATGGTGTTGCACTAAATACTTACTTAGACCCACATAAGTATTGA

Antitoxin


Download         Length: 106 a.a.        Molecular weight: 11705.63 Da        Isoelectric Point: 10.4711

>AT23788 WP_001232701.1 NC_012667:c991996-991679 [Vibrio cholerae MJ-1236]
MRKTKRRPVSVGEMLKVEFLEPMGITSKALAEAMGVHRNTVSNLINGGVLTAPVAIKLAAALGNTPEFWLNIQHAVDLWD
TRNRYQEEAKFVKPLFVSLEQSART

Download         Length: 318 bp

>AT23788 NC_012667:c991996-991679 [Vibrio cholerae MJ-1236]
ATGCGTAAGACAAAACGTCGTCCAGTTAGCGTTGGGGAAATGTTAAAAGTTGAATTTCTTGAACCAATGGGCATCACATC
AAAAGCGCTCGCTGAAGCGATGGGCGTACACAGAAATACGGTCAGTAATTTAATTAATGGTGGTGTGTTAACAGCTCCGG
TAGCAATCAAGTTAGCCGCGGCATTAGGTAACACACCAGAATTTTGGCTTAACATTCAACATGCAGTTGATCTTTGGGAT
ACGAGAAATCGTTATCAAGAAGAAGCAAAGTTTGTAAAGCCGTTGTTTGTTTCGCTGGAACAAAGCGCACGTACATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0F2HI36

Antitoxin

Source ID Structure

References